Hi Everyone,

Been almost 2 years since I posted, so apologies for my absence! I've noticed a number of people sharing their experience with Skilarence and I just thought I'd do the same, in case it could help anyone.

I've had guttate psoriasis 8/9 years. Not sure of any of my scores, but my derm considers it severe. I have tried topical treatments with no success as well as light treatment with limited success. Approx 4 years ago I was put on Fumaderm and it was like magic, 100% clear. 2 years ago I did have a mini flare up when my dosage was reduced too low but it corrected itself once I increased my dosage and it stayed steady on 4x120mg a day.

This summer I was moved onto skilarence. Initially I noticed no difference, except I had no side effects. Literally no flushing which I used get with Fumaderm every couple of weeks. After 6/7 weeks on skilarence I had noticed a few spots here and there, however nothing to be worried about. At the start of September I got the flu and 2 weeks later I encountered my first full blown flare up in 4 years. I have since been moved up to 6x120mg a day and the hope is it will bring things under control. I am currently on the higher dosage just over 2 weeks so it may take more time to kick in. I will keep this updated for anyone going through something similar.

So far I definitely think Fumaderm was the better drug, but beggars can't be choosers and I'm gonna stay optimistic for Skilarence

If anyone has any suggestions on supplements that can be taken with skilarence please let me know, I am considering getting Vitamin D tablets and have seen people mention Omega 3???

Hi, I'm John. Been battling with Plaque psoriasis for a few years now. I'm pretty sure got it from taking Rivaroxaban (Xarelto). Had been on Warfarin for 16yrs + and body was no longer having it.  Now on Pradaxa and blood is good. Plaque not so good. Derm started me with cream and injections, he loved those injections.  Sadly they only briefly help out and help his wallet and hurt mine.

Primary Dr put me on Acitretin and about the same time I went on Keto and have lost 50lbs in a year and 80 lbs total. I did go off the acitretin for a month since I was almost 100% clear was hoping it was the clean diet. But alas it wasn't and went back on the drug. I have almost every side effect they list, and as I was searching the net I see more added that I hadn't put down as the medicine as well. Losing my eyebrows and eyelashes was no big deal. Hair loss also doable, the skin on fire and scratching my face and knees just about unbearable.  Would wake up bloody each morning, from scratching.  Night blindness and messing with my head I can't bear any longer. Months ago had asked the Dr to change up the med, but she didn't want me to have to start over with all new side effects. I've been on it for over a year and 2 weeks ago took my last dose.  

Had an awful day and made it through but was searching for ways to see how to get it out of my system. Found this group and hope to gain some insight and try out the next treatment for me. Going cold turkey for a bit, to let my body rest. It's no longer short season and mine is normally on my knees, elbows, feet. Praying the medicine will wear off and get my head back together and nails no longer cracked, chipped and thin so thin I get cut/scratched, like when I was on Warfarin.  

Sorry for such a long intro. Not looking forward to the recurrence and snow storm that follows me and my side of the bed.
Thanks for listening.
John

Oddly enough, I only recently heard of lazer therapy.  I was a bit surprised when my dermatologist offered it as a bit of a "let's see if this works while we regroup" type of thing. So I am now going for appointments twice per week for XTRAC.

So a little history, I was on three biologics, Stelara, Cosentyx and Taltz.  I did not notice any big improvements while on them.  There were times when it looked a bit better, but then would go back.  So this is where I am currently.

I should tell you that behind my ears and inside ears HAS improved!  About 3 weeks ago, the doctor took me off Taltz and started the process of getting the Lazer therapy approved.  Immediately after that appointment, I started using Taclonex again as I did not want to go backwards.  I had told the doctor a few times that the biologics along WITH the Taclonex would show improvement but she stated that I shouldn't need the Taclonex while on the biologic (as in the biologic should work on it's own)  So since I didn't want to skew things by using both, I stopped the Taclonex except for very few times when the scalp was REALLY bothering me.  I mention all of this as to be honest, I don't know now if finally the Taltz started to work or if it has been these last few weeks using the Taclonex, but my ear is clear and behind it is only slightly raised and red.  I am going with the Taclonex or combination of the two.

