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Psoriasis Club is a friendly on-line Forum where people with psoriasis or psoriatic arthritis
can get together and share information, get the latest news, or just chill out with others who understand. It is totally
self funded and we don't rely on drug manufacturers or donations. We are proactive against Spammers,
Trolls, And Cyberbulying and offer a safe friendly atmosphere for our members.
So Who Joins Psoriasis Club?
We have members who have had psoriasis for years and some that are newly diagnosed. Family and friends of those with psoriasis
are also made welcome. You will find some using prescribed treatments and some using the natural approach. There are people who
join but keep a low profile, there are people who just like to help others, and there are some who just like
to escape in the Off Topic Section.
Joining Couldn't Be Easier: If you are a genuine person who would like to meet others who understand,
just hit the Register button and follow the instructions.
Members get more boards and privileges that are not available to guests.
OK So What Is Psoriasis?
Psoriasis is a chronic, autoimmune disease that appears on the skin. It
occurs when the immune system sends out faulty signals that speed up the
growth cycle of skin cells. Psoriasis is not contagious. It commonly
causes red, scaly patches to appear on the skin, although some patients
have no dermatological symptoms. The scaly patches commonly caused by
psoriasis, called psoriatic plaques, are areas of inflammation and
excessive skin production. Skin rapidly accumulates at these sites which
gives it a silvery-white appearance. Plaques frequently occur on the
skin of the elbows and knees, but can affect any area including the
scalp, palms of hands and soles of feet, and genitals. In contrast to
eczema, psoriasis is more likely to be found on the outer side of the
joint.
The disorder is a chronic recurring condition that varies in severity
from minor localized patches to complete body coverage. Fingernails and
toenails are frequently affected (psoriatic nail dystrophy) and can be
seen as an isolated symptom. Psoriasis can also cause inflammation of
the joints, which is known as (psoriatic arthritis). Ten to fifteen
percent of people with psoriasis have psoriatic arthritis.
The cause of psoriasis is not fully understood, but it is believed to
have a genetic component and local psoriatic changes can be triggered by
an injury to the skin known as Koebner phenomenon. Various
environmental factors have been suggested as aggravating to psoriasis
including stress, withdrawal of systemic corticosteroid, excessive
alcohol consumption, and smoking but few have shown statistical
significance. There are many treatments available, but because of its
chronic recurrent nature psoriasis is a challenge to treat. You can find more information
Here!
Got It, So What's The Cure?
Wait Let me stop you there! I'm sorry but there is no cure. There are things that can help you
cope with it but for a cure, you will not find one.
You will always be looking for one, and that is part of the problem with psoriasis There are people who know you will be
desperate to find a cure, and they will tell you exactly what you want to hear in order to get your money. If there is a
cure then a genuine person who has ever suffered with psoriasis would give you the information for free. Most so called cures
are nothing more than a diet and lifestyle change or a very expensive moisturiser. Check out the threads in
Natural Treatments first and save your money.
Great so now what? It's not all bad news, come and join others at Psoriasis Club and talk about it. The best help is from accepting it and talking
with others who understand what you're going through. ask questions read through the threads on here and start claiming
your life back. You should also get yourself an appointment with a dermatologist who will help you find something that can
help you cope with it. What works for some may not work for others
I am a retired Science Teacher and I have plaque psoriasis. My old Army buddy is a retired Orthopedic Surgeon. We both suffer from Osteoarthritis in the knees. He suggested that I try a prescription topical anti-inflammatory treatment named PENNSAID that he had had good results from. I did, and also found a great deal of relief from knee pain. The problem for me was that the prescription was not covered by my insurance plan and the out-of-pocket cost was hideously expensive.
Stay with me. I'm getting to the good part.
We noticed that the two active ingredients of PENNSAID are Diclofenac Sodium and DMSO (Dimethyl Sulfoxide). We did some research and discovered that another prescription topical gel named VOLTAREN is nothing more than Diclofenac Sodium and is rather cheap at $20 per tube. We also found that DMSO in gel form is cheap and readily available at any tack shop (those stores that sell horse and equestrian equipment), where it's sold as a horse liniment.
We both began using VOLTAREN and DMSO mixed half-and-half and had the same pain relief as we'd had with PENNSAID at much less than a tenth the cost.
Now the good part:
My plaque psoriasis is on the top of my left foot. Covered with a sock and shoe it itched constantly. I have been to several dermatologists and I have tried everything except the systemic medications.
