I had my Stelara yesterday, and the nurse told me about Humira having had an ingredients change - I don't know if anyone else knew this?

He said they changed the preservative because it used to sting so much, but afterwards people started saying it wasn't working as well. They claimed the ingredient change shouldn't cause it to work any differently, but anecdotally it may have. I don't know when the change came about but when I tried it it didn't sting, nor did the drug work on me.

Hello, I hope it's okay to start a new thread. I tried searching to see if there was one for this topic, and didn't see one, but I'm new to the forum so could be wrong. 
I have been on a corticosteriod (Clobetosal .05%) for the last 2-3 weeks for the first time in 17 years for fairly vigorous guttate psoriasis. The intent was just to give me a break, and boy have I enjoyed it! but now I need to taper off. Any advice? I figure I'll start with going to once a day, then every other day then after that maybe begin to add plain lotion to the bottle to weaken strength? Or is that last bit unnecessary?
I would like to hope that I won't have a massive flare as I taper off. I know it's a possibility. If at all possible, please do not reply with horror stories, because I want to remain positive and hopeful! Thank you for understanding.

Hi, I'm happy to see if this is a place that will be supportive and helpful. I was on Inspire before it was Inspire and after, and I really got discouraged with the snarkiness factor. 
I've had psoriasis since my late 20s, in my mid 50s now. I also have other autoimmune conditions like interstitial cystitis and what I thought was Hashimotos thyroidosis, but that just got challenged by a new ND who said she thought it wasn't, that I had hypothroidism for sure but not Hashis. Lately (menopause, death of beloved pet, depressing state of nation/world) the guttate has gotten worse and worse. Because I was treating primarily with diet and supplements, I was starting to blame myself for not dialing in the diet and supplements adequately.
I recently (two weeks ago) used a topical corticosteriod. I will post a question about that in another thread. I also started LDN.  My new ND is going to test for Strept, which she says is correlated with Guttate P. Also viral load, also she suspects Lyme disease! So I guess I'm starting a new phase of my healing journey. 
Thanks for reading!

Hello,

I am suffering of a mild psoriasis for a good whilw now. It's going to be my one year anniversary soon, and honestly I don't think i am up for celebration as I am completely fed up. Sometimes I am thinking of cutting my elbows and slammng it againts the wall. 

It began during my college study, i was stressed, i smoked a lot. I began to devellop a bronchitis, and ... Both of my elbows Began to itch. The two conditions combined with a great fatigue i couldn't sleep trought. It's also worthy to say that i was hospitalized for a "non specified psyschosis" for 6 months prior my return in college. This long period of prolonged stress may have triggered the P.

Since the beginning of my P on my elbows, i have noticed I have somehow probably suffered of it for many years but it wasn't a big concern as it wasnt flaring up furiously but rather would only itch a bit here and there on my scalp, or on my torso.

As of today the only part of my body that is still a concern is my left elbow. My right elbow is 98% clear. The left elbow is where lies my problems and concerns.

The problem is how thick, and how deep it is. Its like if I have wood in my elbow. I Think of it as the famous Hans Ruedi Giger's Alien creature. Imagine the tail of the creature, the shell, and the repetitivenes of the structure... It is as if tails are creping inside of my elbow. It is my analogy, as silly ostupid as it may sound. Another analogy is cat Claws. The "hook" shaped hardened skins interlocked, braided togheter. 

It is my impression that some P is "older" and thikier and looks like its a sort of root. It wasnt what i was expecting whn it first started to itch one year ago. I couldnt imagine i had studs of skin deep inside. I was upset however by the claws tips poking out. 

I became less and less hopeful as I understood that the elbow skin structure is complicated, that it couldnt be scratched away with my nails alone. Sort of like the tip of the iceberg, the deeper it goes the more complicated and hellish it is. No matter how desperate i am, i am not able to get the dead stuff (or semi dead..) skin studs out. 

