Psoriasis Club
  • Forum
  • Home
  • Portal
  • Member List
  • Psoriasis Score
  • PQOLS
  • What is psoriasis
  • Search
  • Help
Hello Guest, Welcome To The Psoriasis Club Forum. We are a self funded friendly group of people who understand.
Never be alone with psoriasis, come and join us. (Members see a lot more than you)
wave
Login Register
Login
Username:
Password:
Lost Password?
 
Psoriasis Club
Portal

What is Psoriasis Club ?
Psoriasis Club is a friendly on-line Forum where people with psoriasis or psoriatic arthritis can get together and share information, get the latest news, or just chill out with others who understand. It is totally self funded and we don't rely on drug manufacturers or donations. We are proactive against Spammers, Trolls, And Cyberbulying and offer a safe friendly atmosphere for our members.

So Who Joins Psoriasis Club? We have members who have had psoriasis for years and some that are newly diagnosed. Family and friends of those with psoriasis are also made welcome. You will find some using prescribed treatments and some using the natural approach. There are people who join but keep a low profile, there are people who just like to help others, and there are some who just like to escape in the Off Topic Section.

Joining Couldn't Be Easier: If you are a genuine person who would like to meet others who understand, just hit the Register button and follow the instructions. Members get more boards and privileges that are not available to guests.

OK So What Is Psoriasis?
Psoriasis is a chronic, autoimmune disease that appears on the skin. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis is not contagious. It commonly causes red, scaly patches to appear on the skin, although some patients have no dermatological symptoms. The scaly patches commonly caused by psoriasis, called psoriatic plaques, are areas of inflammation and excessive skin production. Skin rapidly accumulates at these sites which gives it a silvery-white appearance. Plaques frequently occur on the skin of the elbows and knees, but can affect any area including the scalp, palms of hands and soles of feet, and genitals. In contrast to eczema, psoriasis is more likely to be found on the outer side of the joint.

The disorder is a chronic recurring condition that varies in severity from minor localized patches to complete body coverage. Fingernails and toenails are frequently affected (psoriatic nail dystrophy) and can be seen as an isolated symptom. Psoriasis can also cause inflammation of the joints, which is known as (psoriatic arthritis). Ten to fifteen percent of people with psoriasis have psoriatic arthritis.

The cause of psoriasis is not fully understood, but it is believed to have a genetic component and local psoriatic changes can be triggered by an injury to the skin known as Koebner phenomenon. Various environmental factors have been suggested as aggravating to psoriasis including stress, withdrawal of systemic corticosteroid, excessive alcohol consumption, and smoking but few have shown statistical significance. There are many treatments available, but because of its chronic recurrent nature psoriasis is a challenge to treat. You can find more information Here!

Got It, So What's The Cure?
Wait Let me stop you there! I'm sorry but there is no cure. There are things that can help you cope with it but for a cure, you will not find one.

You will always be looking for one, and that is part of the problem with psoriasis There are people who know you will be desperate to find a cure, and they will tell you exactly what you want to hear in order to get your money. If there is a cure then a genuine person who has ever suffered with psoriasis would give you the information for free. Most so called cures are nothing more than a diet and lifestyle change or a very expensive moisturiser. Check out the threads in Natural Treatments first and save your money.

Great so now what? It's not all bad news, come and join others at Psoriasis Club and talk about it. The best help is from accepting it and talking with others who understand what you're going through. ask questions read through the threads on here and start claiming your life back. You should also get yourself an appointment with a dermatologist who will help you find something that can help you cope with it. What works for some may not work for others

  Dermatologist
Posted by: HenryB - Thu-14-05-2015, 21:02 PM - Replies (3)

Got an appointment to see my GP in two weeks' time. Want to ask her to refer me to a Dermatologist. The last time I asked that, I had to wait 6 months for an appointment. Is there any other way to get to see one quicker? I do not mind if I have to pay as I am getting desperate to find some relief.

Print this item

  Purchasing a sunbed
Posted by: HenryB - Thu-14-05-2015, 20:49 PM - Replies (13)

Hi,

Just wondering if getting a sunbed with the proper UVB lights will be worth it?
My work takes me away from home during the week. I am only home on weekends. Thus going for UVB light treatment after seeing a dermatologist is not an option for me.
Thought the idea of having one of these units in the house that I can use on the weekend would be great as I cannot overuse it if I had been home all the time.

Has anyone ever purchased a unit and the main question is, does/did it work?

Print this item

  Hello all
Posted by: HenryB - Thu-14-05-2015, 19:07 PM - Replies (11)

Hi there.

New to this forum thing but think this is the best thing since sliced bread.

I am 46 years old. Have been first diagnosed with Psoriasis in 1992. Back then I was living in South Africa - born there!. Over there the treatment was easy as I only had outbreaks on my scalp.
We moved to Scotland in 2009 and my psoriasis has really flared up since. I have been to the GP's to get the same treatment as I had in South Africa but they refused to give it to me as they said it was too strong to use regularly. Even went for UV light treatment at the local hospital a few years ago. Due to my nature of work it is very difficult for me to attend another UV light treatment.

Currently I am using Elocon cream, Diprosalic lotion and Etrivex shampoo to try and keep my psoriasis contained (probably not the right word but I am sure you'll understand.) I have to use these medications very sparingly which means they are not really effective. I only use it in abundance when it flares up on my face.

