I have just warched a local programme called Inside Out in which 40 people in UK have died from fire through using emmollient creams like Cetraben , Diprobase and that type containing paraffin . The latest was recently in Beverley were a person with psoriasis was smoking in the lounge watching tv after using the cream just burst into flames and died later in hospital with over 30% burns, no warnings are on the containers at all, this is a widespread problem that I have never heard of.

Following on from this report Scotland says no for Kyntheum to treat psoriasis The National Institute for Health and Care Excellence (NICE) has issued draft guidance recommending Kyntheum (brodalumab) for psoriasis.

Quote:

---

Brodalumab is recommended as an option for treating plaque psoriasis in adults, only if:

The disease is severe, as defined by a total Psoriasis Area and Severity Index (PASI) of 10 or more and a Dermatology Life Quality Index (DLQI) of more than 10.

The disease has not responded to other systemic therapies, including ciclosporin, methotrexate and PUVA (psoralen and long-wave ultraviolet A radiation), or these options are contraindicated or not tolerated.

The company provides the drug with the discount agreed in the patient access scheme.

Hello  everyone, I am new to this forum and new to psoriasis although it is in my family. My father had it, my sister started when she was 18 and my two daughters have it. I am 67 years old and have been clear of it, how lucky is that? My sister had it all over her body and is now in a wheelchair due to Psoriatic Arthritis. 

About 18 months ago I was diagnosed with psoriatic arthritis although I had no skin problems. I was certainly in denial of the diagnosis. But not now! I have now been diagnosed with Flexural/Inverse Psoriasis and boy does it itch and so sore. It is at present in my armpits and genital areas and now on my eyelids and slowly spreading. I have been prescribed a topical cream for my arms and other areas except for my eyelids. It was suggested I use Vaseline on my eye lids.

My question is anyone any thoughts of deodorants I would be able to use and also ideas of anything for my eyelids apart from vaseline?

Many thanks and thanks for being there

Bumble bee  

I lost you all - but have found you again - jeeze a lot has happened x

Novartis have announced a label update to the use of Cosentyx for scalp psoriasis in the USA.

Quote:

---

Novartis announced today that the US Food and Drug Administration (FDA) has approved a label update for Cosentyx® (secukinumab) The updated label includes Cosentyx data in moderate-to-severe scalp psoriasis - one of the difficult-to-treat forms of the disease, which affects approximately half of all psoriasis patients.The label update is effective in the US immediately, and is based on the proven efficacy and consistent safety profile of Cosentyx from a dedicated Phase III scalp psoriasis trial.

Having been prescribed enstilar by my dermatology department, and given a letter to take to my doctor so he could issue it ...I was surprised when I opened the package to have been given dovobet gel ...I queried this with the pharmacy department who assured me it was a generic version ....

Had I not been a member here I would probably have accepted that

But I said have you got your facts right the letter from the hospital clearly said Enstilar foam .....I asked her to double check with the doctor ......Because there is no generic version of enstilar
That evening I got a call saying that enstilar would be waiting for me to collect

Now I know there's no difference in the active ingredients to the gel, but the foam is supposed to be easier to apply and  from what I've read the propellant makes it easier for the skin to absorb...

The reason for bringing this up is so others can question if given gel instead of foam and be sure they are correct ....there is no generic version

This study assessed the effect of systemic and biological drugs on psoriasis patients carotid intima-media thickness (IMT).

Quote:

---

Background:
Psoriasis has been related to a large number of cardiovascular risk factors such as hypertension, diabetes mellitus and arteriosclerosis. The increased carotid intima-media thickness (IMT) could be considered to be a marker of generalized arteriosclerosis.

Objective:
To assess the effect of systemic and biological drugs on psoriatic patients′ carotid IMT.

Methods:
A prospective study was performed. We studied 53 patients with moderate and severe psoriasis from our psoriasis dermatological unit, analyzing lipid and glucose metabolism and performing a carotid IMT sonography before introduction of systemic and biological drugs. After that, we performed an 8-month closely analytic and sonographic follow-up.

Results:
The IMT of the psoriatic patients treated with biological drugs tended to decrease, although this occurrence was not statistically significant (p=0.086). The subgroup analysis revealed that patients treated with Methotrexate (p=0,045) and Anti Il-12/23 (p=0,010) presented a decrease of their IMT levels. This analysis also showed a decrease in glycaemia and insulin levels in patients treated with TNF-alpha Inhibitors and Ustekinumab.

