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Psoriasis Club is a friendly on-line Forum where people with psoriasis or psoriatic arthritis
can get together and share information, get the latest news, or just chill out with others who understand. It is totally
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So Who Joins Psoriasis Club?
We have members who have had psoriasis for years and some that are newly diagnosed. Family and friends of those with psoriasis
are also made welcome. You will find some using prescribed treatments and some using the natural approach. There are people who
join but keep a low profile, there are people who just like to help others, and there are some who just like
to escape in the Off Topic Section.
Joining Couldn't Be Easier: If you are a genuine person who would like to meet others who understand,
just hit the Register button and follow the instructions.
Members get more boards and privileges that are not available to guests.
OK So What Is Psoriasis?
Psoriasis is a chronic, autoimmune disease that appears on the skin. It
occurs when the immune system sends out faulty signals that speed up the
growth cycle of skin cells. Psoriasis is not contagious. It commonly
causes red, scaly patches to appear on the skin, although some patients
have no dermatological symptoms. The scaly patches commonly caused by
psoriasis, called psoriatic plaques, are areas of inflammation and
excessive skin production. Skin rapidly accumulates at these sites which
gives it a silvery-white appearance. Plaques frequently occur on the
skin of the elbows and knees, but can affect any area including the
scalp, palms of hands and soles of feet, and genitals. In contrast to
eczema, psoriasis is more likely to be found on the outer side of the
joint.
The disorder is a chronic recurring condition that varies in severity
from minor localized patches to complete body coverage. Fingernails and
toenails are frequently affected (psoriatic nail dystrophy) and can be
seen as an isolated symptom. Psoriasis can also cause inflammation of
the joints, which is known as (psoriatic arthritis). Ten to fifteen
percent of people with psoriasis have psoriatic arthritis.
The cause of psoriasis is not fully understood, but it is believed to
have a genetic component and local psoriatic changes can be triggered by
an injury to the skin known as Koebner phenomenon. Various
environmental factors have been suggested as aggravating to psoriasis
including stress, withdrawal of systemic corticosteroid, excessive
alcohol consumption, and smoking but few have shown statistical
significance. There are many treatments available, but because of its
chronic recurrent nature psoriasis is a challenge to treat. You can find more information
Here!
Got It, So What's The Cure?
Wait Let me stop you there! I'm sorry but there is no cure. There are things that can help you
cope with it but for a cure, you will not find one.
You will always be looking for one, and that is part of the problem with psoriasis There are people who know you will be
desperate to find a cure, and they will tell you exactly what you want to hear in order to get your money. If there is a
cure then a genuine person who has ever suffered with psoriasis would give you the information for free. Most so called cures
are nothing more than a diet and lifestyle change or a very expensive moisturiser. Check out the threads in
Natural Treatments first and save your money.
Great so now what? It's not all bad news, come and join others at Psoriasis Club and talk about it. The best help is from accepting it and talking
with others who understand what you're going through. ask questions read through the threads on here and start claiming
your life back. You should also get yourself an appointment with a dermatologist who will help you find something that can
help you cope with it. What works for some may not work for others
Posted by: Fred - Wed-07-08-2013, 13:48 PM
- No Replies
Telormedix is a biopharmaceutical company focused on targeted immunity and modulation of the innate immune system for treating cancer and autoimmune diseases.
Quote: Telormedix SA, a clinical stage biopharmaceutical company focusing on toll-like receptor 7 (TLR7) small molecules in the treatment of cancer and inflammatory diseases, today announced that it has raised funding from the European Eurostars Programme to coordinate an international research project involving a consortium of companies aimed at developing new formulations of one of the Company’s promising drug candidates, TMX-302, for the treatment of psoriasis. The psoriasis anti-inflammatory treatment project, operating under the acronym PAT, will have a total budget of €1.77 M and will involve consortium partners Biopta, Midatech Biogune, Molecular Profiles and the University Hospital Zurich (USZ).
