Hi! Am new and appreciative of finding this site via google.
Think I am lucky to have only lived with psoriasis since I turned 40, am 44. It coincided with job difficulties and heavy drinking. I have it on the palms of my hands and soles of my feet, also my lower legs. A week ago the scales which often split turned into puss blisters and my diagnosis is now palmer-plantar pustular psoriasis, I was still prescribed dovobet. I had to go a walk in clinic rather than my GP. My  knuckles are alsoswollen.
Previously I have pretty much used under foot blisters to ease the pain of the cracks on my feet, which helped. But this time when I changed the blisters to keep them clean, the skin peeled off too leaving raw soles and making it impossible to walk on one foot and painful on the other. Does anyone have any suggestions how I might relieve this pain. Am used to thick scales with cracks, not large patches of raw skin?
Also has anyone's psoriasis disappeared when they have stopped heavy drinking (and not come back)?
Excuse  me for asking questions on my very first post.
Hope this finds a lot of you well and coping.
Kind  regards

Hi all

I would like to share another clinical study. It's about palm Psoraisis and Dupuytrens contractore. I have it very bad palmoplantar P. and have managed to contol it thru a constant regime. If anyone is interested I will be happy to share. It's on the bottoms of my feet too!

What the clinical study I read about actually found a connection between Dupuytrens Contracture & a high % of the patients had DC also had palm Psoriasis. Much is not understood by many doctors about treatment of DC.

Dupuytrens is the thickening of palm tendons & nodules pulling the tendons in while also pulling the fingers into a curl. There is no cure. It's the collagen constantly attacking the tendons as the antibodies send out signals to the tendons the same way that plaque psoriasis is in overdrive building up skin before shedding can occur. Thru the interluken pathway found in psoriasis, a lot of new drugs block that pathway the IL-17 or the
IL-23 both for Psoriasis and psoriatic psoriasis. Both which are the same pathways extra collagen is building up on tendons causing Dupuytrens Contracture. That was the connection in the clinical study.

I have had surgery, needle apenuroctomy and biologic drug injections in the fingers called XIAFLEX. The bio drug opened the 4th & fifth fingers from a closed position that surgery caused. At the time of surgery palmoplanter psoriasis flared and also the Dupuytrens flared in all four fingers.

Long story short the XIAFLEX also removed all the scar tissue from the surgery to open my frozen shut fingers. Now the bio drug is in another study to help burn victums and removing scar tissue from burn victims, surgeries etc. This is not a bio drug for the faint of This bio drug has many painful side effects. My fingers are still painful after 2 months and swollen. A splint is worn nightly for a year. Hand therapy for use to strengthen fingers is important for continued use, hopefully. my hand is still in a claw position and does not lay flat on a table with limited movement.

The bad news my fingers are curling again. I am suspicious that there could be another issue in my case at work here.

The Keobner Phenomenon. This is when anything can set off a reaction such as surgery, insect bite with DC & Psoriasis in my case then causes a flare . In my experience every time I try something to help my claw hand, it just makes it flare and far worse. However, at least the XIAFLEX a enzyme totally eliminated the thicken scar tissue and now my two fingers are not curled in a fist like position. I can put on my garden gloves. and shake hands.

If you have hand P. & you have nodules on the tendons & thickened tendons that predominantly show up in your palm or both it could be DC.

I hope this makes sense. Please google the psoriasis & Dupuytrens contracture clinical study for more info.

Have a good day !

Hi everyone, I used to post on Psoriasis-help, but the website just randomly disappeared one day.

I suffer from plaque psoraisis, PPP and Psoriatic Arthritis.  I'm currently on Cyclosporine, and just about to begin Stelera.

Not much else to say, any questions feel free to ask

Humira is now available in the EU for the treatment of severe chronic plaque psoriasis in children and adolescents from four years of age who have had an inadequate response to or are inappropriate candidates for topical therapy and phototherapies.

Quote:

---

AbbVie announced today that the European Commission (EC) has granted marketing authorization for HUMIRA® (adalimumab) for the treatment of severe chronic plaque psoriasis in children and adolescents from four years of age who have had an inadequate response to or are inappropriate candidates for topical therapy and phototherapies. With the EC decision, HUMIRA now has approval for use in this indication in all member states of the European Union.