A week ago I began to read about medical treatments. First, i got OTC ointment/cream at 1% cortisol. Does nothing but Sooth and relax my skin, a bit of improvement in comfort. But then I added another cream into the mix. Salicilyc acid, which is i think a weak equivalent of some precribed cream approved for pso in several countries. 

The mix of cortisol and salicilyc makes it easier to losen the thick skin. It's now possible for me to get rid of the thickiest skin that make my life impossible. But, this is a process. Sort of like dismantling a complicated puzzle.

But, this is where i am coming to you. I have read a lot, I am quite surprised on how some persons are resilient or patient. May be i am not going to get any relief from working on my elbow skin "mechanically" with a thin needle and my nails rather than waiting passively for some improvement with some cream. 

It is known that the condition is re-trigerred when the skin is damaged or tampered with. I've experiemented it. I am tring to be gentle with it when i am fighting no matter how F**king fed up I am.  

So is this a story that ressemble yours ? Where were you able to get rid of the bony skin with salicilyc acid ? Is this a good way to get my elbow back or this is just Unrealistic ?

I understand that it may seem unpraticable. That some P is stubborn, and that its not recommended to "Scratch it away", as it can worsen, or it could get infected. But may be you get the point. 

So that is all for now, go ahhead with your toughts. Please try to keep in mind that i am not stupid as I may sound And i am not encouraging anyone to do what i am doing. I hope i am clear, it isnt simple as it sound, i am doing what seem to be the bes thing in my own particular situation. If yours is simillar and you went by the same path then share your toughts.



Thanks for reading !
Mogwai

This study suggest almost 50% of psoriasis patients suffer with substantial fatigue.

Quote:

---

Background:
Fatigue is associated with various chronic inflammatory diseases, but few studies have focused on its occurrence in psoriasis.

Objectives:
To describe fatigue prevalence and degree among patients with chronic plaque psoriasis vs. age- and sex-matched healthy subjects, and to examine how fatigue is influenced by essential clinical and demographic factors.

Methods:
In 84 patients and 84 healthy subjects, fatigue severity was assessed using three different generic fatigue instruments: the fatigue Visual Analogue Scale (fVAS), the Fatigue Severity Scale (FSS) and the Short Form 36 (SF-36) Vitality scale. Cut-off scores for clinically important fatigue were defined as ≥ 4 for FSS, ≥ 50 for fVAS and ≤ 35 for the SF-36 Vitality scale. Disease activity was evaluated using the Psoriasis Area and Severity Index (PASI), and the impact on quality of life with the Dermatology Life Quality Index (DLQI).

Results:
Patients and healthy control subjects, respectively, showed median fVAS scores of 51 [interquartile range (IQR) 21–67] and 11 (IQR 3–20); FSS scores of 4 (IQR 2·5–5·3) and 1·6 (IQR 1·1–2·2); and SF-36 Vitality scores of 43 (IQR 25–85) and 73 (IQR 65–85). The rates of clinically important fatigue among patients vs. healthy controls, respectively, were 51% vs. 4% (fVAS); 52% vs. 4% (FSS); and 42% vs. 2% (SF-36 Vitality) (P < 0·001 for all differences). Fatigue was associated with DLQI scores, but not PASI scores, in univariate analysis but not in multivariate analysis.

Conclusions:
Nearly 50% of patients with psoriasis suffered from substantial fatigue. Fatigue severity was associated with smoking, pain and depression, but not with psoriasis severity.

This study looked at the drug survival rate of methotrexate in psoriasis patients and suggests only 15% stay on it past 5 years.

Quote:

---

Background:
As methotrexate (MTX) is a widely used treatment for psoriasis, it is important to gain insight into the reasons for the discontinuation of MTX and to understand the determinants for drug survival.

Objectives:
To describe 5-year drug survival for MTX in patients with psoriasis, split according to different reasons for discontinuation, and to identify the determinants for drug survival.

