As I live in France I found this study albeit small interesting as I have never experienced any prejudice against people with psoriasis, but then again I do live in the country where people don't tend to judge each other on the appearance or worth.

The survey looked at misconceptions, negative prejudice and discriminatory behaviour towards psoriasis patients in France, and I found some of the percentages in the results shocking to be honest.

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Background:
The perception of stigmatization of patients with psoriasis is largely due to misconceptions and negative prejudice about this skin disease. ‘Uneducated’ judgements can give rise to discriminatory behaviours.

Objective:
Evaluate the prevalence, in France, of misconceptions, negative prejudice and discriminatory behaviour towards psoriasis patients.

Methods:
Online survey conducted in June 2011, aimed at 1005 persons aged 16–64 years, representative of the French population. The representativeness of the sample was ensured by quota methodology (gender, age, occupation of the interviewed person) after stratification by region and location category. The respondents were asked to respond to a questionnaire on their knowledge of psoriasis, their attitude and main feelings/perceptions towards psoriasis patients.

Results:
About 62.4% of respondents recognize a lack of information about psoriasis and 19.7% have misconceptions about this disease. About 16.5% believe that psoriasis is contagious, 6.8% believe this skin disease is related to personal hygiene and 3.2% believe that it affects more people with low personal hygiene. About 50.0% of respondents show discriminatory behaviour towards psoriasis patients, reflected by reluctance to maintain friendship ties/a relationship of friendliness (7.6%), to have lunch or dinner with a person with visible manifestations (17.9%), to give a kiss on the cheek in greeting (29.7%), to shake hands (28.8%) and to have sexual relations/intercourse (44.1%). Patients with negative prejudice about the psoriasis frequently have misconceptions towards psoriasis patients. About 52.8% of respondents do not know anyone with psoriasis. Socio-demographic indicators such as gender, education level and rural or urban way of life are not associated with an increased prevalence of misconceptions and/or discriminatory behaviour.

Conclusion:
The lack of knowledge about psoriasis in France is important. There is an urgent need to strengthen information campaigns about psoriasis intended for the General Public.

Can psoriasis spread to your eyes? Currently have psoriasis in then lashes of my right upper eye lid. It is very flakey and sore. In the 23 years that I have had psoriasis I have never had it that close to my eye.

Do you know that Psoriasis is the beginning of Zombie? And we are the lucky one, the founder        
If you started to feel that you want to bite the people next to you that is the sign of being a Zombie...
So come and start to rock the world            






This is just a joke...      Just want to laugh and forget our problems hahahaha

Can-Fite BioPharma Ltd have announced they are disappointed that their results from the Phase II/III trial of CF101 for psoriasis as it did not meet its primary endpoint after seeing no real benefit over placebo, but they will continue the analysis of secondary endpoint and sub-group analysis and intend to complete it in the near future.

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Can-Fite BioPharma Ltd, a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, announced today that its Phase II/III psoriasis trial for the Company's drug candidate CF101 did not achieve its primary endpoint.

This Phase II/III double-blind, placebo-controlled study was designed to test the efficacy of CF101 in patients with moderate-to-severe plaque psoriasis. Can-Fite enrolled a total of 326 patients through 17 clinical centers in the U.S., Europe, and Israel. The first study segment was comprised of three arms with 103 patients who received either 1 mg of CF101; 2 mg of CF101; or placebo. All patients receiving placebo were switched to either 1 mg or 2 mg of CF101 after 12 weeks and continued receiving treatment until week 24. Following a positive interim analysis, Can-Fite continued to enroll patients to the second segment of the study. The second study segment was comprised of two arms with 223 patients receiving either 2 mg of CF101 or placebo. All patients receiving placebo were switched to 2 mg of CF101 after 16 weeks and continued receiving treatment until week 32. The primary efficacy endpoint was  a statistically significant improvement in the Psoriasis Area Sensitivity Index (PASI) score relative to placebo treatment, and the secondary endpoints were, among others, the Physicians' Global Assessment (PGA) score as well as various safety parameters.