"Several treatments have been shown to be effective in subgroups of patients with pediatric psoriasis. However, a limited body of supporting data is available. The approval of adalimumab is an important milestone in particular for children with severe disease because it extends the armamentarium of the physicians who are working to reduce the burden of this chronic disease in this sensitive young patient population," said Marieke M.B. Seyger, MD, PhD, Associate Professor of Dermatology, Radboud University Medical Center in Nijmegen, Netherlands.

The marketing authorization is based on the positive results of a Phase 3 study, which will be presented at an upcoming medical meeting. Since first gaining approval 12 years ago, HUMIRA has been approved in more than 87 countries. It is currently being used to treat more than 851,083 patients worldwide1 across 11 globally approved indications.2

"With the approval from the European Commission, HUMIRA is now the only biologic approved in Europe to treat children with this condition starting at four years of age, offering an important new option for physicians treating pediatric plaque psoriasis," said Michael Severino, M.D., executive vice president, research and development and chief scientific officer, AbbVie. "This new indication contributes to the increasingly broad spectrum of indications for HUMIRA, and supports its strong record of efficacy and safety in treating pediatric populations who are managing challenging chronic diseases."

Good news for people with Psoriatic Arthritis in the Haverhill area as West Suffolk Hospital announce Haverhill's rheumatology clinics will increase from one per month to four per month.

The first rheumatology clinic for Haverhill was set up in September 2012 and caters for all types of inflammatory and non-inflammatory rheumatic disorders, including rheumatoid arthritis, psoriatic arthritis, polymyalgia rheumatic and osteoporosis.

They will be held on the first and third Wednesday of every month, and staffed by a consultant rheumatologist and specialist nurse. They accept referrals from local GPs, and new patients will now wait just two weeks for an appointment.

As I live in France I found this study albeit small interesting as I have never experienced any prejudice against people with psoriasis, but then again I do live in the country where people don't tend to judge each other on the appearance or worth.

The survey looked at misconceptions, negative prejudice and discriminatory behaviour towards psoriasis patients in France, and I found some of the percentages in the results shocking to be honest.

Quote:

---

Background:
The perception of stigmatization of patients with psoriasis is largely due to misconceptions and negative prejudice about this skin disease. ‘Uneducated’ judgements can give rise to discriminatory behaviours.

Objective:
Evaluate the prevalence, in France, of misconceptions, negative prejudice and discriminatory behaviour towards psoriasis patients.

Methods:
Online survey conducted in June 2011, aimed at 1005 persons aged 16–64 years, representative of the French population. The representativeness of the sample was ensured by quota methodology (gender, age, occupation of the interviewed person) after stratification by region and location category. The respondents were asked to respond to a questionnaire on their knowledge of psoriasis, their attitude and main feelings/perceptions towards psoriasis patients.

Results:
About 62.4% of respondents recognize a lack of information about psoriasis and 19.7% have misconceptions about this disease. About 16.5% believe that psoriasis is contagious, 6.8% believe this skin disease is related to personal hygiene and 3.2% believe that it affects more people with low personal hygiene. About 50.0% of respondents show discriminatory behaviour towards psoriasis patients, reflected by reluctance to maintain friendship ties/a relationship of friendliness (7.6%), to have lunch or dinner with a person with visible manifestations (17.9%), to give a kiss on the cheek in greeting (29.7%), to shake hands (28.8%) and to have sexual relations/intercourse (44.1%). Patients with negative prejudice about the psoriasis frequently have misconceptions towards psoriasis patients. About 52.8% of respondents do not know anyone with psoriasis. Socio-demographic indicators such as gender, education level and rural or urban way of life are not associated with an increased prevalence of misconceptions and/or discriminatory behaviour.

Conclusion:
The lack of knowledge about psoriasis in France is important. There is an urgent need to strengthen information campaigns about psoriasis intended for the General Public.

Can psoriasis spread to your eyes? Currently have psoriasis in then lashes of my right upper eye lid. It is very flakey and sore. In the 23 years that I have had psoriasis I have never had it that close to my eye.

