AbbVie to take Nimbles IL23R for psoriasis

[Fred]

AbbVie have paid $200 million to get Nimble Therapeutics investigational oral peptide IL23R inhibitor in preclinical development for the treatment of psoriasis.

Quote:

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IL-23 is a cytokine that activates Th17 cells, promoting an inflammatory response that contributes to tissue damage and organ dysfunction.

IL-23R is a receptor involved in the IL-23/IL-17 immune pathway, crucial in the pathogenesis of psoriasis and IBD. Upregulation of IL-23R expression is associated with increased susceptibility to IL-23 signaling, amplifying inflammation and immune responses in psoriasis and inflammatory bowel diseases (IBD), and underpinning the significant clinical efficacy of IL-23 blocking antibodies in these diseases. IL-23R antagonists block the interaction between IL-23 and its receptor, inhibiting the Th17 inflammatory pathway, cytokine production and IL23R upregulation, alleviating inflammation.

We are developing an innovative oral IL-23R antagonist by combining potent activity with gut stability and extended half-life. This medication will offer a more effective oral therapy option for patients seeking less invasive, more effective and convenient treatments.

 

Source: nimbletherapeutics.com

[mataribot]

I don’t see how an oral option for IL23 is going be better than the biologics. My guess it’s going to be worse overall. But guess will have to wait and see.

[Caroline]

I don’t see how an oral option for IL23 is going be better than the biologics. My guess it’s going to be worse overall. But guess will have to wait and see.

Depends on how effectively is will pass the bowel into the body I guess. I love the idea of oral medication versus injections.

[Fred]

I don’t see how an oral option for IL23 is going be better than the biologics. My guess it’s going to be worse overall. But guess will have to wait and see.

Depends on how effectively is will pass the bowel into the body I guess. I love the idea of oral medication versus injections.

Yes only time will tell, but I prefer injections. Having said that there isn't much else for me to try, so if it came down it I would have to try but I've found 23s are not so good.

[Forest Walker]

If an oral worked as well as an injection, it would eliminate a lot of waste in both manufacture and disposal of syringe and pen.

[mataribot]

It’s much easier to take a shot every month or so vs having to take a pill daily. If the adverse side effects are worse than shots, I don’t see many Dermatologists prescribing them here in US. I wonder what the dosing scheme will be…

[Fred]

It’s much easier to take a shot every month or so vs having to take a pill daily.

Yep I agree.

[Caroline]

It’s much easier to take a shot every month or so vs having to take a pill daily.

Yep I agree.

Well I can’t add to that as I have never had injections, only pills, which I consider as easy and so not longing for injections.

[Kat]

I don't find a pill or an injection easier than the other to be honest. There could be arguments (as far as ease) on which is best but I would imagine that it comes to personal preference.

[mataribot]

Shots get a bad reputation because of auto injections and lack of training on how to administer them. There’s very little to no pain involved with syringes if done correctly.