CJM112 for psoriasis safety and efficacy study

[Fred]

This study assesses CJM112 effects on safety and efficacy in patients with moderate to severe plaque psoriasis.

Quote:

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Background and objective:
Anti IL‐17A IgG/κ monoclonal antibody CJM112 binds both IL‐17A and IL‐17AF. The purpose of this First‐in‐Human study was to assess CJM112 effects on safety and efficacy in patients with moderate to severe plaque psoriasis.

Methods:
This study had two parts: single ascending doses of 5–450 mg subcutaneous (s.c.) CJM112 (SAD) and multiple‐dose parallel‐groups of CJM112 15 mg, 50 mg, 150 mg s.c. low frequency or high frequency (MD). SAD/MD were double‐blind, randomised and placebo controlled; MD also included a secukinumab 150 mg s.c. arm as an active comparator. Patients 18‐65 years with moderate to severe psoriasis were included in this study. The efficacy outcome was the change in Psoriasis Area Severity Index [PASI] from baseline to Week 4 in the SAD part of the study, and from baseline to Week 12 in the MD part.

Results:
96 patients were enrolled in this study (SAD, n=42; MD, n=54). In SAD, CJM112 doses from 15 mg and above demonstrated higher PASI responses compared to placebo at Week 12. CJM112 450 mg did not add further efficacy, but efficacy was prolonged compared to CJM112 150 mg. CJM112 MD resulted in a dose‐dependent decrease in PASI over time to Week 12. CJM112 150 mg high frequency did not exceed the effect of CJM112 150 mg low frequency, and had similar efficacy to secukinumab 150 mg. The safety profile of CJM112 was as expected for an antibody targeting IL‐17A/IL‐17AF.

Conclusions:
CJM112 had clinical efficacy in moderate to severe psoriasis and was generally safe and well tolerated in the doses tested. Additional neutralisation of IL‐17AF did not translate to increased clinical efficacy compared to secukinumab.

Source: onlinelibrary.wiley.com

Cosentyx (secukinumab)

[Caroline]

Hmmm, interesting but it does not say much.

Better PASI score.. great.. but... how much better? 90% ? 75% ? 40% ? 1% ?

The safety profile is as expected. Nice ! We just have to check what this was with IL-17A

Still a bit of reporting to go.

And... IL-17 is mostly related to Psoriatic Arthritis, sometimes also efficient for Psoriasis. Interesting is that it seems to have  a very detailed target(s).