Methods:
Data were extracted from a prospective psoriasis registry of patients treated with MTX (MTX-CAPTURE). Drug survival was analysed using Kaplan–Meier estimates and the determinants for discontinuation were analysed using Cox regression analysis. Analyses were split according to the reason for discontinuation: side-effects or ineffectiveness.

Results:
We included 85 patients treated with MTX, with a maximum treatment duration of 5·2 years. The overall drug survival rates were 63%, 30% and 15% after 1, 3 and 5 years, respectively. The median survival was 1·8 years. Overall, 55 patients (65%) discontinued MTX for the following reasons: side-effects (35%), ineffectiveness (26%), combination of side-effects and ineffectiveness (13%), other reasons (16%) and 11% were lost to follow-up. The most reported side-effects were gastrointestinal symptoms, despite the use of folic acid in 99% of patients. Based on univariate analysis, a high Psoriasis Area and Severity Index score and a high score on the visual analogue scale for disease severity at baseline were possible determinants for a short drug survival.

Conclusions:
Drug survival of MTX was low with 15% of patients ‘on drug’ after 5 years. Side-effects alone or in combination with inadequate disease control were more important in the context of treatment discontinuation than inadequate disease control alone.

Hello Everybody.

I've got the plaque psoriasis. I've tried tons of medication. Really Stelara is the only one that has worked.

Very beginning stages here for Tremfya, (the new medicine out by the same makers of Stelara). Doctor suggested it since last time I was on Stelara, I didn't see near as improvement as I did the first time I was on Stelara.

Trying to get insurance to approve this new medication. Hopefully I can start within the next few weeks.

Will update when I hear from insurance.

Following on from this thread Should Dovonex be available without prescription Dovonex will now be available without prescription in the UK.

Quote:

---

Today the Medicines and Healthcare products Regulatory Agency (MHRA) announced the approval of Dovonex Psoriasis 50microgram/g Ointment which will be available through pharmacies without prescription.

Over a million people are estimated to be affected by psoriasis in the UK. The availability of this medicine from pharmacies will increase the choice patients have of where to obtain treatment when their condition recurs.

‘Dovonex Psoriasis Ointment’ contains calcipotriol, a vitamin D analogue and the medication will be supplied as ointment in a 60gtube.

It will be sold after a consultation with a pharmacist and is suitable for adults aged over 18, with mild to moderate plaque psoriasis which has been previously diagnosed by a doctor.

This treatment can be used for up to 12 weeks after which people will be advised to see their doctor about ongoing treatment.

Pharmacists and their staff will be able to provide suitable advice to the patient to ensure that the product is suitable for them. The outer packaging and the patient information leaflet also include an image of plaque psoriasis which will help both pharmacists and patients in this respect.

MHRA is committed to widening access to medicines for the benefit of public health when it is safe to do so. The product was reclassified following a public consultation held earlier this year.

Hello All!!

Ive had plaque/scalp psoriasis since I was 17 (Now 30). I have been anywhere on the scale from mild to moderate to severe. Tried tons of medications, from topicals to injections to pills.

A few years ago, I was covered with spots and my dermatologist suggested Stelara. OMG this is a miracle drug. I went from my back completely covered in plaques to %100 clear. I seriously LOVED this medication. Buuuuut, I became pregnant with my first child, So I had to come off of the medicine for the duration of my pregnancy. And the plaques started flaring back up.

After I had my first baby, I tried to get back on Stelara, but my insurance made me try Humira first (im assuming because its cheaper). I HATED Humira. My husband hated Humira. He was the one that would have to pull the trigger on those self injecting pens they give you, and they suck. I cried every time. More importantly I never saw any improvement. Went Back to my doctor and we tried again for Stelara, Insurance approved it this time, however, I only saw about 50% clearance.

