Theres a bit of a craze at the moment with a lot of people starting up their own business within a company called "F------ l------" which sells Aloe Vera products (and possibly other products)

I do not have an issue with Aloe Vera being used for Psoriasis, BUT I have a huge issue with people selling it to Psoriasis sufferers telling them its a "cure" which I have been targeted with.  Aloe Vera is incredibly soothing for Psoriasis in personal experience, but it doesn't cure it and I just wanted to make a topic on this as I'm getting fed up of people taking advantage of people with health problems and selling them a product that won't cure them just so they can earn an extra buck!

While I'm at it, you can shove your aloe vera juice as well that will "cure" my Crohns.  

I have faithfully applied Doveobet in cream and in fluid on psoriasis for the past four or five years or so, I never had psoarisis before and developed this at about 55 yrs of age, I related this to stress working in Wirral Borough Council call center which was worse than torture. I suffered the ordeal for 9 years. I have left now. However, to get to the point, the more Dovobet I have been prescribed the worse the psoriasis, which covers my lover and upper limbs, backside and my arms. The psoriasis has never been on my chest or back, but only on my arms. Up to last week, skin was so red and sore and peeling off, I found an old bottle of cod liver oil in the cupboard, I though what to loose, I applied this smelly old stuff on arms and legs one time, just so I could get some sleep. I was burning up. Also my friend has psoriasis and is given Donovex as part of his treatment. I said let me have some, can't be any worse that this suffering.  I have applied the Dovonex twice a day for about 8 days, The red burning and scales and rough skin dust has ceased, the area on which I apply, is still pinkish, but the skin is suddenly very smooth, it still itch, but I notice almost white patches of normal slkin where last week was red and bloody and scales, Reading about Dovobet and my experience is that this has been the greater cause of the psoriasis, this application has actually increased the severity of symptoms of psoriiasis, Reading about Dovobex, which I have borrowed, this is a vitamin D substitute, but Is cod liver oli also vitamin D.  All I can say is that The Dovonex is working very much better in recent days that Dovobet has in the five years I have been using.  Is anyone who might read this post experienced clearup using the Dovonex  ?  Is the cod liver oil, I used in despair have anything to do with clearing this ? I doubt it has anything to do with leaving the council, I am still traumatised having had to endure this suffering in a call center. I really really hated it, but I suppose having no alternative you have to do something.  I thought some days I was going to die, having to listen to the rubbish these people in Wirral talk about. I suppose not being a native to North West is no help, I native to South London where we have better things to do than call the council about a bit of litter in Liscard. I don't know what  I suffered the worse the torture of psoriasis or the torture of working for Wirral Borough Council.

One of the questions that I've always wanted to pose to another suffer of psoriasis is whether or not smoking and drinking have any real impact on the way that the plaques deal with such toxins.

As mentioned in a previous thread, I smoke and drink but not to any real extent. Perhaps five or six cigarettes a day and maybe a bottle of wine or so every couple of weeks; I think that's a fair average.

As a very recent prescribed user of acetretin, I have read a confusing degree of information regarding alcohol. The question I have here is; does anyone else think twice before enjoying a pint of hoppy craft beer with their pub lunch or is it an absolute no-no? My partner works with someone who was prescribed methotrexate for psoriasis treatment and apparently drank* throughout the treatment without any problems at all. The effects of psoriasis have all but left.

With regards to smoking, I had my gall bladder removed recently and a nurse in theater said quite plainly that smoking was very bad for psoriasis yet it seems that there is 'no scientific suggestion' that it does otherwise. 

Has anyone recently quit and have noticed a considerable improvement with their skin?

*when I say 'drank throughout', my partners colleague isn't a functioning alcoholic, she just enjoys a drop like most. Just to clear that up! 

Much love, Hellosimon. 

hey there everybody, hope you are having a great start to the weekend.

