Hello my name is Janet and would like to hello. I have struggled with psoriasis for at least 4 years. I can`t use the common treatments for it because of the damage it does to my kidney. Had to have one removed in 2003 and everything i`ve tried reduces my kidney function. Am looking forward to talking to someone with similar problems and hope for a  treatment besides creams and oils.

HELLO MY NAME IS MANUEL RODRIGUEZ . I DO JUST GET PSOREASIS IN ALL MY BODY IS SO BAD FOR ME I NEED HELP

How have you managed to deal with having psoriais mentally? I don't think anyone really questions this or how you cope everyday? So I would like to ask.

What does it feel like having psoriais?

I have moved Karaokekings question to its own thread  here rather than take ccar's thread off topic

Karaokeking wrote

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Hi Jim. Here is my question. As i said in my introduction i am at the moment in Tenerife. I will be going back to the U/K at the end of April, so when i go back i am going to see my doctor and as about Fumaderm. Will i have to ask him to see a Dermatologist or can he prescribe them himself.
You also mention about being firm with the doctor, so can i insist on seeing the Dermotologist, if he won´t prescribe Fumaderm. Now i only have it mildly, so will that be relivant, on getting it prescribed.. Thanks again.

Lots of psoriasis biosimilar treatments coming forward these days and here is good news from another one. Oncobiologics ONS-3010 adalimumab (Humira®) biosimilar candidate met the primary endpoints in its first clinical study.

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Oncobiologics, Inc.,a biotherapeutics company focused on developing and commercializing biosimilars,announced today that ONS-3010, its adalimumab (Humira®) biosimilar candidate met the primary endpoints in its first clinical study.

A 3-arm single-dose pharmacokinetic (PK) study was performed in healthy volunteers to compare ONS-3010 to both the US- and EU-sourced Humira® reference products, and the two reference products to each other.  All of the PK endpoints met the bioequivalency criteria of the geometric mean ratios within 90% confidence interval of 80-125%.  These included: maximum serum concentration (Cmax), area under the time-concentration curve from first time point extrapolated to infinity (AUC0-inf), and area under the time-concentration curve from first to last time point measured (AUC0-t).  Safety and immunogenicity were similar across the three arms.  An exploratory ex vivo pharmacodynamic study also showed encouraging results between ONS-3010 and the reference products on TNF-α blockade and the induction of specific inflammatory responses.  This first-in-human study was conducted by the Centre for Human Drug Research (CHDR) in Leiden, The Netherlands.

ONS-3010 is being developed as a biosimilar to adalimumab, an anti-TNF-α monoclonal antibody, which is approved in many countries for the treatment of multiple inflammatory diseases that include rheumatoid arthritis, plaque psoriasis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis, as well as several pediatric indications.  ONS-3010 has the same amino acid sequence, pharmaceutical dosage form, and strength but contains a formulation of different composition.

“The clinical PK similarity study is a required regulatory milestone for biosimilar development.  We are excited to report that ONS-3010 has met the PK endpoints, which strengthens our confidence in achieving the global development of ONS-3010 as a biosimilar to Humira®,” stated Claude Nicaise, M.D., Chief Medical Officer at Oncobiologics.

I just thought I would introduce myself.  
I have had PPP for donkeys years and apart from a brief sojourn to the specialist some 20 years ago have always just put cream on to moisturise and just got on with life.  Over the last few years however, having got divorced and then found happiness together with lots of old family stresses and deaths etc. suddenly kerblam major breakout!  Instead of just a little on one foot I now have it majorly on both.  Slightest little bit of stress sets it off.  Am currently under specialist and having had light treatment and various creams I have now been told I need to get on Acitretin, which to be frank, scares me to death!  

Back on 6th December I last visited and was told I would be recalled in 4 to 6 weeks.  I had to have all the bloods taken in readiness ........... I am still waiting to see him and haven't even had an appointment yet!  I am still using steroid cream which he wants me to get off but when I do it flares up immediately.  I am not a happy bunny with it all.  But hey, I am also patient and will just wait; ringing occasionally of course to find out that they "have not forgotten me" lol.

So I have lots of questions, which will not doubt come out over time.  I have joined this forum because I thought I was the only person who suffers with this thing!  Everything is usually just down to me right! How wonderful to find that I am not alone in it.  (although I would prefer it if no one had it or that they find a cure!)

I look forward to chatting over time.

S

Hi all

Sorry to be a nuisance, I have a couple of quick questions. Think i have maybe asked one on the introduction thread, when I should have stared a new thread, in the right place.

Caroline I seen somewhere, you said about the rules to follow when taking fumaderm, (not sure rules is the right word you used but hopefully you know what I mean).  I have read about eating when taking them (certain foods, yoghurt etc) but apart from that I am not doing anything else different.  Did you mean things that interact with them or things to help the side effects? thanks.

