Following on from this report in 2012 XenoPort gets patent for Fumarate Analog XenoPort announced it has started a phase 2 trial of XP23829 in patients with psoriasis, XP23829 is a fumaric acid ester compound that is a prodrug of monomethyl fumarate (MMF).

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XenoPort, Inc. announced today that it has initiated a Phase 2 clinical trial of XP23829, its proprietary investigational next-generation fumaric acid product candidate. The trial is a multi-center, randomized, double-blind, placebo-controlled study designed to assess the efficacy and safety of XP23829 as a potential treatment of patients with moderate-to-severe chronic plaque-type psoriasis.

Richard Kim, M.D., XenoPort's chief medical officer, stated, "We are excited to take this next step in the advancement of the development of XP23829. From this Phase 2 trial, we hope to further our understanding of the efficacy, safety and tolerability of XP23829. In addition, the study is designed to generate information on the effect of dose and treatment duration on potential reduction in psoriatic lesions and modulation of sub-populations of blood immune cells. Based on historical enrollment rates of psoriasis studies conducted in the U.S., we expect top-line results of the trial in the third quarter of 2015."

XenoPort expects to enroll approximately 200 subjects in this trial, which is being conducted in the United States. The study will include a screening and washout phase of up to four weeks, a 12-week treatment phase and a four-week post-treatment phase. Eligible study subjects will be randomized to placebo or one of three treatment arms of XP23829: 400 mg or 800 mg once daily or 400 mg twice daily. The primary endpoint of the study will examine the percent change in Psoriasis Area and Severity Index (PASI) score from baseline at the end of week 12. Secondary endpoints will include the proportion of subjects who achieve a reduction of 75% or greater from baseline in PASI (PASI-75) score and subjects who achieve a Static Physicians Global Assessment (sPGA) score of "clear" or "almost clear."

Ronald W. Barrett, Ph.D., XenoPort's chief executive officer, further commented, "Fumaric acid ester drugs have been previously shown to be effective in psoriasis, although there are no products in the class that are approved by the U.S. Food and Drug Administration (FDA) for this indication. We believe that this trial will begin to define the distinguishing attributes of XP23829 as a potential best-in-class drug. These attributes could potentially include convenient once-a-day dosing, reduced flushing and gastrointestinal side effects and possibly more rapid onset and increased magnitude of efficacy. We believe that the results from this trial, if positive, could allow advancement of XP23829 directly into Phase 3 studies as a potential treatment for psoriasis. In addition, based on the strong correlation of results in psoriasis and relapsing forms of multiple sclerosis (MS) observed for other fumaric acid based drugs, we believe that this study could also form a basis for moving XP23829 into Phase 3 studies as a potential treatment for relapsing forms of MS."

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In a 39-page decision, Pasay court Branch 114 Judge Edwin Ramizo said Rev. Magnolia Nova Mendoza was “put in a situation wherein she was being subjected to a rigid inspection through no fault of her, thus bringing so much embarrassment, humiliation and anxiety on her part…”

The court took this embarrassment to award her with P1 million. The judge also ordered CebuPac to pay P1 million in exemplary damages because it acted in “wanton, fraudulent, reckless, oppressive, or malevolent manner” when it breached its obligation with Mendoza.

Mendoza was also granted P100,000 in lawyer’s fees and P129,123 cost of suit.

Mendoza, a Psoriasis sufferer and a professor at the Siliman University Divinity School, was about to board a flight from Manila to Dumaguete on March 11, 2010 at 8:50 a.m. when the check-in personnel returned her ticket and asked about the rashes on her face. She was then asked to produce a medical certificate before she could be allowed to travel.

In the afternoon she was allowed to continue with her flight, but was asked to sign a Special Handling Form.

In awarding the money, the judge also noted that CebuPac has no rule about the presentation of medical certificate for Psoriasis sufferers on their own Basic Operations Manual (BOM).

Mendoza’s legal counsel Harry Roque described the decision as a proud moment the justice system.

CebuPac corporate communications manager Michelle Pestano-Fojas said the company has yet to receive the copy of the decision.

This study tried to evaluate the diagnostic accuracy of noninvasive methods to detect fibrosis compared with liver biopsy (reference standard) in people with psoriasis taking Methotrexate, and suggests that larger prospective studies are required in this population to validate newer non-invasive methods.

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People with psoriasis taking methotrexate may be at increased risk of developing liver fibrosis compared with the general population. Noninvasive methods of detecting fibrosis have been widely adopted but their clinical utility is uncertain.