Once again I became pregnant with my second child so I had to come off of Stelara. After the baby, the doctor suggested I try Otezla. I am currently on Otezla. Ive been on Otezla since January. Im really not seeing any results. Plus, I feel like my stomach hurts more often than not now. And i'm not liking taking 2 Otezla pills every single day.

I've got a doctors appointment this Thursday to see if I can try something else, I just don't know which way to go. Ive seen commericals for cosentyx or Taltz, how does everyone feel about these? Should I try the Stelara again? Do I have any other options?

Thanks,
aecrawford1

For anyone who needs a new natural remedy, I've found that Aloe Vera Gel (helps soothe itching and moistures the skin) and Argon oil which also soothes the itching right away and also helps the skin to return to its pigment works best.For the best results apply the Aloe and Argon oil 3times a day. It is best to do this after a shower.

Not sure if this is a natural product or to become prescribed - I've just come across articles on something called endolysins - apparently people with eczema have been found to have their skin bacterial flora changed to mostly staphylococcus aurea and the endolysins redress the balance. The website for the product doesn't have a psoriasis targeted product but it does mention psoriasis.
The reason I'm putting it this way is that I don't want to be advertising a product but I'm certainly interested in finding out more. I believe it has been developed in the Netherlands..

Any more info on this?

I found my first patch back in 2000 it was small just at my hairline on top of my forehead. I was 33 then. I didn't give it much thought  chalked it up to the hair colour I had just applied. But the patch grew and flaked and not long after my Dr, confirmed it was psoriasis. For the past 17 years it has completely covered my scalp, my knees. various spots on my back, toe nails etc. then just last week it is invading my face.
My Dr. is setting me up now to have cosentyx. I am excited and nervous at the same time. Afraid of the possible side effects, afraid it won't work, trying hard not to let this condition own me, But I am thankful to have the chance at being clear in nearly 20 years
Will be nice not to leave flakes everywhere I go..So glad to come across this site..Reading the experiences of others has helped put my some of my worries to rest.

Hi all,
Just joined the forum today. 
I'm from bonnie Scotland nearly 62 yrs old. As most of yourselves suffered from psoriasis for a long time   and now have diabetes type 2 as well, how lucky am i   .

