Low energy levels on fumaderm

[Grizzly Bear]

I know what nuber 10 is :




Injection time

[jiml]

No you've not done anything wrong it but your question would be more visible in a thread of its own
I'm sure Caroline doesn't mind ....I was thinking it might help you get other answers elsewhere as only Caroline will disagree with me here  

he knows me too good...  

Was number 10 Jim was right

[braye lodge]

No you've not done anything wrong it but your question would be more visible in a thread of its own
I'm sure Caroline doesn't mind ....I was thinking it might help you get other answers elsewhere as only Caroline will disagree with me here  

he knows me too good...  

Was number 10 Jim was right  

You put up a good fight jim

[jiml]

No you've not done anything wrong it but your question would be more visible in a thread of its own
I'm sure Caroline doesn't mind ....I was thinking it might help you get other answers elsewhere as only Caroline will disagree with me here  

he knows me too good...  

Was number 10 Jim was right  

You put up a good fight jim

.... I have to with Caroline or she gets the whip out

[Caroline]

No you've not done anything wrong it but your question would be more visible in a thread of its own
I'm sure Caroline doesn't mind ....I was thinking it might help you get other answers elsewhere as only Caroline will disagree with me here  

he knows me too good...  

Was number 10 Jim was right  

Jim was partly right. It is not as bad as it seems.
So:

[Bill]

It was the case of the patient with a 0.8 count getting PML that caused the concern. There is also concern that the JC virus may also act more slowly and cause dementia over a longer period. I stress this is speculative, but now that DMF is being used on large numbers of patients the uncommon side effects can be a problem. Personally I find DMF to be neuroprotective, but I wouldn't go as far as saying that the caution is an over-reaction. It would be nice if MTX were treated with the same level of concern instead of presenting statistical marvels to show how great it is.

[jiml]

It was the case of the patient with a 0.8 count getting PML that caused the concern. There is also concern that the JC virus may also act more slowly and cause  dementia over a longer period. I stress this is speculative, but now that DMF is being used on large numbers of patients the uncommon side effects can be a problem. Personally I find DMF to be neuroprotective, but I wouldn't go as far as saying that the caution is an over-reaction. It would be nice if MTX were treated with the same level of concern instead of presenting statistical marvels to show how great it is.

I think it's better to warn and point out facts, if they are available and then let people make up their own minds. How to deal with them
I know the cases are rare but that doesn't mean you should put yourself at risk by maintaining a low lymphocyte count, and not take any action i.e. Reduce dose or retest blood levels .

I agree that there should be more warning about methotrexate. But the problems caused by that are more or less ignored