Enbrel treatment for psoriasis may be associated with an increased risk for multiple squamous cell carcinomas (SCCs), suggest results from a case series and review of the literature.

There is some prior evidence to suggest that anti-tumor necrosis factor drugs such as Enbrel may increase the risk for skin cancers such as SCC, but reports to date have been conflicting.

Writing in the International Journal of Dermatology, Jerry Brewer (Mayo Clinic, Rochester, Minnesota, USA) and colleagues describe four cases of patients with psoriasis and multiple SCCs thought to be a result of Enbrel treatment.

The patients in the series were aged 53 to 85 years and all had lifelong psoriasis. The mean time to first SCC onset was 11 months (range 1-17 months) after beginning Enbrel therapy, with all patients having between five and more than 50 SCCs in total and three of the four patients having aggressive grade III or IV SCCs.

The four psoriasis patients did not have a family history of skin cancer, but all four had previously had SCCs before using Enbrel.

Brewer and team reviewed the literature to evaluate previous reports of links between Enbrel and SCC. They found four further reports of psoriasis patients (n=10) who were treated with Enbrel going on to develop SCC, in one case in addition to non-Hodgkin lymphoma.

In contrast, another study found no increased risk for SCC with Enbrel treatment in 1440 patients with psoriasis. In addition, mice deficient in tumor-necrosis factor-α were shown to be resistant to skin cancer in a further study.

"Although some studies suggest there is no increased risk of cutaneous malignancy in patients treated with Enbrel, more research is needed to better characterize the effect of Enbrel on the development of SCCs in patients with psoriasis," say Brewer and co-authors.

"Until further research is available, sun-protective behavior, education into skin cancer prevention, and regular self-examinations and dermatologic examinations are warranted for patients with psoriasis treated with Enbrel," they conclude.

Source: medwire-news.md

I'm wondering if others have had this with their skin, I find it a little worrying!

I have found some strange patterns with my skin, dots going in lines across my body!!
My first lot was a diagonal line from my side (up near breast) comming down across my stomache towards my groin!
I have noticed it on the back of my thigh, and a new line of dots going from the bottom of my ear comming down diagonally accross my neck!!

I spoke to my skin nurse and explained that I had also hurt my hip on the side where the P was comming across stomache, she and a few others said that there is a nerve that runs there and my P was along that line.

I have Koebnerization (cuts turn to P) so can hurt nerves also cause P to come up?

Has anyone else seen similar to this? P along nerve area's
My other thought is that it's something work related.......getting jumped on by over excited dogs!!!

x

Sorry if you have this in old threads.

Is there a blood test that rules out P.A? Ill go online shortly...

I am questioning it because i am still nervous about going on drugs, as i may want to get pregnant.
My other question is If you don't have PA, then is the prognosis for
rheumatoid arthritis attacking the ligaments, tendons etc;. the same?
So, possibly one might buy some time without the drugs.

Thanks

Best regards,
LL

Just took a look at psoriasis dot org, an american website on psoriasis.
Did not get a well impression. The impression is more that is in fact is driven by pharmacy and that they have all cures and knowledge.
And you and I know that that is impossible and certainly not true.
Bit of an arrogant impression so to feel.

They also have a forum talkpsoriasis dot org, don't know if that is something valuable.

Just curious of anyone had any success with a particular medicine or protocol.

Thx

LL

private messages welcome.

Moberg Derma AB (STO: MOB) has entered into a distribution agreement with Menarini Group for Emtrix® – for discolored and damaged nails caused by nail fungus (onychomycosis) or nail psoriasis. Under the agreement Menarini’s OTC Division is granted exclusive rights to market and sell Emtrix® in Italy under the trademark YouDerm Emtrix®.

“The agreement is part of our international commercialization of Emtrix®. As the leading Italian pharmaceutical group, ranked 34th in the world, Menarini is well positioned to make Emtrix® a success in Italy. Emtrix® will now be marketed in all large markets in Europe, in US and Australia”, says Peter Wolpert, President and CEO of Moberg Derma.

About Emtrix® and nail disease
Emtrix® is a topical treatment used to treat nail disease. Launched in the Nordic region in autumn 2010, it quickly became market leader. Emtrix® is a prescription free, over-the-counter product sold under the name Nalox™ in certain markets and under the name Kerasal® Nail in the U.S. Safety and efficacy have been demonstrated in several clinical studies including more than 600 patients. Emtrix® has a unique and rapid mechanism of action which brings visible improvements within 2-4 weeks of treatment. Nail fungus is the most common nail disease and afflicts approximately 10% of the general population and increasing with age. The estimated global market potential exceeds USD 1 billion. The untapped potential is significant since many patients remain untreated. It is generally recognized that there is a need for new efficacious and safe topical treatments.

About Moberg Derma
Moberg Derma AB (publ), based in Stockholm, develops patented topical pharmaceuticals for the treatment of common disorders through the use of innovative drug delivery. The company’s products are based on proven compounds, which reduce time to market, development costs and risk. Moberg Derma’s first product Nalox™/Emtrix® - for nail disorders - became the Nordic market leader directly after launch in autumn 2010 and international launch is ongoing. The portfolio includes approved and launched products to projects in the preclinical and clinical phase. The company began operations at the Karolinska Institute in Stockholm in 2006.

About Menarini Group
The Menarini Group celebrates it’s 125thAnniversary this year and is the leading Italian pharmaceutical group in the world, ranking 15thout of 4,881 companies in Europe*and 34thout of 14,051 companies in the world* (*Sources:  IMS World Review 2010, IMS World Review Pack 2010 per number of companies).  The Group’s 2010 global turnover was 3,031 million Euro. In 2010 the number of employees was 12,890 (91% of which graduates and technicians). The Menarini Group has always pursued two strategic objectives: Research and Internationalisation, both of which have allowed them to achieve outstanding results in today’s global market and to invest in the research of innovative drugs, making them available to patients all around the world.

Source: mobergderma.com

MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) announced today that Janssen Biotech, Inc. (formerly Centocor Ortho Biotech, Inc.) has initiated a phase 2 clinical trial in psoriasis patients with the HuCAL-derived antibody CNTO 1959. The event triggered a clinical milestone payment to MorphoSys. Further financial details were not disclosed.


“With every clinical milestone and every new phase 2 start the time where the first HuCAL-based antibody drug could enter the market gets closer. MorphoSys’s antibody pipeline has substantially matured over the last 18 months,” commented Dr. Marlies Sproll, Chief Scientific Officer of MorphoSys AG.


In total, MorphoSys’s clinical pipeline now comprises nine partnered programs in phase 1 and seven in phase 2 development as well as the Company’s proprietary programs MOR103, which is in a phase 1b/2a trial for rheumatoid arthritis, MOR208, which is in a phase 1 trial for chronic lymphocytic leukemia and MOR202, which is in a phase 1/2a trial for multiple myeloma.


About MorphoSys:
MorphoSys developed HuCAL, the most successful antibody library technology in the pharmaceutical industry. By successfully applying this and other patented technologies, MorphoSys has become a leader in the field of therapeutic antibodies, one of the fastest-growing drug classes in human healthcare. The company’s AbD Serotec unit uses HuCAL and other antibody technologies to generate superior monoclonal antibodies for research and diagnostic applications.

Together with its pharmaceutical partners, MorphoSys has built a therapeutic pipeline of more than 70 human antibody drug candidates for the treatment of cancer, rheumatoid arthritis, and Alzheimer’s disease, to name just a few. With its ongoing commitment to new antibody technology and drug development, MorphoSys is focused on making the healthcare products of tomorrow.

Source: morphosys.com

Hi all.
Although I don't suffer from it much myself now, it is in the family coming from my mothers side, I do get Psoriasis in my hair from time to time and find that shampooing it at least every two days holds it in check. Having a very positive attitude to life is very useful.
One product which I have discovered here in France is natural olive oil soap, not only for Psoriasis but any heat rash related fungal infections like under the arms. We have used soap nuts for all our washing for a number of years and thoroughly recommend it, another very good natural cream is Karite butter, in the UK it is known as shea butter very thick so mix with sweet almond oil. sourced from Akamuti
Sorry if I have repeated some things already online but have only just joined.

