Sat-26-04-2014, 22:34 PM
Hi Caroline,
DMF is very reactive and has a metabolic half life of a few minutes, so it converts to MMF very quickly after absorption. The MMF has a metabolic half life of about 1 hour and causes the flushing you experience via its action as a nicotinic acid receptor agonist. Both substances have an anti-inflammatory effect, but the precise mechanism is not currently understood.
Cheers,
Bill
DMF is very reactive and has a metabolic half life of a few minutes, so it converts to MMF very quickly after absorption. The MMF has a metabolic half life of about 1 hour and causes the flushing you experience via its action as a nicotinic acid receptor agonist. Both substances have an anti-inflammatory effect, but the precise mechanism is not currently understood.
Cheers,
Bill