Oh, forgot to mention, at the moment my body is basically 80% covered in patches (scales). It's beginning to really affect me as I do not wear short sleeve shirts or shorts anymore. Even if we do manage to get some sun in Scotland  Cool  

My wife has urged me to join up and ask questions because I am a man and do not ask for directions. Just kidding  Big Grin . I do feel that I can find answers I am looking for in here as there are people out there that feel the same as I do.

Thanks

Print this item

  Coming off my meds!
Posted by: Luckystars182 - Thu-14-05-2015, 14:35 PM - Replies (6)

I'm having such a poop time at the moment!
So for the past 8 months I've been taking ciclosporin but after suffering with tonsillitis every month since starting the meds and many other infections they've decided it's time to come off them!
It's lovely it worked wonders and made me feel a little bit like a normal 27 year old I could wear shirts and pin my hair up cause it had all cleared.
Now I'm excited to be coming off the tablets cause hopefully i shouldn't be so poorly but since being weaned off the tablets my scalp has flared up so much and little patches are coming back so I'm scared a nervous about the flare up! Got 2 months before I see the dermatologist again to discuss what's next! It's just so obey ointment again and Canada's shampoo again! He knows it never works on me but still insists on me using it.
Anyone know what might be the dermatologists next move or will I just be back to my flaky nasty sore self?

Print this item

News Increased risk of Kidney disease in psoriasis patients.
Posted by: Fred - Thu-14-05-2015, 13:15 PM - No Replies

This study looked at the association between glomerulonephritis (GN) and chronic kidney disease (CKD) in patients with psoriasis.

Quote:
Background:
Few studies have examined the association between psoriasis and glomerulonephritis (GN) as well as chronic kidney disease (CKD).

Objectives:
To determine the risk of CKD in patients with psoriasis and evaluate the impact of the severity of psoriasis, comorbidities and concomitant drugs on the risk of GN and CKD in patients with psoriasis.

Methods:
We identified 4344 patients with psoriasis for the study cohort and randomly selected 13 032 subjects as a control cohort. Each subject was individually followed for up for 5 years to identify those who subsequently developed GN and CKD.

Results:
After adjustment for traditional CKD risk factors, psoriasis was found to be independently associated with an increased risk of CKD during the follow-up period [hazard ratio (HR) 1·28; 95% confidence interval (CI) 1·14–1·44]. The increased incidence of GN in patients with psoriasis (HR 1·50, 95% CI 1·24–1·81) may contribute to the positive association between psoriasis and CKD. Patients with mild and severe psoriasis had an increased risk of CKD and GN compared with the control cohort; the risk increased with severity. Patients with psoriasis and arthritis exhibited a higher risk of CKD than patients without arthritis (HR 1·62 vs. 1·26). Among drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) have the strongest association with CKD in patients with psoriasis (adjusted odds ratio 1·69, 95% CI 1·14–2·49).

Conclusions:
Psoriasis was associated with a higher risk of developing CKD and GN. High severity, psoriatic arthritis involvement and concomitant NSAIDs use further increased the risk of CKD in patients with psoriasis.

Source: onlinelibrary.wiley.com

*Funding: National Taiwan University Hospital Hsin-Chu Branch.

Print this item

Information rotavirus on stelara?
Posted by: bzybee - Wed-13-05-2015, 10:23 AM - Replies (8)

Hi everyone, I have a question if ye wouldn't mind helpin me out.
Started stelara 3 weeks ago and doing brilliant on it with very few side effects. I have caught the rotavirus from my kiddies who have been sick for a week. Will this take longer to clear up with me because I'm on Stelara? Is this something I need to contact my dermatologist about?
Thanks for any info

Print this item

News Stelara for psoriasis patients undergoing hemodialysis
Posted by: Fred - Wed-13-05-2015, 09:24 AM - No Replies

This Japanese study of three people with psoriasis undergoing hemodialysis, looked at the use of Stelara (Ustekinumab)

Quote:
Patients with psoriasis undergoing hemodialysis have additional difficulties in treatment compared with general patients. Conventional treatments such as cyclosporin, retinoids and methotrexate are not widely administrated due to the chances of an increase in adverse effects and the possibility of risk to patient survival.

Recently, biologic treatments have been recognized as having sufficient efficacy for severe psoriasis with low incidence of organ toxicities. For this reason, biologic treatments may be more preferable for patients on hemodialysis; however, there is not sufficient evidence.

We have treated three patients with psoriasis with ustekinumab for 1 year, who had been undergoing hemodialysis. They were previously treated with conventional treatments before ustekinumab treatments; however, they did not respond to these treatments sufficiently.

Following treatment with ustekinumab, rapid and maintained improvement in psoriasis was observed. Over the course of treatments, two of the three patients encountered no adverse events during their first year of treatment. The other patient discontinued ustekinumab due to elevated levels of C-reactive protein.

These findings suggest that ustekinumab may be an appropriate treatment for patients undergoing hemodialysis who are suffering from psoriasis. However, the risk of developing infection remains higher than in general patients.

Source: ncbi.nlm.nih.gov

*Article ahead of publication.
Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
2Department of Dermatology, Nippon Medical School, Tokyo, Japan.


More about Stelara (ustekinumab)

Print this item

News Effects of ultraviolet (UV)B on Haptoglobin in psoriasis.
Posted by: Fred - Mon-11-05-2015, 22:09 PM - No Replies

This study ahead of publication set out to investigate the effects of ultraviolet (UV)B on Haptoglobin (Hp) and to clarify the role of Hp in psoriasis.