The PAT project will initially focus on developing new oral and topical formulations of TMX-302 using Midatech’s nanoparticles formulated using Molecular Profile’s technology. Both routes of administration are viewed as practicable for the treatment of psoriasis. Once a range of formulations has been developed, Biopta will screen them by using human fresh tissue in vitro assays to select the best candidates. These candidates will then be studied and compared to currently used therapies in well-established humanized animal models of psoriasis at the Department of Dermatology of the USZ.
Dr. Johanna Holldack, CEO at Telormedix, commented:
“We are absolutely delighted to have secured this funding with such a world class consortium to bring TMX-302 to preclinical proof of concept. We believe that modulators of TLR-7 have a significant chance of being important new treatments for inflammatory diseases like psoriasis.”
Posted by: Fred - Tue-06-08-2013, 16:27 PM
- Replies (1)
NICE (National institute for health and care excellence) UK have just released QS40 Quality standards for the treatment of psoriasis in the UK. This follows on from the last report about guidance for GPs which you can read here: NICE issues new guidance for GPs treating psoriasis
The QS40 is a bit long and boring to put it all on here but here a few basics.
Quote:
Psoriasis is an inflammatory skin disease, which most commonly presents as red, scaly plaques. These may vary in extent from a few patches to generalised skin and associated joint involvement. The disease typically follows a relapsing and remitting course, and can result in significant functional, psychological and social morbidity.
The prevalence of psoriasis is estimated to be around 1.3–2.2% in the UK. Men and women are equally affected. Psoriasis can occur at any age, although is uncommon in children (0.71%) and the majority of cases occur before 35 years. Psoriasis is associated with joint disease in a significant proportion of patients (reported in 1 study at 13.8%).
Psoriasis has a significant impact on health and wellbeing with consequent effects on employment and income, underlining the need for prompt, effective treatment, and long-term disease control. Symptoms related to the skin, problems related to treatments, psoriatic arthritis, and the effect of living with a highly visible, stigmatising skin disease have an important bearing on wellbeing. Even people with less severe disease state that psoriasis has a major effect on their day-to-day life.
A variety of treatment options are available, ranging from topical therapies to phototherapy and systemic therapy (non-biological and biological). For most people, psoriasis is managed in primary care, with specialist referral being needed at some point for up to 60% of people. Specialist tertiary care is needed in the very small minority of people with especially complex, treatment-resistant or rare forms of psoriasis. People receiving systemic therapy need ongoing supervision in specialist settings, sometimes with shared care arrangements for drug monitoring in primary care.
A recent UK audit in the adult population found wide variations in practice, particularly in relation to access to specialist treatments (including biological therapy), appropriate drug monitoring, specialist nurse support and psychological services.
NICE quality standards are a concise set of prioritised statements designed to drive measureable quality improvements within a particular area of health or care. They are derived from high-quality guidance, such as that from NICE or other sources accredited by NICE. This quality standard, in conjunction with the guidance on which it is based, should contribute to improvements.
The quality standard for psoriasis specifies that services should be commissioned from and coordinated across all relevant agencies encompassing the whole psoriasis care pathway. A person-centred, integrated approach to providing services is fundamental to delivering high-quality care to people with psoriasis.
The quality standard should be read in the context of national and local guidelines on training and competencies. All healthcare practitioners involved in assessing, caring for and treating people with psoriasis should have sufficient and appropriate training and competencies to deliver the actions and interventions described in the quality standard.
Posted by: Fred - Mon-05-08-2013, 22:53 PM
- No Replies
Background:
Humira (Adalimumab) approval by the European Medicines Agency on December 2007 as second-line therapy of moderate to severe chronic plaque psoriasis was based on scientific evidence from clinical trials, but patients in daily clinical practice are different and results may differ in different geographical settings.
Aims:
To analyse the efficacy, safety and retention of treatment with adalimumab in a cohort of patients with moderate to severe psoriasis at a referral centre in Barcelona, Spain.
Methods:
Retrospectively collected efficacy and safety data of a cohort of 119 consecutive patients treated with adalimumab for moderate to severe psoriasis in daily practice between January 2008 and March 2013. Efficacy was determined using as treated (AT) and intention-to-treat (ITT) analysis. Drug survival was analyzed by the Kaplan-Meier method with log-rank test and Cox regression.
