Hello everyone,

I decided to join tonight, I like many have been dealing with this for years, 1993 to be exact, I was using a topical treatment that helped for the most part. Then went through a divorce and could no longer afford the doctors visits or medication. For the last 13 years  I have been basically just using hand cream , my areas that were affected were limited to my ankles so socks is a constant .  I must admit the last doctor I went to years ago when I showed him my legs which was very bad at the time, well he almost looked disgusted, so I am reluctant to show another doctor, I am sure they will want to know why I have not sought treatment before now.  Over the last two weeks I noticed the skin color had changed on my elbows an area where I had problems years ago, it looked as if all my pigment was gone  then about a week later I had scales again in the areas that had been clear for years.  I am now experiencing it on the palms of my hands and it itches like crazy.  Because I am in at a better place financially i have am considering  making an appointment with a dermotogogist and see if any of these new products I hear about can help.  I get so scared though when they start listing symptoms for so many of these new drugs like lymphoma, so I ask myself is it worth the risk.  I am hoping to hear what is working for others and hopefully gain some confidence to seek help.

I my names Ali ..had psoriasis for a long time now ..covers most of me body ..never been clear just always thier ..tryed loads of steroid creams ..find doublebase moisture seems to easy it little.  Anyway thank-you for letting join cheers

Hi, I'm Rosella, poke my nose in and isn't sure what's my type as suffer as well, had use home clinic provided cream and other. I gain a lot of weight for foot pain because it's where it start. I won't say I'm frustrated, because telling myself it isn't to live with. 

I saw Foundation on twitter, and screw my moody issue to come here because my friend always cheers on her favorite idol Misha Collins and cast. I don't have foot pain any more, but random small patches had show up back of the neck and up into hair scalp. Back of foot heal partially as whole should be, at least it is better than last time, nearly cover two toes.

I agree to see clinic soon as don't want to scare them with my back of neck and hair scalp also starting to show. This few years are despondent.

I've been given this piece of information from one of our roving reporters and thought it may be of interest to our members from the USA. If any member from the USA has more information please add it here or let me know, but this is all I have for now.

Quote:

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The FDA is holding a public meeting to gain patient perspectives on treatments for psoriasis.

The meeting — scheduled for March 17, 2016 — is part of the agency’s Patient-Focused Drug Development initiative. Under that initiative, the agency plans to obtain patient perspectives on at least 20 disease areas during the course of PDUFA V. For each area, the agency will conduct a public meeting to discuss the disease and its impact on patients' daily lives, the types of treatment benefits that matter most to patients, and patients' perspectives on the adequacy of the available therapies.

The meeting will focus on patients' perspectives for plaque psoriasis, nail psoriasis and guttate psoriasis.

The public can submit comments to regulations gov

Morning Everyone!!
                  It's a wonderful morning sitting at my computer waiting for the sun to come up and thinking about stuff! So i was thinking about making a doctors appointment and maybe trying to get on one of those new meds......I was on Methotrexate about 6 years ago and it cleared me right up but I was the most tired I have ever been in my life and it was hard working feeling like there was a bag of rocks tied to me 24 hours a day. And where I live is in the middle of nowhere and getting anything done is a severe pain in the a$$!!! So what I'm asking is.....will it be worth it??? I'm ok most days about my skin as it's ugly but bearable....I would post pics but it doesn't seem that easy....anyway any feedback would be appreciated.

I had my first outbreak of psoriasis in 1998. I was 22 I'm now 41. I have plaque psoriasis and it's super aggravating and I would say I'm moderate to mostly severe. I have tried creams, lotions, ointments and methotrexate. Methotrexate worked the best for me but it really screwed with my liver levels so I no longer take it. I am wondering if anyone has tried Otezla? I live in Canada and can not find where to buy this medication and I also can't find any reviews on it. 
TIA

Stumbled onto some article in the new scientist magazine (Dutch version) about CRISPR. This is a technology, no a "thing" in the DNA, that interacts with the immune system.
It looks promising as it is a gene changing technique and it is possible that it might produce a cell type or a change in a cell that increases the resistance against inflammatory reactions e.g. against arthritis.
So basically it might be a possibility to attack autoimmune diseases by gene adaptation.

If your search for Breakthrough DNA Editor CRISPR on google you can find information on it better than I can describe.

The interesting thing again is.... It is not patentable as it is in all cells in your body. Which is of course great, because now everyone on earth can work with it and the money rats cannot touch it.

I joined this site just one week ago, and have already appreciated its true value. Having suffered with psoriasis for 24 years it was well over due! But I'm glad I did. Never a friendlier bunch of crazy people have I encountered in one space (apart from maybe my Facebook friends), but the big difference is our shared experience of this unpleasant (and for many, distressing) condition.

If anyone should stumble upon this site just as I did, please stay and join in, you will be made very welcome

And so my journey begins. I started taking Fumaderm on 5th November 2015, so I shall back track a little to create a fuller picture.

Week 1, Day 1. Very excited! One dose of Fumaderm initial each day for one week. No adverse effects to report for the week.

Week 2, day 1. So far so good. Two initial doses, all good for a few days.

Week 2 day 3(approx). My first flush today around 2.00pm - wow! Looked and felt like a beacon, lasted around 20 minutes. Nothing there after.

Week 2, day 4. My first cramp - and I felt it. Happened around same time, accompanied by a milder flush. Was unpleasant but copable, lasted around 10 minutes then as good as new.

-this pattern continued for the rest of that week-

Week 3 day 1. Increased initial dose to 3 per day. First day, same as above though symptoms lessening.

Week 3, day 2. Woken with flushes but not severe (quite pleasant!).  Later, nausea lasting around 20 minutes. Not pleasant!

-these symptoms continued through the course of the week, though for brief periods -

Week 4, day 1. Increased dose to 1 x 120mg. Normal day, slight cramps and flushes.

Week 4, day 2. Woke to severe nausea and cramps. Very painful and unpleasant, lasted approx 30 minutes and felt  fatigued afterwards - worse day so far. When passed, felt normal for rest of day.

Week 4, day 3. Woke poorly again, severe cramps and nausea, flushes now extending to hands accompanied with itching. Once passes, very tired then all OK.

Week 4, day 4. Woken with severe cramps and nausea, this time extending to sickness, extreme fatigue afterwards, slept and woke half hour later feeling normal again.

Week 4, day 5. Woken with cramps/nausea and sickness again. Mild flushing. Lasted approx an hour, felt OK once passed. No side effects for rest of day. Took decision to change timing of meds from dinner to lunch time to avoid morning side effects. Experienced brief cramps in evening but very mild.

Week 4, day 6 (today). Woke this morning with no side effects at all! Took meds at lunchtime, experiencing a little nausea and cramp whilst writing this and feel a flush coming on but very mild all considered, compared to morning experiences.

That is all for now folks, will update when necessary.

Hi all am new here,had psoriasis all my life, just like everyone else looking for the way out.

Good morning everyone 

I'm looking for some recommendations for controlling the side effects I'm getting with Fumaderm. I've just finished the initial course where I suffered cramps and nausea, which passed quickly and I managed with a dose of liver salts when necessary.

Last night I took the first dose of 120 mg, and woke up early this morning with the worst cramps and nausea which led to vomiting for Wales (where I live ).  This has happened before though never as bad as today. They've passed now and I feel great!  My concern is that I start a new job next week and I really need to curb these side effects as much as possible not to allow it to affect it.

Can current Fumaderm users recommend may over the counter remedies that may prevent the severity of these side affects? I've still got a lot of increase in doseing to go and its worrying me a bit...

Thank you 

I'm sure lots of people get hangovers after drinking but I am zombie for a day or two after Cosentyx. So has anyone figured out how to sober up after an injection?

Following on from the report about Otezla getting refused by NICE (National Institute for Heath and Care Excellence) for psoriatic arthritis NICE says no to Otezla for psoriatic arthritis they have also now confirmed it will not be used for psoriasis.

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NICE does not recommend apremilast (also called Otezla and manufactured by Celgene) for treating adults with moderate to severe chronic plaque psoriasis.

People whose treatment with apremilast was funded by the NHS before this guidance was published should be able to continue treatment until they and their NHS clinician consider it appropriate to stop.