Out of desperation, I began treating my plaque psoriasis with the same mixture of VOLTAREN and DMSO I've been using on my knees and IT HAS DISAPPEARED! I have been in remission for four months, now, plaque- and itch-free.
I am not suggesting that this is a cure, and I am not suggesting that you try it yourself before consulting with a physician. I am suggesting that you and your physician both read the cautionary notes on PENNSAID, and that you apply the mixture as instructed on the PENNSAID website. You will need a prescription for the VOLTAREN, but not for the DMSO. If you can't find a local tack shop, you can find DMSO for sale on Amazon. Buy the small jar of DMSO in gel form. I apply the VOLTAREN first, enough to cover the plaque, and then apply about the same amount of DMSO. Luckily, my German wife can buy double-strength VOLTAREN FORTE over-the-counter in Germany and bring home a few tubes for me. It's possible that you may also be able to buy VOLTAREN on Amazon, but use caution if you don't trust the supplier.
Good day folks . First time on any forum so here goes . Had P for about 40 years or more and like most people have tried every flipping thing good and bad . Puva has been my number one choice and it always worked like a dream normally for 6 to 12 months . Sadly the doctors are getting nervous about how much sun I have accumulated over the years so change of tactic . Today I have started a course of treatment using Humira 80 mg today , then down to 40 mg . Had a bad time with the self injection but will have to get used to it . It took a long time to get on this treatment "penny pinching" in my mind £7000 a year a read . My big concern is a whole list of side effects . Are any of you guys on the medication and if so any advise . Fingers crossed it goes well . Thanks for the invite .
Posted by: kev-n - Fri-27-02-2015, 01:48 AM
- Replies (8)
well as the title really looking at what works for other people, i'm a 45 yr old male and suffred with psoriasis for quite a few years now, currently got patches on my face, scalp, behind my ears, 2 large patches on my knees, bottom of my belly. most of it is plaque psoriasis apart from my scalp, the problem i find is whatever i use only works for about a week, then i need to change.
i've now also got patches appearing under my nails.
i was using neutragena thereaputic shampoo which worked for a while even cleared the patches on my knees for 3 or 4 years until the patches came back recently and now nothing seems to work. i changed shampoo recently to capsal theraputic shampoo this seemed to work again for about a week, now it's making no difference.
i've also tried exorex treatment, worked wonders for me before now just dries my skin out (even with moisteriser) several different 'dermo' shower gels, i'm now using a pure coconut oil gel, i've also tried e45, several over the counter creams from the chemist, cider apple vinegar both drinking diluted or applying to the legions with no effect. currently the itching is getting really bad i just want to scratch myself to bits.
tried going to my local doctor on several occasions (they are quite useless around here) first one said it was ringworm and gave me a cream, within 24 hours i was back at the doctors because the cream he prescribed made the psoriasis spread like wild fire. he then said he would send a skin sample off to be tested and i never heard another word. last doctor i saw told me to change my diet and cut out all sweet food, anything with caffine in and all red meat.
so i'm now at the point to try suggestions of best next course of action.
Hi guys, I have bern suffering from psoriasis just over 10 years now. I have been prescribed everything from steroid creams, UV, puva etc. Spending a fortune on this debilitating disease. So after so many different derms I have finally found one who is listening to me!! Might be due to the fact that im seeing him privately, but hey its worth it. So, he has prescribed me Fumaderm which I started yesterday! All good so far just some tingling going on through my body. Il be taking the second tab tonight with dinner. Really find this group so helpful and accommodating!! Will keep you all updated with progress. If anyone has any tips please share them with me as I am nervous after reading up on the side effects. However all the good stories of relief and keeping clear have me motivated to get passed that and keep going. I am getting married in August and really hoping to be clear.
As i have said i only have mild ps to some of you, and i asked in a previous post about tablets. I have never been offered tablets, and it was said my doctor probably wont´put me on them, because i haven´t got it severe enough. Surely taking tablets is a lot easier than putting cream, and ointment on every day. So if you think my doctor won´t prescribe fudamern, will he give me something milder.
I am in Tenerife for another two months and as was mentioned, using dovonex, and being in the sun it says don´t mix. I come over here for six months of the year for the sun which helps a lot, so i don´t want any creams or ointments that will be detrimental to my ps. I would still like to know what creams, or ointments other members have found to keep it under control.Thanks
Hello my name is Janet and would like to hello. I have struggled with psoriasis for at least 4 years. I can`t use the common treatments for it because of the damage it does to my kidney. Had to have one removed in 2003 and everything i`ve tried reduces my kidney function. Am looking forward to talking to someone with similar problems and hope for a treatment besides creams and oils.
