I know that the leaflet prescribed with betnovate and dovobet says it shouldn't be used on the face and doctors/dermatologists advise the same but I have the smallest red circle on the very end of my nose that only responds to betnovate or dovobet. I was given another cream to use on my face if I needed to but this cream does absolutely nothing. 

I recall someone on here mentioning in another topic that they have used dovobet on their face without problems and that is stronger than betnovate right? Do you think it would be a problem to apply a little bit of betnovate daily? Or even every other day? If I stop using betnovate for a couple of days the spot returns.

Again, the area on my nose is tiny, I don't even have to rub the cream in to cover the area. It's about the size of one of the dots on a small dice.

Hey all! I'm a 29 year old male that has had psoriasis since I was about 13. I have been on Raptiva when I was 18 (and it worked great, until it was pulled from the market), Otezla (It did not work on my P or my PsA), Humira (Worked wonders on my PsA, but did absolutely nothing for my P), and I just took my first loading dose of Cosentyx last week. I am hoping it works, as I'm tired of using topical steroids. Glad I found a forum with others with this awful, awful condition. Just wanted to say hi!

I've just signed up today as I feel I need to share this with all fellow sufferers. I've suffered for years, nails, feet, elbow, knees, bottom. I've used every potion known to no avail.  however I recently suffered extremely bad back pain and have had steriod in junctions to my facet joints...i am 2 weeks post injections and I do not have one patch on my body....true, honestly, have any doctors on this forum a reason behind this and why is it not being offered as a solution to the terrible creams and medication? ...  Has anyone else had the same injections with the same results?

Hello there fellow sufferers,
Thankyou very much for accepting me to this forum and I hope you can help me with some questions that I have regarding my current medication. 
I've suffered with guttate psoriasis for almost 20 years now but until the last couple of years it's been kept fairly under control with various emollients and topical steroid cream/ointments. It became much more severe and more widespread following my hysterectomy 2 years ago, though this could just be a coincidence, my consultant thinks it could be but is a bit noncommittal. In the past 9 months, I've had two courses of light therapy, the last one ending at the beginning of July, within a week, my psoriasis started appearing again so I immediately contacted dermatology, saw the consultant and was put on Acetretin 25mg daily. 
I've been taking it for almost 4 weeks now and disappointingly my condition seems so much worse, with terrible itching, burning and flaking skin, EVERYWHERE!! 
I hoped I might see an improvement by now, my consultant said I should. I was just wondering if anyone else could provide me with any advice or their experiences with this  drug.
I wait with eager anticipation.

Many thanks
Mandy x

Hello, I have had psoriasis for 26 years and had all the usual topical treatments , had 5 treatments of UVB and 1 of uva but took puva pain. Neotigison didn't work and methotrexate caused me liver problems. Now on Stelara and I am very hopeful it works. Had first injection on Friday and don't know if it's my imagination but my skin feels different. Happy to hear any other experiences

Recently diagnosed with psoriasis of buttocks. had seen family physician for rash and he diagnosed it as a fungal infection. After treating it for two week with very expensive anti fungal cream with no results, made an appointment with dermatologist. He diagnosed it as psoriasis and prescribed a steroidal cream which I could only use for two weeks. it was better but not gone. he then prescribed an antibiotic pill which I took for 10 days. That also helped but it didn't go away. I had about two weeks of releif and it came back. Now I am trying saturating it with apple cider vinegar using cotton balls and taking one tablespoon of apple cider vinegar with honey in a cup of hot water. Too soon to tell if this is going to work.

Hi very new to this. I have had psoriasis for 42 years and I'm having the worst flare up I've ever suffered all because of a viral sore throat and I'm 90% covered in guttate psoriasis feeling miserable to be fair

Been perscribed Dovobet by my dermatologist for my psoriasis. It has worked well on some patches but not so much on the biggest and most stubborn patch that I have on the side of my lower leg. Seems to have removed much of the background redness but there are like 4-5 small spots on a pinkish background. The spots are quite sensitive to touch like when you get a pimple.

I was perscribed the dovobet scalp application which my dermatologist and the leaflet says is fine to use on psoriasis elsewhere on the skin. Just wondering if it's worth getting it in ointment form or whether results will be exactly the same?

Finally, would it be worth looking in to trying Dovonex? I've seen the Dovonex V Dovobet comparison thread but was just wondering whether any one has had any experience with Dovobet not working too well but Dovonex improving their psoriasis?

Thank you.

Another newbie on the horizon for psoriatic arthritis. More study needed, but the future is looking towards these types of treatments.

