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Psoriasis Club is a friendly on-line Forum where people with psoriasis or psoriatic arthritis
can get together and share information, get the latest news, or just chill out with others who understand. It is totally
self funded and we don't rely on drug manufacturers or donations. We are proactive against Spammers,
Trolls, And Cyberbulying and offer a safe friendly atmosphere for our members.
So Who Joins Psoriasis Club?
We have members who have had psoriasis for years and some that are newly diagnosed. Family and friends of those with psoriasis
are also made welcome. You will find some using prescribed treatments and some using the natural approach. There are people who
join but keep a low profile, there are people who just like to help others, and there are some who just like
to escape in the Off Topic Section.
Joining Couldn't Be Easier: If you are a genuine person who would like to meet others who understand,
just hit the Register button and follow the instructions.
Members get more boards and privileges that are not available to guests.
OK So What Is Psoriasis?
Psoriasis is a chronic, autoimmune disease that appears on the skin. It
occurs when the immune system sends out faulty signals that speed up the
growth cycle of skin cells. Psoriasis is not contagious. It commonly
causes red, scaly patches to appear on the skin, although some patients
have no dermatological symptoms. The scaly patches commonly caused by
psoriasis, called psoriatic plaques, are areas of inflammation and
excessive skin production. Skin rapidly accumulates at these sites which
gives it a silvery-white appearance. Plaques frequently occur on the
skin of the elbows and knees, but can affect any area including the
scalp, palms of hands and soles of feet, and genitals. In contrast to
eczema, psoriasis is more likely to be found on the outer side of the
joint.
The disorder is a chronic recurring condition that varies in severity
from minor localized patches to complete body coverage. Fingernails and
toenails are frequently affected (psoriatic nail dystrophy) and can be
seen as an isolated symptom. Psoriasis can also cause inflammation of
the joints, which is known as (psoriatic arthritis). Ten to fifteen
percent of people with psoriasis have psoriatic arthritis.
The cause of psoriasis is not fully understood, but it is believed to
have a genetic component and local psoriatic changes can be triggered by
an injury to the skin known as Koebner phenomenon. Various
environmental factors have been suggested as aggravating to psoriasis
including stress, withdrawal of systemic corticosteroid, excessive
alcohol consumption, and smoking but few have shown statistical
significance. There are many treatments available, but because of its
chronic recurrent nature psoriasis is a challenge to treat. You can find more information
Here!
Got It, So What's The Cure?
Wait Let me stop you there! I'm sorry but there is no cure. There are things that can help you
cope with it but for a cure, you will not find one.
You will always be looking for one, and that is part of the problem with psoriasis There are people who know you will be
desperate to find a cure, and they will tell you exactly what you want to hear in order to get your money. If there is a
cure then a genuine person who has ever suffered with psoriasis would give you the information for free. Most so called cures
are nothing more than a diet and lifestyle change or a very expensive moisturiser. Check out the threads in
Natural Treatments first and save your money.
Great so now what? It's not all bad news, come and join others at Psoriasis Club and talk about it. The best help is from accepting it and talking
with others who understand what you're going through. ask questions read through the threads on here and start claiming
your life back. You should also get yourself an appointment with a dermatologist who will help you find something that can
help you cope with it. What works for some may not work for others
Posted by: Fred - Fri-25-04-2014, 16:21 PM
- Replies (2)
New drugs and cosmetics are currently tested on animals, but a team led by King's College London has grown a layer of human skin from stem cells which could pave the way for testing without animals.
Quote:
Stem cells have been turned into skin before, but the researchers say this is more like real skin as it has a permeable barrier.
It offers a cost-effective alternative to testing drugs and cosmetics on animals, they say.
The outermost layer of human skin, known as the epidermis, provides a protective barrier that stops moisture escaping and microbes entering.
Scientists have been able to grow epidermis from human skin cells removed by biopsy for several years, but the latest research goes a step further.
The research used reprogrammed skin cells - which offer a way to produce an unlimited supply of the main type of skin cell found in the epidermis.
They also grew the skin cells in a low humidity environment, which gave them a barrier similar to that of true skin.
Lead researcher Dr Dusko Ilic, of King's College London, told BBC News: "This is a new and suitable model that can be used for testing new drugs and cosmetics and can replace animal models. "It is cheap, it is easy to scale up and it is reproducible." He said the same method could be used to test new treatments for skin diseases.