A little background before I present my query. I am now 27 and have had P since age 16. I have always had it on my scalp and also various parts of my body, however on my body it seems to be sparse and it is worse on my scalp. It has never totally gone. I have been eating much better for the past 6 months and have taken away any refined sugar, dairy, vegetable oil or fried food, white rice and potatoes and red meat (only eat fish now).. I don't smoke and have always exercised but more more these days. This has helped a lot but I do fall down and drink alcohol once every week or 2. 

My point here is that I purchased some Dr Bronner's 1 in 18 natural lotion to wash with in the shower, scalp and body. It is very natural and I have heard so many good things about it for people with P, however it seems to aggravate my plagues by making them dryer and more inflamed, a sort of angry red. I have heard people with skin conditions speak highly of this stuff and the ingredients do seem to be very natural, the only questionable thing may be hydrogen peroxide, but I am not chemist. I do recall though that tea-tree oil had a similar reaction with my P and this stuff contains that, but again others have spoken highly of tea-tree oil.. Could this just be me? Do I need to dilute the solution when using it to wash because I do not want to use soaps that are full of chemicals anymore, something all natural. Can anybody offer their experience with Dr Bronner's and other natural ways to wash? 

Tom

Hello! 

What can I say, well.... I've had P since I was 10...so that's 35 years of fun...visiting dermos, some of which were interested, some of which were merely passing through never to be seen again and some who should really never have started a career in medicine! The P has always been bad and I've always avoided the riskier (?) treatments and opted for topical with some UVA thrown in for good measure ...but it's getting to the point now where I'd quite like some relief - or at least enough time to be able to teach my small children how to swim.. So, I'm going back to the Derm...and armed with the advice I've already seen here and undoubtedly some questions I'll pose here too, see what can be done.  Onwards! And thanks for reading.

So hey, im lori and im new to this site! ?
Im 29 and have suffered with psoriasis since i was 12 ?
Believe it or not i didnt realise till recently how common it was as i dont know anyone that has psorisis so havent really spoken to other sufferers! So please bare with me ?

Following on from XenoPort starts phase 2 trial of XP23829 in patients with psoriasis there are reports that xenport shares have taken a knock of 25% following their release of the results, though they said they met their primary endpoint in both 800 mg and 400 mg doses of the drug XP23829 investors have been put off by side effects, particularly diarrhea rates ranging from 22 percent to 40 percent at the highest, most effective dose. Other gastrointestinal side effects included nausea, abdominal pain and vomiting, and 15 percent of psoriasis patients treated with the highest dose of XP23829 discontinued the study compared to 2 percent for placebo patients.

Quote:

---

XenoPort, Inc. announced today positive preliminary top-line results from its Phase 2 clinical trial of XP23829 as a potential treatment for moderate-to-severe chronic plaque-type psoriasis. XP23829 met its primary endpoint in both 800 mg once daily and 400 mg twice daily doses, demonstrating statistically significant improvements in percent change from baseline to week 12 in Psoriasis Area and Severity Index (PASI) score. XP23829 is a patented prodrug of monomethyl fumarate (MMF) in a novel oral formulation that was designed to potentially offer physicians and patients an effective, better tolerated and easier to use therapeutic option to currently available fumarate products.

Richard Kim, M.D., chief medical officer of XenoPort, stated, "We believe these clinical data demonstrate for the first time that a MMF prodrug other than dimethyl fumarate (DMF) can be effective in reducing lesions in psoriatic patients. The magnitude of XP23829's effect on the primary efficacy endpoint met our expectations for this relatively short duration trial and we are particularly encouraged by the results with 800 mg once-daily dosing. Based on what is known about fumarates, we believe that the efficacy of XP23829 is likely to improve with a more extended duration of treatment beyond 12 weeks. We are also pleased with the safety and tolerability profile of XP23829 emerging from this study. We believe that this demonstration of efficacy, safety and tolerability of XP23829 could lead to a differentiated product in psoriasis. We also believe that there is potential for the observations from this study to read through to other potential indications such as multiple sclerosis (MS)."