Do you know that Psoriasis is the beginning of Zombie? And we are the lucky one, the founder        
If you started to feel that you want to bite the people next to you that is the sign of being a Zombie...
So come and start to rock the world            






This is just a joke...      Just want to laugh and forget our problems hahahaha

Can-Fite BioPharma Ltd have announced they are disappointed that their results from the Phase II/III trial of CF101 for psoriasis as it did not meet its primary endpoint after seeing no real benefit over placebo, but they will continue the analysis of secondary endpoint and sub-group analysis and intend to complete it in the near future.

Quote:

---

Can-Fite BioPharma Ltd, a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, announced today that its Phase II/III psoriasis trial for the Company's drug candidate CF101 did not achieve its primary endpoint.

This Phase II/III double-blind, placebo-controlled study was designed to test the efficacy of CF101 in patients with moderate-to-severe plaque psoriasis. Can-Fite enrolled a total of 326 patients through 17 clinical centers in the U.S., Europe, and Israel. The first study segment was comprised of three arms with 103 patients who received either 1 mg of CF101; 2 mg of CF101; or placebo. All patients receiving placebo were switched to either 1 mg or 2 mg of CF101 after 12 weeks and continued receiving treatment until week 24. Following a positive interim analysis, Can-Fite continued to enroll patients to the second segment of the study. The second study segment was comprised of two arms with 223 patients receiving either 2 mg of CF101 or placebo. All patients receiving placebo were switched to 2 mg of CF101 after 16 weeks and continued receiving treatment until week 32. The primary efficacy endpoint was  a statistically significant improvement in the Psoriasis Area Sensitivity Index (PASI) score relative to placebo treatment, and the secondary endpoints were, among others, the Physicians' Global Assessment (PGA) score as well as various safety parameters.

The proportion of patients treated with CF101 who achieved at least a 75% improvement from baseline in disease severity at week 12, as measured by PASI 75 was 8.5% vs. 6.9% in the placebo group. With respect to PGA, 6.4% of patients treated with CF101 achieved clear or almost clear skin at week 12 compared to 3.4% of the placebo patients. CF101 was found to be safe and well tolerated.

"We are disappointed that our trial did not meet its primary endpoint. Regretfully, in the PASI 75 and PGA we did not see any real effect in patients over placebo. We have not yet completed our analysis of secondary endpoint and sub-group analysis and intend to complete it in the near future. Can-Fite is continuing its research and development efforts in relation to its drugs and indications in the pipeline." stated Can-Fite CEO Dr. Pnina Fishman.    