Quote:
Background:
Haptoglobin (Hp) is one of the acute phase proteins, whose main function is to bind free haemoglobin (Hb) and transport it to the liver for degradation and iron recycling. In addition to its role as an Hb scavenger, Hp has been shown to behave as an anti-inflammatory, antioxidant and angiogenic factor. We previously investigated the role of Hp in the pathogenesis of psoriasis, and found that it displays some structural modifications that might be associated with protein function in the disease. Phototherapy is an efficacious treatment for psoriasis, although the biological mechanisms by which phototherapy improves psoriasis are still unclear.

Aim:
To investigate the effects of ultraviolet (UV)B on Hp to clarify the role of Hp in psoriasis.

Methods:
Expression of the genes encoding Hp, interleukin (IL)-6 and IL-10 was assessed in UVB-irradiated and unirradiated HaCaT cells. The biological significance of Hp modulation of UVB treatment was confirmed by ELISA and Western blotting. The Hp gene and protein expression in the skin of patients with psoriasis was also investigated.

Results:
In vitro results showed that UVB modulated IL-6 and IL-10 gene expression and Hp gene and protein expression in HaCaT cells. The in vivo data also showed that Hp levels were increased in the skin of patients with psoriasis compared with healthy controls.

Conclusions:
UVB irradiation was able to modulate Hp production in immortalized keratinocytes. The higher levels of Hp in vivo in both lesional and nonlesional skin suggest that it might have a role in the pathogenesis of the disease.

Source: onlinelibrary.wiley.com

*Early view before publication, no funding known.

Print this item

News Bone mineral density and VitD3 in patients with psoriasis and/or psoriatic arthritis
Posted by: Fred - Mon-11-05-2015, 21:59 PM - Replies (11)

This study ahead of publication looked into correlations between vitamin D status and bone mineral density (BMD) in patients with psoriasis and/or psoriatic arthritis.

Quote:
Limited data are available on the vitamin D3 status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis.

Our study intended to explore possible correlations between vitamin D status and BMD, as well as among these parameters and the features of the underlying disorder.

Seventy-two patients with psoriasis/or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 ± 11.6 years; mean duration of follow up, 142.7 ± 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlying disease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25(OH)D3 levels of the patients, and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters.

The proportion of patients with a low BMD value did not exceed that seen in the general population. We found an inverse correlation between the serum level of vitamin 25(OH)D3 and body mass index, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D3 status. In patients with psoriatic arthritis, BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only.

Our findings suggest the importance of evaluating the vitamin D3 status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosis D3 in provoking the development of skin lesions and joint symptoms.

Source: onlinelibrary.wiley.com

*This is an early view before publication.
Funded by: Hungarian Research Grants.

Print this item

News Bone changes in psoriatic arthritis and psoriasis patients.
Posted by: Fred - Mon-11-05-2015, 21:48 PM - No Replies

This is an abstract ahead of publication that set out to evaluate bone microstructure and volumetric BMD (vBMD) in patients with psoriatic arthritis and psoriasis.

Quote:
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by periarticular bone loss and new bone formation. Current data regarding systemic bone loss and bone mineral density (BMD) in PsA are conflicting.

The aim of this study was to evaluate bone microstructure and volumetric BMD (vBMD) in patients with PsA and psoriasis.

We performed HR-pQCT scans at the ultradistal and periarticular radius in 50 PsA patients, 30 psoriasis patients, and 70 healthy, age- and sex-related controls assessing trabecular bone volume (BV/TV), trabecular number (Tb.N), inhomogeneity of the trabecular network, cortical thickness (Ct.Th), and cortical porosity (Ct.Po), as well as vBMD. Trabecular BMD (Tb.BMD, p = 0.021, 12.0%), BV/TV (p = 0.020, –11.9%), and Tb.N (p = 0.035, 7.1%) were significantly decreased at the ultradistal radius and the periarticular radius in PsA patients compared to controls. In contrast, bone architecture of the ultradistal radius and periarticular radius was similar in patients with psoriasis and healthy controls. Duration of skin disease was associated with low BV/TV and Tb.N in patients with PsA.

These data suggest that trabecular BMD and bone microstructure are decreased in PsA patients. The observation that duration of skin disease determines bone loss in PsA supports the concept of subclinical musculoskeletal disease in psoriasis patients. © 2015 American Society for Bone and Mineral Research.

Source: onlinelibrary.wiley.com

*This is an early view before publication, no funding known.

Print this item

News Psoriasis Study says higher risk of non alcoholic fatty liver disease.
Posted by: Fred - Mon-11-05-2015, 21:38 PM - Replies (1)

This small study investigated the prevalence of non alcoholic fatty liver disease (NAFLD) in a population of Iranian patients with psoriasis, it concludes the same as other studies that we should all modify our lifestyle, give up smoking and loose some weight.

Quote:
Background:

Psoriasis is a chronic, immune-mediated inflammatory skin disease with many extracutaneous manifestations. Several recent studies have indicated an increased prevalence of nonalcoholic fatty liver disease (NAFLD) among patients with psoriasis. In the present study, we investigated the prevalence of NAFLD in a population of Iranian patients with psoriasis.

Methods:
NAFLD was assessed and graded using ultrasonography in 123 patients with psoriasis and 123 healthy controls (HCs) matched by age, sex and body mass index (BMI).