Description of the Trial:

This randomized, double-blind, placebo-controlled Phase 2 clinical trial of XP23829 was conducted in 33 sites in the United States in subjects with moderate-to-severe chronic plaque-type psoriasis. Two hundred eligible subjects were randomized to placebo or one of three treatment arms of XP23829: 400 mg or 800 mg once daily (QD) or 400 mg twice daily (BID). The 12-week treatment period included a three-week titration period followed by nine weeks of treatment at the targeted dose. There was a washout phase of up to four weeks prior to randomization for subjects who were previously taking systemic agents for the treatment of psoriasis. Treatment assignment was stratified based on prior biologic use and approximately 35% of randomized subjects had previous experience with biological treatments for their psoriasis.

XP23829 was safe and generally well tolerated. There were no deaths or life-threatening adverse events. No subjects met the safety discontinuation criteria and the majority of treatment emergent adverse events were non-serious and mild or moderate in severity. Diarrhea adverse event rates were consistent with other drugs in the fumaric acid ester class ranging from 22% to 40% in the XP23829 treatment groups compared with 15% for placebo. Other treatment emergent adverse events occurring at an incident rate of greater than or equal to 10% were nausea, abdominal pain, vomiting and headache. The incidence of flushing in the XP23829 dose groups was similar to placebo. Gastrointestinal events were the most frequent adverse event leading to withdrawal during XP23829 treatment. There were two treatment emergent serious adverse events assessed as possibly related to treatment with XP23829: acute cholecystitis and enterocolitis. Both subjects recovered.

No subjects experienced Grade 3 or Grade 4 lymphopenia. Less than 5% of subjects in any XP23829 treatment group reached Grade 2 lymphopenia and less than 15% reached Grade 1 at any visit. Lymphocyte levels in all subjects experiencing lymphopenia returned to within normal limits after treatment.

"I'm excited to have participated in this phase 2 study with positive efficacy data that we believe justifies further development of XP23829 into moderate-to-severe chronic plaque-type psoriasis," stated Alice Bendix Gottlieb, M.D., Ph.D., Dermatologist-in-Chief; Harvey B. Ansell Professor of Dermatology, Tufts University School of Medicine and Lead Investigator for the XP23829 trial. "Despite the wide availability of biologics, there still remains a significant unmet medical need for a more effective, safe, well-tolerated, and convenient oral treatment for patients with psoriasis. Fumarates have been the leading treatment for psoriasis in Germany for more than 2 decades. With this long-term real-world fumarate experience and these data in consideration, I look forward to the potential of seeing XP23829 in Phase 3 development for moderate-to-severe chronic plaque-type psoriasis."

"We are extremely pleased by the preliminary top-line results from this Phase 2 study. I want to thank the clinical investigators and the psoriasis sufferers who participated in the study. We look forward to getting the complete data set for this trial later this month and to presenting more comprehensive results at future medical conferences and in publications," stated Ronald W. Barrett, Ph.D., chief executive officer of XenoPort.

Dr. Barrett continued, "In the near future, we intend to share these data with psoriasis and multiple sclerosis experts, speak with regulatory authorities regarding next steps and explore potential partnerships that could accelerate the development of XP23829 globally. We recently completed non-clinical development studies and manufacturing activities necessary to support Phase 3 development and we believe we will be ready to potentially initiate Phase 3 studies in 2016."

Hello

I've just joined the site and I thought I'd introduce myself. 

I was diagnosed around five years ago and have tried a variety of topical treatments, varied diets and have very recently been prescribed acetretin so I'm hoping for positive results.

The psoriasis* is spreading pretty much everywhere and it has knocked my confidence for six. My partner is really supportive and I owe so much to her. I guess I'm in a similar if not exact situation to many other members here.