I started writing here about what I believe triggered my Psoriasis & what I've discovered helps but it soon became a rival to War & Peace  
I really think I'm on to something and tho' I'm sure it won't help every one I do think it might resonate with some.
One sorry sad sack day late last year I realised I needed to pull my finger out and stop whining. I wrote down every event that could possibly be connected to my Psoriasis. This is how it went. I've have the P on my scalp, in my ears, a good dose on my hands and fingers. I also have it on each elbow but I have that area under control with Daivobet 50/500 ointment. Every joint in my hands and fingers were always swollen and stiff and the pointer fingers were becoming crooked.  I've had it for over 3 years.  
In October I went to my doctor desperately looking for relief, all I left there with was a box of tissues. Next day I started eating totally gluten free and I felt so much better just 3 days later that I've kept with it and have I lost 10 Kg with no effort but it didn't ease my P.  In September it had suddenly dawned on me that the cycle of flare ups (it never went away just wasn't as bad) matched my monthly cycle (or what had been) I also out of nowhere started getting a bad tummy after I had eaten food with dairy in it (and now I suspect eggs), mayonnaise, aioli and especially cream and ice cream, it became a pattern that within 30 minutes of eating I'd have to break the one mile minute to get to the ladies.  Now I know what some people say about the 8 hour digestion cycle but I don't believe a word of it. It also occurred to me that 3 times in a row of going to the movies and eating an icecream that the meaty area of my palms were burning and blisters under the skin were trying to erupt thru the skin after about an hour. It had happened many times over the years, I just didn't put the pattern together. I am in the early stages of full menopause now but my bloods showed only a small dip in numbers, I felt like crap but I thought the only symptoms I had was minor hot flushes just thru the day. It was like a light bulb being switched on, a diary entry every day for the next 4 weeks tied hot flushes with my psoriasis flare ups. 90% of the month I was having to wear 20 band aids on my fingers just to be able to use cutlery, write with a biro and do my job. At it's worst I would only have to straighten my pointer finger and the skin would split and it was like having 100 paper cuts.  My scalp was unbearable, I'd pour vinegar on it just to change the feel of the itching to stinging. Resting my hands on a hot kettle almost felt so good it tickled.
After going to a new lady doctor who was right up on the latest HRT info I had bloods and scans done and after getting results started on HRT on Feb 17th. Today is the 27th March and I can tell you that I have not had one eruption or flare up for 2 weeks. The band aids were making it worse and I started getting plaques on my knuckles but they are looking better. My hands are dry but I am so happy they are feeling so much better, it will be some time before the hard plaques are gone. The splits are healing and I haven't had a bleed for weeks.
Another thing I know gave me relief within a day was scrubbing my whole body with chlorhexidine and scrubbing my scalp with a product containing ketoconazole (that was for you jiml... not giving you a spanking opportunity    )  in fact I used the keto on every area there is hair, particularly the eyebrows, they itched like mad and the plaques were ugly. I had also had a reoccurring crazy itching inflamed area down the right side of my entire nose. I know from being a nurse that humans develop skin bacteria, we use microshield at work, it comes from warmth, sweating and just living. I must have been in denial! I smelled funny! I blamed the water coming out of the taps, I had collected water in a container intending to take it to be tested. I really smelled generally off. By the time I had scrubbed twice in a  week the smell disappeared.  For 3 weeks I have also cut milk products and eggs. I checked my calendar and am not surprised that my cycle would have started yesterday for this month. Last night my left pointer finger started itching and it became inflamed, exactly in the same area I believe the first signs started after continually opening and closing a spring water bottle for 3 weeks. I am a strong believer now about petrochemicals in plastic causing skin disorders and I know this is where mine started 3 years ago. I also notice now that if I become stressed/ over tired/ my anxiety levels pitch that my hands and scalp start heating up and become itchy. Sorry for the book length story. I hope it helps some body.  

Following on from the report about Leo Pharma submitting their new aerosol for psoriasis to the FDA, today they announced they have also submitted a Marketing Authorisation Application to 30 European Health Authorities for Enstilar.

Quote:

---

LEO Pharma today announced it submitted a Marketing Authorisation Application to 30 European Health Authorities for Enstilar (calcipotriol/betamethasone dipropionate 50 micrograms/g / 0,5 mg/g) cutaneous foam for the treatment of psoriasis vulgaris, a chronic, inflammatory skin disease that can significantly impact quality of life for patients. Enstilar has the potential to be the first fixed combination cutaneous foam approved for the treatment of psoriasis vulgaris.

The new cutaneous foam formulation is a fixed combination of calcipotriol and betamethasone (as dipropionate) developed with the aim of improving treatment for patients with psoriasis vulgaris the most common form of psoriasis.

The European submission is based on the phase 3a trial, the PSO-FAST trial, which evaluated the efficacy, safety, itch relief and improvement of itch-related sleep loss across a four week period with Enstilar as well as the phase 2 maximum use systemic exposure safety study of Enstilar.

Kim Kjøller, Senior Vice President, Global Development at LEO Pharma, commented:

“We believe Enstilar has the potential to provide a new, topical treatment option for patients living with psoriasis. Helping people suffering from skin conditions is at the heart of what we do and this regulatory submission, along with our existing treatment portfolio and patient support offerings such as QualityCare, reinforces our commitment and takes another step toward improving quality of life for people living with psoriasis.”

Hi - I'm about to start using magnesium chloride flakes (mixed with water and put in a spray), as I've read encouraging things about it on another website.  Has anybody here been using it?  If so, good results?

Thanks,
Mary

They are still often recommending using methotreaxte with bio treatments in some cases, this large study of 95,941 patients suggests you may also need to take a herpes zoster preventive vaccine too.