Conclusions:
Our study suggest that the carotid-IMT may benefits from treatment with biological drugs, particularly Anti IL-12/23, and methotrexate in patients suffering from moderate and severe psoriasis. However, larger longitudinal studies should be performed in order to fully confirm these results.

This study set out to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe chronic plaque psoriasis.

Quote:

---

Aim:
Warren et al set out to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe chronic plaque psoriasis.

Setting and design:
This is a prospective, double-blind, randomised (3:1), placebo-controlled study, conducted across 16 centres in Germany, France, the Netherlands, and the UK.

Study exposure:
Methotrexate-naïve adults with a diagnosis of moderate to severe chronic plaque psoriasis for at least 6 months before baseline were randomly assigned to receive weekly subcutaneous injections of either methotrexate at a starting dose of 17.5 mg, or placebo for 16 weeks (first phase).Dose escalation to 22.5 mg/week was implemented after 8 weeks if patients did not achieve PASI 50. Treatment was combined with folic acid 5 mg/week. The first phase of the study was followed by an open-label period from 16-52 weeks (second phase), in which both groups received weekly methotrexate injections. At week 24, dose escalation to 22.5 mg/week was possible in patients not achieving PASI 50.

Outcomes:
Psoriasis severity was measured using the PASI (Psoriasis Area and Severity Index). The authors also used two other psoriasis severity measures and two quality of life measures, looked at safety indices and performed a sub-study analysing paired skin biopsies at baseline and week 16 (histopathology, immunohistochemistry and expression of interleukin (IL)17A, interferon-γ and tumour necrosis factor-α).

Primary outcome measures:
The primary outcome was the proportion of patients reaching PASI 75 at week 16.

Results:
120 patients were included in this trial, most of whom were middle-aged white men with longstanding psoriasis and a mean BMI of 30.1 kg/m2. PASI 75 was achieved in 41% of patients receiving methotrexate vs. 10% of patients receiving placebo (RR 3.93, 95% CI 1.31–11.81; p=0.0026) at week 16. Subcutaneous methotrexate was generally well tolerated, with no serious adverse events related to this treatment over the 52-week study.

Conclusions:
Warren et al conclude that the 52-week risk-benefit profile of subcutaneous methotrexate is favourable in patients with psoriasis.

The reason I decided to post is that Ive been battling with this soul swallowing , life ruining monster since I was about 48 (and now Im 55) on my own as far as financially. I would pay cash to see a derma and he would give me samples since I was on a budget and I only had it on my knees and elbows a little bit but it never for 1 minute stopped its slow but sure progression...once it takes an area it keeps it. So Ive tried every topical known to man the last one bieng enstilar which works for a minute by the time I got through the can it wasnt working any more and the monster came back with a vengeance. Well now a few years down the road its on pretty much 80 percent of my body including my face and hands which u cant cover with chlothes.I live in southern california with my beautiful and understanding for now girlfriend who offered insurance thru her work and im signed up and went in last week to see if I could get hooked up with a derma and get some of the"good stuff" like stelara it may kill me which is what my old derma used to say but I am dying anyways inside and out so I gotta try it cause the road im on rite now is real dark and twisty . I basically go to work and thats it and I spend about 2 to 3 hours fixing my face every day and I always wear gloves and long pants and long sleeves which kills me....I used to be a surf rat shorts no shirt endless summer shit. I used to be cool now I have trouble even talking to people for fear of my makeup wiping off and my red face peeking out so Im hoping for the best and Ill keep posting when something good happens i got my TB test done so I can go into the new dermas with my results in hand so he knows im serious if he tries to give me some kind of cream youll probably hear about me in the newspapers...I dont want to kill again. Ha ha just kidding! ttys

As of today I have increased my stelara from 45mg every 12 weeks to 90mg every 8 weeks moreso because of my crohns.

I was collecting my injection today and they mentioned that the initial dose for crohns is a stelara infusion generally around 325mg.

It made me wonder though, why do they not do this for psoriasis?

Just musing.. I wonder if they will end up combining bios? I got taken off Humira because my skin didn’t improve, but I realised after it may have been helping my aches and pains. So how about a bit of Humira and a bit of something else!

 Hello everyone. I have been diagnosed recently with Pamoplanter p. Prescribed Acitretin and also waiting on apt for uv treatment. Prior to this using topical steroids and oral steroids for really bad episodes. Only 4-days on acitretin tabs and am hopeful they will, along with uv, work.

Protopic as far as I know is not prescribed for psoriasis but I thought this may be of interest to some as it gets 15 thread results in a search on the forum.