To evaluate the diagnostic accuracy of noninvasive methods to detect fibrosis compared with liver biopsy (reference standard) in people with psoriasis taking methotrexate.

A systematic search using Ovid/Medline, Embase, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library and Clinical Trials Register was performed. Diagnostic cohorts or case–control studies of adults taking or being considered for methotrexate therapy were considered.

Study quality was evaluated using the Quality Assessment tool for Diagnostic Accuracy Studies (QUADAS-2). Pooled data analysis was performed using RevMan 5.1. Bayesian meta-analysis was conducted using Markov chain Monte Carlo simulation. Seventeen studies were included. Sensitivity and specificity were 38% and 83% for standard liver function tests (LFTs), 74% and 77% for procollagen-3 N-terminal peptide (P3NP), 60% and 80% for Fibroscan, and 55% and 49% for ultrasound.

Confidence in these results is limited owing to low-quality data; old, small studies displayed significant selection bias and significant variation in the prevalence of fibrosis. No studies were identified evaluating recently developed markers. The clinical utility of LFTs, P3NP and liver ultrasound is poor.

Therefore if these tests are used in isolation, a significant proportion of patients with liver fibrosis may remain unidentified. Larger prospective studies are required in this population to validate newer non-invasive methods.

Having received narrowband UVB treatment since the 1980s for chronic widespread psoriasis, I have now been told by the hospital that they cannot authorise any further UVB treatment as I have exceeded the safe limit. They say medically they cannot continue even although it works well for me and clears the condition and I have never shown any signs of skin cancer. They are now saying that I must consider Fumaerm or Biologics and I am understandably concerned re any potential side effects or long term effects they may have. At least with UVB I KNOW the risks as they have been tried and tested over the years also with such excellent developments on the treatment of skin cancer if caught early I really would like to continue but can't as my doctors are now refusing to give me that option. Has anyone else out there been in this position, any feedback would be very welcome.

hi everyone first i want to say thankyou for letting me become a member very much appreiciate it.
Im saz i am 39 years old im from Scotland and i live with my 3 teenagers 2 girls 15 n 17 and my son 18 i first developed phsorisis at 18 which has always been pretty bad but at age 30 i was diagnosed with phsoratic arthritis too i was having photo therapy until last week but i developed a horrendous sunburn like rash so treatment is on hold until skin biopsy n blood results come back which is a shame as it really was making a big improvement to my phsorisis.
Anyway im really glad i have found a place to talk to people who dont think im contagious and keep me at arms distance lol look forward to getting to know you all have a great day guys

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Kadmon Corporation, LLC, today announced the initiation of a Phase 2 program for KD025, the Company’s orally bioavailable, potent and highly selective inhibitor of ROCK 2, in the treatment of subjects with moderately severe psoriasis vulgaris who have failed first-line therapy.

The Phase 2 program will begin with a Phase 2a open label study designed to evaluate the activity, safety and tolerability of 200 mg of KD025 administered orally once daily (QD) for 4 weeks in up to eight subjects.  The Phase 2a study is expected to be followed, in the third quarter of 2014, by a larger, Phase 2 study which will test KD025 at higher doses.  In Phase 1 studies, KD025 was generally well tolerated in healthy volunteers at doses ranging up to 1,000 mg daily, with significant activity, as measured by inhibition of Th17 cell cytokine secretion, at doses as low as 120 mg daily.

Psoriasis is an autoimmune disease that affects many parts of the body but is primarily manifested in the skin.  It is characterized by red, scaly plaques that range in coverage from localized areas to almost the entire body surface.  While the pathogenesis of psoriasis is not fully understood, it has been recognized that the recently discovered T helper 17 (Th17) cells, highly proinflammatory cells that enhance the clearance of extracellular pathogens but are also associated with multiple autoimmune diseases, may play a critical role.  Recent in vitro and in vivo studies with KD025 have demonstrated anti-inflammatory activity mediated by the inhibition of IL-17 and IL-21, cytokines secreted by Th17 cells, as well as promotion of the regulatory function of the immune system’s Treg cells through upregulation of pSTAT5.

“Antibodies directed against IL-17 have demonstrated therapeutic benefit in treating psoriasis, but must be injected and can be associated with immunologic adverse events,” said John Ryan, Ph.D., M.D., Executive Vice President and Chief Medical Officer of Kadmon.  “KD025 inhibits a novel target in this disease, where an oral drug that acts against IL-17, and which can restore balance to the immune system without suppressing its function, would be a significant advancement.  We look forward to the results of this program, and to elucidating KD025’s potential as a treatment for psoriasis.”