Researcher Dr Theodora Mauro said it would help the study of skin conditions such as ichthyosis - dry, flaky skin, psoriasis or eczema. "We can use this model to study how the skin barrier develops normally, how the barrier is impaired in different diseases and how we can stimulate its repair and recovery," she said.
Research and toxicology director Troy Seidle said: "This new human skin model is superior scientifically to killing rabbits, pigs, rats or other animals for their skin and hoping that research findings will be applicable to people - which they often aren't, due to species differences in skin permeability, immunology, and other factors."
Hi I am new to this forum. I have had my Psoriasis for around 8yrs it started after I had my hip operation. I have it severe on the soles of my feet, making some days impossible to walk. I have now been taking Fumaderm for 5 weeks dosage now 390mg a day, but not seeing any sign of improvement. Can someone give me some light at the end of the tunnel and advise me the more I increase my dosage by week, it will start to see an improvement.
Posted by: Fred - Wed-23-04-2014, 11:35 AM
- Replies (2)
A 30k photo-therapy machine paid for by voluntary fund-raising to treat people with psoriasis is laying dormant in Ireland.
Quote:
A €30k phototherapy machine, paid for by voluntary fundraising efforts, was installed in 2010 in Bantry hospital, but has not been used to treat psoriasis since last August. Now people in West Cork, for whom photo-therapy is recommended to treat psoriasis, must travel over 160km a couple of times a week to avail of a few minutes of therapy at Cork University Hospital.
The €30,000 phototherapy machine was paid for by the voluntary fundraising efforts of the Friends of Bantry General Hospital Ltd. It was installed in 2010, but has not been used since August.
Friends’ spokesman Robert Fennell said they were “disgusted” the equipment was lying idle.
“We raised money to buy the equipment for people who are already paying their taxes,” he said. “The State should be providing the service, but it is not. We fundraised so that phototherapy could be delivered locally and now that isn’t happening.”
The HSE blamed the unavailability of the Bantry service on staff shortages. It said the standards for the delivery of phototherapy changed in 2012, and the revised standards advised “that to ensure a safe dose was delivered, an additional staff member was required”.
“In August 2013, due to the limited number of staff available, the service had to be suspended.”
A similar situation exists at Beaumont in Dublin, where a phototherapy service was “temporarily suspended” in November 2012 due to staff losses, but has yet to be reinstated.
Posted by: Fred - Fri-18-04-2014, 10:56 AM
- Replies (7)
This survey looked at the use of Methotrexate for the treatment of psoriasis from 62 countries, and suggests there are significant differences concerning the doses, routes of administration and safety monitoring among clinical practices.
Quote:Background:
Methotrexate is one the most commonly used systemic therapies for psoriasis. Despite its widespread use in psoriasis therapy, dermatologists' practice regarding the use of methotrexate has not been investigated on global scale.
Objective:
To evaluate the real life use of methotrexate for psoriasis treatment in the dermatological community worldwide.
Methods:
A questionnaire consisting of 41 questions was designed by the Psoriasis International Network (PIN). Questions focused on safety, dosing, administration, folic acid supplementation and combination therapy aspects of methotrexate use. The anonymous web-based survey was distributed to dermatologists by the national coordinators of PIN.
Results:
Between 2 April and 7 August 2012, 481 dermatologists from 63 countries completed the questionnaire. Most respondents were from European and South American countries, whereas the response rate from Central America and the Near East was lowest. The majority of responders were experienced dermatologists (86% had more than 5 years of experience in psoriasis treatment). Starting and maintenance doses of 10 mg of methotrexate or lower were reported by 67% and 42% of respondents respectively. Thirty-eight per cent of respondents stop treatment at a cumulative dose of 2 g, whereas 36% did not consider cumulative dose important in this respect. The primary mode of administration was oral, and the majority of respondents administer folic acid supplementation. Almost all respondents monitored full blood count, liver and renal function tests, whereas procollagen 3 amino terminal peptide measurement and transient elastography is used by only a minority of dermatologists. There were significant differences concerning the doses, routes of administration and safety monitoring among the clinical practices in different geographical locations.