The proportion of patients treated with CF101 who achieved at least a 75% improvement from baseline in disease severity at week 12, as measured by PASI 75 was 8.5% vs. 6.9% in the placebo group. With respect to PGA, 6.4% of patients treated with CF101 achieved clear or almost clear skin at week 12 compared to 3.4% of the placebo patients. CF101 was found to be safe and well tolerated.

"We are disappointed that our trial did not meet its primary endpoint. Regretfully, in the PASI 75 and PGA we did not see any real effect in patients over placebo. We have not yet completed our analysis of secondary endpoint and sub-group analysis and intend to complete it in the near future. Can-Fite is continuing its research and development efforts in relation to its drugs and indications in the pipeline." stated Can-Fite CEO Dr. Pnina Fishman.    

I started writing here about what I believe triggered my Psoriasis & what I've discovered helps but it soon became a rival to War & Peace  
I really think I'm on to something and tho' I'm sure it won't help every one I do think it might resonate with some.
One sorry sad sack day late last year I realised I needed to pull my finger out and stop whining. I wrote down every event that could possibly be connected to my Psoriasis. This is how it went. I've have the P on my scalp, in my ears, a good dose on my hands and fingers. I also have it on each elbow but I have that area under control with Daivobet 50/500 ointment. Every joint in my hands and fingers were always swollen and stiff and the pointer fingers were becoming crooked.  I've had it for over 3 years.  
In October I went to my doctor desperately looking for relief, all I left there with was a box of tissues. Next day I started eating totally gluten free and I felt so much better just 3 days later that I've kept with it and have I lost 10 Kg with no effort but it didn't ease my P.  In September it had suddenly dawned on me that the cycle of flare ups (it never went away just wasn't as bad) matched my monthly cycle (or what had been) I also out of nowhere started getting a bad tummy after I had eaten food with dairy in it (and now I suspect eggs), mayonnaise, aioli and especially cream and ice cream, it became a pattern that within 30 minutes of eating I'd have to break the one mile minute to get to the ladies.  Now I know what some people say about the 8 hour digestion cycle but I don't believe a word of it. It also occurred to me that 3 times in a row of going to the movies and eating an icecream that the meaty area of my palms were burning and blisters under the skin were trying to erupt thru the skin after about an hour. It had happened many times over the years, I just didn't put the pattern together. I am in the early stages of full menopause now but my bloods showed only a small dip in numbers, I felt like crap but I thought the only symptoms I had was minor hot flushes just thru the day. It was like a light bulb being switched on, a diary entry every day for the next 4 weeks tied hot flushes with my psoriasis flare ups. 90% of the month I was having to wear 20 band aids on my fingers just to be able to use cutlery, write with a biro and do my job. At it's worst I would only have to straighten my pointer finger and the skin would split and it was like having 100 paper cuts.  My scalp was unbearable, I'd pour vinegar on it just to change the feel of the itching to stinging. Resting my hands on a hot kettle almost felt so good it tickled.
After going to a new lady doctor who was right up on the latest HRT info I had bloods and scans done and after getting results started on HRT on Feb 17th. Today is the 27th March and I can tell you that I have not had one eruption or flare up for 2 weeks. The band aids were making it worse and I started getting plaques on my knuckles but they are looking better. My hands are dry but I am so happy they are feeling so much better, it will be some time before the hard plaques are gone. The splits are healing and I haven't had a bleed for weeks.
Another thing I know gave me relief within a day was scrubbing my whole body with chlorhexidine and scrubbing my scalp with a product containing ketoconazole (that was for you jiml... not giving you a spanking opportunity    )  in fact I used the keto on every area there is hair, particularly the eyebrows, they itched like mad and the plaques were ugly. I had also had a reoccurring crazy itching inflamed area down the right side of my entire nose. I know from being a nurse that humans develop skin bacteria, we use microshield at work, it comes from warmth, sweating and just living. I must have been in denial! I smelled funny! I blamed the water coming out of the taps, I had collected water in a container intending to take it to be tested. I really smelled generally off. By the time I had scrubbed twice in a  week the smell disappeared.  For 3 weeks I have also cut milk products and eggs. I checked my calendar and am not surprised that my cycle would have started yesterday for this month. Last night my left pointer finger started itching and it became inflamed, exactly in the same area I believe the first signs started after continually opening and closing a spring water bottle for 3 weeks. I am a strong believer now about petrochemicals in plastic causing skin disorders and I know this is where mine started 3 years ago. I also notice now that if I become stressed/ over tired/ my anxiety levels pitch that my hands and scalp start heating up and become itchy. Sorry for the book length story. I hope it helps some body.  