Results:
The prevalence of NAFLD was significantly higher in the psoriatic group compared with the HC group (65.6% vs. 35%, P < 0.01, OR = 3.53). Median NAFLD grade was significantly greater in patients with psoriasis compared with HCs (grade 2 vs. grade 1, P < 0.01). In patients with psoriasis, NAFLD was associated with a higher frequency of hypertension (16.5%), abnormal liver function test (LFT) results (16.4%) and metabolic syndrome (46.6%). Moreover, patients with psoriasis and NAFLD tended to have significantly higher values for BMI, waist circumference (WC), Psoriasis Activity and Severity Index (PASI), and levels of serum triglyceride, cholesterol, low-density lipoprotein and fasting blood sugar (FBS). Multivariate logistic regression revealed that WC, PASI, LFT abnormalities, hypertension and cigarette smoking were independent predictors of NAFLD grade.

Conclusions:
Our findings warrant a detailed assessment of metabolic comorbidities including NAFLD in patients with a primary diagnosis of psoriasis. Lifestyle modifications, including weight loss and smoking cessation, may be necessary for patients with psoriasis to decrease the risk and severity of NAFLD.

Source: onlinelibrary.wiley.com

*Funding: Tehran University of Medical Sciences

Print this item

  A wee suggestion.
Posted by: bav101 - Fri-08-05-2015, 22:42 PM - Replies (17)

hey guys!  Wave

Not sure if this has been suggested before but I found a mod that will allow users to tag people on the forum and they are sent a PM and told about it so they can go into the thread where they are mentioned.

(not sure if this works with 1.8 but i think its possible to configure it to do so.)

Yesterday / earlier when i was mentioned in the compliment's thread I had no idea until I went through and checked unread posts, this would definitely speed up gaining people attention imo.

Print this item

Smile the end of ciclosporin....the beginning of fumaderm
Posted by: MaDbEaR - Fri-08-05-2015, 10:19 AM - Replies (50)

Hi everyone,

I finally got my fumaderm initial tablets yesterday, I took my first tablet last night half way through my dinner, followed by a yoghurt (after reading lots of your advice) I'm on 1 tablet for a week, then going to two a day for a week, then up to 3 a day for a week, by which time I will be going back to see my derm. I felt quite sick last night, but not so bad this morning. Not suffered any stomach cramps yet, but I do keep going rather warm! I have another week or so on 100mg of ciclosporin, then dropping down to 50mg for two weeks before coming off them altogether. Hopefully there won't be any interaction between the two, as it will be bad enough suffering side effects from both for a week!

MaDbEaR
Xx

Print this item

  question about applying prescription ointment on arms and other areas
Posted by: goofyshoes - Fri-08-05-2015, 01:36 AM - Replies (6)

hi just a simple question.i have a prescription ointment from my doctor that im suppose to apply to twice a day (salacytic acid and fluocin) .my question is do i rub in to apply? or do i apply it and let it stay on? then on the 2nd time do i wipe the original ointment off?or just overlay another application?thank you for any help

Print this item

  What's it like having psoriasis?
Posted by: Fred - Thu-07-05-2015, 21:00 PM - Replies (34)

I have been asked many times by friends and family "What's it like having psoriasis" I always say it is difficult to explain, I usually say you will never understand. A bit like a Man can never understand what it feels like for a Woman to have premenstrual syndrome, and a Woman can never understand how it feels for a Man to get a whack in the testicles.

Sometimes however I do try to get it across, and I was wondering how other members would explain What it's like having psoriasis?

I would say first off when you find out you have psoriasis, it's not so much of a big deal as you are given some cream to slap on and it will go away. That by the way is absolute bull**** as you soon find out once you get it it's you buddy for the rest of your life.

You constantly search for a cure, you listen to advise from your family and friends, you spend a fortune on fake scams or expensive simple moisturises, you believe it will go away one day. But as much as you appreciate your friends and family trying to help, one day you realise it's not going to go away.

That's when the fun starts as you suddenly become aware that others are always looking at you, you also start to feel like a leper, you start to get self conscious over your appearance, you start to get depression. You know the genuine members of your family and friends are trying to help, but sometimes you just wish they would leave you alone to have a damn good cry.  Sad

After a few years you realise there is no cure and you're stuck with it, you are that leper that no one wants to know, you are that person that everyone looks at, you still get friends and family saying "Have you seen in this magazine how this person got cured" Grrrrrrrrrrrrrrrrrrrrrrrrrr Leave me alone.

Your life is completely changed, you are constantly checking for psoriasis on your clothes or in your hair. You don't want to visit other peoples houses as you will feel so embarrassed if you notice even a tiny bit of psoriasis on their sofa, and as much as you try with all those greasy creams you just can't hide the psoriasis on your face or your cracked and bleeding hands.

It goes on and on and on, your friends and family will keep telling you to try this or try that. Your doctor will keep throwing creams at you and telling you to come back if it's not clear in a few months. Grrrrrrrrrrrrrrrrrrrrrrrrrrrrrrr It Won't Fooking well clear  Angry

Then one day you are covered in the stuff, there are flakes as big as large coins, you are pulling out clumps of hair, you are leaking sebum or in some cases blood from those horrendous sores all over your body. You itch like hell and then you start to see how big a scale you can get off in one piece, it becomes an addiction to just keep picking at those scales to see if you can better your last one.

One day you notice you are starting to get more and more tired and you just feel like crying yourself to sleep, you may even get to the stage of thinking enough is enough and you just can't cope any more. And still your friends and family (if you have any left) say "Why don't you try this" Grrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrr

You want me to explain what it's like having psoriasis? Go and rip the top layer your skin off and rub stinging nettles all over the raw flesh, and just for good measure rub in a good dose of Salt and Sand. Wait don't go away were not done yet, you now need to go walking down the street with everyone pointing at you, you also have to stop going out as you feel to embarrassed by your appearance, you also have to keep going to your Doctor who will give you even more greasy cream or if your lucky enough you may get something like a modern treatment (No change of plan keep trying the cream or a bit of sitting under a light) then one day you get slight relief but it comes back again, you are sore you look like a leper, your confidence has by now completely gone out the window.