Conclusion:
Current clinical practice of methotrexate use in psoriasis is not uniform, depends on geographical location, and is not in full agreement with clinical guidelines.
Hi I thought it was time to introduce myself properly, my Name is Looby and i've had Psoriasis for as long as i can remember and can't really remember not having it somewhere on my person, for the last 16 years I've been on Methotrexate, sometimes tablets and sometimes the injections but my Dermatologist has just started me on Fumaderm and stopped my Methotrexate (eeeeeeekkkkkk) I am at the moment beginning to wonder if I have made the right decision? It's not so much the side effects it's that my P is raging out of control!! Can any of you fabulous forumers help? L x
Quote:
“Study JAK116679 was a phase 2a multi-centre, randomised, double-blind, placebo-controlled, dose ranging study (100mg bid, 200mg bid, 400mg bid) that evaluated the safety and efficacy of GSK2586184 compared with placebo in 66 patients with chronic plaque psoriasis. Preliminary results showed that a significantly higher proportion of patients treated with GSK2586184 at the 400mg bid dose met the primary endpoint compared to placebo. The primary endpoint was defined as achieving ≥75% improvement from baseline in Psoriasis Area Severity Index (PASI75) score at Week 12. PASI75 for patients randomised to placebo was in the range expected.
During the treatment period the most common adverse events occurring with a frequency of more than 20% on either placebo or pooled GSK2586184 were headache (36% placebo, 27% GSK2586184) and nasopharyngitis (21% placebo, 29% GSK2586184). A final analysis of the data from study JAK116679 will be submitted for presentation at an upcoming scientific congress and/or a peer-reviewed publication. GSK remains responsible for the study and intends to review the complete data from all GSK2586184 studies before determining next steps.”
“We at Galapagos are pleased to hear that GSK2586184 met the primary endpoint in GSK’s psoriasis study. This is the second selective JAK1 inhibitor and candidate drug based on Galapagos’ novel target approach to show efficacy in patients. The next patient readout from our pipeline is expected in June 2014: our Phase 2 Proof of Concept study with GLPG0974, a fully proprietary and novel mode of action in ulcerative colitis,” said Dr Piet Wigerinck, Chief Scientific Officer of Galapagos.
GSK2586184 is a selective JAK1 inhibitor which was discovered and developed within Galapagos’ inflammation alliance with GSK. GSK in-licensed the molecule in February 2012, gaining worldwide rights to further development and commercialization. Galapagos is eligible, without further financial investment from Galapagos, to receive from GSK up to €34M in additional milestones, plus up to double-digit royalties on global commercial sales of all therapeutic indications of GSK2586184.
Posted by: Fred - Thu-10-04-2014, 16:27 PM
- Replies (3)
This study published in The Journal of Rheumatology suggest that the chance of depression and anxiety are higher for people with psoriatic arthritis than those with only psoriasis.
Quote:Objective:
(1) To determine the prevalence of depression and anxiety in patients with psoriatic arthritis (PsA) and to identify associated demographic and disease-related factors.
(2) To determine whether there is a difference in the prevalence of depression and anxiety between patients with PsA and those with psoriasis without PsA (PsC).
Methods:
Consecutive patients attending PsA and dermatology clinics were assessed for depression and anxiety using the Hospital Anxiety and Depression Scale. Patients underwent a clinical assessment according to a standard protocol and completed questionnaires assessing their health and quality of life. T tests, ANOVA, and univariate and multivariate models were used to compare depression and anxiety prevalence between patient cohorts and to determine factors associated with depression and anxiety.
Results:
We assessed 306 patients with PsA and 135 with PsC. There were significantly more men in the PsA group (61.4% vs 48% with PsC) and they were more likely to be unemployed. The prevalence of both anxiety and depression was higher in patients with PsA (36.6% and 22.2%, respectively) compared to those with PsC (24.4% and 9.6%; p = 0.012, 0.002). Depression and/or anxiety were associated with unemployment, female sex, and higher actively inflamed joint count as well as disability, pain, and fatigue. In the multivariate reduced model, employment was protective for depression (OR 0.36) and a 1-unit increase on the fatigue severity scale was associated with an increased risk of depression (OR 1.5).
Conclusion:
The rate of depression and anxiety is significantly higher in patients with PsA than in those with PsC. Depression and anxiety are associated with disease-related factors.
