Fumaderm - questions.

[Caroline]

Hi Kath  I have had a look around and the only reference I can find to the German guidelines is this

Quote:

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Current German guidelines recommend a gradual increase in FAE dosage to determine optimal efficacy and tolerability for each patient. During the first week of treatment, patients typically receive one tablet daily of a low-strength 'Fumaderm® initial' formulation (30 mg dimethylfumarate; 75 mg monoethylfumarate as Ca, Mg and Zn salts), increasing over the next 8 weeks to a maximum of six tablets daily of full-strength Fumaderm® (120 mg dimethylfumarate; 95 mg monoethylfumarate as Ca, Mg and Zn salts) taken as a divided dose of two tablets three times daily.[74,75] Clinical benefit is typically observed after 4-6 weeks of treatment.[75] Following psoriasis remission, use of a reduced dose for maintenance should be attempted.[75]

Source medscape.com 
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And it is exactly those "monoethylfumarate as Ca, Mg and Zn salts", that form the trouble. They are completely useless and limit the max dosage.