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Psoriasis Club is a friendly on-line Forum where people with psoriasis or psoriatic arthritis
can get together and share information, get the latest news, or just chill out with others who understand. It is totally
self funded and we don't rely on drug manufacturers or donations. We are proactive against Spammers,
Trolls, And Cyberbulying and offer a safe friendly atmosphere for our members.
So Who Joins Psoriasis Club?
We have members who have had psoriasis for years and some that are newly diagnosed. Family and friends of those with psoriasis
are also made welcome. You will find some using prescribed treatments and some using the natural approach. There are people who
join but keep a low profile, there are people who just like to help others, and there are some who just like
to escape in the Off Topic Section.
Joining Couldn't Be Easier: If you are a genuine person who would like to meet others who understand,
just hit the Register button and follow the instructions.
Members get more boards and privileges that are not available to guests.
OK So What Is Psoriasis?
Psoriasis is a chronic, autoimmune disease that appears on the skin. It
occurs when the immune system sends out faulty signals that speed up the
growth cycle of skin cells. Psoriasis is not contagious. It commonly
causes red, scaly patches to appear on the skin, although some patients
have no dermatological symptoms. The scaly patches commonly caused by
psoriasis, called psoriatic plaques, are areas of inflammation and
excessive skin production. Skin rapidly accumulates at these sites which
gives it a silvery-white appearance. Plaques frequently occur on the
skin of the elbows and knees, but can affect any area including the
scalp, palms of hands and soles of feet, and genitals. In contrast to
eczema, psoriasis is more likely to be found on the outer side of the
joint.
The disorder is a chronic recurring condition that varies in severity
from minor localized patches to complete body coverage. Fingernails and
toenails are frequently affected (psoriatic nail dystrophy) and can be
seen as an isolated symptom. Psoriasis can also cause inflammation of
the joints, which is known as (psoriatic arthritis). Ten to fifteen
percent of people with psoriasis have psoriatic arthritis.
The cause of psoriasis is not fully understood, but it is believed to
have a genetic component and local psoriatic changes can be triggered by
an injury to the skin known as Koebner phenomenon. Various
environmental factors have been suggested as aggravating to psoriasis
including stress, withdrawal of systemic corticosteroid, excessive
alcohol consumption, and smoking but few have shown statistical
significance. There are many treatments available, but because of its
chronic recurrent nature psoriasis is a challenge to treat. You can find more information
Here!
Got It, So What's The Cure?
Wait Let me stop you there! I'm sorry but there is no cure. There are things that can help you
cope with it but for a cure, you will not find one.
You will always be looking for one, and that is part of the problem with psoriasis There are people who know you will be
desperate to find a cure, and they will tell you exactly what you want to hear in order to get your money. If there is a
cure then a genuine person who has ever suffered with psoriasis would give you the information for free. Most so called cures
are nothing more than a diet and lifestyle change or a very expensive moisturiser. Check out the threads in
Natural Treatments first and save your money.
Great so now what? It's not all bad news, come and join others at Psoriasis Club and talk about it. The best help is from accepting it and talking
with others who understand what you're going through. ask questions read through the threads on here and start claiming
your life back. You should also get yourself an appointment with a dermatologist who will help you find something that can
help you cope with it. What works for some may not work for others
This looks like a great group to belong to, I've been peeking around a bit.
I've had plaque psoriasis for 30 years, as well as a few bouts with guttate and palmo-plantar.
I have tried just about every cream, lotion and potion plus UV, nothing really works for very long though.
So I have lately decided to go au naturel, and just live around it.
Eh, could be better, but it certainly could be worse so I'm a happy camper!
Posted by: Fred - Tue-21-07-2015, 20:00 PM
- Replies (3)
This cohort study looked at whether patients with psoriasis have an increased risk of arrhythmia, arrhythmia also known as cardiac dysrhythmia or irregular heartbeat, is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
Quote:Background:
Psoriasis is associated with cardiovascular morbidity and mortality. However, the association between psoriasis and arrhythmia has not been adequately studied.
Objective:
We sought to investigate whether patients with psoriasis have an increased risk of arrhythmia.
Methods:
This population-based cohort study identified 40,637 patients with psoriasis and 162,548 subjects without psoriasis matched by age, sex, history of coronary artery disease, hypertension, and diabetes in the Taiwan National Health Insurance Research Database during 2004 through 2006.