Hi I am new to Fumaderm (I started on 01.04.14) for those of you unlucky enough to experience any of the side effects how long was it before they started? I'm wondering if my imagination has gone into overdrive!!
I have a quick question – does any of the women (most men don't have this problem) on this site have any magic solution for yeast infections? I am the unlucky recipient of a bacterial infection and now have a yeast infection in just about any place that has a fold in my body. To make things worse, I know have inverse psoriasis in several of those locations. Drying out the areas where the yeast infection occurs helps with that problem, but causes my inverse psoriasis to spread. I have been mixing antifungal creams with low dose corticosteroid cream without much luck.
This part may be too much info. Stop reading if you do not want to hear about the bacterial infection. I have postulates all over certain locations of my body. My GP said it’s a bacterial infection. I am ½ way done with my antibiotic and I have more postulates than before. I can’t see my dermatologist until the 21st, and I am ready for my Stelera injection. My dermatologist says to go ahead and take it, but not sure I am comfortable.
Posted by: Fred - Tue-01-04-2014, 11:34 AM
- Replies (7)
Following on from the European Commission, USA, Canada, and Scotland. England have decided Stelara will not be used for psoriatic arthritis. It works and I'm living proof of that, Boo Hiss to you England.
Quote:Final draft guidance, from the National Institute for Health and Care Excellence, published today does not recommend ustekinumab (Stelara) for psoriatic arthritis.
Ustekinumab (Stelara) is not recommended within its marketing authorisation for treating active psoriatic arthritis, that is, alone or in combination with methotrexate in adults when the response to previous non-biological disease-modifying antirheumatic drug (DMARD) therapy has been inadequate.
People currently receiving treatment initiated within the NHS with ustekinumab that is not recommended for them by NICE in this guidance should be able to continue treatment until they and their NHS clinician consider it appropriate to stop.
The Committee concluded that ustekinumab is not a cost-effective treatment option for people who have not previously received TNF alpha inhibitors, for those cannot take them, or for those who have received TNF alpha inhibitors. In the economic analysis for people who have not previously received TNF alpha inhibitors (the ‘TNF alpha inhibitor-naive' population), ustekinumab was dominated by - that is, was more expensive and less effective than - adalimumab. In all other populations, including people who have previously received TNF alpha inhibitors (the ‘TNF alpha inhibitor-exposed' population) and people for whom TNF alpha inhibitors are not appropriate, the most plausible incremental cost-effectiveness ratio (ICER) for ustekinumab is likely to exceed £30,000 per quality-adjusted life year (QALY) gained.
Come on England the rest agree it works, and what about people like me where nothing else worked.
Hello all, my name is stacey and I'm looking for some advice on being able to purchase coal tar paste like they use in hospitals, I was diagnosed from the age of 5yrs old and have suffered on and off since (I'm now 30) the only treatments that work for me is UVB treatment and coal tar paste, I used to as a child be taken into hospital for up to 5 weeks at a time and be slathered daily in the coal tar paste and had bandages put on over the cream, I'd also have UVB treatment 3times per week, I'm now a single mother of 4 and I'm unable to do so anymore, I'm struggling being able to get hold of coal tar paste from my local pharmacy can any one help with any links that I can purchase this miracle cream please xxxxxxxx I'm suffering at the moment with gut taste psoriasis but I also have the plaques my official diagnosis is chronic psoriasis xxx[/size][/b][/font]
I'd like to start by saying that I have never submitted anything online before but with recent events I feel that I need to share my experiences with you.
I'm a 41 year old male who has suffered from Psoriasis for 28 years. I have been prescribed everything from Steroid creams to Methotrexate. Even though the methotrexate worked a little, I wasn't happy taking such strong medication due to severe long term side effects like damaging your liver etc...
My partner fell ill and was very unwell for 18 months, tried various clinics, hospitals and medication but nothing worked for her. I suggested to her that maybe she should try alternative therapy so we visited a Chinese herbalist.
She had a five minute consultation and was prescribed some simple vitamins, within a couple of weeks her symptoms improved significantly, she is now on the road to recovery. On the back of this I also visited the herbalist and explained the severity of my Psoriasis.
She told me to take Celedrin, Milk Thistle, Selenium, Multi Antioxident vitamins, vitamin D3 spray and some Chinese tablets called Shi Du Qing, all of which will help me with my liver as this was the cause of my Psoriasis.