I've joined as I would like to hear others stories regarding treatment, diet and how they get on with smoking and drinking. I smoke and drink but not in any particular quantity.

*I'm a little funny about calling psoriasis 'my' psoriasis. I don't own it. It doesn't belong to me, I didn't ask for it therefore it is not mine. I hope everyone is ok with me using this terminology and in my posts, I will be referring to it as exactly that. 

I look forward to discussing everything psoriasis with you all and I will keep the forums posted with progress and personal feelings about it, and the treatment.

I am currently having a lovely time in Menorca whilst I am really enjoying (if a little paranoid) about getting my skin out in the sun so if I don't respond immediately, please don't be put off. I will respond to all posts and I hope to play a positive part as a  community member on this board. 

Much love, Hellosimon.

Hi I'm Lindsay..... A newbie to this site but has psoriasis on hands and feet for the last 20 odd years! 

I've have been on the Cosentyx trial for the last year and now able to continue using i. Although I'm not clear I am 80% better and almost pain free. I'm looking forward to following the progress of Cosentyx users. 

Hi -- I'm new.

I've never been on drugs for psoriasis, but I do find that sunlight helps tremendously.  So all summer and into the fall, I'm doing ok.  But then winter comes.  The sunlight isn't very strong and I'd get frostbite if I went out without clothes.  Things get worse and I find I'm just holding on until spring.

So I'm wondering what the options are for home phototherapy.  Is anyone actually doing this?  If so, what equipment would be recommended?

It's mostly in my nails, but I have wondered if the winter time arthritis I get is also related.

I didn't take up the flu jab when I was on mtx but now I'm on Humira I'm feeling the pressure to conform.. However I know more than one person who gave the flu jab a go for a couple of years, and were very poorly after. One ended up on very specific unpleasant antibiotics to clear a chest infection which began straight after and would not go away.

Now, don't shout me down, I have biology a level and I understand that the jab is not a live vaccine so you can't catch the flu from the jab. But this doesn't help explain the anecdotes which have put me off.

So, I thought I'd have a look on the nhs website to see what ingredients are in it, and was surprised by the number of people who say they were ill straight after and many said it left their arm weak and painful for a long time. I have booked myself in but I'm not sure I want to go through with it (like all medicines I get given lol)

Who on here does take up the annual flu jab and have you had any issues please?

Manu thanks in advance, and anyone who doesn't read this properly and starts the lecture on how you can't catch flu from the jab is getting deleted

My skin is 50% affected with psoriasis and my doctor treat me with 2x of 25g of Mtx every 12hrs for 3x then followed by folic acid on the next 6 days. After 3 weeks of treatments my psoriasis totally gone with only white scars remain on my skin. She advise me also to stop using soap and shampoo instead I use VCO as a soap on my skin then not using harsh detergents on my clothes. I stop also using fabric conditioner. I'm really happy about the result then I started to expose my skin to the sun to balance the color of my skin, but after a month a red dot with itchy feeling started to grow again on my skin. I'm worried to take Mtx again although base on my blood test I'm still good with normal readings. In your experience did the Mtx need to take every 1 month to control our skin problem?

Here's a potential treatment for psoriasis, psoriatic arthritis, and other autoimmune disorders. VTP-43742 is Vitae's first-in-class, wholly owned product candidate for the potential treatment of a variety of autoimmune disorders and orphan diseases.

Quote:

---

Vitae Pharmaceuticals, a clinical-stage biotechnology company, today announced positive top-line results from its Phase 1 single ascending dose clinical study of VTP-43742 in autoimmune disorders. VTP-43742 is Vitae's first-in-class, wholly owned RORγt inhibitor being developed for the treatment of a range of autoimmune disorders, potentially including psoriasis, psoriatic arthritis, rheumatoid arthritis, multiple sclerosis and irritable bowel disease (IBD), as well as numerous orphan diseases.