“Psoriasis is an autoimmune disease that affects millions of individuals and, beyond its social and psychological burdens, is often associated with cardiovascular disease, depressive illness, and psoriatic arthritis,” said Samuel D. Waksal, Ph.D., Chairman and CEO of Kadmon.  “KD025 has demonstrated the ability to induce immune homeostasis in a variety of disease models, an effect which, if translated to the clinic, holds transformative potential for psoriasis and other autoimmune disorders.  We look forward to the results of this program, and to initiating studies in other autoimmune disorders, including lupus nephritis and non-alcoholic steatohepatitis.”

Hello my name is Vanda and I don't use forums Facebook or Twiiter but after finding this website a year ago I wanted to come and let you know that this is the best psoriasis website I have found. Yesterday I contacted psoriasis club as I wanted to post my feedback and a nice man named Fred replied almost immediately explaining that only members could give feedback on the website. He gave me two options, I could reply to his email or follow the link and register to post my feedback. I thought how refreshingly honest of psoriasis club it was to let people post feedback without asking what it was about.

I have had psoriasis for 8 years and I had got to the stage of giving up on life as it had taken me over. My doctor tried with all sorts of creams but although it did help for a while, it would suddenly come back again mostly on my legs and my husband always said I had the most beautiful legs. He still tries to tell me that and he is so good to me putting up with my moods when I just don't have any confidence left any more to show my legs to anyone.

After researching the internet I found some websites and was amazed at the information available sometimes it was just to much to take in and I would just break down and sob, some of those websites looked to be wanting to sell me something and some looked like they are run by the makers of my creams. I kept on looking and with my husbands help narrowed my search down to three websites to read, there was lot's of useful information but not being the sort of person to use a website I just kept on reading.

Please forgive me I will finish now as I have taken up so much of your time, I just wanted to come and say thank you very very much psoriasis club for all of the information and hope that you have given me. I now no longer look at the other two websites any more as this one has the best information and encouraged me to get an appointment with a dermatologist which I have done and things are now going well for me again

Thank you psoriasis club for being here and not showing me product placement or asking me to donate, though if you would accept a donation from me I would like to know how I could do this.

With my deepest thanks Vanda.

Hello everyone,

I was just randomly reading about tips to help me with my psoriasis journey, and i am very glad to have come across this forum, so this is me introducing myself. Prepare yourself for it will be quite a long one!

I am 21 years old, living in the United Arab Emirates and recently graduated from uni, and I have had psoriasis for about 6 years, and psoriatic arthritis for around 5 years. It started with red itchy patches on my head, and then overtime i started noticing pains and swelling on both feet (around the ankles) and toes, and then the pain spread to my lower back up to the point of not being able to get out of bed without screaming in pain. It was at that point that my doctor decided to start me on steroidal meds (methotrexate), and thankfully over the years that took care of my back pains, and somewhat reduced my feet pains, although i do get the occasional swelling and throbbing pains whenever Mr. P decides to flare up.

Today, the main patches are on my scalp (around 50%), in the genital area, I have severe nail pitting, and my feet joints are pretty much always in pain.

Im currently using a cream called daivobet for the scalp, and protopic for the genital area, while still on a weekly dose of methotrexate for the PA.

I have been trying for years to figure out a pattern or the reason why sometimes psoriasis decides to hit harder than others, but to be honest i have not been trying hard enough. I apply the creams mentioned above whenever the flaring becomes really bad, but i dont feel too comfortable using them on a regular basis, because im afraid of side effects (especially in some areas more than others!).

I try to keep an active life (sports-wise) although it is sometimes difficult with the feet pain, but I found that swimming is pretty great and it helps with the joint pains.
I still want to and need to change my lifestyle and find ways to control and reduce the effects of psoriasis.

And this is why I'm really glad I found this forum, because not many people know about psoriasis around here.

Im sorry for such a lengthy intro; just thought I should share everything about my psoriasis situation in case someone can relate, and i would very much appreciate any advice any one has, and I hope I can benefit you guys aswell!

Yaseen

This study looked at the Danish population and investigated the death rate of it's people with psoriasis and concluded that patients with psoriasis demonstrated a reduced lifespan.