The vitamins weren't cheap at £80 for one months supply but I thought I'd give it a go.
I've been on the vitamins for 6 weeks now and can say that there has been between a 30-40% improvement and is improving still. There is very little flaking, no bleeding and have started to develop completely clear patches of skin in areas where the Psoriasis was extremely severe.
I have not changed my lifestyle at all, even though my doctor says that I need to give up smoking 20 cigarettes a day and still have a terrible diet, all I do is take the vitamins in the morning and again in the evening.
I'm not saing that this will work for everyone but it is definitely worth trying as all the vitamins are natural and not full of chemicals.
I wish you all well and hope that the treatment works for you as well as its worked for me
I have only just joined today, and have already found answers to questions I had. Jiml has made me welcome, and has made it easier for me to get involved. I wish that I had found this forum earlier!
One of the reasons why I have joined this forum is because I would like to learn what others have found, as we can all benefit from a pooling of information.
I have had Psoriasis for most of my life, and it has got worse and improved periodically, as it does with most people. However, I have recently been diagnosed with PsA, which has changed how I feel about Psoriasis, and how I will deal with the other more recent symptoms that I am faced with.
Through the forum I hope to find other treatments as well as new ways of improving my quality of life in general.
In my short time on the forum I have been very impressed with the professional approach and wide range of topics. I look forward to learning so much more useful information.
Posted by: Fred - Wed-26-03-2014, 19:45 PM
- Replies (7)
The Irish Examiner reports that Waterford has closed it's doors to all but urgent cases.
Quote: It has been reported that the Dermatology Department at Waterford Regional Hospital has closed its doors to all but urgent cases.
Several hundred thousand living in the south-east of Ireland currently rely on the services provided by the hospital.
However, according to Newstalk Radio, as of last week one of the specialist departments in that hospital shut its doors to all but urgent cases.
That is the Dermatology Department where people receive treatment for a variety of skin conditions, including psoriasis, eczema, scarring acne and even skin cancer.
The station reported that last week GPs in the region received a letter from one of the hospital's two Dermatology Consultants.
In it, he stated that the department is at crisis point and that a critical incident is waiting to happen.
Given that, they are unable to accept any new patients other than the most urgent cases involving suspected skin cancer.
Hi everyone,
It's one of those times when psoriasis is totally dominating my thoughts all the time. It is worse than it has ever been and I am getting to the point where I can't go swimming because I get stared at and don't even want to wear t-shirts. And the itching!! It is driving me crazy.
It is all over my back and my backside is covered and it itches a lot. It is gradually covering my arms and legs too. (And scalp)
Regarding lifestyle, I am about to start a new job which I am finding quite stressful. In the weeks leading up to my start date, I can feel myself getting more and more stressed. My work hours are 5am-1pm so tiredness is an issue too, perhaps, with P.
I have tried lots and lots of different creams etc in the past and my GP says she will send me to a dermatologist to look at the possibility of using a UV light treatment for it. Does this work?
I'm using dovobet at the moment but it isn't doing any good... Maybe my body has become immune to it?
I have read about using coconut oil.. Does this work? Do you ingest and put it on your skin?
I have also read about banana skins? Anyone tried these?
In terms of lowering stress, I am planning to do yoga when I start my new job and maybe have a massage more often (all costs money though).
Diet-wise, I'm seeing all sorts of recommendations online.. It is so hard to know what to do!
I know this is a really long post but it's one of those moments when P is just dominating my thoughts and I wondered if anyone has any suggestions?
Posted by: Fred - Sat-22-03-2014, 23:45 PM
- Replies (6)
Apremilast is now known as Otezla after getting FDA approval for psoriatic arthritis.
Quote: Celgene Corporation today announced that the U.S. Food and Drug Administration (FDA) has approved OTEZLA® (apremilast), the Company's oral, selective inhibitor of phosphodiesterase 4 (PDE4), for the treatment of adult patients with active psoriatic arthritis.
"OTEZLA works differently from other therapies approved for psoriatic arthritis through the intracellular inhibition of PDE4," said Philip Mease, MD, Director of the Rheumatology Clinical Research Division of Swedish Medical Center and Clinical Professor, University of Washington. "The approval of an oral therapy with a novel mechanism of action for patients with psoriatic arthritis offers a different approach to patient care."