Anyway, I started Laser therapy this week.  Today was my second appointment.  I won't provide pictures because I just can't get decent ones of my scalp due to it being the back of my head mostly and the hair covering.  I know for those of you who followed my other journeys how much you will miss those ear pictures!    But I will let you know if it works.  Although my ear area is improved, the scalp area is still scaly (although it also improved a bit, just not nearly as much as the ear area, but it is much easier to apply topical to the ear and behind the ear as opposed to under areas covered by hair)

From what they say, I should notice results between 6-10 sessions, clearance between 10-20 sessions and it lasts for about 3-6 months. 

So right now I'm on a bit more of short term solutions. I will let you know how it goes and also let you know how unhappy I am making the rheumatologist next time I see him.  But I do NOT miss those Taltz injections 

Editing to add: The XTRAC is only being used on my scalp, NOT ear area at all currently. That's another reason why no pics, since this is about the laser therapy which currently isn't being used on or behind ears. I need to ask why because I honestly don't know. It's a nurse doing the treatment.

Eli Lilly makers of Taltz say they have beaten Tremfya in a head to head study.

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Eli Lilly today presented detailed data at the 5th Annual Maui Derm NP+PA Fall meeting from the Phase 4 IXORA-R study, the first head-to-head (H2H) study between an IL-17A inhibitor and an IL-23/p19 inhibitor using the Psoriasis Area Severity Index (PASI) 100 score as the primary endpoint. Taltz met the primary endpoint of superiority vs. TREMFYA in the proportion of patients with moderate to severe plaque psoriasis achieving complete skin clearance as measured by PASI 100 at Week 12, as well as key secondary endpoints. The study is ongoing through Week 24.

"Healthcare providers and patients value speed of response when evaluating treatment options for moderate to severe plaque psoriasis," said lead study investigator Andrew Blauvelt, M.D., M.B.A., dermatologist and president of Oregon Medical Research Center in Portland, OR. "The results from the IXORA-R study demonstrate that Taltz was effective in helping more patients achieve completely clear skin by Week 12, with a 50 percent improvement in skin plaques seen as early as Week 1."

The primary endpoint of the study was superiority for Taltz compared to TREMFYA in the proportion of patients achieving complete skin clearance as measured by PASI 100 at Week 12. Key secondary endpoints included superiority over TREMFYA in the proportion of patients achieving PASI 75 at Week 2, PASI 90 at Weeks 4 and 8, PASI 100 at Weeks 4, 8 and 24, static Physician's Global Assessment (sPGA) 0 at Week 12 and PASI 50 at Week 1.

Patients treated with Taltz demonstrated statistically significantly higher improvements than those treated with TREMFYA as measured by PASI 100 at Week 12 (41.3 percent versus 24.9 percent, P<0.001). Additionally, all major secondary endpoints up to Week 12 were achieved (P<0.001).

"As new medicines become available for people living with psoriasis, there's an increasing need to directly compare the efficacy and safety of these treatments to help healthcare providers and patients make informed treatment decisions," said Rhonda Pacheco, Pharm.D., global brand development leader for immunology at Lilly. "These results demonstrate that Taltz can provide high levels of skin clearance early in treatment for people with psoriasis."

A total of 1,027 patients with moderate to severe plaque psoriasis were enrolled in the study to evaluate the efficacy and safety of Taltz compared to TREMFYA. Participants were randomized to receive Taltz or TREMFYA at the approved dose for a total of 24 weeks, with the primary analysis conducted at 12 weeks.

In IXORA-R, the safety profiles of Taltz and TREMFYA were consistent with those previously reported for both treatments. As the IXORA-R study is ongoing, not all data will be presented at this meeting to prevent unblinding for investigators and participants. Lilly plans to share results on the remaining key secondary endpoint of proportion of patients achieving PASI 100 at 24 weeks in 2020.

I'm starting some various at-home treatments for my skin.  Over the weekend I combined 2 cups baking soda with colloidal oatmeal bath.  This combination really seems to help with itching and redness, and making the bumpy/lumpy plaques much softer and less prominent.  This bath treatment by far has given me the greatest relief I've had in over a year and noticeable change in the appearance (from almost black to lightish-red/dark pink).

I ordered Dead Sea Salts (which are very pricey) and I'm going to try that in a bath tomorrow morning or evening and compare with the baking soda/oatmeal.

I've started taking 2 tablespoons of apple cider vinegar in the morning diluted in a full glass of water.

One turmeric/curcumin supplement mid day with a meal.

I have been applying the mometasone cream at night before bedtime.  It's indicated to apply twice daily however I run out the cream early due the amount of area I have to apply, so I've limited that to once a day.