In this double-blind, randomized, placebo-controlled study that evaluated the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profile of single oral doses of VTP-43742 in 53 healthy human volunteers, VTP-43742 was safe and generally well tolerated at all dose levels across a 60-fold dose range. No serious adverse events were reported and there were no drug-related clinical laboratory or electrocardiogram (ECG) abnormalities.

VTP-43742 was also evaluated in an ex vivo assay for its ability to inhibit the production of pro-inflammatory cytokine IL-17A in blood obtained from study subjects. Subjects receiving VTP-43742 showed a dose-dependent suppression of RORγt dependent IL-17A production by more than 90 percent, with the effect largely sustained over the full 24-hour measurement period.

In animal studies, steady inhibition of RORγt was necessary to achieve full therapeutic efficacy, indicating the importance of a relatively long plasma half-life. The plasma half-life of VTP-43742 was observed to be approximately 30 hours in this clinical trial, supporting the potential for effective once-a-day dosing in humans.

"VTP-43742's robust and sustained lowering of IL-17A production observed in the ex vivo blood assay, paired with its favorable safety, tolerability and PK profile, demonstrate that this first-in-class drug candidate has the potential to safely and effectively treat a range of autoimmune conditions," said Dr. Richard Gregg, Chief Scientific Officer of Vitae. "We are extremely encouraged by the PK and PD data, and look forward to reporting additional clinical results, including top-line proof-of-concept data in psoriasis patients, by the end of the year."

Vitae is currently conducting a Phase 1 multiple ascending dose clinical trial of VTP-43742, which was initiated in August 2015. This trial includes both healthy human volunteers and patients with moderate to severe psoriasis. The Company plans to begin dosing psoriatic patients in the second half of 2015, with top-line clinical efficacy results expected by the end of 2015.

Good news for South Korea after Merck (known as MSD outside the United States and Canada), and Samsung Bioepis announced the approval of BRENZYS™ (etanercept), a biosimilar of the immunology medicine Enbrel, by the Ministry of Food and Drug Safety (MFDS) in Korea.

Quote:

---

Merck (NYSE:MRK), known as MSD outside the United States and Canada, and Samsung Bioepis Co., Ltd. today announced the approval of BRENZYS™ (etanercept), a biosimilar of the immunology medicine Enbrel, by the Ministry of Food and Drug Safety (MFDS) in Korea. BRENZYS is indicated for the treatment of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis (non-radiographic axial spondyloarthritis and ankylosing spondylitis) and psoriasis in adult patients (age 18 years and older).

The approval of BRENZYS in Korea represents the first product approval under Merck’s collaboration with Samsung Bioepis, which is designed to offer high-quality biosimilar alternatives to existing biologic medicines to help address patient and healthcare system needs worldwide. Merck plans to launch BRENZYS in South Korea by the end of this year or early next year.

“We are very excited to receive this first regulatory approval of a biosimilar product resulting from our late-stage development pipeline,” said Christopher Hansung Ko, CEO of Samsung Bioepis. “The approval of BRENZYS in Korea is especially gratifying, and underscores our commitment to advancing healthcare through innovation and groundbreaking technology. We look forward to building on this progress in our collaboration with Merck.”

“The approval of BRENZYS in Korea is a key milestone in Merck’s longstanding commitment to improving access to important medicines,” said Dora Bibila, general manager, Merck Biosimilars. “We are excited by the opportunity to deliver on the promise of biosimilars overall – and on the promise of BRENZYS – by combining Merck’s deep global customer expertise with the extensive development and manufacturing capabilities of Samsung Bioepis.”

Merck’s launch of BRENZYS will include comprehensive education and support services for healthcare professionals, patients and their caregivers, including biosimilars education, disease education, and reimbursement and access support.