Hell I can't explain what it's like having psoriasis, and don't even get me going on psoriatic arthritis (I would rather be covered in flakes of dead skin as opposed to not being able to move) But I can tell you this, be very very careful of what you think of people with psoriasis, as It Could Be You Next.  Tongue

To sum up: It's painful, annoying, embarrassing, and will change your life for ever.

Maybe other members will post their answer to "What's it Like Having Psoriasis"

Print this item

News Further studies required for psychiatric & quality of sleep in psoriasis patients
Posted by: Fred - Wed-06-05-2015, 21:02 PM - Replies (8)

This little study looked at General psychiatric symptoms, quality of sleep, and coping strategies in patients with psoriasis, and concluded that further experimental studies were required to explain the findings.

Quote:
Background:
Psoriasis is a common dermatological disorder with psychiatric comorbidity. Psoriasis is associated with a variety of psychological problems, including poor self-esteem, sexual dysfunction, sleep disturbances, anxiety, depression, and suicidal ideation.

Objectives:
We aimed to investigate general psychiatric symptoms, quality of sleep, and coping strategies in patients with psoriasis vulgaris.

Methods:
A total of 79 subjects (37 patients with psoriasis vulgaris and 42 control subjects) were enrolled in the study. Coping strategies were measured using the Coping Orientations to Problems Experienced (COPE) Scale. General psychopathological status was assessed using the Symptom Checklist-90-R (SCL90R), and sleep quality and disturbances were assessed using the Pittsburgh Sleep Quality Index (PSQI).

Results:
The mean age of the patients was 39.18 ± 16.85 years. The mean age of control subjects was 39.33 ± 11.61 years. The mean score on the Psoriasis Area and Severity Index (PASI) was 7.56 ± 3.66. There were no significant differences in scores on the SCL90R and COPE subscales between the patient and control groups. However, significant differences between the groups emerged on the PSQI subscales for subjective sleep quality and habitual sleep efficiency (Z = −1.964, P = 0.049, and Z = −2.452, P = 0.014, respectively).

Conclusions:
The present study found no significant differences in general psychiatric symptoms and coping strategies between the psoriasis patients and the control group, by contrast with findings reported elsewhere in the literature. We think that the low PASI scores of our patients, which indicate the low severity of disease in the present group, is the main reason for this finding. However, sleep quality is lower in psoriasis vulgaris patients than in healthy controls. This may be associated with the itch and pain caused by lesions. Further experimental studies are required to explain these findings.

Source: NO LINKS ALLOWED

*International Journal of Dermatology, no funding disclosed

Print this item

  Psoriatic Arthritis in the lumber region
Posted by: Grizzly Bear - Wed-06-05-2015, 20:03 PM - Replies (26)

A question to anyone whom may know please......

I have read somewhere that you can get Psoriatic Arthritis in the lower part of your spine, lumber region.

How do doctors know that you have PA in the lumber please or anywhere ?

What tests do they do if anyone knows please ?

I ask as i had my coccyx, lower area of my spine removed 11 years ago.
Now, before they were removed, i had no P at all on my back, totally clear but 4 - 6 months after the operation, tiny P spots appeared on my lower back & in time, the P covered my lower back area, spreading upwards & also attacking the 8 inch scar down there if you know what i mean.

Now, with all the pain killing medication etc i take, my back kills me.
I noticed that over the last couple of years, my walking / hobbling is getting worse.
It's bad enough trying to sleep with the pain but i read somewhere that you can get PA anywhere on your body but with the amount of P on my lower back, it made me question if it was possible if i had it ?
I bloody hope i don't have it.

Does a doctor take blood tests etc ?

Thank you all

GB

Print this item

News Rogne Bioscience will present Topical Biologic for psoriasis at SID meeting
Posted by: Fred - Tue-05-05-2015, 19:41 PM - Replies (2)

Here's a new one for people with Psoriasis, Rogne Bioscience are developing a Topical Biologic for the treatment of psoriasis and will present data at the Society of Investigative Dermatology (SID) Annual Meeting being held May 6-9, 2015 at the Hilton Atlanta, in Atlanta, Georgia.

Quote:
Rogne Bioscience, a privately-held biotechnology company developing a topical biologic for psoriasis, today announced that preclinical and mechanism of action data will be presented during a poster session at the Society of Investigative Dermatology (SID) Annual Meeting being held May 6-9, 2015 at the Hilton Atlanta, in Atlanta, Georgia.

Rogne is advancing the development of RON2315, a novel, low MW (<1700 daltons) peptide as a topical treatment for psoriasis. The peptide demonstrates highly potent anti-inflammatory activity in vitro, and when applied topically to an IL-23 dependent model of dermal inflammation, RON2315 inhibits inflammation in a dose-dependent manner. Cellular and biochemical studies in human dendritic cells show that RON2315 acts by regulating the activity of NFKB-p65, thereby inhibiting the secretion of IL-23. Dendritic cells have been shown to be the primary dermal source of IL-23 driving the psoriatic disease process.