Mornings I have applied either coconut oil or CeraVe psoriasis cream.  I have noticed that the coconut oil works much better than the CeraVe (and is less expensive).

I'm trying to limit sugar and processed foods, nightshades (makes me sad, I love tomatoes).

3x a week - 12 min sessions in UVB tanning bed.  I also have the dermalight wand, which I think possibly works better than the tanning bed.  The only drawback to the dermalight wand is the amount of time involved treating.  It can take up to an hour and a half of 1 min sessions on each site vs. 12 mins for all over coverage in a tanning bed.  I'm considering taking a break from the tanning bed and trying the dermalight at home and see if there's a difference.

Happy Tuesday!
Lillie

This study looked at tattoo complications in psoriasis patients.

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Background:
Tattooing is a widespread phenomenon, with an estimated prevalence of 10–30% in Western populations. For psoriasis patients, current recommendations are to avoid having a tattoo if the disease is active and they are receiving immunosuppressive treatments. Although scientific data supporting these recommendations is lacking, dermatologists are often reluctant to advocate tattooing in psoriasis patients.

Objective:
We aimed to evaluate the frequency of tattoo complications in patients with psoriasis and determine if the occurrence of complications was associated with psoriasis status and treatments received at the time of tattooing.

Methods:
We performed a multicentre cross‐sectional study. Adults with psoriasis were consecutively included and classified as tattooed or non‐tattooed. Prevalence of complications associated with tattoos was then evaluated according to psoriasis onset and treatments. The study was divided into three parts, in which data were collected through a series of questionnaires filled in by the dermatologist. Complications included pruritus, oedema, allergic reaction/eczema, infection/superinfection, granuloma, lichenification, photosensitivity, Koebner phenomenon and psoriasis flare after tattooing. Diagnosis of complications was made retrospectively.

Results:
We included 2053 psoriatic patients, 20.2% had 894 tattoos. Amongst non‐tattooed patients, 15.4% had wished to be tattooed, with psoriasis being stated as a reason for not having a tattoo by 44.0% and 5.7% indicating that they planned to have a tattoo in the future. Local complications, such as oedema, pruritus, allergy and Koebner phenomenon were reported in tattoos in 6.6%, most frequently in patients with psoriasis requiring treatment at the time of tattooing (p<0.0001). No severe complications were reported.

Conclusions:
The rate of tattoo complications in psoriasis patients was low. Although the risk of complications was highest amongst patients with psoriasis requiring treatment at the time of tattooing, all the complications observed were benign. These results can be helpful for practitioners to give objective information to patients.

This study suggests effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.

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Aim:
The purpose of this randomized controlled clinical study was to evaluate the effect of non‐surgical mechanical periodontal therapy on the inflammatory status and severity of psoriasis in subjects with psoriasis.

Material and methods:
The study population consisted of 92 periodontitis patients with psoriasis vulgaris suffering from an untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal therapy (test group, n = 46) and delayed periodontal therapy (control group, n = 46). Periodontal clinical measures, on salivary interleukin 2, interleukin 6 and secretory immunoglobulin A levels and the Psoriasis Area and Severity Index (PASI) scores were evaluated at baseline and on the 8th week in control and test groups.

Results:
8 weeks after completion of non‐surgical periodontal therapy (test group) or initial examination (control group), a significant decrease was observed in interleukin 2, interleukin 6 level and in PASI score, whereas a significant increase was observed in secretory immunoglobulin A levels in the test group (p < 0.05).

Conclusion:
Within the limits of this study, the results suggest that effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.

Hi Fred or someone!

I wanted to start a thread and accidentally pressed God knows what and it got posted....can you delete it?  Please!

Thanks

Hi everyone!  I'm happy to have found this forum while doing a  google search for natural remedies.  I was diagnosed around 1983 (about 10 years old) with a generic "psoriasis" diagnosis.  In the beginning it covered both of my legs.  I don't recall at the time if they gave me any treatment?  That was thirty some odd years ago....

In my twenties it emerged again on my scalp, a spot here and there on my arms, elbows, back, stomach.  Using various natural and over-the-counter lotions, creams, and sunlight/tanning beds have kept it pretty under control and felt very fortunate.