Following on from the report about Leo Pharma submitting their new aerosol for psoriasis to the FDA, today they announced they have also submitted a Marketing Authorisation Application to 30 European Health Authorities for Enstilar.

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LEO Pharma today announced it submitted a Marketing Authorisation Application to 30 European Health Authorities for Enstilar (calcipotriol/betamethasone dipropionate 50 micrograms/g / 0,5 mg/g) cutaneous foam for the treatment of psoriasis vulgaris, a chronic, inflammatory skin disease that can significantly impact quality of life for patients. Enstilar has the potential to be the first fixed combination cutaneous foam approved for the treatment of psoriasis vulgaris.

The new cutaneous foam formulation is a fixed combination of calcipotriol and betamethasone (as dipropionate) developed with the aim of improving treatment for patients with psoriasis vulgaris the most common form of psoriasis.

The European submission is based on the phase 3a trial, the PSO-FAST trial, which evaluated the efficacy, safety, itch relief and improvement of itch-related sleep loss across a four week period with Enstilar as well as the phase 2 maximum use systemic exposure safety study of Enstilar.

Kim Kjøller, Senior Vice President, Global Development at LEO Pharma, commented:

“We believe Enstilar has the potential to provide a new, topical treatment option for patients living with psoriasis. Helping people suffering from skin conditions is at the heart of what we do and this regulatory submission, along with our existing treatment portfolio and patient support offerings such as QualityCare, reinforces our commitment and takes another step toward improving quality of life for people living with psoriasis.”

Hi - I'm about to start using magnesium chloride flakes (mixed with water and put in a spray), as I've read encouraging things about it on another website.  Has anybody here been using it?  If so, good results?

Thanks,
Mary

They are still often recommending using methotreaxte with bio treatments in some cases, this large study of 95,941 patients suggests you may also need to take a herpes zoster preventive vaccine too.

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Importance:  
The risk for herpes zoster (HZ) in patients with psoriasis treated with biologic medications or other systemic treatments has been given little attention to date.

Objective:  
To describe the risk for HZ in patients with psoriasis and its relation to treatment.

Design, Setting, and Participants:  
A cohort study was performed using the administrative database of Clalit Health Services, the largest public health care provider organization in Israel, in the setting of general community clinics, primary care and referral centers, and ambulatory and hospitalized care. We extracted information for all patients who received a psoriasis diagnosis from January 2002 to June 2013. Follow-up was conducted until the end of July 2013. The study included 95 941 patients with psoriasis in the analysis, with 522 616 person-years of follow-up. Incidence of HZ events was calculated for each systemic antipsoriatic medication provided, during a follow-up period of 11 years and 7 months. We used a generalized estimating equation Poisson regression model to examine the effect of each systemic treatment for psoriasis on HZ incidence, adjusting for age, sex, psoriasis severity, Charlson comorbidity index, steroid treatment, and socioeconomic status.

Main Outcomes and Measures:  
Incidence of HZ associated with systemic therapies.

Results:  
In a multivariate analysis, it was observed that treatment with phototherapy (rate ratio [RR], 1.09 [95% CI, 0.62-1.93]; P = .99), methotrexate (RR, 0.98 [95% CI, 0.78-1.23]; P = .83), cyclosporine (RR, 1.16 [95% CI, 0.48-2.80]; P = .49), and biologic medications as a single agent (RR, 2.67 [95% CI, 0.69-10.3]; P = .14) was not associated with HZ. The use of combination treatment with biologic medications and methotrexate was significantly associated with an increased incidence of HZ (RR, 1.66 [95% CI, 1.08-2.57]; P = .02). The use of acitritin was associated with decreased incidence of HZ (RR, 0.69 [95% CI, 0.49-0.97]; P = .004).