Just thought I would share,

I just has my 4th - first session of UVB

I hope I'm doing the right thing by having more, it's always scary when a treatment stops.

But I'm trying to stay positive, I gave up smoking 6 weeks ago and I'm hoping this with the UVB will give me a longer remission

(the top of my back started to clear a little while ago!!)


just one Q, can my work force me to change my day off to fit one of the treatments in? UVB clinic is mon and Thurs my day off is Tues I work weekends too!!


x

The most poisonous substance on Earth could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases. Botox is already used medically in small doses to treat certain nerve disorders and facial wrinkles.

Edwin Chapman and colleagues explain that toxins, or poisons, produced by Clostridium botulinum bacteria, cause of a rare but severe form of food poisoning, are the most powerful toxins known to science.

Doctors can inject small doses, however, to block the release of the neurotransmitters, or chemical messengers, that transmit signals from one nerve cell to another. The toxins break down a protein in nerve cells that mediates the release of neurotransmitters, disrupting nerve signals that cause pain, muscle spasms and other symptoms in certain diseases. That protein exists not just in nerve cells, but in other cells in the human body. However, these non-nerve cells lack the receptors needed for the botulinum toxins to enter and work.

Chapman’s group sought to expand the potential use of the botulinum toxins by hooking it to a molecule that can attach to receptors on other cells.

Their laboratory experiments showed that these engineered botulinum toxins do work in non-nerve cells, blocking the release of a protein from immune cells linked to inflammation, which is the underlying driving force behind a range of diseases. Such botulinum toxin therapy holds potential in a range of chronic inflammatory diseases and perhaps other conditions, which could expand the role of these materials in medicine.

Get your favourite RSS reader. I use the Brief feed reader add-on with Firefox, but there are many others you can use and some email clients let you set them up.

Now you want your feeds. you can find them whilst on Psoriasis Club via your feed reader or you can click RSS Syndication at the foot of the home page and make your own. *Note: the latter will only find the thread version, to get the post version add 2 after syndication.

Now you choose which version you want:

This one gives you new threads: https://psoriasisclub.org/syndication.php?limit=15

This one gives you new posts: https://psoriasisclub.org/syndication2.php?limit=15

*Change the limit=** to the umber of threads/posts you want.

Click them and you will see the difference. *Note: Members only posts are shown if you are logged in. if you log out you will see the same as guests.

There you go you have the Psoriasis Club RSS feed.

Hi everyone,
Thought I would introduce myself and my Psoriasis story!!

I've had Psoriasis since I was 4years old (although after my flare cleared when I was 4 I only had it on my elbows for years)

When I was about 17 I had a major flare (I started training to be an aircraft engineer which was extremely stressful and my sister started to have suicidal tendencies another stress)

About the age of 20 my skin was doing well and was mainly affecting my knee's and elbows, but it wasn't to be for long

I'm now 26 and still covered in the stuff.

My treatments so far have been all the lotions and potions which turns out I'm allergic to pretty much all of them including things like E45 and diprobase, and any other cream starting with D
3 lots of UVB, 2 courses of methotrexate, and 2 courses of cyclosprin.
I'm starting another round of UVB on monday, I'm not expecting miricles just a little while of less vacumming!!

I left all my aircraft stuff behind as to stressful and I now work for an animal rescue center, I work with the dogs - training and rehoming and loving them.

I also have a wonderful Husband who is so supportive and helps me to stay strong in difficult times. I wouldn't say I'm totally depressed about my skin I don't mind so much especially in winter when it's ok to cover up I just need paper bags to come into fashion now for my face LOL

For me my challange now is just getting through the pain my skin brings me!


Hope to get to know some of you

Hanna x

When I'm Tweeting threads on @Psoriasisclub I sometimes like to think of something positive to tweet.

Here are a few I remember doing:

Quote:If I didn't have psoriasis I wouldn't know so many great people around the world

Quote:I may be flaky on the outside but just like you I'm soft in the middle

Quote:Psoriasis is not contagious you CAN use that shopping trolley after me. your hands will not fall off I promise!