Two years ago, during an extremely stressful period of my life, it explodes on my scalp and I lost all of my hair. Well, half of my hair and then I cut the rest off because I was tired of handfuls coming out in the shower every day.  I'm happy to say my hair has grown back fuller and thicker than ever and my scalp has calmed down.  Currently, I use shea moisture coconut oil on my hair about every other day, massaging through hair and scalp and leave it on overnight.  Coconut oil has seemed to provide the best relief for my scalp.

But a year ago the rest of my skin went nuts with P.  Arms, elbows, torso, legs, back.  At that time, I'm guessing it was covering about 60% of my body.  I've been using a combination of prescribed steroid cream (Mometasone), coconut oil, UVB tanning bed 2-3x a week, CeraVe Psoriasis Cream, and now adding baking soda baths.  My family doctor prescribes the Mometasone and asked me if I wanted to be referred to a dermatologist however I don't have any health insurance right now.  I'm interested in natural/cost friendly treatments.

I've had many flares and remissions over my life.  It doesn't seem to be triggered by anything consistently other than stressful times.  Hangs around a year or a couple and then fades away again.  The baking soda baths have given me much relief from the itching, redness, scaling.  This flare has been going on exactly a year so far, but it is getting better and gradually clearing.  I would estimate it's down to about 30% of my body.

I've found so much great information here already, and it's a comfort to know there are people out there who understand.   

Glad to be here, this seems like a great group!
Lillie

Could images help in psoriasis diagnosis in parts of China ?

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Background:
Psoriasis is a chronic inflammatory skin disease which holds a high incidence in China. However, professional dermatologists who can diagnose psoriasis early and correctly are insufficient in China, especially in the rural areas. A smart approach to identify psoriasis by pictures would be highly adaptable countrywide, and could play a useful role in early diagnosis and regular treatment of psoriasis.

Objectives:
Design and evaluation of a smart psoriasis identification system based on clinical images (without relying on a dermatoscope) that works effectively similar to a dermatologist.

Methods:
A set of deep learning models using convolutional neural networks (CNNs) were explored and compared in the system for automatic identification of psoriasis. The work was carried out on a standardized dermatological dataset with 8021 clinical images of 9 common disorders including psoriasis along with full electronic medical records of patients built over the last 9 years in China. A two‐stage deep neural network was designed and developed to identify psoriasis. In the first stage, a multi‐label classifier was trained to learn the visual patterns for each individual skin disease. In the second stage, the output of the first stage were utilized to distinguish psoriasis from other skin diseases.

Results:
The area under the curve (AUC) of the two‐stage model reached 0.981±0.015, which outperforms a single‐stage model. And the classifier showed superior performance (missed diagnosis rate: 0.04, misdiagnosis rate: 0.03) than 25 Chinese dermatologists (missed diagnosis rate: 0.09, misdiagnosis rate: 0.27) in the diagnosis of psoriasis on 100 clinical images.

Conclusions:
Using clinical images to identify psoriasis is feasible and effective based on CNNs, which also builds a solid technical base for smart care of skin diseases especially psoriasis using mobile/tablet applications for teledermatology in China.

hi all, I’m new to the forum.  I started taking Skilerence three weeks ago and Ive worked my way up to 120 mg per day so far.  Side effects are ok at the moment. A bit of skin irritation but only lasts 10-20mins so bearable.  The only thing is that my skin looks worse! Is this something that can happen? Does it look worse before it gets better or does it take a while to kick in if it works? Confused.

Skilerance is a great drug and works but the side affects for me on 120 mg is not bearable.
I've tried it with food and yogurt, I've even cut the tablet in half and hid it in a soft sweet and swallowed half in the morning and half late afternoon but the cramps i get and sweats and going red is crazy.
I need to inform my dermatologist but after being on methotrexate and cyclosporine, I don't now what other options I have.
Any suggestions would be welcome as i'm sure you all know how i'm feeling. 

Hi.. Ive been search this place and also the inspire page in the US and although GI / diarrhea is a listed side effect there doesnt seem much else on it: Novartis is stating it cannot cause IBD... it can only bring it on if the person had it already but I have seen one person on this page and another in the US who did not have it before, and do have it now. 
I think I fall into this category... the pain started on my second monthly dose after the 5 loading doses...I was doing really well until then and the GI issues were severe: severe diarrhea for a week with severe cramping.. this lasted a month, now I am on anti ulcer meds which help a little with pain but the pain was across the whole system from stomach down to colon. though mostly upper. 
Am waiting for tubes and cameras but the wait list is a while! ... has anyone else experienced this? They are suggestingI change to a different biologic but I am quite worried about trying something new now.... I basically lost a month of my life lying in bed or running to the loo!