Quote:

---

Importance:  
The risk for herpes zoster (HZ) in patients with psoriasis treated with biologic medications or other systemic treatments has been given little attention to date.

Objective:  
To describe the risk for HZ in patients with psoriasis and its relation to treatment.

Design, Setting, and Participants:  
A cohort study was performed using the administrative database of Clalit Health Services, the largest public health care provider organization in Israel, in the setting of general community clinics, primary care and referral centers, and ambulatory and hospitalized care. We extracted information for all patients who received a psoriasis diagnosis from January 2002 to June 2013. Follow-up was conducted until the end of July 2013. The study included 95 941 patients with psoriasis in the analysis, with 522 616 person-years of follow-up. Incidence of HZ events was calculated for each systemic antipsoriatic medication provided, during a follow-up period of 11 years and 7 months. We used a generalized estimating equation Poisson regression model to examine the effect of each systemic treatment for psoriasis on HZ incidence, adjusting for age, sex, psoriasis severity, Charlson comorbidity index, steroid treatment, and socioeconomic status.

Main Outcomes and Measures:  
Incidence of HZ associated with systemic therapies.

Results:  
In a multivariate analysis, it was observed that treatment with phototherapy (rate ratio [RR], 1.09 [95% CI, 0.62-1.93]; P = .99), methotrexate (RR, 0.98 [95% CI, 0.78-1.23]; P = .83), cyclosporine (RR, 1.16 [95% CI, 0.48-2.80]; P = .49), and biologic medications as a single agent (RR, 2.67 [95% CI, 0.69-10.3]; P = .14) was not associated with HZ. The use of combination treatment with biologic medications and methotrexate was significantly associated with an increased incidence of HZ (RR, 1.66 [95% CI, 1.08-2.57]; P = .02). The use of acitritin was associated with decreased incidence of HZ (RR, 0.69 [95% CI, 0.49-0.97]; P = .004).

Conclusions and Relevance:  
Physicians may need to consider offering an HZ preventive vaccine to patients receiving combination treatment with biologic medications and methotrexate, particularly if they have additional risk factors for HZ.

Hi All,

New member here and must say I find this site very helpful to all the p suffers out there good to know your not alone.
I know there has been few threads on fumaderm but would just like to ask if anybody had success on it with gutte P, I am on my second week of fumaderm have gone up to two tablets a day I know about the side affects and am willing to continue and hope for the best as have been suffering with P now for 16 years since I was 14 now am 31. I have exhausted all other treatments with no relief the sun those clear it completely but always comes back within two weeks my arms torso and legs are the worst affected sometimes get it on my face but able to control p on my face.

I am just hoping fumaderm will help with my p make it more controllable so I can live a better life and be able to wear a tshirt again and hopefully go for a swim without stares

Any feedback would be much appreciated.

Thanks
Steve

Hello all. Some here have asked that I start a thread and talk about my experience with Cosentyx. At this point I don't have a lot to say as I just started it this past Monday. The shot itself was the new skin activated pen and I felt nothing, so that is good news. The second dose was delivered yesterday to my house and I'll take it Monday. Not sure if it's wishful thinking but it does look like some plaque is going away. I'll keep everyone posted as I get more treatments

Hi I'm Brad from Florida.  I've had psoriasis for nearly 15 years. I've been on most biologics including enbrel, stalera, methotrexate thrown in with some, remecade and now cosentyx. I've used enough creams and lotions to fill up a swimming pool. I'll keep you all posted on how well the cosentyx works. Glad to be here with fellow sufferers

hello every one I am new here and I'm not looking for help I am here to help you if you want, this is a terrible condition and in my case was easy to hide (legs) but can't imagine how hard is for some people that can't hide it, I am writing and makes me happy just to think how good it feels and makes me feel good that finally I can help other people around the world, so lets gets started.

First of all if you decide to do this it's because you need it and you believe you can cure your self, if you don't believe in this is because you don't have psoriasis and don't need help.

I am not looking for money, yes guys no money I have a good leaving and not asking for money.

ok I will give you the cure but read my true story and ask me whatever you want I am not hiding anything.

