Psoriasis Club
  • Forum
  • Home
  • Portal
  • Member List
  • Psoriasis Score
  • PQOLS
  • What is psoriasis
  • Search
  • Help
Hello Guest, Welcome To The Psoriasis Club Forum. We are a self funded friendly group of people who understand.
Never be alone with psoriasis, come and join us. (Members have more privileges)
wave
Login Register
Login
Username:
Password:
Lost Password?
 
Psoriasis Club › HealthHealth Boards › Psoriasis In The News v
« Previous 1 2 3 4 5 … 47 Next »

Drug survival for methotrexate in psoriasis patients

Threaded Mode
Drug survival for methotrexate in psoriasis patients
Fred Offline
I Wanted To Change the World But Got Up Far Too Late.
Moderator
Posts: 54,251
Threads: 3,446
Joined: Aug 2011
Gender: Male
Location: France
Psoriasis Score: 1
Psoriatic Arthritis Score: 2
PQOLS: 2
Treatment: Ilumetri / Coconut Oil
#1
News  Thu-20-05-2021, 20:26 PM
This study evaluated drug survival for methotrexate (MTX) monotherapy in patients with plaque psoriasis.

Quote:
Background:
Drug survival is useful to evaluate long-term drug performance in daily practice. The aim of this study was to evaluate drug survival for methotrexate (MTX) monotherapy in patients with plaque-type psoriasis.

Methods:
We reviewed 3,512 follow-up charts of patients with psoriasis at five tertiary referral centers between January 2012 and January 2020. We analyzed baseline data and treatment outcomes of patients under MTX monotherapy. Drug survival was analyzed using Kaplan-Meier and Cox regression analyses.

Results:
Patients with psoriasis who were treated with MTX monotherapy were enrolled (N = 649). The median duration of drug survival was 15 months (95% CI: 13.2–16.8). The overall drug survival rate was 54.7%, 17.4%, and 8% after 1, 3, and 5 years, respectively. The main reasons for discontinuation were adverse effects (n = 209, 32.2%) and inefficacy (n = 105, 15.6%). Based on multivariate Cox regression analysis, the presence of nausea/vomiting (HR: 2.01, 95% CI: 1.49–2.71; P < 0.001) was observed as a statistically significant risk factor for drug discontinuation. Age over 50 years (HR: 0.68, 95% CI: 0.48–0.97; P = 0.03) and using MTX dose ≥15 mg/weekly were positive predictors for drug survival (HR: 0.72, 95% CI: 0.54–0.95; P = 0.02).

Conclusions:
The average drug survival of MTX was 15 months. MTX is still the first-line treatment of moderate-to-severe plaque psoriasis, as highlighted in guidelines. To prevent premature discontinuation, physicians need to look at the response time of at least 16–24 weeks, especially when a stepwise dose increment is used. The presence of nausea/vomiting seemed to be associated with an approximately twofold risk of discontinuation.

Source: onlinelibrary.wiley.com

*Early view funding unknown
Quote
Caroline Offline
You must hurry if you ever want to catch a chicken...
*
Forum Helper
Posts: 19,998
Threads: 92
Joined: Nov 2011
Gender: Female
Location: In between the tulips
Psoriasis Score: 3
Psoriatic Arthritis Score: 3
PQOLS: 4
Treatment: Got back to DMF slow release
#2
Thu-20-05-2021, 21:06 PM
That is a average that is a lot shorter than I had thought.
Quote
jiml Offline
Forum Helper
*
Forum Helper
Posts: 47,609
Threads: 355
Joined: Oct 2013
Gender: Male
Location: Norwich England
Psoriasis Score: 3
Treatment: Skilarence 5x120mg a day
#3
Thu-20-05-2021, 21:16 PM
I would have guessed a short duration on methotrexate as it mirrors my experience of nausea and sickness I don't think I made a year on it myself
Quote
Caroline Offline
You must hurry if you ever want to catch a chicken...
*
Forum Helper
Posts: 19,998
Threads: 92
Joined: Nov 2011
Gender: Female
Location: In between the tulips
Psoriasis Score: 3
Psoriatic Arthritis Score: 3
PQOLS: 4
Treatment: Got back to DMF slow release
#4
Thu-20-05-2021, 21:21 PM (This post was last modified: Thu-20-05-2021, 21:23 PM by Caroline. