On week 3 and pleased with results so far. Can anyone share longer term experiences of skin improvement / failure assuming all the side effects are tolerated?

Hi lads, completely new to this so bare with me when I ask basic questions   Im 20 and have had psoriasis for nearly 4 years, just started Fumaderm after many other methods such as light treatment and Otezla. I have been on it for 7 weeks now and my dose is 360mg a day until Saturday in which my dose will be 480mg a day. I have seen no change in my skin and am getting a lot of the side effects which are making re-think staying on the tablet. Is there a reason that it is not working yet or is it just standard? 
All the best,
Michael

This study looked at adverse events associated with discontinuation of systemic treatments in psoriasis patients.

Quote:

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Background:
Little is known about the adverse events (AEs) that lead to suspension of systemic treatments of psoriasis in clinical practice.

Objective:
The study aimed to investigate to AEs associated with discontinuation of systemic therapy in patients with psoriasis in a clinical setting (Biobadaderm).

Materials and methods:
Multicenter, prospective, cohort study of patients with moderate-to-severe plaque psoriasis receiving systemic therapies from January 2008 to November 2015, in 12 hospitals in Spain. The incidence rate (IR) was used to compare biologics and classic systemic therapies.

Results:
A total of 4218 courses of treatment were used in 1938 patients. A total of 447 (11%) treatments were discontinued due to AEs. The IR of AE associated with discontinuation of systemic therapies was 13 events/100 patient-years (PY) (95%CI:12.14-13.93), 9.34 events/100PY (95% CI:8.44-10.33) for biologics and 19.67 (95%CI:17.9-21.6) events/100PY for classics (p< 0.001). Of 810 discontinuation-related AEs, 117 (14%) were serious. The highest IRs were for cyclosporine [49.18/100PY (95%CI:41.91-57.72)] and infliximab [26.52/100PY (95%CI:20.98-33.51). Ustekinumab presented the lowest IR (2.6/100PY (95%CI:1.83-3.69).

Limitations:
Observational study with potential selection bias.

Conclusion:

Biologic therapies are associated with a lower rate of discontinuation-related AEs than are classic therapies in real clinical practice. Ustekinumab showed the lowest incidence.

just thought I would join up to see how many people are going through the same PsA as me. I have been told back in 2007 that this is what I have. I had been on humira for 6 years which was great for me but sadly it stopped working for me so now I am to start cosentyx. Anybody tried this drug?

Hello!

I'm Nathan, nat965, from Australia

Hi, I'm Lisa and I have been newly diagnosed with sebopsoriasis, although I have been dealing with these symptoms on my face for about a year.  I'm married, have three grown children and work full time. I've browsed this site since yesterday and I am very pleased to be accepted as a member.

After my last trip to the rheumy, i've been swapped from Sulfasalazine to leflunomide. 
fingers crossed it is more successful 

i am also being scheduled in for a shot to my thumb, have others had much success with steroid injections? my thumb is pretty much useless now and i'm hoping the shot will let me at least be able to move it

Hi, I have been suffering with a painful itchy rash on my eyelids, corners of my eyes, and my upper cheekbones for about a year.  I have tried eliminating skin care products, detergents, moisturizers, almost everything over the last year and nothing seems to help. I even modified my diet, but that does not seem to matter either. The only way I can keep it under control is to use an OTC steroid cream.  I use it around my eyes about 4-5 nights a week.  I do not like using steroids on my face, but I feel it is the only thing that keeps it at bay.  I have been to two dermatologists and an allergist.  I had the "thin layer rapid use epicutaneous patch test" back patch test and all 36 items were negative.  They have called it sebopsoriasis, so now I am learning about this problem.  My sister has had similar problems for about 40 years and she only uses OTC Cetaphil.  I started using this recently and it helps somewhat, but not entirely. Any suggestions would be appreciated.

This study looked at the risk of Schizophrenia patients getting Psoriasis.

Quote:

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Background:
Schizophrenia is a complex disease proceeds from an interaction between genetic background and environmental factors. Recent studies showed T helper 17 (Th17) signaling, which is the main downstream immune response of psoriasis, is activated in schizophrenia.

Objective:
To investigate if patients with schizophrenia have higher risk of psoriasis.

Methods:
In this nationwide retrospective cohort study, we analyzed the 1-million-enroll cohort from Taiwan's National Health Insurance Research Database. Psoriasis and schizophrenia were ascertained by International Classification of Diseases, 9th revision, Clinical Modification coding. The study cohort was comprised of enrollees diagnosed with schizophrenia during the period from January 1, 1996 through December 31, 2010, while the comparison population consisted of enrollees who had not been diagnosed with schizophrenia during the study period. Hazard ratio (HR) and 95% confidence interval (CI) were calculated for the risk of psoriasis associated with schizophrenia using Cox proportional hazards regression.

Results:
The adjusted HR of psoriasis associated with schizophrenia was 2.32(95% CI = 1.81-2.98). After 15 years, the cumulative incidence of psoriasis in patients with schizophrenia and comparison population was 2.82% and 1.17%, respectively. The Kaplan-Meier curves for the cumulative incidence of psoriasis in individuals with and without schizophrenia differed significantly(P<0.0001, log-rank test).

Conclusions:
Patients with schizophrenia have higher risk of psoriasis, which may be due to common genetic susceptibilities and/or immunologic mechanisms in both diseases. Th17 signaling and pro-inflammatory cytokines may act as a link between these two diseases and are potential therapeutic targets for schizophrenia.

I just developed Sebopsoriasis for the first time ever in the last 40 yrs i have never had to deal with it but typical plaque psoriasis on elbows and knees. Has anyone else had a major flare up this year?

Hello,my name is terina. I have had psoriosis since I was 18. I just started stelara after my humira didt work. I thought I was the only person going through this wierd type of hell. But I stumble upon this and I find it so helpful and great. I will learn how to do everything properly. Enough rambling. I really just wanted to touch base on myself. And thank everyone in advance. 

But unfortunately not new to psoriasis.  My name is Kathryn.

I got my first spot at 23 and had only the one until my early 30's.  Then the system went nuts. I have all five types of psoriasis including the arthritis.  

At 35 my doctor told me I would be in a wheelchair within two years unless something changed.  From then on my life has been a constant round of any and all medicines and almost constant fights with a variety of insurance companies who fight to keep me off the very expensive medicines that  need.  I never got that chair and I am determined not to!

I found this forum while researching Taltz vs Cosentyx.  The dermatologist has decided to change me off Embrel and feels that Cosentyx is the best option but the insurance company is fighting for the cheaper option.  I didn't much care until I did the research and found that Taltz is not recommended for arthritis at all.

Now I would love to have cleared skin but I have taken everything under the sun from the early years of methotrexate and gold injections to more than 15 years of Embrel, Stelara and Humira.  If I have to choose skin vs joints - no contest!

Would love to hear what works best for other people with the arthritis.....

Hi 

Before i begin i have to say its a credit to the creator and administrators of such sites. People who honestly give up their time and money just so the internet and world can become a much more open and sharing space.. Well done. 

Ok. 

I live in Australia and i have been on Cosentyx since feb. Its the first bilogical i have used and from reading other posts i am very grateful for the health system we have over here... Seeing a dermo took about 1 week and getting on the biological took about a year. But we did try the less expensive and ones first. 

Cosentyx is amazing.. i feel like a new person... especially when my kids say how happy they are i can now take them swimming. 

Anyway... just want to get in touch with someone who is on cosentyx and a few issues which may or may be caused by it. 
Keep getting eye infections. Have been using antiboitc drops which work but obviously cant use them for ever. 
Also for all us pale skin people out there have you noticed that parts that are not exposed to the sun are taking longer to go away. 

Seen the specialist on Thursday and my scrore went from 18.5/20 to 2.7/20.... buns and guns will be out for summer... so if you hear screaming, thats just people running away.

Has anyone experienced a correlation with high blood pressure medication and onset of psoriasis? Curious.

Good Morning All,

I have joined this forum for my father, Jim, who has Plaque Psoriasis. 

My father is 60 years old and he had the first flare in about 2007 and it all started for there. It started from a little spot underneath his knee cap and then just started to spread all over his body until his upper back within a year and at that point my father consulted a doctor - this is when we found out that this is called Psoriasis. The doctor had given my father some steroid type of medication and it all went away for 3-4 months but then it came back twice as much when he was taken off the medication.

In mid 2008, we consulted a homeopathic doctor and with his medication it almost cleared up almost the entire body with a few spots on the body until recently in mid 2016. During his homeopathic treatment we also had various other treatments which are still ongoing to relieve everyday pain:

Olive Oil as a moisturizer
Vaseline as a moisturizer 
Turmeric in a glass of warm water - I read somewhere this has worked for people with psoriasis so we started this.

For the last 8 months or so it started to come back and has gotten worse to the point where his entire body until his ears has been effected. We recently consulted a dermatologist and he has put him on Humira and Triamcinolone Acetonide Ointment, 0.1% starting February 23, 2017. At first the doctor gave him 2 shots in the first visit, 1 more shot the following week, 1 shot 15 days following that, 1 shot 15 days following that, and now has recommended a shot every week due the recent flare up. 

I would appreciate any information on what else we could be done or anything that has worked for any member on this forum. I will post pictures of his current status when i get home later this evening or tomorrow morning. 

Again thank you for your help!

I suffer autoimmune condition psoriasis and psoriasis arthritis. Mostly under control. Have couple of psoriasis patch in scalp all year around. There is one condition that bothers me and this the doctors have not been able to answer why it happens. Post winter as the weather warms I get this prickly itch under the skin. I can feel the prick ever part of the body that is about the sweat. What it could be, how to manage this. Thank you for reading and many things if you provide further inputs.

To: those with Psoriaticarthritis who may have received treatment that did not work

Today I am reporting a serious ‘Error’ made by Radiology Interpreters
that has been causing the physicians who had ordered the tests to choose 'wrong' treatments - thereby placing patients in a harmful situation.
 
 (fact) Some people were diagnosed as having Psoriaticarthritis by Rheumatologists and Osteoarthritis by Radiologists. 
I am one of them. Fact is I have Psoriaticarthritis only, not both.  Please read on:

MAGNITUDE OF SERIOUSNESS
The problem that I am reporting here is not considered to be limited to two U.S. states that I experienced in but is estimated to be in many other states within the United States, evidenced by people reporting the same problem in several patient forum websites.
 
"ERROR" BY RADIOLOGY READING DOCTORS
Radiology Interpreters are Medical Doctors.
These doctors read and then interpret the MRI, X-ray, and other radiological test results ‘without’ much knowing the medical history of individual patients.
Although they know that there are different types of Arthritis [ (1)  Rheumatoid Arthritis. (2) Psoriaticarthritis. (3) Osteoarthritis], they simply base their interpretation on the patient’s age – making the Physicians who had ordered the test choose ‘wrong’ treatments.
 
For example:
I have a history of treatment for Psoriasis and have had Psoriaticarthritis pain in hip joints. When I had a lower back pain, an Orthopedic physician,Tennessee ordered MRI. Without knowing me having Psoriatic Arthritis, the interpreter (name undisclosed, Medical Doctor, Cookeville, TN 38501) diagnosed me as having Osteoarthritis simply based on my age, in addition to a condition in my lumbar spine. 
The wrong interpretation made my Orthopedic physician to send me where I ended up receiving injections, which not only failed to work on me but put me in increasing pain. I did not find the causation until after the second incident as below.
 
Years later after my engineering job relocated me to Kentucky,  my new primary care physician (Glasgow, KY 42141) ordered me to take a hip X-ray test. Without knowing my history of having Psoriaticarthritis, the interpreter (name undisclosed, Medical Doctor, Glasgow, KY 42141) read the X-ray test result and diagnosed me as having Osteoarthritis, simply based on my age.
 
Recently, a pain intervention specialist, whom I was referred to by my primary care, prescribed me a medication for Osteoarthritis (cost me hundreds of dollars out of pocket) which I found out later after having a serious side effect. The medication did not alleviate my pain at all after more than a week of taking two types of prescribed pain killers.  7 days later I reported the specialist through his nurse that the drugs not working at all or worse. Did they (doctor's nurse and doctor) tell me to stop or to replace with other medication? No. They instead told me to continue on for 5 more weeks.  It was not until 11 days after started taking when they finally told me to discontinue because I had a serious side effect and reported.  I then had my primary care to check the side effect who told me that I was prescribed to a wrong medication.  It was a scary experience. It was all caused by 'erroneous' radiology interpretation by the medical doctor of Radiology.   
My fellow patients with Psoriaticarthritis, please be aware!   Hope that you all are doing well.
 
Radiology Interpreters must quit writing diagnostic assumption in Arthritis. Or, it can cause a serious consequence  <<  I say it aloud!

Hello, 
My father is 92 years old and has had psoriasis for at least 65 years. That's my age and he had it before I was born. Obviously he has had many of the treatments I have read on your site.  He was on Cosentryx with some good results but lately it flaired back up again. He's been going to the VA for his treatments because the cost of the drugs are less expensive. They put him on Acitretin again but it causes the all sorts of problems with lips and hands and other side effects including anxiety and not sleeping well. He's just tired all the time. 

On top of his psoriasis he has skin cancers because of the light treatments he's had over the years. He now has a hard time knowing whether his spots are skin cancer or psoriasis. Lots of sore spots all over.

Any words of wisdom.

Hi,

I'm 26 with PPP on hands and soles of feet (diagnosed 2016 after stressful split with husband)and I cant sleep with the itching! Currently on momentasone steroid and aveeno and certobane moistueusers.  And an anti- histamine. In about my 5th week of light therapy also but not really seeing any difference.  Can anyone give we any tips/ advice? 

Thanks

I'm 19 years old and a male, about a year ago I started getting dermatitis on my hands and it made an impact on my work. as I'm a plumber I'm very hands on, so I'm constantly getting dusty and dry skin whether I like it or not.
But around a month or two ago I've slowly been flaring up with psoriasis on my arms and legs, I've not yet gone to the doctors about this as I've read up on a lot of sites saying they just give you steroid creams which is all I was given for my dermatitis which did not work.
At the moment I'm trying the homeopathic stuff.. Whether it works or not I don't know I'm just trying to grab at anything that will get rid.
But I was just wondering whether anyone has any advice or info as it's making a big impact on my home and work life and is quite depressing to say the least,
Thanks.