A leading French medical journal Prescrire has said that Protopic has disproportionally undesirable effects that include skin cancer and Lymphoma, also termed lymphatic cancer and are warning people to avoid it.

Hi All! My name is Fred and I suffer from Psoriasis. 

I've had it for about 6 years now and it has been getting progressively worse and worse. I'm a 49 year old male. Have been seeing a good dermatologist PA for years. His office practice sucks but he's one of the most caring and helpful people I've had the pleasure of meeting. 

My condition is unique from what my derm tells me. Rather than having it in one spot I have it in many many spots all over my body. Small red spots on my thighs, arms, belly, and oh boy my back. The worst was my head. LARGE flakes always coming from there. They were typically raised and very scaly. I flaked all of the time. They were also itchy. Often scratched myself to bleed. No fun.

Anyway, I tried Stelara last year. Took it in April. Two shots to start. Started to see results in about 2 months. I was pleased! Then, I got a single shot to follow up and a short time later I noticed that my plaque was back. Each shot after did nothing to help really. At $19,000 a shot through my insurance I was clearly disappointed. I took my last Stelara shot on December 7th 2017.

My derm had been working to get me approved for Taltz. I just took my first two doses of Taltz on January 12th. One in the arm and one in my belly. It hurts like hell (I guess I'm a wimp) going in. You need to really press that button to make it work and to me it goes in slow. That last click takes a while. 

The good news though is things have been GREAT. I am seeing TREMENDOUS effect from it. My head is smooth as is behind my ears. No flaking from the scalp. All of my patches are reduced or nearly gone! I can't believe how fast. 

Today though, about a week and a half after the two starters I developed a raised red rash around the injection sites. They are somewhat itchy and painful to the touch. Some googling around lead me here and it appears that this is somewhat common. My derm told me to watch it and see if it spreads beyond what I see now. Also asked me to watch for any other symptoms like nausea, fever, and fatigue. Said he might want me to go get some blood work just to be safe.

Anyway, I am due to take my next single shot Friday the 26th. He told me to do it in the fatty portion of my leg and to avoid the other two areas. More than willing to share my results down the road if there is interest.

Thanks for reading!

Update: 1/28/2018

Just as an update for anyone who might be interested. The swelling and rash has gone down on my arm and on my belly were my first two injections went on the 12th. Last Friday I gave my injection in the fatty part of my thigh. This time I did let the medicine sit out for approximately 45 minutes before I administered. Unfortunately this time it would appear that the pain and swelling came within hours of the injection and is in fact still there. The central part of the raised area is nearly purple and hot to the touch. I’m taking Benadryl per recommendation of my derm and also Advil to try to reduce the pain. Honestly, I’m currently contemplating whether this is all worth it.

Hi, I'm a new member. I am 55 years old and my first outbreak of psoriasis was when I went to university at 18. Since then I have had the usual range of treatments but always stuck to topical remedies and one course of uvb. To date I have been lucky as my psoriasis has never itched too much and I had learned to live with it. Apart from applying diprobase 2 time a day I did little else. Last summer it disappeared completely and I thought that I had got rid of it! Unfortunately it came back with a vengeance in october and vaseline was the only way I could moisturise it sufficiently. I resorted to vaseline at the end of the year and it started to clear up. Around this time I developed some very itchy bumps on my shoulders and back. There are not very many but they itch like crazy. I have applied betnovate to calm them down a little and have an appointment with a dermatologist in a couple of weeks. I think that the vaseline may be responsible as it can cause heat rash type symptoms but the itchy bumps have been there almost a month now. has anybody else experienced something like this?? Thanks.

hello out there to all my new ichy friends

This study looked at 10 years of real-world data on the effectiveness of biological treatments for psoriasis.

Quote:

---

Background:
Few studies have analysed the long-term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and now includes 10 years of real-world data on the effectiveness of biological treatment.

Objectives:
To analyse the long-term real-world outcome data of patients who are biologically naïve with moderate-to-severe psoriasis after switching to biological treatment.

Methods:
An observational study of patients who are biologically naïve with at least one registration of outcome before switching to biological treatment while included in PsoReg and at least one follow-up visit. Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI) and EuroQol-5D (EQ-5D) values were analysed at 3–5 months, 6–11 months and at least once after ≥ 1 year, up to 9 years after the switch to biological treatment.