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Background:
Psoriasis is a common chronic disease, mediated by type 1 and 17 helper T cell-driven inflammation. Epidemiological studies have demonstrated a wide range of comorbidities and increased mortality rates. However, the current evidence on psoriasis-related mortality is limited and nationwide data have not been presented previously.

Methods:
In a nationwide population-based cohort we evaluated all-cause and cause-specific death rates in patients with psoriasis as compared to the general population.

Results:
The entire Danish population aged 18 and above, corresponding to a total of 5 458 627 individuals (50.7% female, 40.9 years ± 19.7), including 94 069 with mild psoriasis (53% female, 42.0 ± 17.0 years) and 28 253 with severe psoriasis (53.4% female, 43.0 ± 16.5 years), was included. A total of 884 661 deaths were recorded, including 10 916 in patients with mild psoriasis and 3699 in patients with severe psoriasis. The age at time of death varied by psoriasis status, i.e. 76.5 ± 14.0, 74.4 ± 12.8 and 72.0 ± 13.4 years, for the general population, mild psoriasis and severe psoriasis respectively. In general, the highest death rates were observed in patients with severe psoriasis. Overall death rates per 1000 patient years were 13.8 [confidence interval (CI) 13.8–13.8], 17.0 (CI 16.7–17.3) and 25.4 (CI 24.6–26.3) for the general population, patients with mild psoriasis and patients with severe psoriasis respectively.

Conclusion:
This nationwide population-based study of cause-specific death rates in patients with psoriasis demonstrated reduced lifespan and increased rates of all examined specific causes of death in patients with psoriasis compared to the general population.

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Histone modifications are associated with Delta(9)-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses
Authors
Background: Marijuana has been shown to have an immunomodulatory activity.
Results: ChIP-seq results show genome-wide changes in histone methylation in immune cells treated with THC.
Conclusion: Histone modifications are associated with THC-mediated alterations in antigen-specific T cell response.
Significance: This study provides insights into the potential role of epigenetic changes induced by THC in gene regulation.
Abstract

Marijuana is one of the most abused drugs due to its psychotropic effects. Interestingly, it is also used for medicinal purposes. The main psychotropic component in marijuana, Δ9-tetrahydrocannabinol (THC), has also been shown to mediate potent anti-inflammatory properties. Whether the immunomodulatory activity of THC is mediated by epigenetic regulation has not been investigated previously. In this study, we employed ChIP-Seq technology to examine the in vivo effect of THC on global histone methylation in lymph node cells of mice immunized with a superantigen, staphylococcal enterotoxin B (SEB). We compared genome-wide histone H3K4, H3K27, H3K9, H3K36 trimethylation and H3K9 acetylation patterns in such cells exposed to THC or vehicle. Our results showed that THC treatment leads to the association of active histone modification signals to Th2 cytokine genes and suppressive modification signals to Th1 cytokine genes, indicating that such a mechanism may play a critical role in THC-mediated switch from Th1 to Th2. At the global level, a significant portion of histone methylation and acetylation regions were altered by THC. However, the overall distribution of these histone methylation signals among the genomic features were not altered significantly by THC, suggesting that THC activates the expression of a subset of genes while suppressing the expression of another subset of genes through histone modification. Functional classification of these histone marker associated genes showed that these differentially associated genes were involved in various cellular functions, from cell cycle regulation to metabolism, suggesting that THC had a pleiotropic effect on gene expression in immune cells. Together, the current study demonstrates for the first time that THC may modulate immune response through epigenetic regulation involving histone modifications.

This is an interesting study that looked at the effects of psoriasis on a cohabitant. We as psoriasis patients are checked for our Dermatology Life Quality Index (DLQI) but we never think of those around us who have to put up with us.

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Background:
Numerous studies have analyzed the influence of psoriasis on the quality of life and psychosocial health of patients. However, few studies have addressed the effect of this disease on individuals living with these patients (cohabitants).

Objective:
To analyze the influence of psoriasis on the levels of anxiety, depression, and quality of life of the cohabitants of psoriatic patients.

Methods:
The study included patients, cohabitants, and controls, a total of 130 participants. Their quality of life was measured with the Dermatology Life Quality Index (DLQI) and Family Dermatology Life Quality Index (FDLQI), and their psychological state with the Hospital Anxiety and Depression Scale (HADS). Demographic data of participants and clinical characteristics of patients were also gathered.