"These data highlight a novel anti-inflammatory mechanism that we believe will be a safe, topical treatment with biologic efficacy for hyper-immune diseases such as psoriasis," said Karl Beutner, CMO. "With the demonstration that we can easily deliver the peptide into the skin and the completion of our safety/toxicology studies, our development program is progressing rapidly. We expect to have clinical proof-of-concept data in Q3 of 2015," said Lena Wu, Ph.D. CEO.

The schedule for Rogne's poster presentation is as follows:

Presentation Title: RON2315: A novel human biologic for the topical treatment of psoriasis
Location: Galleria Exhibit Hall
Poster number: 001
Date and Time: Poster Session I, Thursday, May 7, 2015, 10:00 am – 12:00 pm

Source: prnewswire.com

Print this item

Smile Hi everyone
Posted by: MaDbEaR - Tue-05-05-2015, 13:13 PM - Replies (20)

Hi guys,

I've had P since I was 15, and I've just turned 30. I'm currently on ciclosporin but my dose is being lowered and I'm being switched on to fumaderm after being told by my dentist that I needed to stop the ciclo. I've been on methotrexate, but that turned me into a grumpy lazy sod, and being a single mum I couldn't carry on like that! I've had 3 lots of light treatment, had a couple of years clear after my first lot but second and third attempts just resulted in quite bad burns so no more of that. I try and avoid steroid creams as I had severe eczema as a kid so went through a lot of them and as a result I seem to have become resistant to them.

My son is great and helps me put my hydromol on if I've had a bad skin day. He has seen me suffer so much with my skin and I'm looking forward to the day my legs are clear so I can take him swimming. I haven't been swimming with him for 5 years, he is only 5 1/2!!
My skin is under control at the minute, but I am feeling a bit apprehensive about going onto fumaderm. Ciclo worked for me in the beginning, then I had a "controlled flare" (only the bits that were already there got worse and one or two bits came back) over winter so the derm upped my dose and I was seeing results less than a week after going up to 175mg then my dentist advised that my gums were getting really bad and I should come off them. I'm hoping that my tablets turn up soon so that I can start them before I worry too much more and cause a stress flare up!!

Print this item

  Getting better thru my Diet.
Posted by: JimO - Fri-01-05-2015, 20:36 PM - Replies (17)

Been a rough road trying to figure out what was causing my condition. I'm not even going to compare the little I have on my hands and feet with others I've read about, so I guess I'm blessed not to have it too badly. But it's bad enough when every time I do anything with my hands it hurts from all the cracks. Couldn't play my guitars even which really bites.

Anyway got to looking around for treatments. Dummy me was starting to believe all the ads for drugs on TV. I made an appointment with the Doc to see about it when I got curious and looked up the price for Stellara. $8000 a shot! Another was like $3500. Hoky Smokes. And then you get the side effects.

In the meantime I was talking to my sister in law who helped me in the beginning and she said she's nearly beat it with just the cream. Don't skip it or it will bite you. So I doubled down and started to see some improvement. Canceled my appointment as I wasn't interested in the drugs. And started reading everything online to try to find a cure.

Well I saw some books on Amazon. One I was able to read 60 pages by Dr. Pagano concerning diet. Made sense as I have done the Atkins diet with success a few years ago and still try to eat halfway healthy. No soda or sweet tea. No McDonald's or junk like that. So I ordered a couple of books and they both said the same thing concerning what foods to avoid and how to treat it. They may be on to something.

So I have been trying to follow this diet and I'm seeing results. Eating all kinds of rabbit food and avoiding the nightshades. Adventuring with new ways to cook fish and chicken and hunting down healthy foods (which in this one horse town can be a challenge). Been trying new ways to cook rice as well. And lots of fruit, my desert when my wife and daughter pull out the chocolate, or cheesecake, or icecream.... LOL!

I'm also taking Fish Oil twice a day, along with Vit D3, calcium, B's and a multivitamin. And drinking lots of water.

Also my wife and I have her parents under our roof. He's Italian and says it at least 50 time a day like it's a miracle or some BS. Everything revolves around food with those two, especially spaghetti. It's like it's a sacred friggin cow. So you can imagine the crap I'm dealing with when I proclaim I can't eat their spaghetti this Sunday when everyone is over for dinner. I finally got him to lay off when I showed what progress I'm having following this diet. Also nothing like fixing two meals for dinner too. Since I work 12 hour days I've been eating dinner at work so I don't have to put up with it.

Well anyway my hands are smoothing out and it's ben a few weeks since I've had a crack in my fingers. Been able to start playing again, especially since I finished my latest guitar. I'm bound and determined to get over this. I'm going to order the Slippery Elm Capsules and Saffron Tea next to really get over this.

I also made a believer of myself. I cheated as I was working a bunch of overtime and came home tired. Wife had pizza in the oven and I didn't want to fix anything. The next night she talked me into fixing a Mexican feast. The next day my hands and feet broke out. Showed her and she's a whole lot more willing to go along with what I'm doing now.