Results:
In total, 583 patients fulfilled the inclusion criteria. Of these, 399, 395 and 373 patients had observed outcome data beyond 1 year on the PASI, DLQI and EQ-5D, respectively, and 164, 168 and 152, respectively, were observed in at least three time periods after the switch. Significant (P < 0·01) improvement in PASI, DLQI and EQ-5D scores was observed 3–5 months after the switch and sustained under the whole observation period. The mean PASI, DLQI and EQ-5D changed from 13·5 ± 9·1, 9·0 ± 8·1 and 0·74 ± 0·22, respectively, before the switch, to 4·0 ± 3·5, 3·7 ± 4·7 and 0·79 ± 0·21, respectively, 1–5 years after the switch.

Conclusions:
Biological treatment, as used in clinical practice, shows a stable long-term effectiveness in all the measured dimensions, PASI, DLQI and EQ-5D.

This study tried to evaluate the safety of psoriasis biological treatments in conception and/or pregnancy.

Quote:

---

Background:
Biological therapies are effective treatments for psoriasis and are often prescribed to women of child-bearing age.

Objectives:
To evaluate the safety of biological therapy in conception and/or pregnancy.

Methods:
We performed a systematic review of pub med, Medline, Embase and Cochrane databases for multivariate-adjusted studies of women exposed to biologics relevant to the treatment of psoriasis during conception and/or pregnancy.

Results:
We identified four population-based cohort studies involving 1300 women exposed to tumour necrosis factor (TNF)-α inhibitors (TNFi) 3 months prior to or during the first 3 months of pregnancy. These studies showed a trend towards drug-specific harm with TNFi exposure in women with different inflammatory diseases, with an increased risk of congenital malformations [three studies; odds ratio (OR) range 1·32–1·64] and preterm birth (one study; OR 1·69, 95% confidence interval 1·10–2·60). This trend did not reach statistical significance in all studies; study heterogeneity, variation across comparator cohorts, inadequate adjustment for important confounding variables such as co-therapy, and an absence of a common constellation of malformations means there is uncertainty about the causal role of TNFi. No studies specifically addressed the effect of TNFi exposure in psoriasis during conception and/or pregnancy, or of interleukin (IL)-17 and IL-12/23 antagonists in any indication.

Conclusions:
When counselling women these findings must be balanced against the potential impact of untreated severe psoriasis on conception and/or pregnancy and maternal wellbeing; ongoing pharmacovigilance via registries remains essential to address this evidence gap.

This study investigated the risk of cancer in patients with psoriasis treated with biological therapy.

Quote:

---

Background:
Biological therapies are highly effective in psoriasis, but have profound effects on innate and adaptive immune pathways that may negatively impact on cancer immunosurveillance mechanisms.

Objectives:
To investigate the risk of cancer in patients with psoriasis treated with biological therapy.

Methods:
We searched Medline, Embase, and the Cochrane Library (up to August 2016) for randomized controlled trials, prospective cohort studies and systematic reviews that reported cancer incidence in people exposed to biological therapy for psoriasis compared with a control population.

Results:
Eight prospective cohort studies met our inclusion criteria. All the evidence reviewed related to tumour necrosis factor inhibitors (TNFi) with the exception of one study on ustekinumab. An increased risk of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma, was reported with TNFi compared with both a general United States population and a rheumatoid arthritis population treated with TNFi. No evidence for increased risk of cancers (reported as all cancers, lymphoma, melanoma, prostate, colorectal and breast cancer) other than NMSC was identified.

Conclusions:
There were important limitations to the studies identified including choice of comparator arms, inadequate adjustment for confounding factors and failure to account for latency periods of cancer. There remains a need for ongoing pharmacovigilance in relation to cancer risk and biological therapy; the NMSC signal requires further investigation to determine the risk specifically attributable to biological therapy using prospectively collected data with adjustment for known NMSC risk factors.

Hello
I am new to The forum. 
A week and a half ago I started Fumaderm. Early days i know.
I moved to 2, 30mg tablets on Tuesday. I took them at night and woke up the next day bright red. It didn't last long and I was my normal colour by 1. 
I let the doc know and they called me in for a look but I was back to nirmal. 
They could not explain this. They said maybe it was flushing and told me to take the tabs at separate times.
Nothing happened Thursday
Today I took a tablet at 630. I had my dinner at 830. At 945 my skin went insane. I felt hot and sore and mad itchy. When I looked i had once again turned pink from head to toe
I was just wondering if anyone else has experienced flushing like this. It is still going at the moment and i am on fire.
The doctor seemed to think flushing was only face and chest... Anyone else has whole body redness??
Thanks in advance
Cheers ☺