The approval was based on safety and efficacy results from three multi-center, randomized, double-blind, placebo-controlled trials.
"Patients and physicians have expressed their desire for a safe and effective therapy for psoriatic arthritis that has the potential to simplify patient management. Celgene is excited to be expanding our transformational science into the therapeutic realm of Inflammation and Immunology, with a new approach for patients with psoriatic arthritis," said Scott Smith, Global Head, Inflammation and Immunology, Celgene Corporation. "The FDA approval of OTEZLA is good news for patients and healthcare professionals who are looking for a different way to manage this disease."
OTEZLA® (apremilast) is expected to be available in the U.S. in March 2014 and will be dispensed through a comprehensive network of specialty pharmacies. For more information about OTEZLA distribution and the exclusive treatment support services (including reimbursement assistance and 24/7 nurse support), doctors and patients can contact Otezla SupportPlus™ at 1-844-4OTEZLA (1-844-468-3952) or visit [web]www.OTEZLA.com[/web] for more information.
Posted by: Fred - Sat-22-03-2014, 21:23 PM
- No Replies
The J&J biologic medicine, guselkumab, achieved the main goal of the Phase II study at all five dosing regimens tested by clearing or reducing the psoriasis to a minimal measure after 16 weeks of treatment in a far greater percentage of patients than in the group that received a placebo. It also appeared to be as good as or more effective than AbbVie's big selling Humira at four of the tested doses.
"The efficacy of guselkumab in the treatment of moderate to severe plaque psoriasis looks promising according to these Phase IIb study results," Dr. Kristina Callis Duffin, one of the study's investigators, said in a statement.
Results were determined using Physician Global Assessment (PGA) scores - a zero to 5 scale in which 0 indicates the disease has been cleared, 1 represents minimal disease and 5 indicates the most severe symptoms.
Guselkumab led to scores of 0 or 1 in as high as 86 percent of patients who received 100 milligrams of the drug every eight weeks, and in 83 percent of patients who were injected with 200 mg of the J&J medicine at the start of the trial and at week 4 and then every 12 weeks.
At the lower end, 34 percent of patients who got 5 mg of the drug to start and at week 4 and then every 12 weeks achieved PGA scores of 0 or 1. That was still deemed to be statistically significant compared with 7 percent for those who got a placebo.
In the Humira (adalimumab) group, 58 percent had scores of 0 or 1 after 16 weeks of treatment.
Results of the 293-patient trial, dubbed X-Plore, were presented at the American Academy of Dermatology (AAD) meeting in Denver. J&J has not yet said which of the treatment regimens would be advanced to larger, pivotal Phase III trials.
Guselkumab, which would be a follow-up treatment to J&J's Stelara, works by blocking interleukin-23, or IL-23, a protein that has been associated with chronic inflammation and is believed to play a role in psoriasis.
Morningstar analyst Damien Conover said the drug "is really under the radar right now." He currently sees sales reaching about $500 million several years after approval, but said estimates could change if later Phase III data were impressive.
In addition to the primary goal, significantly higher proportions of guselkumab patients achieved at least a 75 percent improvement in psoriasis as measured by the Psoriasis Area Severity Index (PASI 75) at week 16. Those results ranged from 44 percent of patients taking the lowest dose up to 81 percent at higher dosing regimens. That compared with 5 percent for placebo and 70 percent for Humira.
A 90 percent improvement was seen in as high as 62 percent of patients who got 100 mg of guselkumab every eight weeks.
The results remained consistent or showed additional improvement after 40 weeks of treatment, the company said.
After a year of treatment, serious adverse side effects were reported in 3 percent of those treated with guselkumab and 5 percent for Humira.
There were no cases of tuberculosis or opportunistic infections. One guselkumab patient reported a malignancy and there were three major adverse heart events, including one fatal heart attack, in patients with pre-existing cardiovascular risk factors, the company said.
Posted by: Fred - Fri-21-03-2014, 13:41 PM
- No Replies
Following on from Secukinumab V Enbrel Novartis announced today that a new phase IIIb head-to-head study of IL-17A inhibitor secukinumab (AIN457) versus Stelara® (ustekinumab) in moderate-to-severe plaque psoriasis has started patient enrolment.