Conclusions and Relevance:  
Physicians may need to consider offering an HZ preventive vaccine to patients receiving combination treatment with biologic medications and methotrexate, particularly if they have additional risk factors for HZ.

Hi All,

New member here and must say I find this site very helpful to all the p suffers out there good to know your not alone.
I know there has been few threads on fumaderm but would just like to ask if anybody had success on it with gutte P, I am on my second week of fumaderm have gone up to two tablets a day I know about the side affects and am willing to continue and hope for the best as have been suffering with P now for 16 years since I was 14 now am 31. I have exhausted all other treatments with no relief the sun those clear it completely but always comes back within two weeks my arms torso and legs are the worst affected sometimes get it on my face but able to control p on my face.

I am just hoping fumaderm will help with my p make it more controllable so I can live a better life and be able to wear a tshirt again and hopefully go for a swim without stares

Any feedback would be much appreciated.

Thanks
Steve

Hello all. Some here have asked that I start a thread and talk about my experience with Cosentyx. At this point I don't have a lot to say as I just started it this past Monday. The shot itself was the new skin activated pen and I felt nothing, so that is good news. The second dose was delivered yesterday to my house and I'll take it Monday. Not sure if it's wishful thinking but it does look like some plaque is going away. I'll keep everyone posted as I get more treatments

Hi I'm Brad from Florida.  I've had psoriasis for nearly 15 years. I've been on most biologics including enbrel, stalera, methotrexate thrown in with some, remecade and now cosentyx. I've used enough creams and lotions to fill up a swimming pool. I'll keep you all posted on how well the cosentyx works. Glad to be here with fellow sufferers

hello every one I am new here and I'm not looking for help I am here to help you if you want, this is a terrible condition and in my case was easy to hide (legs) but can't imagine how hard is for some people that can't hide it, I am writing and makes me happy just to think how good it feels and makes me feel good that finally I can help other people around the world, so lets gets started.

First of all if you decide to do this it's because you need it and you believe you can cure your self, if you don't believe in this is because you don't have psoriasis and don't need help.

I am not looking for money, yes guys no money I have a good leaving and not asking for money.

ok I will give you the cure but read my true story and ask me whatever you want I am not hiding anything.

At the age of 28 years old move to Canada because of violence in El Salvador and decide to start again it was not easy and got stress etc. etc. anyways 1 year later was this patch appears in my legs and hand but not to aggressive but got worst really bad and bigger, itchy with blood and everything could not believe it I am healthy guy wearily had cold or flu I am talking about good health, so this was driving me insane try our free and good health care in Canada and many doctors said WE have NO cure, that killed me right there, but like a good stubborn Spanish guy could not give up, so one day visiting my country my uncle and good friend told me go to see our natural medicine doctor and I said yes, I know this doctor we are natural medicine people in my family " not all of us " , make you story short this guy is amazing switch from what we know as doctor study so many years like all of them at the university, and after years practicing his profession he decide to look for something else because could not help a lot of patients, so he went MAYAN medicine and now here is the cure.

do it exactly as he says or don't do it at all.

for the next 40 days 2 lemons first day second day 4 lemons third day 6 lemons until you reach 40 lemons and then you start reducing 2 lemons per day until cero lemons. it can be mixed with water and drink it through the day if necessary.

NEVER AGAIN in your entire life eat or try or taste MILK and PORK yes you are reading right NEVER AGAIN

For the next three months you need natural pills for DETOX that he sells they are made of plants don't know what kind but the name is in Spanish and you can search.

for the next 3 months avoid or don't eat any dead animals , NO meat is better.

breakfast must be mostly fruits

lunch 50% salads

avoid heavy dinners

8 glasses of WATER as MINIMUN, no matter if you live in a f... igloo drink WATER.
it will start clearing after a month remember your whole life been putting stuff in your body that he doesn't like any more, be patient

and that's it for now I have to go to work wish you the best, be well.

I have just read an article in the Mail on Sunday. March 15th, about a pill called Apremilast. I did a search on this site and found it has been mentioned in earlier posts. It says it is now available on the NHS. I wondered if anyone has tried to get on this pill.