Hi All,
This is my first post.
Let me give a history of my Psoriasis (P)/ Psoriatic arthitis (PSA). 
I first developed (P) in 1978, mainly outbreaks on my skin, my wife who is a nurse decided to buy an infrared/ultraviolet lamp, which cleared the (P) up, I've been fortunate since then it's never re-appeared. Fast forward to 1985, my finger nails started with a very small dark patch in the centre of the nails one at a time and hence since then I've had Nail (P) with badly pitted nails, the only other psoriasis was on my scalp and groin area. In 1989 I was put on methatrexate to try and clear up my nail P, unfortunately after 18 months I had to come off this as it was damaging my liver, it wasn't really improving my (P) anyway .
Around 2000 the only treatment I was getting for (P) was Alphosyl shampoo for my scalp nothing else, but I noticed the joints in my fingers were swelling  slightly and painful mostly in the cold weather.
 In 2009 both my hands exploded literally they went 4 times their size. I was assigned to a rheumatology consultant. I was given the option of either Leflunomide or Sulphasalzine, I opted for Leflunomide.This had been working ok up until 2015, my PSA then gradually spread to my feet shoulders, hips and spine. By mid 2016 after a utrascan of my hands, I was also given an addition of Naproxen to my Leflunomide . Taking this made me feel ill and it also gave me a stomach bleed so this was discontinued. Oct/nov 2016 I was then put on Sulphasalzine in addition to my Leflunomide, all was ok until dec of same year when I went seriously ill ended up in hospital,they thought I had pnumonia then sepiticemia,I had an ecg and xrays taken, all were clear and given intravenous antibiotics, released on xmas eve, taken off all meds for PSA, started feeling slightly better just had a thirst and feeling lethargic. 
I then restarted my Leflunomide all was ok a week later started  the sulphsalazine in the morning, by afternoon I went ill again phoned my doctor and told him I wasn't taking sulphasalizine any more. For anybody who has regular blood tests done, I've had monthly tests since 2010. One of the tests is called LFT (liver function Test), they check your CRP levels, mine's normally sits around 6, when I went ill it jumped to 122.
On January 17th  2017  I developed type 2 diabetes,. In February I had a massive flare up of my PSA,it got so bad I couldn't dress myself , my wife had to dress and shave me and cut up meat when having dinner, it took me almost half an hour from my bedroom upstairs to downstairs.
By this time I've also been allocated a Rheumatology Led nurse, so phoned my doc he told me to contact my nurse which I duly did seen her a few days later, she took measurements of my hands and feet (swelling), I was given two general cortizone injections, these helped slightly but not enough, my painkillers were changed co codamol 8/500 to 30/500.Two weeks later I returned to see my Rhuematology nurse who then informed me
that the coventional drugs for PSA were'nt going to work any more, but there was a new biological drug called Cosentyx (sekukinumab), Due to the costs of this treatment I would have to wait for it to be approved. It took 7 weeks to be approved ( I live in Scotland so I'm under the auspices of the NHS), this was approved by April.
My first dose (week 0) was the 18th of April (i'm on 150mg dose), five days later the pain had gone completely I kid you not , the swelling in my hands reduced by week 2, I've just had my month 4 dose and swelling still down.
The only side effects I've had are a runny nose when I eat and very slight herpes on my lips.
 Since December I'd been off work until early July, when I had my flare up I thought that was the end of my working career ,but thanks to Cosentyx
I've started on a phased return to work and really my only concern just now is learning to work with Diabetes too.
Anyone reading this who suffers from PSA I highly recommend get in touch with your doctor and get on this. It's only a young drug if fact i believe it's only been available since 2013, (I'm still taking Leflunomide as well, this maybe due to one injection per month).
Please note, injections are delivered to your home as they have to kept in the fridge.

Hi - been on Fumaderm since Oct 16 - progressed from white to blue tablets but not passing 120mg X 3 per day.( Liver results and extended 11 weeks travel thro US suspended dose to higher levels ) .
Following return had to suspend for 5 weeks due to significant foot surgery ....restarted but after 3 weeks severe itching thro body - face ,ears, head, ands etc ......saw my Derm Dr today and she says we are not really progressing with FUM tablets ......altho some improvement on the PS but not enough with going fwd on a higher dose.


So we are moving along the road and kicking in with Methotrexate........so just wondering if any folks have had any experience good or bad going along this road
Kind regards
Vincent

While the above information is from the manufacturer, it seems strange to me that it's basically the same as Fumaderm and yet the common side effects differ greatly from my experience

Skilarence lists as common side effect as high total white cell count
Common side effects (may affect up to 1 in 10 people):
- increase in all white blood cells (leukocytosis)
- increase in specific white blood cells called eosinophils

Whereas Fumaderm warns to watch the white cell count for dropping

Leukopenia ( reduction of white blood cells)  Treatment with FUMADERM must be discontinued immediately in the presence of a significant reduction in leukocyte count- particularly if values are below 3,000ul

Lymphopenia ( reduction in specific white cells   if the lymphocyte count drops below 500ul treatment must be discontinued immediately

I'm on Fumaderm and my blood count goes down from time to time .....but has never gone above normal. And from other people's experiences that I've read, it's been the same

After I was told I had psoriasis I was given all different types creams on a try this one systems. I was then given methrotrexate . I was on it for nearly 2 years when my doctor at the hospital told me to stop taking methrotrexate and I had to go for a liver biopsy which was very painful, I was told that the methrotrexate had scared my liver. I was then put onto Acitretin 2x 10 mg caps for about 2 to 3 years then it was increased to25mg caps but that made me I'll so it was put back to 2x10 mg caps which I am still on.I still have my palms and the soles of my feet pealing but rest of my body is almost clear. My advice to anybody on methrotrexate to keep having your blood tested at regular times.