Hi!

Found this site while browsing for information on biologics.  I have been diagnosed with plaque psoriasis , which is hereditary in my family, 25 years ago and psoriatic arthritis  (the first in the family) 10 years ago.  Wow, writting this down  makes me feel old!

Started on biologics 2 years ago because of the arthritis.   I was tired of being in pain. Still am!

I am on Cosentyx which pretty much cleared up my psoriasis   but my rheumatologist just increased the dose as it wasn't doing anything for the arthritis.  Hope it works!

Tried humira and stelara before.

Thanks for letting me join!
Kat

Figures vary on how many people with psoriasis will go on to get psoriatic arthritis but it is around 1/4.

Psoriatic arthritis (PsA)
• When joints are inflamed they become tender, swollen and painful on movement.
• Joints are typically stiff after resting, early morning or resting in the evening.
• Tissues such as ligaments, tendons around the joints may be involved.
• Inflammation of tendon or muscle (such as tennis elbow (Lateral Epicondylitis) and pain around the heel) is also a feature in those with psoriatic arthropathy.
• In approximately 80% of cases the arthritis develops after the appearance of psoriasis.
• In 20% of cases the joint inflammation comes first.

Joints normally function to allow movement to occur between bone ends, which are important for the body to move. Bone ends are covered with cartilage around which is a capsule lined by a membrane called synovium.
This membrane normally makes the fluid that lubricates the joint space allowing movement. In arthritis the synovial membrane becomes inflamed - and releases substances that cause inflammation.
The inflamed synovium releases more fluid than normal and so the joint becomes tender and swollen. Persistent inflammation may lead to damage to the cartilage and erosion of the underlying bone.
Synovial membrane also lines and lubricates tendons and so they become inflamed too.

There are several features that distinguish (PsA) from other forms of arthritis:
• Particular patterns of joints that may be involved.
• One pattern of inflammation is usually in the end joints of fingers often corresponding with the fingers that have psoriatic nail involvement, which is more common in men than women.
• Another pattern is involvement of the joints of the spine and sacroiliac joints which is called spondylitis similar to ankylosing spondylitis.
• Neck pain and stiffness.
• An entire toe or finger can become swollen or inflamed which is termed dactylitis.
• There is a tendency for joints to stiffen up and sometimes to fuse together.
• Importantly the absence of rheumatoid factor in the blood helps distinguish psoriatic arthritis from rheumatoid arthritis.
• Distinguishing features are not always present and the individual may have swelling of a few or many joints that is similar to other types of arthritis making diagnosis difficult.

In 80% of individuals with arthritis, psoriatic nail changes are found, which is more common than with psoriasis alone.
Nail changes include pitting, discolouration of the nail due to abnormalities in the growth of tissue in the nailbed.
The risk of developing arthritis is greater in individuals with severe psoriasis, yet occasionally severe arthritis may occur with minimal skin disease.

Howdy - Currently on Cosentyx for 4 mo, generally feeling better yay! 

But having sudden sharp mental decline. Can still recite and analyze passages from Chaucer and Shakespeare no prob (retired Engl Lit teacher) but cant remember to lock the front door when I go out, turn off the coffee pot, pay bills on time, and recently had a “spell” where I was driving to a dr’s appmnt, got confused, then lost, and ended up driving all over town for an afternoon - didnt know where I was going, or why, or where I was, or how to get home. I have lived in this same small town for 20 years! 

Has anyone else experienced mental confusion while on Cosentyx? It is not listed as a side effect. Or could this be something else? 

TIA,

I’m not really a cowboy, it’s just an avatar. I’m really a middle aged urban Texan (having lived in NYC, LA, Wash DC, San Fran, as well as Houston and various DFW ‘burbs.), although I have Tx cred via various relatives. Diagnosed w psoriasis as a teen, and PsA at midlife. It ebbs and flows, and I am not entirely certain any of my meds are doing much to control it. So glad I found this forum, bc I don’t know anyone else who has it, that I can talk to, who understands.

This study evaluates the efficacy and safety of recommended Taltz (ixekizumab) dose over 4 years.

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Background:
Psoriasis, a chronic disease usually requires long‐term disease management.

