[split] Dimethylfumarates and Psoriasis

[Fred]

Is there a big difference between fumaric acid tablets that are available from online retailers for the treatment of psoriasis at relatively low cost compared to Fumaderm or psorinovo
which are prescription only drugs.

Yes probably no regulation, so they could be anything.

Just my opinion

[jiml]

Is there a big difference between fumaric acid tablets that are available from online retailers for the treatment of psoriasis at relatively low cost compared to Fumaderm or psorinovo
which are prescription only drugs.

Yes probably no regulation, so they could be anything.

Just my opinion

You are possibly right in that assumption, I don't have a problem I can get mine readily from the hospital (Fumaderm) but I was thinking of others in far flung places that haven't got access to Fumaderm or psorinovo for their psoriasis as a possibility.

[Fred]

Is there a big difference between fumaric acid tablets that are available from online retailers for the treatment of psoriasis at relatively low cost compared to Fumaderm or psorinovo
which are prescription only drugs.

Yes probably no regulation, so they could be anything.

Just my opinion

You are possibly right in that assumption, I don't have a problem I can get mine readily from the hospital (Fumaderm) but I was thinking of others in far flung places that haven't got access to Fumaderm or psorinovo for their psoriasis as a possibility.

Caroline is your best bet for a proper answer Jim, but I would always say only use Prescribed treatments especially ones that can affect you body in a big way.

[Caroline]

Is there a big difference between fumaric acid tablets that are available from online retailers for the treatment of psoriasis at relatively low cost compared to Fumaderm or psorinovo
which are prescription only drugs.

Yes probably no regulation, so they could be anything.

Just my opinion

You are possibly right in that assumption, I don't have a problem I can get mine readily from the hospital (Fumaderm) but I was thinking of others in far flung places that haven't got access to Fumaderm or psorinovo for their psoriasis as a possibility.

Caroline is your best bet for a proper answer Jim, but I would always say only use Prescribed treatments especially ones that can affect you body in a big way.

I would not know if there is a big difference between the online stuff and the registered stuff. But you can look at it from two ways.
1) they are fake, there is no DMF in the pills, it's kind of a smartie, is then the most lucky one, as they don't do anything, or they are containing garbage DMF, which is not good for your body, I guess.
2) there is DMF in it, no problem as the basic compound is very cheap, and it just can work, BUT then you have to deal with the side effects that Fumaderm and Psorinovo do not have. I don't know if you would want that.

Basic problem is that you are not sure if it is (1) or (2), the last one could give you a cheap and effective solution.

[Nancylr]

Thanks for the info on Dimethylfunarates, frankly it was above my ability to follow it all, but got that this helps make psoriasis more livable. I have two MTHFR gene mutations which affect my ability to use unmethylized B vtamins.
This isn't rare about 40% of the general population has this defect. Some of the things mentioned such as low energy and such seems to go along with what I have read about the MTHFR defect. Just curious.

How does one get the Dimethylfunarates in the US?

Thanks.

Nancylr

[Caroline]

Hi Nancy,
Welcome to the forum at first.
Nice that you found my post.

I don't know how to get DMF in the US, but maybe it is already there.
Fumaderm might the product that is available at your side. The product I use, Psorinovo, is only produced in the Netherlands. I guess it will be quite impossible to import it to the US, although you might have a try.
Anyway it is of importance to be guided by a doctor when using it. Up to now only very few incidents, basically 2 in the last 10 years have happened, one quite sure as a result of failing in the guidance. This guidance consists mainly of a 2 times a year check of certain elements in your blood.
There is a Dutch site, which tells more, but in Dutch. (You might use googl translate of course) there is a bit of English info on that site. [web]psoriasistherapie dot nl[/web]
Dimethylfumarates are gaining more interest lately because of the positive effect it has on multiple sclerosis.
On this forum Jiml is the one who uses Fumaderm.

Cheers
Caroline

[jiml]

Firstly Nancylr let me wish you a warm to the forum. Have a read through the prescribed treatment section. There are many good threads to gain information for psoriasis treatments

I Agree with Caroline. Be very careful I don't think Fumaderm is available in the US yet for psoriasis sufferers
I believe that the FDA have approved Tecfidera in the US for MS sufferers. Tecfidera is a very similar drug to Fumaderm and made by the same Company Biogen Idec if one of their DMF based drugs is approved it is possible that Fumaderm may also be on the list

With your problem MTHFR gene disorder I would not attempt to buy online without proper medical advice as here we just speak of our own experiences.

Look forward to more updates on your progress good or bad, we are all here to help each other through good and bad times, so don't think you have to talk just about psoriasis in the off topic anything goes. So hope to see you there soon

[Caroline]

Specifically also for Jim.
An article on Psorinovo, which is basically DMF as we know.
The article is about a known case and this case is blown out of proportion by the victim, as she appears to have a lot of connections in the publications world. Her way of acting, which I can understand partly, can damage a very promising medication for our disease.

The out of proportionality is because of the fact that this is the second calamity in 20 years of DMF usage, where the product gets the blame, but where the lack of treatment and control is the real cause.
Again if you look at the rate of calamities of this order with MTX, than you will be shocked.

[web]https://www.nejm.org/doi/full/10.1056/NEJMc1215357[/web]

This research is only on paper, and cannot be named a scientific research, this is only "one" case, which is quite unique.
An excellent example of a tunnel vision.

[jiml]

Ooh Caroline
You keep scaring me.
Having now read the article I doubt very much if that one case will have any effect on the prescribing of DMF in the future. The one case may make approval in different countries a bit more difficult. But the medical profession know there is always a risk with any drug including Asprin.
Although interesting I wouldn't lose any sleep over it
But thanks for keeping us informed

[mataribot]

I'm going to be evil - Long term use NSAIDs are probably just as bad as many drugs used to treat Psoriasis. it's always recommend to use them for a short periods of time.

Lots of drugs, including biologics, get an bad wrap for no good reason. I don't put much stock in it