Jiml, I looked at the info you had put on about the 16 week mark, thanks.  I have not found decent info on what levels should be or not. i.e lymphocytes etc.  Is this something you can help me with?

My bloods on Wednesday show Lymph at 0.8.  Are there others I should keep an eye on?  Not been feeling great this week since going up to 6 and wondered if it could be settling into that dose or i'm just a hypochondriac ! ha

Thanks for reading.

Angie

I'm stuck in a big problemo which I can't find a reasonable answer to.
I've recently been referred back to light treatment but the hospital is over half an hour away, I don't drive And I rely on public transport I also have a 3 month old daughter. I'm also moving further away from where I live which doesn't have a train station nor busses that travel to where I need to go. The other thing is I'm going back to college in August. I'm struggling to deal with the fact my psoriasis is getting worse.

I need advice on what I shoud do as I feel like giving up with the treatment before it's even started for the fact of not being able to make my appointments.






Try and stay positive  

Hi, I am taking Embrel 50mg injections once per week, and I feel I am putting weight on. Is there anything I can do to counter act this? Any help or suggestions would be greatly appreciated, thanks.

I have had psoriasis for approx 15 years .I feel onset was either colouring my hair henna red or, treatment for fungal toe infection. I had a massive flair up after using dovabet,light treatment helped greatly.I have it under control at the moment using salysalic cream on my scalp and coconut oil on my patches (elbows and knees) I am now finding my hair is going grey!!!! (It's my age57)so I am thinking about colouring it has anyone any hint s or tips for me please.

Hi All,

I am hoping someone might be able to give me some advice on Fumaderm.

To give you some background, I have had moderate widespread psoriasis for the last 6 years. It started as one small 'dot' on one arm and quickly spread pretty much everywhere (arms, legs, trunk, inside nose & ears, face, scalp, PPP on palms and soles). I have been prescribed around 15 steroid/vit D analog creams which have maintained my skin but never helped clear any of it up & of course didn't stop new patches from forming.

I have had two courses of UVB treatment, both of which compeltely cleared my skin but only for about a week after finishing each 37 session course. My psoriasis would be back to 'normal' within a month of finishing.

I went to see a new Dermatologist who agreed we needed to look at other options as it wasn't even really feasible for me to even apply the creams as I had SO many isolated patches, all of which were extremely red and inflamed.

We discussed the options available to me and decided to give Fumaderm a try. I started out on just 30mg a day and now 6 months later I have just increased my dose from 6x120mg (720mg total daily) up to 8x120mg (960mg total daily).

My skin has responded fantastically and pretty much all my old patches have gone, leaving only discoloured skin. However, I'm still getting a LOT of new small patches mainly around my hips and the top of the backs of my legs. My Derm advised me to go up to 8 per day if they hadn't cleared up.

I'm a little worried that this dose is VERY high but I have nothing to compare it to. My blood work is all fine but now I'm getting the horrendous gastric side effects again & would just generally like to know about other people's experiences.

Any advice appreciated!

Thanks :-)

Hi everyone :-)

Just to introduce myself, I was diagnosed with Psoriasis around 6 years ago having had no previous skin problems or family history of Psoriasis.

I do struggle to find enough information/advice on Psoriasis & treatments so I'm hoping this is the go to place!

Hopefully I might also be able to help anyone else from my experiences so far.

Kath

I have been reading about the different pills some of you are on I have only been on skin cream. I would like to know what other members are using on there skin, and what results they are getting. As i have said when i first got ps 32 years ago i was put on that coal tar stuff, then for a lot of years i was on Dovobet, but these last few weeks i have been on Dovonex, and have stated it seems to be useless.
I have to say after reading a lot of your posts, that i have it only slightly. I have never ever got rid of it at all for for any period, i have kept it under control, but thats all.

Following on from India getting a biosimilar of Remicade last year, it's now also been launched in Europe by Hospira under the name Inflectra.

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Hospira, Inc, a world leader in the development of biosimilar therapies, today announced the launch of the first biosimilar monoclonal antibody (mAb), Inflectra (infliximab), in major European markets. Inflectra is licensed for the treatment of inflammatory conditions including rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, adult and paediatric Crohn's disease, adult and paediatric ulcerative colitis and plaque psoriasis.

Infliximab is a cornerstone treatment for many inflammatory diseases, with over 15 years' worth of clinical data and experience. Inflectra is a biosimilar medicine to the reference product, Remicade® (infliximab), and is the first biosimilar mAb to be approved by the European Commission (EC). A biosimilar developed in-line with EU requirements can be considered a therapeutic alternative to an existing biologic.

