There is hope.. Part 2

[Thadius]

Ok here we go....

I have tried to keep this brief and if there are any questions please, please ask.

I have left out the Sponsors name and the code reference to the product.

The product has been given to more than 2500 in other studies of psoriasis, rheumatoid arthritis, inflammatory bowl disease and dry eye.

I am one of 660 patients in 12 countries being asked to take part in the study because I have chronic plaque psoriasis. I am one of 50 patients in the UK. The study is over a period of 56 weeks.

I am currently in phase 3 of a mixed blind treatment, withdrawal and re-treatment study of 2 oral doses in subjects with moderate to severe plague psoriasis.

The product is a blocker of an enzyme called "Janus Kinase"' which acts like a gate into the cells of the immune system ( our body's defence against infection). By blocking the enzyme, the cells of the immune system are expected to produce fewer chemicals believed to cause psoriasis.

The study is looking at the good and bad effects. I attend a Hospital clinic every 4 weeks. I give several blood samples and have a full health scan including an inspection of my skin condition. Periodically I have full ECG etc. Apart from checking my vitals the study monitors blood, urine, my genes (DNA),RNA, proteins and metabolises.

During the study I am not allowed to use any other form of treatment or spend time in sunlight.

I keep a diary of my doses and I have a questionnaire at each clinic which asks about my mental and emotional state, if there are any restrictions on my work, study, sex life and general social being.

I took photos on the first day of my treatment ( I have no problems at anyone seeing them ) which when I work out how to upload etc.

The product is not a cure but it is a suppressor. At this moment in time ( week 44) my skin is 100% clear and yes I look sexy again I feel good about myself but not confident enough to go shopping in a mankini just yet.

I will give out more info as I progress into the extension study.

So for now folks..... There is hope x

Thadius

[Fred]

Thanks for sharing Thadius that sounds like the trial I was going on, but couldn't in the end. I look forward to following your progress. Krissie explained more about Janus Kinase here for those that are interested. RE: I need more Psoriasis

I notice you say your skin is 100% clear, but you have 49 Psoriasis Score on your profile. Do you have psoriatic arthritis and is that why your score is high? or have you pushed some wrong buttons

[Thadius]

Thanks Fred,

Had to read it a couple of times, .. Finally sunk in. A lot of it ties in with the trial detail.

Thadius

[Thadius]

Sorry Fred,

Just read the last bit of your reply. I went through the score system on how my skin condition was prior to the trial. Yes my skin is 100% clear at present, I just wanted to show from start to finish, if that makes sense. Although my skin is clear I am still classed as a severe case. I can also see faint marks where the plaque has been, more so after a hot shower or bath. I will adjust the count shortly. I am hoping to document a photograph all aspects including "after-skin" appearance.

Thadius

[Fred]

Sorry Fred,

Just read the last bit of your reply.  I went through the score system on how my skin condition was prior to the trial. Yes my skin is 100% clear at present, I just wanted to show from start to finish, if that makes sense.  Although my skin is clear I am still classed as a severe case. I can also see faint marks where the plaque has been, more so after a hot shower or bath. I will adjust the count shortly. I am hoping to document a photograph all aspects including "after-skin" appearance.

Thadius

No problem

If you get stuck with adding images this thread may help: [Group Specific] if not give me a shout.

We also have the Members Only Photo section here: [Group Specific] if you want to use that too.