Results:
One hundred and nineteen patients received adalimumab therapy with mean treatment duration of 25 months (median 25, range, 2-60). In 49 (41%) of our cases, adalimumab was the first biologic ever used. PASI75 response rates at week 16, 6 months and 1 year of treatment were 64%, 67%, and 76% (AT) and 64%, 60%, and 54% (ITT), respectively. The corresponding PASI90 response rates were 49%, 60%, and 70% (AT), and 49%, 52%, and 50% (ITT), respectively. Biologic naïve patients had significantly higher PASI75 and PASI90 response rates at week 16, 6 months, and one year of treatment. Combination treatment (used in 22% of our patients) was associated with increased PASI75 and PASI90 response rates at 6 months. The variables which were associated with a significantly higher probability of drug survival were PASI75 response status at week 16, 6 months and 1 year, PASI90 response status at 6 months and 1 year, and biologic-naïve status of the patient. The ability to lengthen and need to shorten injection intervals to maintain response were respectively associated with higher and lower probability of drug survival. Multivariate analysis using Cox regression model showed PASI75 response status at 1 year (P=0.002) and lengthening of injection intervals (P=0.015) as the only significant variables.
As regards safety, 48 adverse events (AE) occurred in 29 patients, and were serious in 8 patients (0.032 serious adverse events per patient-year). Paradoxical flares of psoriasis were seen in 3 patients and flares of arthritis in 2. Infections accounted for 53% of recorded AE and 88% of serious AE, and were the reason for discontinuation in 2 patients.
Conclusion:
The efficacy results are consistent with those of a previously published U.K. study. Even though biologic-naïve status and efficacy parameters denoting a good or excellent response at different time points appear to be associated with a higher probability of drug survival in this cohort of patients, PASI75 response status at 1 year and the ability to maintain response lengthening the injection intervals were the only independent variables predicting drug survival on multivariate analysis. Infections, including de novo infection by M. tuberculosis, accounted for most serious AE, and paradoxical flares of psoriasis and psoriatic arthritis are a relatively frequent occurrence in daily clinical practice.
Posted by: Fred - Mon-05-08-2013, 22:25 PM
- No Replies
This article was published in The British Journal of Dermatology and suggests it is difficult to assess the clinical relevance of plant extracts for the treatment of psoriasis.
Quote:
Psoriasis sufferers frequently use preparations of plant extracts. Physicians need to be aware of the current evidence concerning of these products.
This review evaluates the efficacy and safety of preparations of plant extracts used topically for psoriasis. Searches were conducted of pub med, EMBASE, Cochrane library, two Chinese databases and article reference lists.
Randomized Controlled Trials investigating extracts of single plants were included. Preparations of multiple plants and combinations of plant extracts plus conventional therapies were excluded.
Two authors conducted searches, extracted data, and assessed Risk of Bias. Outcomes used in meta-analyses were: clinical efficacy, Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), and symptom scores.
The 12 included studies investigated extracts of: Mahonia aqulifolium (n=5), Aloe vera (n=3), Indigo naturalis (n=2), Kukui nut oil (n=1), and Camptotheca acuminate nut (n=1). Methodological quality was variable. Six studies provided data suitable for meta-analysis of clinical efficacy versus placebo (RR 3.37, 95% CI: 1.36-8.33). Experimental studies indicate components of Indigo, Mahonia and Camptotheca have anti-inflammatory, anti-proliferative and other actions of relevance to psoriasis.
The clinical trial evidence provides limited support for preparations containing extracts of Mahonia aquifolium, Indigo naturalis and Aloe vera for the topical management of plaque psoriasis based on multiple studies. No serious AEs were reported.
Due to the small size of most studies and methodological weaknesses, strong conclusions cannot be made. The magnitudes of any effects cannot be measured with accuracy, so it is difficult to assess the clinical relevance of these preparations.
This is my first post on the forums but I have been here in the past when looking for advice after a bad flare up.
I currently have pustular psoriasis and I'm taking methotrexate to keep it under control. I've found it works pretty well but I find that any intense sun exposure causes a flare up.
