Psoriasis and IGA nephropathy link, has anyone ever heard of this?

[Caroline]

Oh, Jim sent me a translation of this article. He is so nice.    

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Besides psoriatic arthritis, of the one in five patients affected with psoriasis, including the incidence of obesity, dyslipidemia, diabetes, hypertension, chronic inflammatory bowel disease and depression are increased in psoriasis patients (see, however, PZ 19/2013 : comorbidities: psoriasis is more than skin). In addition, there were smaller studies again evidence that the kidneys are drawn from the chronic inflammatory disease suffer. Researchers led by Professor Dr. Joel M. Gelfand of the University of Pennsylvania studied these suspicions now by means of a population-based cohort study.

In patients with severe psoriasis not only the skin, but, among other things, the kidney suffers.


They analyzed data from 136,529 patients with mild and 7354 patients with severe psoriasis, as well as 689 702 control subjects from a British electronic patient folder. Moderate to severe but not mild psoriasis was associated with an increased risk for chronic kidney disease, the scientists report in the "British Medical Journal" (doi: 10.1136 / bmj.f5961). The risk increased with age. The researchers calculated based on their results indicate that severe psoriasis in 40- to 50-year-old is responsible for an additional case of chronic nephropathy per 134 patients per year, every year in the age group of 50- to 60-year-old even for an extra case per 62 patients ,

The relationship was independent of traditional risk factors such as diabetes, hypertension and taking nephrotoxic drugs. The underlying mechanism is still unclear, but the authors suggest disorders of T-cell function and increased levels of immune complexes as a possible cause. Another possible explanation they suggest damage the tubules ago by elevated levels of uric acid.

test kidney function

As a consequence, in practice, the researchers advise to close monitoring of renal function in patients with psoriatic lesions on at least 3 percent of body surface. Before using potentially nephrotoxic drugs such as cyclosporine or methotrexate, a particularly critical benefit-risk assessment should be done with them.