Quote: A total of twenty-five secukinumab abstracts, including two pivotal phase III convenience studies to be presented for the first time, will be unveiled at the 72nd Annual Meeting of the American Academy of Dermatology (AAD), taking place in Denver, Colorado, USA from 21-25 March 2014.
"We are pleased to announce the start of CLEAR, our global phase IIIb head-to-head psoriasis study of secukinumab versus Stelara at the 2014 AAD annual meeting, which will provide further evidence regarding the benefit IL-17A inhibitor secukinumab brings to patients," said Tim Wright, Global Head of Development, Novartis Pharmaceuticals. "We initiated this study following the positive results from the phase III FIXTURE study, which showed secukinumab was significantly superior to Enbrel in clearing skin, and we look forward to presenting additional new phase III data from our specialty dermatology portfolio at AAD."
About the CLEAR phase IIIb head-to-head study of secukinumab versus Stelara
CLEAR (Comparison to assess Long-term Efficacy, sAfety and toleRability of secukinumab vs. ustekinumab), the new 52-week, multicenter, randomized, double-blind study, is the second head-to-head phase III study initiated with secukinumab, and will compare the long-term safety, tolerability and efficacy of secukinumab versus Stelara, a current standard-of-care therapy, in patients with moderate-to-severe plaque psoriasis. The target enrollment for this global phase IIIb study is approximately 640 patients with sites in 25 countries across North America, Europe, Asia and Australia.
The primary endpoint measured at Week 16 is at least 90% reduction in the severity of psoriasis symptoms (redness, thickness and scaling) and the extent of skin affected by the disease, known as Psoriasis Area and Severity Index (PASI) 90. PASI 90 is considered the best evidence of efficacy and is therefore a more robust measure of the extent of skin clearance compared to the standard efficacy measures used in most psoriasis clinical studies.
The CLEAR study follows the pivotal phase III head-to-head FIXTURE study, which showed secukinumab was significantly superior to Enbrel® in clearing skin. Enbrel is a current standard-of-care anti-TNF-alpha medication approved to treat moderate-to-severe plaque psoriasis, and results from the FIXTURE study were first announced in October 2013
Hi my name is Pam,
I am having what I think is psoriasis. I am finding small patches of red itchy scaly patches of skin here and there, and am battling very thick patches of it all over my scalp.
I live in Po-Dunk, and have not told my Dr. about this yet. If I sneeze he wants to send me in for every invasive test known to western medicine.
Really, I am just in the last few days figuring out what is going on.
I had the scalp issue before many years ago, and remember finding a tar shampoo that I used diligently and it did eventually go away. But it is back with a vengeance.
The small patches, (The biggest one is approaching the size of a dime) are popping up here and there, and am finding more everyday.
I am so frightened I am afraid to share this new discovery with anyone in my life.
~Pam~
For a large portion of my life I had my psoriasis treated with various topical steroid ointments and creams,which were quite effective at reducing the plaques. I was told by my doctors and dermatologist that one of the side effects was skin thinning, but being foolish I just wanted to be rid of the scales. I used them on and off for many years. I just kept putting in for repeat prescriptions and without question they were prescribed. I found after a few years that the slightest knock on my legs would rip the skin open. I used to be very self conscious about my psoriasis, and as an engineer I was constantly banging my legs, when out on sites and often excused myself and went to the privacy of my van to roll up my trousers to reveal blood pouring out so I got to carrying a roll of tube gauze with me and steri strips to repair the damage.
When I stopped using steroid creams it seemed as if my skin recovered a bit. But I still have to be careful, and was wondering if others have had the same experience or worse. Or was I just unlucky
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Psoriasis Cure!
How many people have Psoriasis?
In 2012 there were approximately 36.5 million prevalent cases of psoriasis, and by 2022, GlobalData epidemiologists forecast that this figure will reach approximately 40.93 million.
The condition affects individuals of both sexes and all ethnicities and ages, although there is a higher prevalence of psoriasis in the colder, northern regions of the world.
The prevalence of psoriasis in the central region of Italy is 2.8 times greater than the prevalence in southern Italy.
Caucasians have a higher prevalence of psoriasis compared with African-Americans, but African-Americans in the US tend to suffer from a more severe form of the disease.
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