What Skilarence is and what it is used for

What Skilarence is

Skilarence is a medicine that contains the active substance dimethyl fumarate. Dimethyl fumarate works on cells of the immune system (the body's natural defences). It changes the activity of the immune system and reduces the production of substances involved in causing psoriasis.

What Skilarence is used for

Skilarence tablets are used to treat moderate to severe plaque psoriasis in adults.  

Response to Skilarence can be generally seen as early as week 3 and improves over time. Experience with related products containing dimethyl fumarate shows treatment benefit for at least up to
24 months.  

Do not take Skilarence

-  if you are allergic to dimethyl fumarate or any of the other ingredients of this medicine

-  if you have severe problems with your stomach or intestines

-  if you have severe liver or kidney problems

-  if you are pregnant or breast-feeding

Monitoring

Skilarence may cause problems with your blood, liver or kidneys. You will have blood and urine tests before treatment and then regularly during your treatment to make sure that you are not getting these complications and can continue to take this medicine. Depending on the results of these blood and urine tests, your doctor may reduce your dose of Skilarence or stop treatment.

Infections
White blood cells help your body to fight infections. Skilarence may reduce the number of your white blood cells. Talk to your doctor, if you think you may have an infection. Symptoms include fever, pain, aching muscles, headache, loss of appetite and a general feeling of weakness. If you have a serious infection, either before starting treatment with Skilarence or during treatment, your doctor may advise you not to take Skilarence until the infection has resolved.

Gastrointestinal disorders
Tell your doctor if you have or have had problems with your stomach or intestines. Your doctor will advise you on what care you need to take during Skilarence treatment.


Children and adolescents

Children and adolescents below the age of 18 years should not take this medicine because it has not been studied in this age group.

Other medicines and Skilarence

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

In particular, tell your doctor if you are taking the following:

-  Dimethyl fumarate or other fumarates. The active ingredient in Skilarence, dimethyl fumarate, is also used in other medicines such as tablets, ointments and baths. You must avoid using other products that contain fumarates to prevent taking too much.

-  Other medicines used to treat psoriasis, such as methotrexate, retinoids, psoralens, ciclosporin, or other immunosuppressants or cytostatics (medicines that affect the immune system). Taking these medicines with Skilarence could increase the risk of side effects on your immune system.

-  Other medicines that can affect your kidney function, such as methotrexate or ciclosporin (used to treat psoriasis), aminoglycosides (used to treat infections), diuretics (which increase urine), nonsteroidal anti-inflammatory drugs (used to treat pain) or lithium (used for bipolar disease and depression). These medicines taken together with Skilarence could increase the risk of side effects on your kidneys.

If you get severe or prolonged diarrhoea with Skilarence, other medicines may not work as well as they should. Talk to your doctor if you have bad diarrhoea and are concerned that other medicines you are taking might not work. In particular, if you are taking a contraceptive medicine (the pill), the effect may be reduced and you may need to use other barrier methods to prevent pregnancy. See the instructions in the patient leaflet of the contraceptive you are taking.


Skilarence with alcohol

Avoid strong alcoholic drinks (more than 50 ml of spirits containing more than 30% alcohol by volume) during treatment with Skilarence, as alcohol can interact with this medicine. This could cause stomach and intestinal problems.

Pregnancy and breast-feeding

Do not take Skilarence if you are pregnant or trying to become pregnant, as Skilarence may harm your baby. Use effective methods of contraception to avoid becoming pregnant during treatment with..