Results:
The presence of psoriasis impaired the quality of life of 87.8% of the cohabitants. FDLQI scores of cohabitants were significantly associated with the DLQI scores of the patients (rs = 0.554; P < .001). Anxiety and depression levels did not differ between patients and cohabitants, but were significantly higher than in the controls (P < .001).

Limitations:
Additional studies with larger numbers of patients and cohabitants are required to analyze differences between groups according to psoriasis severity.

Conclusion:
Psoriasis markedly worsens the global well-being of patients and their cohabitants, who experienced an impairment of their quality of life and higher levels of anxiety and depression.

Just wondering how people deal with the redness and soreness with psoriasis in the buttcrack. Do you use moisturizers or ointments or steroid creams? Having a terrible time down there.

Strides Arcolab an Indian pharmaceutical company headquartered at Bangalore in southern India has been given FDA approval for Methoxsalen

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Strides Arcolab today announced that it has received approval from the United States Food & Drug Administration (USFDA) for Methoxsalen Capsules USP, 10 mg (Soft Gelatin Capsules).

According to IMS data, the US market for generic Methoxsalen Capsule is approximately USD 13.6 Million, with no generic player.

The product will be manufactured at the Company’s USFDA approved Oral dosage facility at Bangalore and marketed directly by Strides in the US Market.

About Methoxsalen Capsules:
Methoxsalen is a drug used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight.

Methoxsalen modifies the way skin cells receive the UVA radiation, clearing up the disease.

This study suggests activation of the Aryl Hydrocarbon Receptor dampens the severity of psoriasis.

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Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis.

AhR-activating ligands reduced inflammation in the lesional skin of psoriasis patients, whereas AhR antagonists increased inflammation. Similarly, AhR signaling via the endogenous ligand FICZ reduced the inflammatory response in the imiquimod-induced model of skin inflammation and AhR-deficient mice exhibited a substantial exacerbation of the disease, compared to AhR-sufficient controls.

Nonhematopoietic cells, in particular keratinocytes, were responsible for this hyperinflammatory response, which involved upregulation of AP-1 family members of transcription factors.

Thus, our data suggest a critical role for AhR in the regulation of inflammatory responses and open the possibility for novel therapeutic strategies in chronic inflammatory disorders.

Hi all,
I am a soap maker by trade. I have been making soap for 22 years and counting.
I have recently been diagnosed with plaque P. I am going to be formulating a recipe for pine tar soap and am trying to decide on using hot process or cold process. Also I may try making an ointment as well. The dr has me using steroid cream right now. I would like to stay away from the steroids if at all possible. Are there any other Soapers here to bat this around with?
Thanks, Pam.

I'm a 48 year old woman. I never had psoriasis in my past. My story starts out last July when I developed a sore on my lower shin that wouldn't go away. It kept peeling and the size slowly increased. It didn't even occur to me then that it was psoriasis. I had previously had rare occurences of eczema, but this didn't feel the same. I had always had ichthyosis vulgaris, with keratosis bumps and the celophane looking legs.

The sore got bigger and then another sore developed on my other leg just below the knee, then it spread to my scalp. This occurred over 3-4 months. I had been on a fairly restrictive diet trying to lose weight, and then around Halloween and into the holidays I fell off the wagon and went back to eating basically anything. The sores multiplied. By the first week of December I had approximately 14 sores over my body, mostly on my upper legs and a few around my elbows. These were very swollen and red and peeled almost daily. By Christmas they had spread to the backs of my arms, I had a couple of small sores on my face, many more sores in my scalp and ears, and across the tops of my buttocks. I was horrified. I started looking at images on google and determined that this was psoriasis.

I picked up OTC psoriasis creams. Nothing was helping. The end of January my mother told me there was a research study she had heard about for psoriasis. I told her I was looking for an holistic approach. I heard the commercial twice. The second time I thought, "Well, I'll just call. Maybe they can confirm that it's psoriasis and maybe I won't qualify." So I called and talked to the research assistant. She said that I needed to have had it for 6 months, that it needed to be predominantly plaque psoriasis and that it needed to cover 10% of my body. She explained that the palm of your hand represents about 1%. Did I have 10 of those? I didn't think I did. I thought maybe 5. She said I should come in anyway and they would take a look and determine if I would qualify. So, I went in that day. It was psoriasis, plaque psoriasis. And I had it on 8% of my body, so I didn't qualify. But, they had another program---something about laser treatments. Did I want to talk to the lady in that department? Sure, I'd talk to her. So Paula came and I followed her to her office. In talking to her, I felt that this wasn't the answer either. The psoriasis was spreading so quickly that I felt that doing lasers in one spot wouldn't stop it from spreading in another spot so I told her I'd keep looking for an holistic approach. She got up and closed the door and asked me if I'd ever heard of NAET. NAET? What is NAET? It's "Nambudripad's Allergy Elimination Technique". I was intrigued. Until that point, I had never really considered my skin issues allergy related.