How have you managed to deal with having psoriais mentally? I don't think anyone really questions this or how you cope everyday? So I would like to ask.
I have moved Karaokekings question to its own thread here rather than take ccar's thread off topic
Karaokeking wrote
Quote:
Hi Jim. Here is my question. As i said in my introduction i am at the moment in Tenerife. I will be going back to the U/K at the end of April, so when i go back i am going to see my doctor and as about Fumaderm. Will i have to ask him to see a Dermatologist or can he prescribe them himself.
You also mention about being firm with the doctor, so can i insist on seeing the Dermotologist, if he won´t prescribe Fumaderm. Now i only have it mildly, so will that be relivant, on getting it prescribed.. Thanks again.
My answer to this is if you only have mild psoriasis you are unlikely to get it prescribed unless you can convince you dermatologist that the psoriasis is profoundly affecting your quality of life.
To get Fumaderm on the NHS you will first have to be refered by your GP to a dermatologist. A GP cannot prescribe it as it is not a licensed drug yet and only available from specialists
My suggestion is to see your doctor and tell him of your concern about using steroid creams and they are doing little or no good and sunlight is damaging your skin ..
Your doctor should refer you to see a specialist but the specialist will decide what to try. And to be honest I don't think you will be offered Fumaderm but may be offered Methotrexate.
Posted by: Fred - Fri-20-02-2015, 22:13 PM
- No Replies
Lots of psoriasis biosimilar treatments coming forward these days and here is good news from another one. Oncobiologics ONS-3010 adalimumab (Humira®) biosimilar candidate met the primary endpoints in its first clinical study.
Quote:
Oncobiologics, Inc.,a biotherapeutics company focused on developing and commercializing biosimilars,announced today that ONS-3010, its adalimumab (Humira®) biosimilar candidate met the primary endpoints in its first clinical study.
A 3-arm single-dose pharmacokinetic (PK) study was performed in healthy volunteers to compare ONS-3010 to both the US- and EU-sourced Humira® reference products, and the two reference products to each other. All of the PK endpoints met the bioequivalency criteria of the geometric mean ratios within 90% confidence interval of 80-125%. These included: maximum serum concentration (Cmax), area under the time-concentration curve from first time point extrapolated to infinity (AUC0-inf), and area under the time-concentration curve from first to last time point measured (AUC0-t). Safety and immunogenicity were similar across the three arms. An exploratory ex vivo pharmacodynamic study also showed encouraging results between ONS-3010 and the reference products on TNF-α blockade and the induction of specific inflammatory responses. This first-in-human study was conducted by the Centre for Human Drug Research (CHDR) in Leiden, The Netherlands.
ONS-3010 is being developed as a biosimilar to adalimumab, an anti-TNF-α monoclonal antibody, which is approved in many countries for the treatment of multiple inflammatory diseases that include rheumatoid arthritis, plaque psoriasis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis, as well as several pediatric indications. ONS-3010 has the same amino acid sequence, pharmaceutical dosage form, and strength but contains a formulation of different composition.
“The clinical PK similarity study is a required regulatory milestone for biosimilar development. We are excited to report that ONS-3010 has met the PK endpoints, which strengthens our confidence in achieving the global development of ONS-3010 as a biosimilar to Humira®,” stated Claude Nicaise, M.D., Chief Medical Officer at Oncobiologics.
I just thought I would introduce myself.
I have had PPP for donkeys years and apart from a brief sojourn to the specialist some 20 years ago have always just put cream on to moisturise and just got on with life. Over the last few years however, having got divorced and then found happiness together with lots of old family stresses and deaths etc. suddenly kerblam major breakout! Instead of just a little on one foot I now have it majorly on both. Slightest little bit of stress sets it off. Am currently under specialist and having had light treatment and various creams I have now been told I need to get on Acitretin, which to be frank, scares me to death!
Back on 6th December I last visited and was told I would be recalled in 4 to 6 weeks. I had to have all the bloods taken in readiness ........... I am still waiting to see him and haven't even had an appointment yet! I am still using steroid cream which he wants me to get off but when I do it flares up immediately. I am not a happy bunny with it all. But hey, I am also patient and will just wait; ringing occasionally of course to find out that they "have not forgotten me" lol.
So I have lots of questions, which will not doubt come out over time. I have joined this forum because I thought I was the only person who suffers with this thing! Everything is usually just down to me right! How wonderful to find that I am not alone in it. (although I would prefer it if no one had it or that they find a cure!)