Quote:

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Objective:
To evaluate the efficacy of clazakizumab, a monoclonal antibody with high affinity and specificity for the interleukin-6 (IL-6) cytokine, in psoriatic arthritis (PsA).

Methods:
In this randomized, double-blind, placebo-controlled, dose-ranging study (ClinicalTrials. gov identifier: NCT01490450), patients with active PsA and an inadequate response to nonsteroidal antiinflammatory drugs were randomized (1:1:1:1) to receive subcutaneous placebo or clazakizumab 25 mg, 100 mg, or 200 mg every 4 weeks, with or without methotrexate. The primary end point was the response rate according to the American College of Rheumatology 20% criteria for improvement (ACR20) at week 16, with secondary efficacy end points at weeks 16 and 24.

Results:
A total of 165 patients were randomized. At week 16, the ACR20 response rate was significantly higher with clazakizumab 100 mg versus placebo (52.4% versus 29.3%; P = 0.039). ACR20 response rates at week 16 were 46.3% with clazakizumab 25 mg (P = 0.101 versus placebo) and 39.0% with clazakizumab 200 mg (P = 0.178 versus placebo). ACR50/ACR70 response rates were numerically higher with clazakizumab versus placebo at weeks 16 and 24. Compared with placebo, clazakizumab treatment significantly improved musculoskeletal manifestations (joint signs and symptoms, enthesitis, and dactylitis), with minimal improvements in skin disease, without clear evidence of a dose response. Clazakizumab was well tolerated.

Conclusion:
This is the first clinical trial of an IL-6–targeted therapy in PsA. Clazakizumab may be an effective treatment option for musculoskeletal aspects of PsA, but because of the lack of a dose response in this study, further studies are required to confirm the appropriate dose. The safety profile is consistent with the pharmacology of IL-6 blockade and prior clinical experience with this antibody in rheumatoid arthritis.

Had these strange red patches come up on my leg about 5 days ago which I initially thought were insect bites. They don't itch at all but they don't seem to be disappearing. Is it psoriasis? No history of it in the family as far as I'm aware.






Thank you.

Howdy interested in what people are using as a moisturizer in the past i having been using a cream which is basically  oils and herbs , i have been using it for about 12 years now and when things get ultra itchy it calms things down . Side effects are stained clothes and strong smell so i only use it at home and mostly at night , hoping that some one might have something for every day use 
Cheers Wobbly

Hi everyone, I am a newbie to this group but have had psoriasis for most of my 57 years. For the past 20 years I have been treated very successfully with methotrexate - tablets mostly but weekly injection for the past 5 years. My dermatologist has told me to stop now though due to recurring sinusitis which has been so bad I needed surgery for it last month. I am using dovobet for now but he has given me literature on acitretin and suggested I start this in a few months. I am very nervous about using dovobet and reading the side effects of acitretin scares me too! 
I know I am getting on a bit and maybe shouldn't be so vain, but one of the side effects was hair loss or thinning and as if psoriasis isn't bad enough already losing my hair would be devastating. Any thoughts??

This study suggests MicroRNAs gene expression regulators are altered in psoriasis.

Quote:

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Background:
MicroRNAs (miRNAs) gene expression regulators are altered in psoriasis suggesting their role in the pathogenesis.

Objective:
To study expression changes of inflammation and toll-like receptor (TLR)-related miRNAs, miRNA-155, let-7i, miRNA-21, miRNA-146a and miRNA-223 in peripheral mononuclear cells (PBMCs) and miRNA-21, miRNA-146a and miRNA-223 in plasma, from chronic plaque-type psoriasis patients who were treatment-naive or had undergone a washout period (n = 11). MiRNAs were evaluated at baseline and after 11 (9–12) months [median (25th–75th percentile range)] of methotrexate (MTX) or topical (betamethasone plus calcipotriene) treatment.

Methods:
MiRNA expression was analysed with quantitative real-time reverse transcription–polymerase chain reaction. Matched controls were studied.

Results:
Psoriasis patients presented, at baseline, increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21 and miRNA-223 in PBMCs, plus miRNA-21, miRNA-146a and miRNA-223 in plasma. Receiver-operator characteristic (ROC) curve analysis and area under the curve (AUC) showed that expression of these miRNAs have the potential to distinguish between psoriasis and controls. At baseline, miRNA-155 expression in PBMCs correlated with Psoriasis Area Severity Index (PASI) [12 (8–14)] (Spearman r: 0.7140, P < 0.05) suggesting a role in psoriasis. After MTX or topical treatment, reduction in PASI was observed [87.5% (75–100)]; miRNA-155 expression in PBMCs decreased; plasma miRNA-21, miRNA-146a and miRNA-223 were down-regulated. ROC analysis showed that miRNA-155 expression in PBMCs from psoriasis patients have the potential to distinguish between patients' samples at baseline and after treatment (AUC: 0.942, sensitivity: 0.91; specificity: 0.91 values; maximum likelihood ratio =10). After treatment, miRNA-146a expression in PBMCs increased; miRNA-155/miRNA-146a ratio decreased, suggestive of a regulatory feedback; let-7i expression decreased; miRNA-21 and miRNA-223 remained elevated.