Print this item

 
Last 50 Threads With New Posts
Uzpruvo
Forum: Prescribed Treatments For Psoriasis
Last Post: D Foster
Today, 09:34 AM
» Replies: 16
» Views: 888
Knee pain and psoriatic a...
Forum: Psoriasis In The News
Last Post: Fred
Thu-09-10-2025, 10:08 AM
» Replies: 2
» Views: 279
Bimzelx for psoriatic art...
Forum: Prescribed Treatments For Psoriasis
Last Post: Fred
Sun-28-09-2025, 13:20 PM
» Replies: 253
» Views: 151,547
Psoriasis to psoriatic ar...
Forum: Psoriasis In The News
Last Post: Caroline
Wed-17-09-2025, 20:43 PM
» Replies: 1
» Views: 575
Lifestyle related serum m...
Forum: Psoriasis In The News
Last Post: Caroline
Wed-17-09-2025, 20:32 PM
» Replies: 1
» Views: 500
Analysis of anxiety and p...
Forum: Psoriasis In The News
Last Post: Caroline
Sat-13-09-2025, 19:25 PM
» Replies: 8
» Views: 1,580
Potential of fibroblast s...
Forum: Psoriasis In The News
Last Post: Caroline
Fri-12-09-2025, 07:04 AM
» Replies: 1
» Views: 641
Ilumetri / Ilumya in psor...
Forum: Psoriasis In The News
Last Post: Fred
Thu-11-09-2025, 15:57 PM
» Replies: 0
» Views: 418
Hello Pyzchiva (from Stel...
Forum: Prescribed Treatments For Psoriasis
Last Post: Fred
Wed-10-09-2025, 13:08 PM
» Replies: 6
» Views: 884
Stelara - On Way!
Forum: Prescribed Treatments For Psoriasis
Last Post: Angie
Mon-08-09-2025, 11:16 AM
» Replies: 216
» Views: 223,079
WHO updates list of essen...
Forum: Psoriasis In The News
Last Post: Fred
Sat-06-09-2025, 13:20 PM
» Replies: 0
» Views: 537
Scientists grow living sk...
Forum: Psoriasis In The News
Last Post: Caroline
Sun-31-08-2025, 18:32 PM
» Replies: 3
» Views: 963
Nail involvement in psori...
Forum: Psoriasis In The News
Last Post: Fred
Sun-31-08-2025, 09:35 AM
» Replies: 2
» Views: 1,209
UK age checks
Forum: Announcements
Last Post: Fred
Mon-25-08-2025, 12:19 PM
» Replies: 10
» Views: 1,416
Switching bio's for psori...
Forum: Psoriasis In The News
Last Post: Caroline
Fri-22-08-2025, 06:02 AM
» Replies: 3
» Views: 1,657
Tremfya goes for psoriati...
Forum: Psoriasis In The News
Last Post: Fred
Thu-21-08-2025, 16:19 PM
» Replies: 2
» Views: 972
Bath-Psoralen & Ultraviol...
Forum: Psoriasis In The News
Last Post: Fred
Sat-16-08-2025, 10:51 AM
» Replies: 4
» Views: 1,123
Psoriasis treated with di...
Forum: Psoriasis In The News
Last Post: mataribot
Wed-13-08-2025, 05:42 AM
» Replies: 4
» Views: 1,080
Icotrokinra seeks approva...
Forum: Psoriasis In The News
Last Post: Fred
Fri-25-07-2025, 11:30 AM
» Replies: 2
» Views: 1,216
Sotyktu accepted for revi...
Forum: Psoriasis In The News
Last Post: Fred
Tue-22-07-2025, 11:41 AM
» Replies: 0
» Views: 949
Ilumya / Ilumetri phase 3...
Forum: Psoriasis In The News
Last Post: Fred
Tue-22-07-2025, 11:24 AM
» Replies: 0
» Views: 849
ORKA-001 for psoriasis ph...
Forum: Psoriasis In The News
Last Post: Fred
Mon-21-07-2025, 12:35 PM
» Replies: 0
» Views: 857
Possible new psoriasis tr...
Forum: Psoriasis In The News
Last Post: mataribot
Mon-21-07-2025, 03:58 AM
» Replies: 3
» Views: 1,290
Psoriasis itching and ele...
Forum: Psoriasis In The News
Last Post: Fred
Sat-19-07-2025, 12:55 PM
» Replies: 0
» Views: 805
Psoriasis and cardiovascu...
Forum: Psoriasis In The News
Last Post: Fred
Sat-19-07-2025, 12:41 PM
» Replies: 0
» Views: 710
Psoriasis and bacterial i...
Forum: Psoriasis In The News
Last Post: Turnedlight
Fri-18-07-2025, 09:49 AM
» Replies: 2
» Views: 930
Spyre SPY072 for psoriati...
Forum: Psoriasis In The News
Last Post: Caroline
Thu-17-07-2025, 20:15 PM
» Replies: 1
» Views: 1,192
Otezla and genital pustul...
Forum: Psoriasis In The News
Last Post: Fred
Tue-15-07-2025, 13:15 PM
» Replies: 0
» Views: 770
Psoriatic arthritis and f...
Forum: Psoriasis In The News
Last Post: Fred
Tue-15-07-2025, 13:09 PM
» Replies: 0
» Views: 753
Psoriasis pipeline is bus...
Forum: Psoriasis In The News
Last Post: Fred
Thu-10-07-2025, 21:07 PM
» Replies: 4
» Views: 1,456
Methotrexate and cardiova...
Forum: Psoriasis In The News
Last Post: Caroline
Thu-03-07-2025, 18:24 PM
» Replies: 5
» Views: 1,338
Hold on VYN202 phase 1b f...
Forum: Psoriasis In The News
Last Post: Fred
Thu-03-07-2025, 13:31 PM
» Replies: 1
» Views: 1,405
Teledermatology vs live m...
Forum: Psoriasis In The News
Last Post: Fred
Thu-03-07-2025, 12:41 PM
» Replies: 2
» Views: 1,349
Potential microRNA biomar...
Forum: Psoriasis In The News
Last Post: Caroline
Wed-02-07-2025, 19:29 PM
» Replies: 1
» Views: 778
Zoryve for psoriasis phas...
Forum: Psoriasis In The News
Last Post: Fred
Wed-11-06-2025, 14:16 PM
» Replies: 3
» Views: 1,734
Psoriasis and riboflavin ...
Forum: Psoriasis In The News
Last Post: Turnedlight
Wed-11-06-2025, 12:54 PM
» Replies: 2
» Views: 1,438
Sun Pharma stops SCD-044 ...
Forum: Psoriasis In The News
Last Post: Caroline
Wed-04-06-2025, 19:13 PM
» Replies: 1
» Views: 948
Efficacy & safety of IL-1...
Forum: Psoriasis In The News
Last Post: Fred
Sun-01-06-2025, 21:56 PM
» Replies: 12
» Views: 3,773
IL-23 and IL-17 inhibitor...
Forum: Psoriasis In The News
Last Post: Fred
Fri-30-05-2025, 15:40 PM
» Replies: 0
» Views: 927
Picankibart for psoriasis...
Forum: Psoriasis In The News
Last Post: mataribot
Fri-30-05-2025, 01:03 AM
» Replies: 1
» Views: 1,105
Cosentyx 9 year psoriasis...
Forum: Psoriasis In The News
Last Post: Fred
Sun-25-05-2025, 11:07 AM
» Replies: 0
» Views: 993
Phase I trial of ASC50 fo...
Forum: Psoriasis In The News
Last Post: Fred
Thu-22-05-2025, 12:13 PM
» Replies: 0
» Views: 1,041
ORKA-002 for psoriasis ph...
Forum: Psoriasis In The News
Last Post: Fred
Wed-21-05-2025, 13:21 PM
» Replies: 0
» Views: 924
Fifteenth Birthday
Forum: Announcements
Last Post: Caroline
Fri-02-05-2025, 19:50 PM
» Replies: 9
» Views: 2,592
Vulval psoriasis and Impa...
Forum: Psoriasis In The News
Last Post: Forest Walker
Fri-02-05-2025, 15:38 PM
» Replies: 7
» Views: 2,862
Cardiovascular safety of ...
Forum: Psoriasis In The News
Last Post: Fred
Thu-01-05-2025, 12:53 PM
» Replies: 4
» Views: 1,868
Old vs young psoriasis pa...
Forum: Psoriasis In The News
Last Post: Fred
Fri-25-04-2025, 11:55 AM
» Replies: 0
» Views: 913
Tanning addiction in psor...
Forum: Psoriasis In The News
Last Post: Fred
Fri-25-04-2025, 11:43 AM
» Replies: 15
» Views: 3,561
Tremfya and liver fibrosi...
Forum: Psoriasis In The News
Last Post: Kat
Sat-19-04-2025, 14:28 PM
» Replies: 3
» Views: 1,483
Jims journey on Skilarenc...
Forum: Prescribed Treatments For Psoriasis
Last Post: Angie
Thu-17-04-2025, 11:05 AM
» Replies: 295
» Views: 245,866