Hi all,
I am new in the forum.
I have been having psoriasis for more than a year and a half now in my private areas (penis and scrotum).
I am mainly treating myself with Trimovate cream which I think is a corticoid (and I think that medicine has the danger of thinning the skin) but is the one that help me the most of all treatments.
I am also sometimes using Protopic cream 0.1% or Advantan cream and when I manage to control it I maintain with Dexeryl.
Last week I had the psoriasis coming bad again and I spend a week using twice a day Trimovate cream until I got a bit better.
After using the Trimovate for a week I had sexual relations with my girlfriend. The penis was extremely red and too sensitive after the sexual relations. The next day the penis was still red and still sensitive with a tiny superficial wound in it. I fear that the skin got thinner due to the use of the cream. 
How could I find out if the reason the skin in that area being so sensitive? how could I find out if is due to the psoriasis or to the skin becoming thinner there?
If part of the cause of this is the thinning of the skin: are they any solutions for this? or would I have a thin skin forever now and would have this problem now for good?.
Anyone with an experience similar to this?.
Any doctors/hospitals out there that are considered the best on this kind of psoriasis?.
I am only 40. Any hopes or ways to improve or recover from this situation?.

Any help or support would be greatly appreciated.

Hi all, I am a bit frustrated with this as I have genital psoriasis in the penis and scrotum. Anyone there with the same problem or any links that could help?.
Thanks!

Had to ask the wifey to put the compound cream on my back tonight cause I couldn't reach it. The first humira shot totally destroyed my skin.. I have worked so hard to be where I'm at and this one shot took everything away. I remember reading all of the comments on the humira site about people having horrible exsperinces with this drug but I thought it would never happen to me.. Well it did , my whole body is nothing but a huge breakout!  Tonight I think my wife cringed when she applied the cream on my back and it sucks so bad..

Hello everyone,
    I'm new to this site and found it by accident on the Talk Psoriasis site. So far so good I think! I've had this P crap for a long time and it hasn't really bothered me much.........but things have changed as I'm recently separated and am horribly worried about dating again. Actually pretty scared about it. Anyway I'll be roaming around this site checking things out and hope to have fun with all of you and share some stories and other junk !! Talk soon

Hello all. I am new to this site and just wanted to introduce myself. I've been a fellow sufferer for 25 years and wish I had looked for a support forum like this right back then.  For most of those years I have suffered mostly alone with this disease, endured all the negative emotional side effects that tag themselves on (and still do) and often felt completely isolated from 'normal' people around me.

I've had so many treatments - like so many of you on here I've no doubt! Finally, it would appear that my condition is being taken seriously and I have recently been prescribed Fumaderm  . It's very early days - just 3 weeks - so too soon to benefit from results, and I'm enduring the side effects but I'm very optimistic about this one!

I'd like now to use the the benefits of my journey to encourage fellow sufferers how not to do it! Not to isolate themselves, but to stand firm in getting the right treatment, not lose as many years as I have having to wait to be offered, and never once being made aware of the range of treatments out there that can offer the quality of life we all deserve.

And if there are any Fumaderm users out there that would like to share their experiences I'd be very keen to listen!

That's it from me for now  .

Hi everybody I'm new to the club I look forward to sharing my exsperince with you. I kinda worried right now.. I took my first humira shot for psoriasis a week ago and I noticed some clearing the first couple of days. But Two nights ago I was itching the and didn't really think much of it.when I awoke the next morning my chest and back were covered in a horrible rash! I took benidryl and went to work. I felt my face start to swell later that day and it was hot feeling. I checked myself when I got home and the rash had spread down to my legs and up my neck to my face. I went to the ER at 130am and they made me set around for hours and pushed me out the door and was told to take benidryl. I went to a urgent care facility and they prescribed me pretnizone which I started taking right away. I'm scared about this cause I read some blogs and some people are having the same issues and they can't make it go away. I was better off before humira and I'm not using it anymore. Has anyone exsperinced this and if so did it go away?

Just wanted to say hello.  I have just joined the site, looking for help, support and understanding from others in my mission to help my 12 year old son who has what was diagnosed as guttate psoriasis in February 2015 (had it from September 2014 but took GP 6 months to diagnose it - don't get me started!) but has spread over at least 50% of his body since then.  I keep him cheerful and optimistic but on my own I despair sometimes.  He seems so young to be plagued with this and I worry about how it will affect his self esteem as he goes through teenage years.  I won't go into all the different things I have tried, but I am still looking at how diet might help him.  I know there is no cure but just want to do all I can to understand psoriasis and keep aware of what works for others that we might try.

Thanks.

This weeks news that there are now bacteria resistant to all current antibiotics, and the estimate for it to be a problem in uk within five years, has got me thinking - is this the beginning of the end for taking immune suppressing drugs?