Do not breastfeed while taking Skilarence

Dose

Your doctor will start your treatment with a low dose (using 30 mg Skilarence tablets). This helps to reduce stomach problems and other side effects. Your dose will be increased every week (switching to 120 mg Skilarence tablets from week 4 onwards).up to a maximum of 720mg a day at week 9

Your doctor will check how well your condition is improving after you start taking Skilarence and will check for side effects. If you have severe side effects after an increase in dose, your doctor may recommend that you temporarily go back to the last dose. If the side effects are not troublesome, your dose will be increased until your condition is well controlled. You may not need the maximum dose of 720 mg per day. After your condition has improved sufficiently, your doctor will consider how to gradually reduce the daily dose of Skilarence to what you need to maintain your improvement.

Method of administration

Swallow Skilarence tablets whole with liquid. Take your tablets during or immediately after a meal. Do not crush, break, dissolve or chew your tablets, as they have a special coating to help prevent irritation of your stomach

Possible side effects]

Like all medicines, this medicine can cause side effects, although not everybody gets them. Some of these side effects, such as reddening of the face or body (flushing), diarrhoea, stomach problems and nausea usually improve as you continue treatment.

The most serious side effects that may occur with Skilarence are allergic or hypersensitivity reactions; kidney failure or a kidney disease called Fanconi syndrome; or a severe brain infection called progressive multifocal leukoencephalopathy (PML). It is not known how commonly they occur. For symptoms see below.

Allergic or hypersensitivity reactions
Allergic or hypersensitivity reactions are rare but may be very serious. Reddening of the face or body (flushing) is a very common side effect which may affect more than 1 in 10 people. However, if you become flushed and get any of the following signs:
- wheezing, difficulty breathing or shortness of breath,
- swelling of the face, lips, mouth or tongue
stop taking Skilarence and call a doctor straight away.

Brain infection called PML
Progressive multifocal leukoencephalopathy (PML) is a rare but serious brain infection that can lead to severe disability or death. If you notice new or worsening weakness on one side of the body; clumsiness; changes in vision, thinking or memory; confusion; or personality changes lasting several days, stop taking Skilarence and talk to your doctor straight away.

Fanconi syndrome
Fanconi syndrome is a rare but serious kidney disorder which may occur with Skilarence. If you notice you are passing more urine, are more thirsty and drinking more than normal, your muscles seem weaker, you break a bone, or just have aches and pains, talk to your doctor as soon as possible so that this can be investigated further.

Very  common side effects (may affect more than 1 in 10 people):
- decrease in white blood cells called lymphocytes (lymphopenia)
- decrease in all white blood cells (leukopenia) - reddening of the face or body (flushing)
- diarrhoea
- bloating, stomach pain or stomach cramps
- feeling sick (nausea)

Common side effects (may affect up to 1 in 10 people):

- increase in all white blood cells (leukocytosis)
- increase in specific white blood cells called eosinophils
- increase in certain enzymes in the blood (used for checking the health of your liver) - being sick
- constipation
- gas (flatulence), stomach discomfort, indigestion
- decreased appetite

- headache

- feeling tired
- weakness
- feeling hot
- abnormal sensations of the skin, such as itching, burning, stinging, tickling or tingling - pink or red blotches on the skin (erythema)

Uncommon side effects (may affect up to 1 in 100 people):
- dizziness
- excess protein in the urine (proteinuria)
- increase in serum creatinine (a substance in the blood used for measuring how well your kidneys are working)

Rare side effects (may affect up to 1 in 1,000 people): - allergic skin reaction

Very rare side effects (may affect up to 1 in 10,000 people): - acute lymphatic leukaemia (a type of blood cancer)
- decrease in all types of blood cells (pancytopenia)

What Skilarence 120 mg contains
- the active substance is dimethyl fumarate. One tablet contains 120 mg dimethyl fumarate. - the other ingredients are: lactose monohydrate, cellulose microcrystalline, croscarmellose
sodium, colloidal anhydrous silica, magnesium stearate, methacrylic acid-ethyl acrylate copolymer (1:1), talc, triethyl citrate, titanium dioxide (E171), simethicone, indigo carmine (E132) and sodium hydroxide.

This post was edited to show very common side effects from modified leaflet