Health Boards
Sun-01-07-2012, 21:47 PM
However a study, by Ionescu and Kiehl in 1992, shows this relationship in a completely different way.
They studied skin and blood cells of psorioasispatiënten and found that in psoriasis there is decreased ATP, ADP and cAMP concentrations and abnormal purine nucleotide concentrations in both cell types.
According to these authors the essence of psoriasis is, a run-beaten (de-railed) purine nucleotide metabolism (4).
For the production of RNA and DNA, cells need the necessary mitochondria. The building blocks of RNA and DNA purines and pyrimidines.
The run beaten purine nucleotide metabolism thus apparently refers to a mitochondrial problem.
And because these abnormalities in both blood cells and in the skin cells were found, this study shows unambiguously that psoriasis is not a disease confined to the skin.
That means that Psoriasis is a mitochondrial disease that manifests in different organ systems.
Scientifically speaking, the idea that psoriasis is a skin disease, is outdated, even while the skin manifestations are usually the ones in the foreground.
The creams as first choice, often for years prescribed are in essence only cosmetics that are bad for the skin (see e.g. the case histories of Hans Graves and Vic Asselberghs on this[the dutch] site).
A further substantiation of this view shows the follow-up study of Ionescu and Kiehl.
They incubated the skin and blood cells of psoriasis patients with fumarate. As a result, an increase of the concentration of ATP and the cyclic AMP levels, while at the same time the purine nucleotide synthesis was inhibited.
Both of these effects are in accordance with these authors, characterized by a stimulation of the citric acid cycle, and both effects inhibit the DNA-and protein synthesis, so that the abnormal cell growth (psoriatic uncontrolled cell growth) decreases.
Nibbering et al in 1993 compared with the help of an in vitro study the effect of the MMF (monomethylfumaraat) and DMF at granulocytes (5).
They concluded, as did Litjens 10 years later (6) - that the principle of operation of both compounds is similar, namely that incubation of a granulocytensuspensie leads to increase in cAMP. The concept of "stimulation of the citric acid cycle" not only explains the beneficial effect of fumarate in psoriasis on the skin, but also the flushing, the measured global (body) warming and its effects on rapidly regenerating cells and tissues.
The latter concerns the slight leukopenia, the eosinophilia, lymphopenia and the irritations of the intestinal mucosa (Ionescu and Kiehl). These often unwanted side effects entered phenomena are in fact a sign of proper operation, however it can be too strong and therefore a nasty side.
Significant effect is that these effects being almost always transient and will disappear, which is also recognized by the skeptics.
The more gradual the dosage is increased, the sooner the body is accustomed to the new situation and the sooner the abnormalities in the blood picture are vanished.
If there would be real toxicity, in laboratory detected abnormalities would obviously only increase and persist after cessation of psorinovo-usage.
The reverse appears to be the case shown. Many patients in the practice of dr Kunst, who initially had more or less of these "side effects", but with mutual patience could still be well set up and use for many years now psorinovo in full satisfaction.
Several case histories on the dutch site show this. And on the forum of that site regular new cases of success appear.
They studied skin and blood cells of psorioasispatiënten and found that in psoriasis there is decreased ATP, ADP and cAMP concentrations and abnormal purine nucleotide concentrations in both cell types.
According to these authors the essence of psoriasis is, a run-beaten (de-railed) purine nucleotide metabolism (4).
For the production of RNA and DNA, cells need the necessary mitochondria. The building blocks of RNA and DNA purines and pyrimidines.
The run beaten purine nucleotide metabolism thus apparently refers to a mitochondrial problem.
And because these abnormalities in both blood cells and in the skin cells were found, this study shows unambiguously that psoriasis is not a disease confined to the skin.
That means that Psoriasis is a mitochondrial disease that manifests in different organ systems.
Scientifically speaking, the idea that psoriasis is a skin disease, is outdated, even while the skin manifestations are usually the ones in the foreground.
The creams as first choice, often for years prescribed are in essence only cosmetics that are bad for the skin (see e.g. the case histories of Hans Graves and Vic Asselberghs on this[the dutch] site).
A further substantiation of this view shows the follow-up study of Ionescu and Kiehl.
They incubated the skin and blood cells of psoriasis patients with fumarate. As a result, an increase of the concentration of ATP and the cyclic AMP levels, while at the same time the purine nucleotide synthesis was inhibited.
Both of these effects are in accordance with these authors, characterized by a stimulation of the citric acid cycle, and both effects inhibit the DNA-and protein synthesis, so that the abnormal cell growth (psoriatic uncontrolled cell growth) decreases.
Nibbering et al in 1993 compared with the help of an in vitro study the effect of the MMF (monomethylfumaraat) and DMF at granulocytes (5).
They concluded, as did Litjens 10 years later (6) - that the principle of operation of both compounds is similar, namely that incubation of a granulocytensuspensie leads to increase in cAMP. The concept of "stimulation of the citric acid cycle" not only explains the beneficial effect of fumarate in psoriasis on the skin, but also the flushing, the measured global (body) warming and its effects on rapidly regenerating cells and tissues.
The latter concerns the slight leukopenia, the eosinophilia, lymphopenia and the irritations of the intestinal mucosa (Ionescu and Kiehl). These often unwanted side effects entered phenomena are in fact a sign of proper operation, however it can be too strong and therefore a nasty side.
Significant effect is that these effects being almost always transient and will disappear, which is also recognized by the skeptics.
The more gradual the dosage is increased, the sooner the body is accustomed to the new situation and the sooner the abnormalities in the blood picture are vanished.
If there would be real toxicity, in laboratory detected abnormalities would obviously only increase and persist after cessation of psorinovo-usage.
The reverse appears to be the case shown. Many patients in the practice of dr Kunst, who initially had more or less of these "side effects", but with mutual patience could still be well set up and use for many years now psorinovo in full satisfaction.
Several case histories on the dutch site show this. And on the forum of that site regular new cases of success appear.