Objective:
This study evaluates the efficacy and safety of recommended ixekizumab (IXE) dose over 4 years (204 weeks) from UNCOVER‐3 study.

Methods:
UNCOVER‐3 was a randomized, double‐blind, multicenter, Phase 3 study wherein patients with moderate‐to‐severe plaque psoriasis received placebo, IXE 80 mg every 2 weeks (Q2W), IXE 80 mg every 4 weeks (Q4W) (both IXE groups had 160 mg starting dose), or etanercept 50 mg twice weekly. At Week 12, all patients switched to IXE Q4W dose for the long‐term extension (264 weeks). After Week 60 and at investigator's discretion, patients could receive dose adjustment to IXE Q2W. The efficacy endpoints at Week 204 were percentage of patients achieving PASI 75/90/100, sPGA score of 1 or 0, and those achieving PSSI=0, NAPSI=0, and PPASI 100. Efficacy data were summarized through 204 weeks using as‐observed, multiple imputation (MI), and modified nonresponder imputation (mNRI) methods.

Results:
The proportion of patients achieving PASI 75/90/100 at Week 204 using mNRI method were 82.8%, 66.4%, and 48.3%, respectively. Using as‐observed and MI methods, 98.2% and 94.8% patients achieved PASI 75, 87.8% and 73.3% achieved PASI 90, and 67.1% and 52.7% achieved PASI 100 response, respectively, at Week 204. The response rates for sPGA (0, 1) were 88.7%, 76.2%, 68.5% and for sPGA (0) were 68.9%, 54.6%, and 49.7% using as‐observed, MI, and mNRI methods, respectively. Similar trends were observed with NAPSI=0, PSSI=0, PPASI 100, and itch NRS=0. There were no new safety concerns through Year 4.

Conclusions:
This study demonstrated sustained high‐efficacy response through 4 years of continuous treatment with ixekizumab in patients with moderate‐to‐severe plaque psoriasis. The safety profile remained consistent with prior findings, with no new or unexpected safety concerns.

Looks like another drug failed due to diarrhoea.
 I tried Oteza. It was working but the longer I was on it, the worse my diarrhoea got.
I am now on Skilerence. Only got to 2x 120mg tablets a day. No will I get to 6 a day. Horrendous stomach pains at times, but the diarrhoea is now bad

Very limited what I can take due to high blood pressure

This study looked at quality of life outcomes in adults with moderate‐to‐severe plaque psoriasis treated with dimethylfumarate (DMF)

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Background:
Psoriasis is a chronic inflammatory skin disease associated with quality of life (QoL) impairment. BRIDGE was a randomised, double‐blind, phase III study comparing the efficacy and safety of dimethylfumarate (DMF) with a fixed combination of fumaric acid esters (FAE) or placebo for the treatment of moderate‐to‐severe psoriasis.

Objectives:
This post‐hoc analysis investigated treatment effect on QoL overall and by patient sub‐groups categorised by disease severity. Week 8 efficacy responses were also investigated as possible predictors of Week 16 Dermatology Life Quality Index (DLQI) outcomes.

Methods:
Patients were randomised to receive a maximum daily dose of 720 mg of DMF, FAE (gradual up‐titration) or placebo for 16 weeks. Psoriasis Area Severity Index, Body Surface Area, Physician's Global Assessment and DLQI were assessed at baseline, Week 8 and 16. DLQI 0–1 indicated ‘no effect on patient life’. Associations between baseline severity,

Week 16 DLQI and Week 8 efficacy (as observed cases) were also examined.

Results:

At baseline, 671 patients were included in the full analysis set (267 randomised to DMF, 273 to FAE and 131 to placebo). DMF was superior to placebo (P < 0.001) and not significantly different to FAE regarding Week 16 DLQI outcomes (P > 0.05). Baseline disease severity did not impact DLQI outcomes at Week 16. In DMF‐ and FAE‐treated patients, Week 8 PASI 50/75 responders reported better DLQI responses at Week 16 vs non‐responders (P < 0.05). Week 8 PASI ≤3 and/or PGA 0–1 responders were also more likely to report DLQI 0–1 at Week 16 vs non‐responders (P < 0.05).

Conclusion:
DMF significantly improved DLQI outcomes versus placebo and was not affected by baseline disease severity. Efficacy responses (PASI 50/75, PASI ≤3 and PGA 0–1) as early as Week 8 were predictive of QoL outcomes at Week 16 in DMF‐ and FAE‐treated patients.