One of the main reasons for joining is that I'm looking to get rid of my UVB sunbed. I bought it about a year ago after a referral for light treatment took over 4 months. It was a bit of an act of desperation as I was getting married and the last thing I wanted was to be covered in psoriasis on my wedding day.
I'm pretty certain that the long time between referral and treatment was what cause my psoriasis to go from gutate to pustular. My dermatologist has said that because of the change that there's no way light treatment would work anymore which is kid of frustrating.
Posted by: Fred - Sat-27-07-2013, 15:11 PM
- No Replies
I've been saying all along that Stelara is helping with my Psoriatic Arthritis, though maybe not as good as Enbrel or Humira this is good news for people with PsA.
Quote: Janssen-Cilag International NV ("Janssen") announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending the use of STELARA® (ustekinumab), alone or in combination with methotrexate, for the treatment of active psoriatic arthritis in adult patients when the response to previous non-biological disease-modifying anti-rheumatic drug (DMARD) therapy has been inadequate.
Based on the CHMP's positive opinion, a final decision from the European Commission is expected during the third quarter of 2013. If approved, STELARA will become available for patients living with active psoriatic arthritis, a chronic autoimmune disease characterized by both joint and periarticular tissue inflammation (enthesitis, inflammation of the site where ligaments or tendons insert into the bones, and dactylitis, inflammation of an entire digit, e.g., finger or toe, often called "sausage digit"), and psoriasis skin lesions. The disease affects approximately 4.2 million people across Europe,1-5 and there is currently no cure.
"We are pleased that the CHMP has issued a positive opinion for STELARA in the treatment of psoriatic arthritis as we look to bring this new therapeutic option to patients living with active psoriatic arthritis," said Jerome A. Boscia, M.D., Vice President, Head of Immunology Development, Janssen Research & Development, LLC. "Data from the Phase 3 clinical program, one of the largest conducted for a biologic to date in psoriatic arthritis, showed STELARA effective in improving symptoms and signs of active psoriatic arthritis in anti-tumor necrosis factor (TNF)-alpha naïve and experienced patients. We believe STELARA has the potential to play a critically important role in the treatment of this chronic disease and look forward to the European Commission's decision."
The CHMP adopted the opinion based on a review of data from two pivotal Phase 3 multicenter, randomised, double-blind, placebo-controlled trials of ustekinumab, a fully human anti-interleukin (IL)-12/23p40 monoclonal antibody, administered subcutaneously, in patients with active psoriatic arthritis (PSUMMIT I and PSUMMIT II), which evaluated the efficacy and safety of subcutaneously administered STELARA 45 mg or 90 mg at weeks 0, 4 and then every 12 weeks. The trials included patients diagnosed with active psoriatic arthritis who had at least five tender and five swollen joints and C-reactive protein (CRP) levels of at least 0.3 mg/dL despite previous treatment with conventional therapies. PSUMMIT II also included patients who had previously experienced treatment with TNF inhibitors. The primary endpoints for both studies were the proportion of patients demonstrating at least a 20 percent improvement in arthritis signs and symptoms (American College of Rheumatology [ACR] 20) at week 24. Secondary endpoints at week 24 included in the submissions were: improvements in Health Assessment Questionnaire Disability Index (HAQ-DI) scores, a 50 or 70 percent improvement in arthritis signs and symptoms (ACR 50 or ACR 70) and at least a 75 percent improvement in psoriatic skin lesions as measured by the Psoriasis Area Severity Index (PASI 75) in patients with at least three percent body surface area involvement at baseline. The studies also captured improvements in enthesitis and dactylitis scores for patients with enthesitis and/or dactylitis at baseline.
To make a long story short, my hip is completely gone and stopped taking the Celebrex. Both my hands started and feet started swell. Fast forward until today, and I wanted to cut my hands off they hurt so bad. So gave in and saw my GP. He suggested Prednisone. Both my derm and Rhumey said absolutely no steriod pills/injections at this point. So I refused and gave me a narcotic instead. So now I am stoned writing this thread. Not sure if I made the correct decision, but don't want to have rebound flare that could possibly unmask something more serious that my plaque.
What do you think; did I have the right to make that choice?
