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Psoriasis Club › HealthHealth Boards › Psoriasis In The News v
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Tremfya & Skyrizi in psoriasis patients with HIV

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Tremfya & Skyrizi in psoriasis patients with HIV
Fred Offline
I Wanted To Change the World But Got Up Far Too Late.
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Treatment: Bimzelx / Coconut Oil
#1
News  Thu-03-04-2025, 15:57 PM
This retrospective cohort study evaluated the clinical outcomes of HIV-positive patients undergoing anti-IL-23 therapy in real-world settings at the Dermatology Units of four leading reference centres in Northern Italy for the treatment of psoriasis.

Quote:
HIV-positive patients with psoriasis often face delays in accessing biologic therapies due to their exclusion from clinical trials and concerns about the impact of immunomodulatory drugs on viral replication.

Anti-IL-23 therapies, such as risankizumab and guselkumab, have shown great promise thanks to their strong efficacy and favourable safety profiles.

A case series from four Italian centres reported sustained effectiveness of these drugs, with no observed effects on viral replication or immune parameters in HIV-positive patients. Although the number of cases is limited, these therapies appear to be a compelling option for patients with extensive or treatment-resistant psoriasis.

Source: onlinelibrary.wiley.com

*Funding: The authors received no specific funding for this work.

Tremfya (guselkumab)

Skyrizi (risankizumab)
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