Conclusion:
In this exploratory study, psoriasis patients presented increased expression of miRNA-155 in PBMCs that correlated with PASI and decreased with disease remission. MiRNA-21, miRNA-146a and miRNA-223 in PBMCs and plasma were increased at baseline and differentially modulated, underscoring different roles of TLR-related miRNAs in psoriasis.

This study compared calcipotriol/betamethasone foam against the gel and suggests that the foam is better than the gel.

Quote:

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Background:
Fixed combination calcipotriol 50 μg/g (Cal) plus betamethasone 0.5 mg/g (BD) foam has been developed as a new treatment option for patients with psoriasis.

Methods:
The randomized, parallel-group, investigator-blinded Phase III, 12-week PSO-ABLE study compared the efficacy and safety of Cal/BD foam with Cal/BD gel. Patients aged ≥18 years with mild-to-severe psoriasis were randomized 4:4:1:1 to once-daily Cal/BD foam, Cal/BD gel, foam vehicle or gel vehicle (NCT02132936). The primary efficacy endpoint was the proportion of patients who were clear/almost clear with a ≥ 2 grade improvement according to the physician's global assessment of disease severity (i.e. treatment success) at week 4 for Cal/BD foam vs. week 8 for Cal/BD gel. Secondary efficacy endpoints included: proportion of patients achieving at least a 75% reduction in modified psoriasis area and severity index (mPASI75), and time to treatment success (TTTS). Safety was monitored throughout.

Results:
A total of 463 patients were randomized: Cal/BD foam (n = 185), Cal/BD gel (n = 188), foam vehicle (n = 47), gel vehicle (n = 43); overall completion rate was 90%. Cal/BD foam achieved higher treatment success rates (38% vs. 22%; P < 0.001) and mPASI75 (52% vs. 35%; P < 0.001) by week 4 than Cal/BD gel by week 8. Median TTTS with Cal/BD foam was 6 weeks; this could not be determined for Cal/BD gel as 50% treatment success was not achieved (P < 0.001). Adverse drug reactions were reported in 14 (7.6%) Cal/BD aerosol foam patients and 7 (3.7%) Cal/BD gel patients; all were single events except for itch with Cal/BD aerosol foam (n = 5; 2.7%) and worsening psoriasis with Cal/BD gel (n = 3; 1.6%).

Conclusion:
Cal/BD aerosol foam showed significantly greater efficacy after 4 weeks, than 8 weeks of treatment with Cal/BD gel, with similar tolerability.

Sorry to be indelicate, but I think my P has spread to my lady bits. I can be incredibly itchy, which then makes it sore, and it just becomes a vicious circle of scratch, itch, etc. am I safe in using my prescribed steroids (Dovobet and Elocon) or can someone recommend a more natural remedy? I currently suffer from palmar-plantar P but I also have it on my scalp and the odd spot here and there on my body. Thank you.

would like to say a big thanks for the support I have received n new friends I have met  I don't feel so alone anymore

Hi 
I have been taking 25mg a day now for 2 weeks , so far no side affects  . Have had blood test done and all is well ,Doctor says  will need to test blood weekly for about a month and then fortnightly , good thing i don't mind needles .I will update as we go along this journey . Hope every body at PC is well Cheers

if I ask my consultant to lower my dose from 25mg to 10mg will this help my hair loss or will I start breaking out again. not been this clear for 20yrs

hello to each of u..... i M 30 YO......please help me  i m fighting with psoriasis since last 3 months which suddenly appeared on my whole body & on medicine Methotrexzate & topical cream bees wax  but last week i changed my doctor  he diagonsis dat I have " ERYTHODERMA Psoriasis"    ...   plz  any any one knows about this  type of psoriasis &  how it cure from it??????

hello ive been on acetretin 25mg since april 2016. my psoriasis was very severe. I'm now clear but I'm losing my hair every day my lips and nose are really dry and sore. being a lady I don't want to go bald but I don't want to be that sore again I get so down. what do I do?