Bill's pure dimethylfumarate thread

[Bill]

Thanks Caroline. That line of reasoning would make my concern with a mild lymphopaenia misplaced. The worry I have with it is that it will keep dropping. Fortunately I get clear warning signs if this happens.

Cheers

[Caroline]

Thanks Caroline. That line of reasoning would make my concern with a mild lymphopaenia misplaced. The worry I have with it is that it will keep dropping. Fortunately I get clear warning signs if this happens.

Cheers

Hi Bill,
What warning signs do you mean? The measurements of your blood?

[Bill]

Well Caroline, when my lymphocyte count drops below 0.8 I get very tired and susceptible to colds. Above 0.8 I don't get any indication of where the count is headed.

[Caroline]

Well Caroline, when my lymphocyte count drops below 0.8 I get very tired and susceptible to colds. Above 0.8 I don't get any indication of where the count is headed.

That is a very interesting reaction Bill. Very good also for alerting you.
Personally i have never found any other reaction to DMF other then the usual flush and the strange phenomenon that I always have warm hands.

[Kat]

Bill your thread here is always interesting and very informative and I'm always amazed at how well you manage on your own.

I hope the lower dose continues to work for you.

[Bill]

Thank you for your encouragement, Kat. A lower dose would be much better.

Cheers

[Bill]

Another test and not much change:



I have reduced my dose to 530mg taken Fridays and Sundays. I have stopped all supplements aside from B vitamins and D3. The only change has been the development of two very small spots on my neck and foot, but I this this part of the normal oscillation of the disease. I was hoping the lymphocytes might recover a bit more, but sadly they did not. At least I can draw consolation from Caroline's suggestion that the lymphocyte drop is a measure of efficacy. I shall continue with twice weekly dosing until my next test.

Well wishes to all.

[jiml]

Another test and not much change:



I have reduced my dose to 530mg taken Fridays and Sundays. I have stopped all supplements aside from B vitamins and D3. The only change has been the development of two very small spots on my neck and foot, but I this this part of the normal oscillation of the disease. I was hoping the lymphocytes might recover a bit more, but sadly they did not. At least I can draw consolation from Caroline's suggestion that the lymphocyte drop is a measure of efficacy. I shall continue with twice weekly dosing until my next test.

Well wishes to all.

Great result Bill only just under normal the lymphocyte count everything else is looking good as well ..on such a low maintenance dose equivalent to arond 4.5 skilarence tablets twice a week .lets hope it keeps working well and your lymphocyte count comes up into the normal range again and stays there

[Bill]

Thank you, Jim. I think Caroline is correct with her observation that a lymphocyte reduction is associated with the efficacy of DMF. This gives me peace of mind as I no longer feel that I need to take a variety of supplements to try and bump up the count, and I am being tested often enough to see that my count is as boring and unchanging as yours.

Cheers

[Caroline]

This is from RE: ArteMie's journey with Stelera, but I do not want to hike Artemie’s Thread on Stelara.

I don't blame you ArteMie. I turn red as a beetroot and feel crappy for about five hours every time I take my drug. That is the trade off for feeling better the rest of the time.

A healthy diet sounds very worthwhile. I shall follow your progress with much interest.

Cheers

Do you really turn beetroot after taking it?
I also have that, now I have restarted DMF again, but with me it is 20-30 minutes. Might that be because of the regularity I take it, as in every day, and in lower dose? Compared to your high dose two times a week.
Seems very inconvenient to have it five hours.

Oh and by the way, I don’t feel crappy during a flush.