Looking at the most recent research, it would appear that individuals who have psoriasis have really benefitted from CBT treatment! I am told this is not available in the UK but I suspect it has been used in the US... anyone heard anything?
I am Nicola and im 29. I have suffered with psoriasis for 15 years (since going to the drs with a small patch on my head, not knowing what it was!) - since then i've had my ups and downs and so has my skin!
I have had so many treatments I struggle to remember, all the topical treatments under the sun, light therapy, ciclosporin, homeopathy, chinese medicine (wouldnt recommend, it stripped my stomach lining), acupunture (prob not the right spelling!), vegetarian diet, brocolli diet, having a child (this is of course, not the only reason I had a baby! and yes, it did clear my psoriasis up, but can back with a vengence!) and have finally settled on camouflage make up for my face (thanks to the wonderful Red Cross who I am forever thankful for! and supermarket creams/olive oil!
More recently the dreaded psoriasis is creeping onto my legs which is the worst thing ever because it was the only thing I had to show off! so I am gutted about it but trying not to let it get me down! I am trying to get the sun on my legs as its always brilliant for me! (although have never used a sunbed).
About three years ago (I was in my mid twenties) I was asked to leave a resturant for offending a 'regular customer' with my psoriasis (i refused to pay the bill) and I have had low points due to my skin but then I have days where I think 'who cares!' - they are the best days and I am experiencing one of those periods now!
I may in the future consider mexotrexate (once Ive had another child) but for now I am focusing on the positives! and its nice to finally have people to share my experiences with!
Hi! My name is Jason and I have had Psoriasis for approximately 6 1/2 years. I was diagnosed with plaque psoriasis in 2007 after having issues with dry, flaking scalp and being convinced it was bad dandruff and going to the Dermatologist. Since that time, and being put on more topicals that can be imagined, it has continued to spead. It is mostly confined to my scalp, but I also have spots pretty much everywhere else. I have a history of autoimmune conditions in my family, with my Mom having RA and I grandfather who had psoriatic (sp?) nails (which I have as well, sadly).
Finally, last week I went to the dermatologist, determined that I would get something that would help. The doctor saw how discouraging my reaction to the topicals was, and put me on the first of what he calls the "Big Guns", Methotrexate. I am taking 5 mg and will be going to 10 mg in two weeks.
I am finally wanting to get serious of knocking this out as best I can, and I want to help others do the same. Thanks again for reading, and hope we can chat soon!
Posted by: Fred - Wed-17-07-2013, 15:22 PM
- Replies (2)
This study published in The Journal of Sexual Medicine suggests that men with psoriasis have fewer female oral sexual partners, and dermatologists need to examine the genital region routinely.
Quote:Introduction:
Epidemiologic data on sexual behavior in psoriasis patients are lacking.
Aim:
We aim to examine and compare the sexual behaviors between men with and without psoriasis in the United States.
Methods:
We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006 and 2009 to 2010. Responses from male participants to the dermatology and sexual behavior questionnaires of the NHANES were collated and analyzed.
Main Outcome Measures:
Outcome measures included sexual orientation, age of first sexual encounter, number of oral and non-oral sexual partners, and frequency of unprotected sex.
Results:
Among 6,444 U.S. men that responded to the psoriasis question, 170 (2.6%) reported a physician-given diagnosis of psoriasis. Heterosexual men accounted for 95.5% and nonheterosexual men 4.5% of the overall study population. On multivariate analysis, psoriasis was not associated with differences in sexual orientation (odds ratio 1.78, 95% confidence interval [CI] 0.75–4.15). Heterosexual men with psoriasis experienced first sexual encounter at an earlier age than those without psoriasis (weighted difference −0.9 years, P = 0.002). Heterosexual men with psoriasis had significantly fewer female oral sexual partners compared with heterosexual men without psoriasis on multivariate analysis (lifetime partner number: rate ratio [RR] 0.65, 95% CI 0.45–0.95; past-year partner number: RR 0.64, 95% CI 0.42–0.97). No significant differences existed between heterosexual men with and without psoriasis regarding frequency of unprotected sex (RR 0.96, 95% CI 0.85–1.09). Among nonheterosexual men with and without psoriasis, no significant differences existed in age first had sex, number of sexual partners, or frequency of unprotected sex.