Sorry to be a nuisance, I have a couple of quick questions. Think i have maybe asked one on the introduction thread, when I should have stared a new thread, in the right place.
Caroline I seen somewhere, you said about the rules to follow when taking fumaderm, (not sure rules is the right word you used but hopefully you know what I mean). I have read about eating when taking them (certain foods, yoghurt etc) but apart from that I am not doing anything else different. Did you mean things that interact with them or things to help the side effects? thanks.
Jiml, I looked at the info you had put on about the 16 week mark, thanks. I have not found decent info on what levels should be or not. i.e lymphocytes etc. Is this something you can help me with?
My bloods on Wednesday show Lymph at 0.8. Are there others I should keep an eye on? Not been feeling great this week since going up to 6 and wondered if it could be settling into that dose or i'm just a hypochondriac ! ha
Posted by: Lostsoul - Fri-20-02-2015, 00:49 AM
- Replies (19)
I'm stuck in a big problemo which I can't find a reasonable answer to.
I've recently been referred back to light treatment but the hospital is over half an hour away, I don't drive And I rely on public transport I also have a 3 month old daughter. I'm also moving further away from where I live which doesn't have a train station nor busses that travel to where I need to go. The other thing is I'm going back to college in August. I'm struggling to deal with the fact my psoriasis is getting worse.
I need advice on what I shoud do as I feel like giving up with the treatment before it's even started for the fact of not being able to make my appointments.
Posted by: evie - Fri-20-02-2015, 00:14 AM
- Replies (12)
Hi, I am taking Embrel 50mg injections once per week, and I feel I am putting weight on. Is there anything I can do to counter act this? Any help or suggestions would be greatly appreciated, thanks.
I have had psoriasis for approx 15 years .I feel onset was either colouring my hair henna red or, treatment for fungal toe infection. I had a massive flair up after using dovabet,light treatment helped greatly.I have it under control at the moment using salysalic cream on my scalp and coconut oil on my patches (elbows and knees) I am now finding my hair is going grey!!!! (It's my age57)so I am thinking about colouring it has anyone any hint s or tips for me please.
I am hoping someone might be able to give me some advice on Fumaderm.
To give you some background, I have had moderate widespread psoriasis for the last 6 years. It started as one small 'dot' on one arm and quickly spread pretty much everywhere (arms, legs, trunk, inside nose & ears, face, scalp, PPP on palms and soles). I have been prescribed around 15 steroid/vit D analog creams which have maintained my skin but never helped clear any of it up & of course didn't stop new patches from forming.
I have had two courses of UVB treatment, both of which compeltely cleared my skin but only for about a week after finishing each 37 session course. My psoriasis would be back to 'normal' within a month of finishing.
I went to see a new Dermatologist who agreed we needed to look at other options as it wasn't even really feasible for me to even apply the creams as I had SO many isolated patches, all of which were extremely red and inflamed.
We discussed the options available to me and decided to give Fumaderm a try. I started out on just 30mg a day and now 6 months later I have just increased my dose from 6x120mg (720mg total daily) up to 8x120mg (960mg total daily).
My skin has responded fantastically and pretty much all my old patches have gone, leaving only discoloured skin. However, I'm still getting a LOT of new small patches mainly around my hips and the top of the backs of my legs. My Derm advised me to go up to 8 per day if they hadn't cleared up.
I'm a little worried that this dose is VERY high but I have nothing to compare it to. My blood work is all fine but now I'm getting the horrendous gastric side effects again & would just generally like to know about other people's experiences.
I have been reading about the different pills some of you are on I have only been on skin cream. I would like to know what other members are using on there skin, and what results they are getting. As i have said when i first got ps 32 years ago i was put on that coal tar stuff, then for a lot of years i was on Dovobet, but these last few weeks i have been on Dovonex, and have stated it seems to be useless.
I have to say after reading a lot of your posts, that i have it only slightly. I have never ever got rid of it at all for for any period, i have kept it under control, but thats all.
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Psoriasis Cure!
How many people have Psoriasis?
In 2012 there were approximately 36.5 million prevalent cases of psoriasis, and by 2022, GlobalData epidemiologists forecast that this figure will reach approximately 40.93 million.
The condition affects individuals of both sexes and all ethnicities and ages, although there is a higher prevalence of psoriasis in the colder, northern regions of the world.
The prevalence of psoriasis in the central region of Italy is 2.8 times greater than the prevalence in southern Italy.
Caucasians have a higher prevalence of psoriasis compared with African-Americans, but African-Americans in the US tend to suffer from a more severe form of the disease.