Remicade (infliximab) has been authorized in the EU since 1999 and recorded European sales of almost €2 billion in 2013. The savings generated by introducing competition in the marketplace could save the European healthcare system millions of Euros, with biosimilars expected to produce savings of over €20 billion by 2020.

"Inflectra has already been launched in Central and Eastern Europe, and some smaller Western European markets due to earlier patent expiry, and has already been prescribed to treat patients in all its licensed indications. We are delighted that the remaining European countries, including many of the major EU countries, will now benefit from the availability of Inflectra. This supports Hospira's commitment to provide patients with better access to high-quality, more affordable care," said Paul Greenland, Vice President Biologics, Hospira.

Inflectra received its license from the EC in September 2013, following adoption of the EMA Committee for Medicinal Products for Human Use (CHMP) positive recommendation for granting marketing authorization. Review by the EMA included detailed analysis of biophysical properties and safety, efficacy and tolerability data from an extensive preclinical and clinical trial program.

In a phase III randomized, double-blind study involving 606 patients, Inflectra met its primary endpoint of therapeutic equivalence to Remicade. In this study, using the ACR20 scoring system, 73.4% of patients receiving Inflectra achieved a greater than or equal to 20% improvement in RA symptoms after 30 weeks of treatment, compared with 69.7% treated with Remicade. In the same study, 42.3% of patients receiving Inflectra achieved a greater than or equal to 50% improvement in RA symptoms after 30 weeks of treatment (measured using the ACR50 scoring system), compared with 40.6% treated with Remicade.8 Comparable safety and tolerability data also demonstrated Inflectra's equivalence to Remicade. There were no marked differences in the immunogenicity profile of the two products up to 54 weeks, and the impact of anti-drug antibodies on efficacy and safety was comparable.

Inflectra is being launched in several major European markets, including Austria, Denmark, France, Germany, Greece, Italy, Luxembourg, Netherlands, Spain and Sweden. With the launch of the product in these new markets, Inflectra is now available in 24 European countries. Hospira's partner, Celltrion, has also submitted an application to the U.S. Food and Drug Administration for biosimilar infliximab.

VBL Therapeutics today announced it will no longer be continuing with developing its experimental inflammatory drug VB-201 to fight psoriasis after it failed to meet their primary endpoints, and the company does not plan to continue development of VB-201.

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VBL Therapeutics (Nasdaq:VBLT), a clinical-stage biotechnology company committed to the discovery, development and commercialization of first-in-class treatments for cancer, today announced that its Phase 2 studies evaluating lead Lecinoxoid compound VB-201 in patients with psoriasis and ulcerative colitis did not meet their primary endpoints. The Company does not plan to continue development of VB-201 in these indications.

"We continue to focus on advancing VB-111 into Phase 3 for recurrent glioblastoma (rGBM). We believe that this drug candidate has significant potential as an anti-angiogenic agent for the treatment of cancer and we look forward to initiating the trial," commented Dror Harats, M.D., Chief Executive Officer of VBL Therapeutics. "We are disappointed by the outcome of these Phase 2 studies in psoriasis and ulcerative colitis. Immune-inflammatory conditions are difficult-to-treat diseases with a limited array of effective treatments. We were honored to work with an excellent team of clinical investigators and would like to thank the patients who participated in the clinical studies for these drug candidates."

In a simultaneous press release, VBL also announced today that the U.S. Food and Drug Administration (FDA) determined that VBL may proceed with a pivotal Phase 3 trial in rGBM and removed the clinical hold previously imposed on the study. VBL plans to initiate this trial in mid-2015 under a special protocol assessment with the FDA.

Psoriasis Study Details:

This Phase 2 randomized, double-blind, placebo-controlled study was designed to evaluate the safety and efficacy of VB-201 dosed at 80 mg or 160 mg daily for 24 weeks. The study evaluated 194 patients with moderate to severe plaque psoriasis. The primary efficacy endpoint of the study was PASI 50, or the proportion of patients who achieve at least 50 percent improvement from baseline PASI score, at weeks 16 and 24.

No effect of VB-201 compared to placebo was observed on the primary or secondary endpoints at either dose level tested. The PASI 50 for VB-201 patients was 26.4% at 16 weeks and 34% at 24 weeks, with no significant difference between the 80 mg and 160 mg dose cohorts. The placebo PASI 50 at week 16 was 38%.