Results:
After adjusting for medical history and medication use, patients with psoriasis were at increased risk of overall arrhythmia (adjusted hazard ratio [aHR] 1.34; 95% confidence interval [CI] 1.29-1.39). The risks of arrhythmia were higher in all subgroups, including patients with severe (aHR 1.25; 95% CI 1.12-1.39) and mild (aHR 1.35; 95% CI 1.30-1.41) psoriasis, and in patients with (aHR 1.46; 95% CI 1.22-1.74) and without (aHR 1.33; 95% CI 1.28-1.39) psoriatic arthritis.
Limitations:
The National Health Insurance Research Database did not contain information regarding Psoriasis Area and Severity Index, cigarette smoking, or alcohol consumption.
Conclusion:
Patients with psoriasis were at higher risk of developing arrhythmia, particularly for those with psoriatic arthritis, independent of traditional cardiovascular risk factors.
Source: jaad.org
Funding: This work was supported by a grant from National Taiwan University Hospital Hsin-Chu Branch.
My dermotologist added another cream to my already endlessly supply. The cream is called Tazorac and is to be applied at nighttime. I'll keep this thread update with my thoughts.
Posted by: Bill - Sun-19-07-2015, 00:39 AM
- Replies (8)
DMF acts slowly, but I have had continuous improvement in my arthritis (less pain and greater flexibility), so the overall effect has been very substantial. A bit of tummy upset a few times a week is no big deal, but to each his own.
Anyone heard of being given statins by the derm to help psoriasis drugs? It's not me, but I heard about it today and was surprised because I've not heard anything about this before.
I did a bit of reading and it seems they can give you psoriasis or help it, all very confusing.
Posted by: annieg - Mon-13-07-2015, 04:25 AM
- Replies (13)
I'm new here, and a new psoriasis patient. I was diagnosed a few months ago. We've tried creams/lotions, but the plaque psoriasis keeps coming back, so now I've been prescribed Methotrexate. I hate taking medications, but I hate long sleeves more, so I'm going to give it a shot. I'm here to connect with others who are dealing with this condition and am looking forward to participating.
My Dermotologists said he has patients without arthritis that has tendon issues. He was suggesting that it was a separate disease. Just curious how many people with psoriasis (not arthritis) have tendon problems? Also, what works for it? So far nothing has helped much besides the TNFs, and even those are not that great.
Hi everyone! I got my first 2 injections yesterday morning! I am using the pen and it hardly hurt at all! Am excited and scared at the same time, of course. No real side effects yet....did have to run to the potty one time unexpected. lololo This is a side effect that I have heard about. I felt achy last night but that has also subsided. My health insurance that I have through my company has EXCLUDED this drug. So I have started the 5 week start up program and then I believe I was told I can then get an additional six months of medication. What happens beyond that is unknown. That is what is so scary too! I am taking pictures and will post them as I get further into my treatment. Thanks for your support and any additional input!
Posted by: Fred - Thu-09-07-2015, 11:11 AM
- Replies (3)
Another new Bio in the pipeline for treating psoriasis has just beaten Humira (adalimumab) in it's phase 2 trial, guselkumab from the makers of Stelara (Janssen) is designed to block interleukin-23 and not IL-12.
Quote:Background:
Little is known about the effect of specific anti–interleukin-23 therapy, as compared with established anti–tumor necrosis factor therapies, for the treatment of moderate-to-severe plaque psoriasis.
Methods:
In a 52-week, phase 2, dose-ranging, randomized, double-blind, placebo-controlled, active-comparator trial, we compared guselkumab (CNTO 1959), an anti–interleukin-23 monoclonal antibody, with adalimumab in patients with moderate-to-severe plaque psoriasis. A total of 293 patients were randomly assigned to receive guselkumab (5 mg at weeks 0 and 4 and every 12 weeks thereafter, 15 mg every 8 weeks, 50 mg at weeks 0 and 4 and every 12 weeks thereafter, 100 mg every 8 weeks, or 200 mg at weeks 0 and 4 and every 12 weeks thereafter) through week 40, placebo, or adalimumab (standard dosage for psoriasis). At week 16, patients in the placebo group crossed over to receive guselkumab at a dose of 100 mg every 8 weeks. The primary end point was the proportion of patients with a Physician’s Global Assessment (PGA) score of 0 (indicating cleared psoriasis) or 1 (indicating minimal psoriasis) at week 16.