Idera Pharmaceuticals, Inc. (NASDAQ: IDRA) today announced the receipt of verbal notification from the Food and Drug Administration (FDA) that the company may proceed with a Phase 2 clinical trial of IMO-3100 in patients with psoriasis based on a trial protocol submitted by the company in October 2011. IMO-3100 is a dual antagonist of Toll-like receptor (TLR) 7 and TLR9 and is in clinical development as a potential therapy for autoimmune and inflammatory diseases.

“We are pleased to have the FDA’s notification that we can proceed with a Phase 2 clinical trial of IMO-3100 in patients with psoriasis,” said Sudhir Agrawal, D.Phil., Chairman and Chief Executive Officer of Idera. “We are now preparing for this Phase 2 trial of our novel dual-TLR antagonist for the treatment of autoimmune diseases and expect to initiate the study in the first half of 2012.”

Idera has selected psoriasis as the initial indication for the first clinical evaluation of IMO-3100 in patients with autoimmune disease. In July 2011, the company submitted a Phase 2 protocol to evaluate IMO-3100 in patients with psoriasis over a 12-week treatment period. As previously announced, this protocol was put on clinical hold by the FDA. In October 2011, the company submitted a new Phase 2 protocol to evaluate IMO-3100 in patients with psoriasis over a 4-week treatment period, for which the company has received notification of FDA authorization to proceed.

About IMO-3100
IMO-3100, an antagonist of TLR7 and TLR9, is a lead clinical candidate in development to treat autoimmune and inflammatory diseases. IMO-3100 is designed to block production of multiple cytokines induced through TLR7 and TLR9. In contrast, many current autoimmune disease treatments aim to block the activity of individual cytokines. IMO-3100 has demonstrated potent activity in reducing pathologic and immunologic manifestations in preclinical mouse models of diseases such as lupus, arthritis, psoriasis and hyperlipidemia. Phase 1 clinical trials of IMO-3100, including an escalating single-dose study and a multiple-dose study, have been completed in healthy subjects.

Source: iderapharma.com

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You have had psoriasis for a number of years and have tried all the prescribed treatments, you have tried all the over the counter drugs, you have tried a diet and life style change, you even fell for the con artist out there and parted with your hard earned cash trying to be rid of psoriasis.

One day you wake up with an idea buzzing around your head that you think could work. After all these years you hadn’t noticed that the cure for psoriasis was staring you in the face! You go about collecting the things you need to mix up a potion and after a few failed attempts; you think you have finally got it right.

OK let’s not get too carried away with it all. You have to try it first before telling anyone. So you start using your potion in small doses as well as keeping a diary of the trials. This goes on for about a year and you haven’t said a word to anyone.
So your potion works. After 2 months you were completely clear and had stopped taking the potion. You can’t believe it yourself so you share your potion with a trusted friend who also gets clear in two months.

You both remain clear and for around 5 years and decide you must share this with the world. But where to start? Should you form a company, should you get a patent, should you even try Dragons Den? Damn all this worry is enough to bring on a flare up. But it doesn’t, you are both still clear.

The cure that everyone has been looking for exists and you and your friend have it. You want to share it with the world for free, it’s easy to make at home and anyone with your instructions could make it. Your friend however wants to sell it and make lots of money; after all it’s got to be worth anyone with psoriasis paying €100 to be clear for the rest of their life.
Luckily you and your friend still get on very well and you both decide to sit down and discuss it. After a few days your friend tells you he has contacted four of the big drug manufacturers to ask if they would be interested in a psoriasis cure. You are livid; you wanted it to be free to the world and just wanted to see everyone cured of psoriasis. 

Within a few days you have offers from the big four drug companies, they are all interested but they all want it removed from the market. They have sent you and your friend an offer of One Hundred Million to remove it from the market, destroy any notes, and never talk about it again. If you break the contract they will take you to court for Two Hundred Million.

So what do you do? Would you say no to One Hundred Million, if you did could you trust your friend? Or would you just give it to the whole world for free and watch the big four drug manufacturers run it into the ground with false allegations about how your potion can kill people!

