Bill's pure dimethylfumarate thread

[ImtheIinteam]

I have a health care background and noticed that in the past, several fumarates were trialed for psoriasis. Trying to ship DMF from China to the US via Alibaba turned out futile, but I did order some liquid diethyl fumarate (notice the absence of the letter "m") from a similarly shady source. I will probably start at a dose of 30mg and slowly work my way up, taking it in water with large meals and supplementing with N-Acetyl-L-Cysteine. Glutathione is an important part of molecular transsulfuration pathways I think I have trouble with anyway, so it doesn't seem intuitive that a substance that uses it up would help, even if that process does trigger anti-inflammatory chemicals. We shall see.

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Edit By Fred.

Please read the posts below this one before rushing out to buy the wrong thing.

[Bill]

Are you crazy? For one thing DMF is not soluble enough to be sold as a liquid agent. It should not be hard to obtain as a powder as it is produced by the tonne for industrial usage. There was certainly nothing dodgy or sinister about the merchant I purchased mine from, and I certainly would not have purchased the drug if I had thought otherwise. If you want to buy DMF as a raw material then do so via a reputable chemical supply company. If you cannot do so you should not be tempted by potentially lethal options. It would be far safer to synthesize your own DMF.

You are seriously risking your life doing what you are doing.

[jiml]

Thanks Bill for the timely warning ,and while I can understand the attraction of trying your method , which in itself could be dangerous in the wrong hands but you are right substituting with similar chemical is unwise

By the way   to the club here as you see you will get honest unbiased advice and  support

Believe me we are a very friendly community always ready with as in your case words of warning   Or support through this difficult disease, with advice about managing it and in the boards you will read about the latest advances in treatment drugs like LAS41008 (DMF) effective in the treatment of psoriasis

[Caroline]

I am right now sitting opposite to my doctor in a meeting.
Like Bill I think that your approach, Iamintheteam, is very risky.
If I have the opportunity, and I think I will have, I will ask him. He is THE expert on DMF.

[Bill]

My treatment has been excellent, but I stress that you need to be absolutely certain of the quality of the DMF you are obtaining. I would like to think that I am sharing my experience as a public benefit. The thought of someone coming to harm from a lack of care and attention is sickening. Unless you have a reagent grade DMF from a supplier like Sigma-Aldrich you should not be proceeding. And taking a liquid is just bonkers. You cannot be certain of the concentration and for all you know the solvent could be something poisonous like methanol.

[Caroline]

Out of my meeting and spoken to my doctor.
Your diethyl liquid is an absolute NO!!
It will do absolutely nothing for you psoriasis. And may very well be toxic.

If you wanna be safe and have something working, you easily can order DMF pills in the Netherlands. There should be no problem with that.

[Fred]

Thank you Bill and Caroline. I have made an edit to RE: Bill's pure dimethylfumarate thread

[Caroline]

Hello ImtheIinteam,

Welcome to Psoriasisclub.

Don't feel shocked that we all so jumped on you. I am sorry for that, but we try to prevent you from a mistake, that might harm you. We do this out of the best of our knowledge.
As I spoke to my doctor today, who has been working on psoriasis for at least thirty years, and asked him, he was very sure that your liquid would not do anything. If it is harmful, he could not tell. But if I were you I would not try I it, it is useless.

So in the mean time, welcome to the club. We are fellow sufferers and lots experiences with all kinds of treatments have passed these pages.
If you want to go DMF, ask Bill how he managed or as I said it must be possible to order from e.g. The Netherlands a complete product. It has been done before by Joanna in Poland.

Cheers,
Caroline

[Bill]

As Caroline says, the advice here is all about directing people toward safe and effective management of your disease. If someone suggests doing something potentially harmful I wont hesitate to warn them. As a starting point you must have medical testing to determine that DMF is okay for you. Then you need DMF of known quality (I have powder of 98% purity). If you are using raw powder you will need accurate scales to weigh doses. You will also require regular monitoring of you blood, especially in the early stages of treatment.

DMF does cause a local depletion of GSH when absorbed, although it ultimately leads to higher GSH through its pharmacological action. Although I find that pre-dosing with l-cysteine reduces the gastric side effects greatly, the mechanism I suggest for this is speculative and not confirmed by research.

Cheers,

Bill

[Bill]

Having read Imintheteam's post again I am even more worried. What he has in his possession is not DMF, but instead diethyl fumarate in an unknown solvent. Diethyl fumarate is toxic and useless as a psoriasis treatment according to PubChem. Hopefully this guy has not harmed himself, and it would be comforting for me to know as much. Imintheteam might want to start his own thread and relate his story. I am sure that he would get plenty of help and sympathy, but I think that the poor knowledge and abysmal communication skills displayed thus far would almost guarantee a catastrophic outcome if this guy were to go diy.