Results:
At week 16, the proportion of patients with a PGA score of 0 or 1 was significantly higher in each guselkumab group than in the placebo group: 34% in the 5-mg group, 61% in the 15-mg group, 79% in the 50-mg group, 86% in the 100-mg group, and 83% in the 200-mg group, as compared with 7% in the placebo group (P≤0.002 for all comparisons). Moreover, the proportion was significantly higher in the 50-mg, 100-mg, and 200-mg guselkumab groups than in the adalimumab group (58%) (P<0.05 for all comparisons). At week 16, the proportion of patients with at least a 75% improvement in Psoriasis Area and Severity Index scores was significantly higher in each guselkumab group than in the placebo group (P<0.001 for all comparisons). At week 40, the proportion of patients with a PGA score of 0 or 1 remained significantly higher in the 50-mg, 100-mg, and 200-mg guselkumab groups than in the adalimumab group (71%, 77%, and 81%, respectively, vs. 49%) (P<0.05 for all comparisons). Between week 0 and week 16, infections were observed in 20% of the patients in the guselkumab groups, 12% in the adalimumab group, and 14% in the placebo group.
Conclusions:
The results of this phase 2 trial suggest that guselkumab may be an effective therapy for plaque psoriasis and that control of psoriasis can be achieved with specific anti–interleukin-23 therapy.
Hello everyone.
I've recently been told to stop taking MTX until I've had more bloods. It may be a blip in my results but who knows? I don't mind admitting, all the messing about has pi**ed me off and been getting me down.
Anyway, I've been putting my insomnia to good use by doing some research and have been chatting with Toby Hadoke. He's an actor, writer and Dr Who geek (amongst other things). My partner Nick met him last year at a Dr Who event. Toby also suffers with psoriasis.
After checking out Toby's blog and commenting, we've been tweeting & messaging.
The upshot is that he has had counselling with a psycho-dermatologist to help with the psychological effects of psoriasis and is also involved in a campaign called See Psoriasis, Look Deeper.
I wont post links, it can be easily googled, but I thought this information might be useful to someone. It's very interesting and they're trying to make more Dermatologists aware of the emotional impacts.
This might be a stupid question but I see threads where people say they had psoriasis over 70% 80% or 90% of their body.
Now I probably have psoriasis over arms, legs, back, bottom, face, scalp and a little on my torso.
So that equates to about 60% of my body but as a total of my skin surface area its only a small amount as its lots of patches and I have a lot of skin.
My consultant said that I rated about 3 out of 10 on a "how bad is my psoriasis scale" which is ok, well I don't want to be a 10 out of 10.
So how do I measure my psoriasis. I have seen the scoring methods but then I have to decide whats good bad or indifferent and it varies every few days on how itchy, angry or generally pee'd off I get.
Posted by: Fred - Tue-07-07-2015, 21:39 PM
- Replies (6)
Even more good news for Cosentyx (secukinumab) after it goes head to head against it's main rival Stelara (ustekinumab), and after the 52-week, double-blind study of 676 subjects Cosentyx won the head to head battle.
Quote:Background:
Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has shown superior efficacy to etanercept with similar safety in moderate to severe plaque psoriasis (FIXTURE study).
Objective:
We sought to directly compare efficacy and safety of secukinumab versus ustekinumab.
Methods:
In this 52-week, double-blind study (NCT02074982), 676 subjects were randomized 1:1 to subcutaneous injection of secukinumab 300 mg or ustekinumab per label. Primary end point was 90% or more improvement from baseline Psoriasis Area and Severity Index (PASI) score (PASI 90) at week 16.
Results:
Secukinumab (79.0%) was superior to ustekinumab (57.6%) as assessed by PASI 90 response at week 16 (P < .0001). The 100% improvement from baseline PASI score at week 16 was also significantly greater with secukinumab (44.3%) than ustekinumab (28.4%) (P < .0001). The 75% or more improvement from baseline PASI score at week 4 was superior for secukinumab (50.0%) versus ustekinumab (20.6%) (P < .0001). Percentage of subjects with the Dermatology Life Quality Index score 0/1 (week 16) was significantly higher with secukinumab (71.9%) than ustekinumab (57.4%) (P < .0001). The safety profile of secukinumab was comparable with ustekinumab and consistent with pivotal phase III secukinumab studies.