Conclusion:
Heterosexual men with psoriasis have significantly fewer lifetime female oral sexual partners compared with those without psoriasis. Dermatologists and other healthcare providers need to examine the genital region routinely and initiate appropriate therapy to improve patients' sexual health.
Posted by: aria - Mon-15-07-2013, 17:56 PM
- No Replies
Hi everyone and good evening afternoon or good morning wherever you are!
I have stopped using exorex for now as my guttate is healing really well and has gone from legs and nearly gone from my tummy. I am starting to feel a lot more happy with my skin now, hurray!
I also have a great tan from all the UK sunshine we have been having and it has faded my spots even more.
I am now still moisturising my skin, taking salt baths and have started using Aveeno cream which is just gorgeous on my skin, no perfume. It is packed with oats and leaves my skin extra soft, wonderful! I love this cream, it is quite expensive but i have heard you can get this on prescription if you need to!
I was just diagnosed 13 months ago with having Palmoplantar Pustulosis, or PPP. It's a form of Pustular Psoriasis which affects the palms of the hands and soles/sides of the feet. I have just recently gone into remission after being drastically affected for a year straight. It made it hard to even open or close my hands, or do something simple like walking. I never thought I would be dealing with something like this. There is no family history and before PPP, I was perfectly healthy - worked out two times per day, ate all organic, and had quit smoking a year prior.
After extensive research, I believe smoking played a huge role in my PPP.
I write for Yahoo! and have written two articles pertaining to my Psoriasis and how it affected my life. Maybe you could have a look at them, and hopefully they might inspire you to not give up and never lose hope.
(See my profile for my article links; unfortunately it won't let me post them in here)
If you have any questions or would like to tell me your story, or even just have someone to listen or be a shoulder, I'm here. I don't want anyone to suffer alone like I had.
Be blessed everyone, and have a WONDERFUL week. It's good to be here.
Posted by: JohnW - Sat-13-07-2013, 08:26 AM
- Replies (7)
Hi all,
Just joined. I have had P for over 20 years, started in early 20's,and over time it's gradually got worse. Been on acritein (or however it is spelt) for 7 months and so far really good, no serious side effects although need to use sun block to stop getting burnt. Interested to hear from anyone who has been on it for a long time as the doctor says I can stay on it forever?
Thanks
John
Hello,
I have just under 780 Fumaderm pills, which I brought back from Germany in May, 2013. I tried the pills for a little over 3 weeks but they didn't agree with me.
Greetings all! I was a member about six to seven years ago and got a lot of great advice. I am hoping I can get a little more now that I am back online for the duration.
I have had P since I was five years old and am now 48. Different spots and different coverage's, but always between 25% and 80% coverage. I am taking Stelara now, courtesy of my derm.
Ive tried about everything and this is the only treatment that remotely helps exception being baby oil for flare ups and sudden itchiness.
I wish everyone pink healthy skin, affordable treatment and hopefully find an actual cure for this/these horrible affliction(s) we have.
Just wondering if anyone is or has taken any vitamins to help their skin. I was taking vitamin e and vitamin d tablets, don't know if they made any difference!
Did anyone notice any change in their skin?
I have cut the vitamin e capsules open and applied them directly to the guttate spots but it didn't seem to be doing anything, has anyone else tried this and had good results?
Thank you and hope the sun is shining where you are
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Psoriasis Cure!
How many people have Psoriasis?
In 2012 there were approximately 36.5 million prevalent cases of psoriasis, and by 2022, GlobalData epidemiologists forecast that this figure will reach approximately 40.93 million.
The condition affects individuals of both sexes and all ethnicities and ages, although there is a higher prevalence of psoriasis in the colder, northern regions of the world.
The prevalence of psoriasis in the central region of Italy is 2.8 times greater than the prevalence in southern Italy.
Caucasians have a higher prevalence of psoriasis compared with African-Americans, but African-Americans in the US tend to suffer from a more severe form of the disease.
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