Hi. I`m very surprised no one has mentioned Aloe-Vera. I have been on you-tube, and there is quite a lot of video´s on using Aloe-Vera. I would like to know if anyone has ever tried this. They have the plant and cut a stem, or a leaf, whatever you want to call it, trim the outside edges off, and then separate the front and back and scrape the inside, out of it. Apparently you can also take it orally. I know you can buy jars of Aloe-Vera, but i wouldn´t think it would be as good as the natural oils.

Just a thought. Thanks.

Following on from the report last December that there could soon be a deal done with the National Institute for Health and Care Excellence (NICE) and the use of Stelara for the treatment of psoriatic arthritis, finally it's been worked out and Stelara will now be available. There is a catch however: It won't be used as a first line bio and you will have to wait till you have tried the others first.

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Janssen's Stelara has been recommended by NICE as a treatment option for patients with active psoriatic arthritis a year after the Institute was minded to reject the treatment.

In final guidance, Stelara (ustekinumab) is now recommended either alone, or in combination with methotrexate, as a second-line therapy.

It is specifically for patients whose response to previous non-biological disease modifying anti-rheumatic drug (DMARD) therapy has been inadequate.

It is also recommended for patients who have had treatment with one of more TNF-alpha inhibitors, such as Janssen's own Simponi (golimumab) and Remicade (infliximab), as well as AbbVie's Humira (adalimumab) and Pfizer's Enbrel (etanercept).

NICE last year said it would not recommend the drug as it was too costly, but a patient access - which cuts the price of the medicine - has since been offered by the firm, helping it get onto the NHS's funding stream.

The recommendation also limits the drug to be used after other have been tried, meaning its sales potential in England will be knocked as it will not be funded as a first-line therapy.

Peter Barnes, medical director at Janssen UK, said of the decision: “We are delighted with today's recommendation from NICE. We know that people living with psoriatic arthritis are in real need of additional treatment choices that can help them manage a debilitating and often painful condition.

“Ustekinumab could have a marked positive impact of the quality of life for many of these patients living with active psoriatic arthritis and represents an important additional treatment option for this condition.”

The list price for the treatment is £2,147 per 45mg vial, and NICE estimates that the average annual cost for a 45mg and a 90mg dose are £10,735 and £21,470 in the first year, and £9,304 and £18,608 per year thereafter respectively.

Hi there, I do not have psoriasis however my mother has been struggling with it for more than a year. She's had it both on her scalp and multiple areas on her body. The plaque on her body has mostly cleared with the help of psoriasis creams she bought otc from Walgreens. However, her scalp psoriasis was only getting worse. She tried many methods both prescribed medication and home remedies.
About two months ago a friend recommended clotrimazole and betamethasone dipropionate cream. I think it's supposed to be used for fungus and it's not normally prescribed for scalp treatment however it worked! And it worked pretty quickly. My mom's head is almost entirely clear.
I'm writing here because I've seen my mom suffer from psoriasis..I watched her everyday cringing from the burning sensations she felt. It broke my heart to watch her go through this because I felt there was nothing I could do... thankfully she's doing a lot better because of this cream.

So I wanted to help anybody else who might still be dealing with scalp psoriasis. If you've tried everything and nothing seems to work, try this cream. Give it a few weeks, hopefully it'll work for you the way it worked for my mom. Nothing else seemed to work for her but this.
clotrimazole and betamethasone dipropionate cream

Hi guys I got psoriasis from 2009 I tried all possible treatments, from February last year I'm on fumaderm.First 3 months was terrible for my stomach now is fine.Question is I been on 6 tablets,than 4 tablets and at the minute just 2.But about 6 weeks when I start take it 2 psoriasis come back on my knees and elbows and is more biggest and thickness. My consultant said that I have take bigger dose again but I had not really good blood test for liver. Maybe someone has similar situation because I take it 4 tablets from last 3 weeks and psoriasis is still the same,maybe I have to use dovobet again??