I started researching NAET. This protocol basically reprograms your brain/body to not react to an allergen, to look at it as a friend rather than a foe. I found a practitioner with 18 years of experience and a couple weeks later did the testing to determine what allergies I had. I had quite a few. They treat one allergen each time. Because of the many allergies, I started going 3 times per week. The psoriasis continued to spread for a time and ultimately I probably had the psoriasis over 40% of my body, but I was seeing improvement in some of the sores. Some seemed to be clearing from the inside, giving a small circle of clear skin with psoriasis bumps around the outside, but none were going away completely. The overall swelling was improving as well and the peeling was lessening, but still the sores remained. But finally, the spreading had stopped. I wasn't getting new sores. I then read something about the benefits of turmeric and how it helps with psoriasis as it's a natural anti-inflammatory. I decided to add turmeric into my routine--1000mg 2x/day. The changes were very quick at this point. The rest of the inflamation went away, the redness started to fade. I began to think that maybe the turmeric itself was the trick, but when I had a reaction to dogs a couple weeks later, I knew that it was the combination because the turmeric didn't stop the reaction, but it helped me to get past it after the flare up.

I have now been through 32 treatments, and have maybe 3 more to do. My psoriasis is healing wonderfully. Most is completely gone. I have no red swollen areas, but just a few little hard bumps that are slowly receding. They don't even peel. They account for about 1/4 palm's worth. In addition, I can eat anything I want, I can be around dogs, and I feel really good. I'm even wearing short sleeves and short pants again.

Did you know...
If you click on portal ( third item along under the green banner) which I think this is a most useful facility
A ) you can see the last ten posts
B) if you scroll down on the right hand side you can see links to polls, and other quick links
C) you can see at a glance if their are messages for you
D) at the bottom are the forum statistics if you click on full statistics you can see which are the most read posts how many hits they have had etc.
And for members that may have trouble navigating around the site there are links to these threads
E) in the main body you can read the latest threads

I just thought that the Portal was an under used facility and may help some members navigating the forum

A study published in The Journal of the American Academy of Dermatology looked at The impact of palmoplantar psoriasis on health-related quality of life (QoL) and concluded Patients with palmoplantar psoriasis experience greater health-related QoL impairment and are more likely to report heavy use of topical prescriptions than those with moderate to severe plaque psoriasis.

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Background:
The impact of palmoplantar psoriasis on health-related quality of life (QoL) is largely unknown.

Objective:
We sought to compare clinical characteristics and patient-reported outcomes between patients with palmoplantar psoriasis and moderate to severe plaque psoriasis.

Methods:
We conducted a cross-sectional study of patients with plaque psoriasis (N = 1153) and palmoplantar psoriasis (N = 66) currently receiving systemic or light treatment for psoriasis.

Results:
Patients with palmoplantar psoriasis were more likely to report Dermatology Life Quality Index scores that correspond to at least a moderate impact on QoL (odds ratio [OR] 2.08; 95% confidence interval [CI] 1.20-3.61); problems with mobility (OR 1.98; 95% CI 1.10-3.58), self-care (OR 3.12; 95% CI 1.24-7.86), and usual activities (OR 2.47; 95% CI 1.44-4.22) on the European Quality of Life-5 Dimensions questionnaire; and heavy topical prescription use of at least twice daily in the preceding week (OR 2.81; 95% CI 1.63-4.85) than those with plaque psoriasis.

Limitations:
Our assessment tools may not account for all dimensions of health-related QoL affected by palmoplantar disease, and these results may not be generalizable to patients with milder forms of psoriasis.

Conclusion:
Patients with palmoplantar psoriasis experience greater health-related QoL impairment and are more likely to report heavy use of topical prescriptions than those with moderate to severe plaque psoriasis.

Apply this for Guaranteed skin improvement...

100% pure Pine Tar

If you live in the US, then you can check this out on Amazon

Forgot prescription medication that are harmful to your body... use 100% pine tar.

What are your thoughts guys? I know this is a little out there