P.S No I haven’t developed a potion. If I had do you think I would be sitting here typing this with my stiff flaky fingers?

T Cells are like Soldiers in your body and their job is to protect you from Viruses, Infections and Foreign Substances.

Cell and Function
B-cell: Production of antibodies
Helper T cell: Helps B-cells in their function
Helper Th2: Helps B-cells
Helper Th1: Helps Cytotoxic T cells
Cytotoxic T cell: Kills and damages the antigens

The dutiful soldiers get into action the moment any foreign substance or agent enters our body. Thereby the immune system is activated. The end result is the elimination of the substance or agent from our bodies.

Usually your Soldiers will just go about their business without you knowing about it, but should you have psoriasis then things go wrong with your army.

Private T cell thinks he knows best and gets a bit carried away with his job. Somehow he gets in your skin, which is not his job. He spots a skin injury and off he goes! He stimulates B cells and other white blood cells into attack mode.
Also amongst his weapons he can stimulate the production of powerful immune factors called cytokines. In small amounts, cytokines are very important for healing. However, a high level of cytokines causes your skin cells to reproduce at a faster rate. This in turn creates a pile of dead skin that Private T Cell thinks are more enemies, and so the cycle begins.

Normally private T cell is very well regimented and obeys his orders, but you and me have inherited in our genetics, some rouge soldiers that have been waiting around for us to have a slight injury, emotional stress, or an infection so he can come out and go wild with his weapons.

Someone throw that soldier in the Cooler!

Hey everyone, been to see my parent's for a couple of weeks but glad to be back home.
Hope everyone is ok, I have had to endure numerous John Wayne films from my aged Father, so I have been bored stupid, but it is still nice to see them, and also nice to be home again.
Regards to all,
Micky.

A new study in Sweden shows high risk of pulmonary embolism in people with psoriasis and other autoimmune disorders.

Background:
Some autoimmune disorders have been linked to venous thromboembolism. We examined whether there is an association between autoimmune disorders and risk of pulmonary embolism.

Methods:
We followed up all individuals in Sweden without previous hospital admission for venous thromboembolism and with a primary or secondary diagnosis of an autoimmune disorder between Jan 1, 1964, and Dec 31, 2008, for hospital admission for pulmonary embolism. We obtained data from the MigMed2 database, which has individual-level information about all registered residents of Sweden. The reference population was the total population of Sweden. We calculated standardised incidence ratios (SIRs) for pulmonary embolism, adjusted for individual variables, including age and sex.

Findings:
535 538 individuals were admitted to hospital because of an autoimmune disorder. Overall risk of pulmonary embolism during the first year after admission for an autoimmune disorder was 6·38 (95% CI 6·19—6·57). All the 33 autoimmune disorders were associated with a significantly increased risk of pulmonary embolism during the first year after admission. However, some had a particularly high risk—eg, immune thrombocytopenic purpura (10·79, 95% CI 7·98—14·28), polyarteritis nodosa (13·26, 9·33—18·29), polymyositis or dermatomyositis (16·44, 11·57—22·69), and systemic lupus erythematosus (10·23, 8·31—12·45). Overall risk decreased over time, from 1·53 (1·48—1·57) at 1—5 years, to 1·15 (1·11—1·20) at 5—10 years, and 1·04 (1·00—1·07) at 10 years and later. The risk was increased for both sexes and all age groups.

Interpretation:
Autoimmune disorders are associated with a high risk of pulmonary embolism in the first year after hospital admission. Our findings suggest that these disorders in general should be regarded as hypercoagulable disorders.

Source: thelancet.com

In the dumps at the moment.I cannot believe this has happened to me in my 70s.i could cheerfully cut my head off.My scalp is giving me so much trouble.The Xamiol the Dr prescribed has made my head worse i have short fair hair and you would think i had been scalded.So now i have decided to stop all the treatment and see what happens.Also stopped the Dovobet on my body.The horrible red patches are sprouting up like mushrooms in the dark.Oh woe is me what a winge i am in fact family are calling me grumpy gertie