Hi, my name is Gilly and I live in Australia.  I'm looking forward to making some friends on here, trying some new treatments and sharing ideas. For 3 years I have seriously thought about poking myself in the eye with a pointy stick    just to take my mind off my skin but here I am all body accessories still intact joining a forum hoping to find "my cure"  

Novartis have announced they will be presenting data on Cosentyx at at the 73rd Annual Meeting of American Academy of Dermatology that shows superiority over Stelara for psoriasis.

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Novartis announced today that new results for Cosentyx (secukinumab) in moderate-to-severe plaque psoriasis, including detailed findings from the head-to-head CLEAR study and long-term data from the Phase III program, will be presented as late breaking research at the 73rd Annual Meeting of American Academy of Dermatology (AAD), from 20 - 24 March in San Francisco, California, USA. In total, 25 posters from the Novartis Dermatology portfolio will be highlighted at this leading congress.

New data from the CLEAR study will include results that demonstrate Cosentyx is superior to Stelara (ustekinumab) in clearing skin (PASI 90 and PASI 100) at Week 16. CLEAR is the first Phase III psoriasis study designed with a PASI 90 objective, which is considered an important measure of treatment success by the European Medicines Agency and an optimal treatment goal for patients.

In addition, new long-term results for Cosentyx up to two years from the Phase III program will be highlighted for the first time at the congress. The data comes from an extension of the pivotal FIXTURE and ERASURE studies. In the FIXTURE study, Cosentyx cleared the skin of 72% psoriasis patients compared to 31% for Enbrel (etanercept) at Week 16.

"We are excited to present new late-breaking research at AAD, following the back-to-back regulatory approvals received earlier this year," said Vasant Narasimhan, Global Head of Development, Novartis Pharmaceuticals. "Our commitment is to keep demonstrating more evidence on the ability of Cosentyx to clear psoriasis skin, to inform physicians and give hope to people living with this life-long disease who need treatments that provide long-term relief."

In January 2015, Cosentyx (at a dose of 300 mg) became the first and only interleukin-17A (IL-17A) inhibitor approved in Europe as a first-line systemic treatment of moderate-to-severe plaque psoriasis in adult patients, and in the US as a treatment for moderate-to-severe plaque psoriasis in adult psoriasis patients who are candidates for systemic therapy (a drug that is absorbed into the bloodstream and distributed to all parts of the body) or phototherapy (light therapy). In addition to the EU and the US, Cosentyx has been approved in Switzerland, Chile, Australia and Canada for the treatment of moderate-to-severe plaque psoriasis and in Japan for the treatment of moderate-to-severe plaque psoriasis and active psoriatic arthritis (PsA).

My first time on the forum . I hope this is the correct place for questions .
If it's not - sorry , but here goes anyway .

Is there any such thing as a "trigger "that can cause the onset of psoriasis ?

Almnost exactly a year ag i was working decorating the bathroom at my home .
I was wearing latex surgical gloves as I was applying neat household bleach to
clean the grout in the tiles . As I was using the bleach I felt it trickling along my
right arm from my wrist to my elbow . It was stinging quite a bit at the point where the latex
glove meets the inner side of my wrist . Because I was almost finished I stupidly carried on for a few
more minutes .

When I removed the glove I could see that my inner wrist was weeping blood .

I washed under cold running water and thought no more of it .

Over the next few days my wrist became quite soe and it was clear to me that the bleach
had burnt me quite badly . Again , stupidly , I did not seek medical attention and just left
it to it's own devices to heal naturally .

Over the following months the burn has settled down with regard to pain but has left a vivid
deep red scar measuring roughly one inch by one half inch . The skin has still not healed properly
and forms small white plaques that continually produce dead white skin with much the sameearance as psoriasis plaques .

Over the following months i began to develop patches of what my doctor told me is psoriasis .

A two inch circle around the entire area of my right elbow .

Several half inch laques on both legs .

One on my stomach .

A few on my lower back .

So here's the question ?

Due to the appearance of the scar on my wrist, and how it appears much the same
as psoriasis , is it possible that the initial burn has triggered the appearance of psoriasis ?

Apart from mild acne as a boy i have never had any skin problems .

It seems strange to me that this has suddenly happened .