Welcome, Guest
You have to register before you can post on our site.

Username
  

Password
  





Members Images

Join Psoriasis Club
Psoriasis Club is self funded, we don't rely on sponsorship or donations. We offer a safe friendly forum and are proactive against spammers, trolls, and cyberbullying. Join us here!

Polls
Satisfied with your Physician?
What age did you get psoriasis?
How symmetrical is your psoriasis?
Depression and psoriasis.
Will there ever be a psoriasis cure?
Longest succesful psoriasis trearment.
How did you find Psoriasis Club?

Quick Links
Types of psoriasis explained
Introductions
Psoriasis & PsA topics
Prescribed treatments
Natural treatments
Off topic
Members photos
Members quotes

Independent Website.
No Thanks
No Advertising.
No Corprate Sponsors.
No Requests for Donations.
No Cyber-Bullying.
No Scams or Cures.
No Recruitment Posts.
No promotions or offers.
No Trolls.
No Spam.
Just a small bunch of friendly people with psoriasis sharing information and support.

Forum Statistics
» Members: 978
» Latest member: Hannaro
» Forum threads: 7,354
» Forum posts: 269,380

Full Statistics

Online Users
There are currently 184 online users.
» 0 Member(s) | 183 Guest(s)
"YOYO" The Psoriasis Club Bot Is On-line

Psoriasis Cure!
Psoriasis Cure

How many people have Psoriasis?
In 2012 there were approximately 36.5 million prevalent cases of psoriasis, and by 2022, GlobalData epidemiologists forecast that this figure will reach approximately 40.93 million.

The condition affects individuals of both sexes and all ethnicities and ages, although there is a higher prevalence of psoriasis in the colder, northern regions of the world.

The prevalence of psoriasis in the central region of Italy is 2.8 times greater than the prevalence in southern Italy.

Caucasians have a higher prevalence of psoriasis compared with African-Americans, but African-Americans in the US tend to suffer from a more severe form of the disease.

Read more here!

*And remember, if you don't have psoriasis please think of those that do.
As it could be your turn next.

Psoriasis Club

Pages (146): « Previous 1 … 85 86 87 88 89 … 146 Next »
Jump to page 
    About | Contact us | Login | Register | Home | Cookies/GDPR | RSS Syndication | Portal | Types Of Psoriasis | Psoriasis Score | Members Only Boards
    Copyright © 2010 - 2025 Psoriasis Club | All Rights Reserved | Founded May 2010 | Psoriasis Club Is Self Funded Without Sponsors Or Donations | Software by MyBB | Social