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Brodalumab an investigational IL-17 inhibitor in development for patients with psoriasis and psoriatic arthritis has been dumped by Amgen, they have commenced termination of its participation in the co-development and commercialization of brodalumab with AstraZeneca.
Source: amgen.com
Quote:
Amgen announced the Company has commenced termination of its participation in the co-development and commercialization of brodalumab with AstraZeneca. Brodalumab, an investigational IL-17 inhibitor, is in development for patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and axial spondyloarthritis. The decision was based on events of suicidal ideation and behavior in the brodalumab program, which Amgen believes likely would necessitate restrictive labeling.
"During our preparation process for regulatory submissions, we came to believe that labeling requirements likely would limit the appropriate patient population for brodalumab," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen.
After Amgen transitions the program to AstraZeneca, future decisions on the clinical development and submission of marketing applications for brodalumab will be at the sole discretion of AstraZeneca for all territories, except for certain Asian territories, including Japan, where Kyowa Hakko Kirin has rights to brodalumab.
Amgen has decided to focus its efforts and resources on other key molecules that address unmet medical needs and deliver value to patients and shareholders. The Company continues to make progress against its strategic and financial commitments and does not expect any meaningful impact from this decision on its ability to meet them.
Source: amgen.com
and about 6 weeks later I was fully inflamed again and quite swollen - the withdrawal was painful to say the least. After some months of total body coverage, swelling, night swearts, weight loss, etc... am now back on track with Enbrel's bridging program (3 months of free supply) also taking Leflunomide. Legs not clearing - but feel much bnetter.
to the club/forum what a shame after a trial that psoriasis came back with a vengeance 
Nor can I stress enough the importance that I get in contact with this individual. I assure you and anyone that I have only the best of intentions. But, Bill, to answer your questions from my own experience this drug brought me to 99 percent clearance in under 12 weeks and sustained it for two years at which point it was canceled. you're right to question the data, but in the case of this particular drug - It's all that and a bag of chips.