Limitations:
The study was not placebo-controlled and of short-term duration.
Conclusions:
Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe psoriasis and improving health-related quality of life with a comparable safety profile over 16 weeks.
Source: jaad.org
*Novartis Pharma AG (Basel, Switzerland) supported this study.
Posted by: Denise - Mon-06-07-2015, 10:20 AM
- Replies (12)
Hi. New to this, usually suffer alone drenched in self pity. Had a bout of above disgusting disease in 1993 till 1997 which inexplicably disappeared when my son was born only for it suddenly to return in all its glory last year. Im 58 yrs old, been taking acetretin this time round and its been a miracle drug, at least on the outside, i can walk (though not as far as i could when i didnt have ppp) and use my hands fairly normally. Thats such a blessing, but i still feel like a monster. How i envy those who can take all this in their stride. Side effects are many but mostly light and livable with. Anyone else hate with a vengeance bloody zipzok. So...i dread if i ever have to come off the medication. Hoping for another remission but dont know why it happened in the first place. Anyway this is me. Just wanted to introduce myself xxx
Been dealing with psoriasis now for over 10 years, always trying new things, products, diets etc to try to find something that would alter my condition.
At the beginning of this year I started a (not due to psoriasis) low fat diet, which indirectly led me to go full vegan. I kept this up for about 1½-2 months and to my surprise this actually affected my rashes. It took a while for it to be noticeable, but today about 80-90% of all my rashes are gone and it has been pretty bad.
I have noticed that for example, a week or so ago I eat crackers several days in a row that contained milk powder and butter. Not in any large quantities at all, but this was apparently enough to flare up. Initially, when I first started the low fat diet I though it was the fat that was the issue, but after eating cod that only has 1% fat it I am sure it is animal protein that is the problem. Be it eggs, milk, butter, meat or fish, I seem to react the same to them all.
I know that not all psoriasis are the same, but if you are looking for an alternative way to handle your psoriasis and you have not tried this, perhaps going full/strict vegan for a couple of months would be worth giving a shot.
Hope life is treating you all kind.. I am a male in my mid thirties and had been suffering now for a few years... I have been put on Acitretin since yesterday and feeling very depressed as heard a lot of bad things about it. I have tried every thing from moisturisers to oral steroids and light therapy but nothing seems to working and now Acitretin..I would appreciate if any one can share their experience with Acitretin. Currently I am on a 25 mg tab..
Thrilled I found this forum! Looks fantastic! Can't wait till I have time to sit and browse through it! I have plaque psoriasis and started it in about 2007. Have done at home phototherapy and most prescription topicals. Sick of it all! Start Cosentyx next week and can't wait. Have health care coverage through my company, but of course this new drug is EXCLUDED! Has me a little worried to say the least..... Most of my psoriasis is located on my legs, arms, but now developing on my eyelids and lips. Very painful and not pretty! Glad to be part of a support group, finally!! Take care!
I have been having a weird feeling that there's a piece of sticky tape stuck to my big toe, especially when walking. I looked it up (as you do!) and to my surprise I'm not alone in this. I keep coming across the word 'neuropathy' which sounds basically to do with nerves.
Do you guys think it could be connected with my pa (as yet confined to carpal tunnel, plantar fasciitis and Achilles tendinitis) as I'm seeing the derm on Friday and I'm wondering whether to bring it up or if it's something to mention to the GP (not that she'll do anything..)
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Psoriasis Cure!
How many people have Psoriasis?
In 2012 there were approximately 36.5 million prevalent cases of psoriasis, and by 2022, GlobalData epidemiologists forecast that this figure will reach approximately 40.93 million.
The condition affects individuals of both sexes and all ethnicities and ages, although there is a higher prevalence of psoriasis in the colder, northern regions of the world.
The prevalence of psoriasis in the central region of Italy is 2.8 times greater than the prevalence in southern Italy.
Caucasians have a higher prevalence of psoriasis compared with African-Americans, but African-Americans in the US tend to suffer from a more severe form of the disease.
This looks like a great group to belong to, I've been peeking around a bit.
