[split] Dimethylfumarates and Psoriasis

[Caroline]

AAANDDD Another one    

(It's quiet at the office, so take part of the lunchtime to do some searching... )

British Journal of Dermatology 1999; 141: 424±429.
Treatment of severe psoriasis with fumaric acid esters: scientifc background and guidelines for therapeutic use

This is a nice PDF file with a complete description (could give you the link of course, but that is against policy you can find it yourself). Interestingly the use of DMF is even older than I thought. The publication is 1999 and they are already talking about 30 years of DMF use. That means that seen from our point in time, it's a 45 year old therapy.  

Will look that one up in my lunch time when my office is quiet ( i.e. When the Ironing is finished )

Just finished reading and can't say I understand it all but was interested to read that the combination therapy i.e Fumaderm was more effective than DMF alone (page426)
Also that it is effective against psoriatic arthritis ( although in the uk not prescribed for that) and we already know that fact
Overall it was a good read but to be honest a bit over my head

That is correct that it is more effective, But that is due to some ion somewhere, that is safer to add via a copper ion, than the addition of MMF, which last is toxic for the kidneys, therefore also the limitation to max 6x120

In the beginning Psorinovo had the copper ion added, but because of some stupid written rule this was gotten out again. So now it's only DMF, just as what Bill is having, only slow release.