Hello to everyone ( those who know me and those who have yet to become acquainted ).
It's a long story but I have had PPP for some time now. Managed (eventually) to stabilise on cyclosporine to the point where I got a full time job. But now I have been kicked off them by a new Dermatologist (another long story).
My dilemma at this point is that the new treatment proposed has the potential to take weeks to kick in, if indeed it does. I haven't been to work for a week. Deterioration has been swift to the point where I can walk no further than 50 yards.
Every morning I have to call in sick and I have been told I have to get sick notes to qualify for SSP. I was under the impression that my employer doesn't pay sick pay so is SSP different? Are they legally obliged to pay me it for 28 weeks? Only £81 a week I think but better than nothing I suppose.
I was originally thinking it was best just to give notice but am not sure now where I would stand ( metaphorically not physically ).
Sorry for the convoluted post and if I have posted in the wrong section.

Hi. I just joined the forum last week.It has been very interesting reading all the different posts. As i said in my introduction i have had this problem for about 32 years. I have only ever had cream, and ointments to put on, and the doctor never ever sugested tablets. It´s only since i came onto this forum, that i ever heard of taking tablets to help with psoriasis.
So first i have seen different tablets been mentioned.Fumarates, Fumaderm, Acitretin, and i think Psorinov. So my question is firstly can i go to my doctor and tell him i want to try one of these tablets, or can he refuse me. By the way i live in the U/K. and the next question is which tablets are the best as it seems everyone is on different medication.

Also as i said in my introduction, i am at present in the Canarie Islands untill the end of June, and i am using Dovonex, But have read to keep out of the sun, while using it, which is quite difficult to say the least.

Hi ,

I have been stalking this forum for quite a while now, following most threads , particularly Fumaderm, which when I get time I will start a post or add to a previous one.

My history of P - diagnosed about 31 years ago. First told it was warts on my elbows and treated with wart paint! (Can't remember the name) . Usual creams, ointments, hospital stays, puva, UVB , diet, holistic, magic creams from internet (which were full of steroids - obviously claiming to be natural). Aceitrin, cyclosporine, methotrexate and now Fumaderm.

Didn't really start on the tabs until November 2013 when my P became erythrodermic . Had tried Aceitrin previously but hair fell out rapidly. Thanks to that, I never wanted another tablet again.

November 2013 had no choice but to accept cyclosporine as 90% coverage and legs had ballooned due to inflammation . Got out of hospital (in time for Xmas) , on and off cyclo , ( was told due to the amount of UVB I had, had in past I would be unable to take cyclo for any length of time). Next was Mtx , hated them, side effects horrendous. Had a fight on my hands to get them to offer me Fumaderm, which I am currently taking.

Not sure of my psoriasis score . For about 28 years I lived with my psoriasis being severe and would get UVB 3 months of the year so I could go on holiday. Rest of time I just got on with it. My turning point was when my p became erythrodermic and I was told I have used up my lifetimes ray's, I decided to go down the tablets route.

So here I am, hoping to get some advice .  On 6 Fumaderm from yesterday and my skin is showing a little improvement - not much.  Certainly less active , flatter and less red, but still all over.  Side effects - not so good. Probably better leaving the details for the prescribed threads. Was really hoping for notable improvement 9 weeks in.

Anyway good to be here, looking forward to hearing your views.  And Hi GB , how you doing ?

Angle

Have you ever made a new post only to find that someone has posted at the same time as you and you missed it?

Here's a little tip for you.

#1 Compose your post.

#2 Click "Preview Post"

#3 Scroll down and you will see Thread Review (Newest First)

That will show you the latest post made, so you may avoid missing a post whilst answering another. It won't always work because if someone posts the same time as you it won't show, but if it's a busy thread and you want to make sure you have seen the latest post it will help.

Click "Post Reply" and if your lucky you won't have missed a post that was made whilst you was posting.

I know what I'm on about.  

This is a snipit of an article ahead of publication that looked into the menstrual cycle and the skin, it found dermatoses that are exacerbated perimenstrually include acne, psoriasis, atopic eczema and irritant dermatitis, and possibly also erythema multiforme.

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Perimenstrual exacerbations of dermatoses are commonly recognized, yet our knowledge of the underlying pathophysiological mechanisms remains imperfect.

Research into the effects of oestrogen on the skin has provided evidence to suggest that oestrogen is associated with increases in skin thickness and dermal water content, improved barrier function, and enhanced wound healing. Research into the effects of progesterone suggests that the presence of various dermatoses correlates with peak levels of progesterone.

Dermatoses that are exacerbated perimenstrually include acne, psoriasis, atopic eczema and irritant dermatitis, and possibly also erythema multiforme.

Exacerbations occur at the peak levels of progesterone in the menstrual cycle. Underlying mechanisms include reduced immune and barrier functions as a result of cyclical fluctuations in oestrogen and/or progesterone. Autoimmune progesterone and oestrogen dermatitis are the best-characterized examples of perimenstrual cutaneous reactions to hormones produced during the menstrual cycle.