At the age of 28 years old move to Canada because of violence in El Salvador and decide to start again it was not easy and got stress etc. etc. anyways 1 year later was this patch appears in my legs and hand but not to aggressive but got worst really bad and bigger, itchy with blood and everything could not believe it I am healthy guy wearily had cold or flu I am talking about good health, so this was driving me insane try our free and good health care in Canada and many doctors said WE have NO cure, that killed me right there, but like a good stubborn Spanish guy could not give up, so one day visiting my country my uncle and good friend told me go to see our natural medicine doctor and I said yes, I know this doctor we are natural medicine people in my family " not all of us " , make you story short this guy is amazing switch from what we know as doctor study so many years like all of them at the university, and after years practicing his profession he decide to look for something else because could not help a lot of patients, so he went MAYAN medicine and now here is the cure.

do it exactly as he says or don't do it at all.

for the next 40 days 2 lemons first day second day 4 lemons third day 6 lemons until you reach 40 lemons and then you start reducing 2 lemons per day until cero lemons. it can be mixed with water and drink it through the day if necessary.

NEVER AGAIN in your entire life eat or try or taste MILK and PORK yes you are reading right NEVER AGAIN

For the next three months you need natural pills for DETOX that he sells they are made of plants don't know what kind but the name is in Spanish and you can search.

for the next 3 months avoid or don't eat any dead animals , NO meat is better.

breakfast must be mostly fruits

lunch 50% salads

avoid heavy dinners

8 glasses of WATER as MINIMUN, no matter if you live in a f... igloo drink WATER.
it will start clearing after a month remember your whole life been putting stuff in your body that he doesn't like any more, be patient

and that's it for now I have to go to work wish you the best, be well.

I have just read an article in the Mail on Sunday. March 15th, about a pill called Apremilast. I did a search on this site and found it has been mentioned in earlier posts. It says it is now available on the NHS. I wondered if anyone has tried to get on this pill.

Hi. I`m very surprised no one has mentioned Aloe-Vera. I have been on you-tube, and there is quite a lot of video´s on using Aloe-Vera. I would like to know if anyone has ever tried this. They have the plant and cut a stem, or a leaf, whatever you want to call it, trim the outside edges off, and then separate the front and back and scrape the inside, out of it. Apparently you can also take it orally. I know you can buy jars of Aloe-Vera, but i wouldn´t think it would be as good as the natural oils.

Just a thought. Thanks.

Following on from the report last December that there could soon be a deal done with the National Institute for Health and Care Excellence (NICE) and the use of Stelara for the treatment of psoriatic arthritis, finally it's been worked out and Stelara will now be available. There is a catch however: It won't be used as a first line bio and you will have to wait till you have tried the others first.

Quote:

---

Janssen's Stelara has been recommended by NICE as a treatment option for patients with active psoriatic arthritis a year after the Institute was minded to reject the treatment.

In final guidance, Stelara (ustekinumab) is now recommended either alone, or in combination with methotrexate, as a second-line therapy.

It is specifically for patients whose response to previous non-biological disease modifying anti-rheumatic drug (DMARD) therapy has been inadequate.

It is also recommended for patients who have had treatment with one of more TNF-alpha inhibitors, such as Janssen's own Simponi (golimumab) and Remicade (infliximab), as well as AbbVie's Humira (adalimumab) and Pfizer's Enbrel (etanercept).

NICE last year said it would not recommend the drug as it was too costly, but a patient access - which cuts the price of the medicine - has since been offered by the firm, helping it get onto the NHS's funding stream.

The recommendation also limits the drug to be used after other have been tried, meaning its sales potential in England will be knocked as it will not be funded as a first-line therapy.

Peter Barnes, medical director at Janssen UK, said of the decision: “We are delighted with today's recommendation from NICE. We know that people living with psoriatic arthritis are in real need of additional treatment choices that can help them manage a debilitating and often painful condition.

“Ustekinumab could have a marked positive impact of the quality of life for many of these patients living with active psoriatic arthritis and represents an important additional treatment option for this condition.”

The list price for the treatment is £2,147 per 45mg vial, and NICE estimates that the average annual cost for a 45mg and a 90mg dose are £10,735 and £21,470 in the first year, and £9,304 and £18,608 per year thereafter respectively.