About to start Fumaderm

[Caroline]

[Fred]

[Bill]

At least you can be prescribed DMF, Caroline. That is one up on my choices. Af's experience shows how challenging the management of psoriasis can be. I think that challenge and disappointment are a given, which is why I am so skeptical of alternative therapies: Bogus reasoning, bogus disease theories managed with bogus therapies, and all working seamlessly. Doesn't that ring alarm bells with you Caroline? It certainly does with me.

Cheers

[Caroline]

Answer to Bill to be found over here in RE: [split] Dimethylfumarates and Psoriasis as we are Hijacking Arsenalfan's thread.

[MrGnomusy]

I'm on the same page as arsenalfan13, for me the desired effect have not been reached with Skilarence at all. At least for me it calmed down my P a little bit for a while but now new spots are appealing everywhere. 
I have an appointment with my derm next month. Real shame tho, as I thought it would work out... 
Bio's here we come (I guess) 


Let's hope we both find something that works arsenalfan13? 

[jiml]

I'm on the same page as arsenalfan13, for me the desired effect have not been reached with Skilarence at all. At least for me it calmed down my P a little bit for a while but now new spots are appealing everywhere. 
I have an appointment with my derm next month. Real shame tho, as I thought it would work out... 
Bio's here we come (I guess) 


Let's hope we both find something that works arsenalfan13? 

Oh dear that's a shame, I'm surprised and disappointed for you as it has been a life changer for me ..can I ask what dose you are on now did you reach 6 tablets a day? ...you did suffer if I remember bad side effect, have they eased now?

[Caroline]

I'm on the same page as arsenalfan13, for me the desired effect have not been reached with Skilarence at all. At least for me it calmed down my P a little bit for a while but now new spots are appealing everywhere. 
I have an appointment with my derm next month. Real shame tho, as I thought it would work out... 
Bio's here we come (I guess) 


Let's hope we both find something that works arsenalfan13? 

Oh dear that's a shame, I'm surprised and disappointed for you as it has been a life changer for me ..can I ask what dose you are on now did you reach 6 tablets a day? ...you did suffer if I remember bad side effect, have they eased now?

Interesting indeed. But I guess that both are. And it’s seen as the max dose by the pharmacists, which it is for Fumaderm.
Skilarence is following that, as in their trials they did not go higher. Why not? They probably don’t know themselves.
In the Netherlands we know that a lot of Psoriasis patients need just a little more DMF, which is made possible by our slow release version. There is in fact no upper limit. Which is not really true of course, it is a medicine so too much shall affect your system. But higher, even up to 12 tablets is no real problem.

[Bill]

Once you have been on the drug a few months and have developed no liver or kidney problems, it is a matter of balancing efficacy with a safe lymphocyte count. I am not so convinced of the slow release concept as I take a large dose of 99% DMF (~830mg) twice weekly. I get greater efficacy for both p and psa with this dose than I would with three daily doses of 240mg. If the slow release concept were valid, I would expect that a number of small doses would be more effective than a large dose over a set time. For me this is not the case. I have tried a number of different doses. A little over 800mg is optimal. Larger doses have greater side effects with a less than proportional increase in efficacy. Smaller doses have a greater than proportional drop in efficacy. But if DMF does not work, try something else.

[Caroline]

Once you have been on the drug a few months and have developed no liver or kidney problems, it is a matter of balancing efficacy with a safe lymphocyte count. I am not so convinced of the slow release concept as I take a large dose of 99% DMF (~830mg) twice weekly. I get greater efficacy for both p and psa with this dose than I would with three daily doses of 240mg. If the slow release concept were valid, I would expect that a number of small doses would be more effective than a large dose over a set time. For me this is not the case. I have tried a number of different doses. A little over 800mg is optimal. Larger doses have greater side effects with a less than proportional increase in efficacy. Smaller doses have a greater than proportional drop in efficacy. But if DMF does not work, try something else.

Continued on RE: [split] Dimethylfumarates and Psoriasis as were are slightly diverting from the direction Arsenalfan's thread is going to.

[MrGnomusy]

I'm on the same page as arsenalfan13, for me the desired effect have not been reached with Skilarence at all. At least for me it calmed down my P a little bit for a while but now new spots are appealing everywhere. 
I have an appointment with my derm next month. Real shame tho, as I thought it would work out... 
Bio's here we come (I guess) 


Let's hope we both find something that works arsenalfan13? 

Oh dear that's a shame, I'm surprised and disappointed for you as it has been a life changer for me ..can I ask what dose you are on now did you reach 6 tablets a day? ...you did suffer if I remember bad side effect, have they eased now?

I've been on 3x120 twice a day (on the box it says 2x120 three times a day), but I always seem to be forgetting the midday one so I changed it. Also yeah a slow release capsule would be the best by far. I have the odd flush, two to three times a week now, and it's really not that bad. Also, because this Skilarence is available for purchase I think you can't Import other DMF medications anymore unfortunately...