The approval of BRENZYS in Korea was supported by rigorous analytical structural and functional testing, as well as a Phase 1 crossover pharmacokinetics study and a Phase 3 clinical study comparing BRENZYS to the originator medicine.

hi every fellow sufferer i have come to realise that creams and moisterises wont cure psoriasis the cure must come from within with that in mind i recently had a bad flare up which affected my body and face i realised i had eaten a lot of biscuits and bread so i decided to give up eating anything which contains wheat let me tell you its in nearly everything so i am carefull to read the ingrediants.
i also have a nutri bullet its a smoothie maker so every day i have one which includes fresh banana and carrot,frozen spinach because its eaier to keep fresh and green vedgtables are very good for the skin also frozen fruits like strawberrys,blueberrys ect.
i avoid drinking tap water because of the flouride i noticed since only using bottled water in my kettle the element is still like new wow since i started this diet about two weeks my psoriasis has faded i no longer have it on my face and i look healthy,it just goes to show i must be doing something right its not difficult the nutri bullet did cost me about £100 but its the best £100 ive ever spent apart from the £130 i paid for my guitar.
so if anyone wants to give it a go the worst thing that can happen is you might loose some weght which in my case is welcome as i weigh 17 stone 
i just hope i can help a fellow sufferer god bless dougie

Evening all

I have got psoriasis on knees and elbows. I have had it for several years and have only tried prescribed creams.

Has anyone tried kalawalla and has it made a difference.

Cheers

Matt

Hi peoples,

Thought i'd post a time-line of what ( and no doubt i'm not alone here )  how where what why etc., regarding the beginnings and following treatments
and whatnot

My psoriasis started after a massive RTA in which i was a helpless passenger.  This RTA was '87 and i was in a ward for 2 months, and another 2 years recovery, wheelchairs, walking sticks, some bone complications, due to the fractures and hip dislocations,  but over the following years, i've got back to almost normal , physically, but with metal hips, and many scars , most of which thankfully, have faded a lot

But 2 years after that in '89 i developed psoriasis, and the med staff tell me that it was probably the crash that kicked it off.  Massive impact trauma can do that, although they also told me that its hereditary.  I've never known any of my immediately family to have P  ( mum, dad and one older sister )  and maybe if i'd thought about it, i could have asked my dad or sister at the time. Mum had already been slaughtered by cancer at the age of 44  so she wasn't around by the time P started, and now my dad is the only one left, as my darling older sister was also taken by cancer at 59 years, 4 years ago

Still,  knowing who else had it is not important to me really. But going back to '89 and the kick starting of P, i was,  like many,  given a succession of useless creams over the next 18/19 years. I'm sure someone benefits from creams or ointments, but they did nothing for me whatsover.
And its not like i had vicious psoriasis like some folk.

Plaque on elbow tips, nothing vast ..about 1" to 1.5" across on each elbow, inside ears, back of ears,  scalp line  ( minimal again )  , a bit in mustache  and beard areas, and centre of chest,  some dotted around on the scars from the previous RTA  ( P seems to love scar tissue for some reason )

That was just about the extent of plaque

Under arms and top of inner thighs where i had the inverse.

Skipping the long boring 18/19 years of useless creams, i get to the point where i get offered tablets.

Those consisted of  MTX,  Acitretin, Cyclosporin, and now Fumaderm 

MTX was the most brilliant drug out of anything i'd ever been given. It killed my P dead, everywhere.  But MTX is a nasty old piece of work, as most know, and during the constant and essential 2 weekly blood tests,  eventually they revealed the start of liver hep. and had to come off the MTX. No problem, the liver recovers. I never felt a thing so its a good job i had the blood tests or i wouldn't have even known. The other side effects  were livable with

Acitretin .. horrible. Nasty. Peeled like a leper on hands and feet to such a degree that i didnt even leave the house. Other side effects were equally nasty. 
Didnt do a lot, weaker than MTX with worse side effcts ( apart from liver damage )

Cyclosporin .. not bad at all, but not in MTX's league. Got shot of all P except inverse top of inner thighs , and it almost got that, but not quite. Side effects not quite as bad as Acitretin but still bad enough.  Kidney functions probolem picked up by blood tests ended the course of Cyclo. Still didnt feel a thing , so, good job the blood tests picked up on the kidney probs, as i wouldn't have known

Fumaderm.. started 9 months ago on initial, and progressed to the max 6 tabs a day.  Again, they have kept all plaque P at bay, ihave none at all. But as with all the others apart from MTX, the top of inner thighs is THE most stubborn area. It simply will not give it up.
The firece red patches ( elephants ears ? )  are a faded pink, but they still look like  P patches, and although i'm grateful that all the plaque disappeared years ago, and the only bit of P i have now is those 2 inverse patches, i'm still greedy and want to clear those up.

Fumaderm seems pretty good ( not as good as MTX in my book ) the side effcts are minimal. I've had the burning, bit in 9 months i've probably had it about 3 times and each time lasted about 1 or 2 minutes.  I sneeze a lot, though it never turns into a cold, and my sleep patterns are pretty grim, but all these are laughable.

At one point, before the Fumaderm was given, i asked about Biologics, as i had read about this on the net, and these were never ever mentioned before by my derm consultant. Well i soon found it why ... the answer given was ' too expensive ' and you have to have pretty bad P to be given Biologics, due to this cost.

Fair enough !

Next derm visit is November, and the consultant has juggled with the idea  ( at my insistance ) of perhaps going back on MTX, just to to get over that last hurdle, and it wouldn't take long for the MTX to do its job, since it would be starting at a point that was much further along the line than when i first had MTX, when it had to deal with what looked burns from a house fire.

Once the MTX had killed the last of it, then back to Fumaderm to keep it down and managed.

Phew !

As you were

Just popping into the intro section to say hello and will be posting  soon.

My sleep patterns keep me awake and then i sleep for 10 hours - weird

Hi new to this site.I am 42 years old and I have had psoriasis since I was 14 years old.I started taking methotrexate about 18 months ago.Started off really well with it.After 6 months during the winter months the effects started to wear off.I came back off holiday on 20th of July and I was totally clear(as is usually the case when I have had 2 weeks in the sun) but usually after being back for about 3 weeks my psoriasis slowly starts to reappear.However this year has been different.I was told by a couple of ladies how marvellous extra virgin raw organic coconut oil was and the health benefits that come with it.I thought I would give it a try and purchased a 1l jar.I used it as a moisturiser all over my body twice a day.Nearly 2 months after my holiday and I am still totally clear and my skin has a really healthy glow about it.Even my elbows and knees are really soft and showing so signs of dryness.People have even commented on how healthy and glowing I look.Thought I would pass this on as I am really made up with its results.Feel free to contact if anyone has any questions.Thanks.

Here's an interesting study that looked at the S100 group of proteins to see if there is a biomarker for disease activity in patients with psoriasis, it suggests S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis.

Quote:

---

Background:
Psoriasis is a chronic skin disease with deregulation of proteins in the immune system. These proteins include members of the heterogeneous S100 family, which have been discussed as potential biomarkers for disease severity.

Objective:
The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease.

Patients and Methods:
S100A7, S100A8, S100A9 and S100A12 mRNA expression was determined in the skin of patients with psoriasis and controls (N = 341) by gene expression analyses. In addition, S100 serum levels were investigated by ELISA in an independent cohort of psoriasis patients (i) untreated, with different manifestations (skin/joints), (ii) under treatment (etanercept) and (iii) healthy controls, (N = 55).

Results:
All S100-subtypes included are significantly upregulated in psoriasis skin lesions when compared with atopic dermatitis, lichen ruber and healthy donors. In untreated psoriasis patients, S100A12-serum levels showed the closest association with disease activity (PASI) (r = 0.542; P < 0.01). Serum levels decreased under treatment with etanercept (P < 0.05).

Conclusion:
Among the investigated S100-proteins, S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis.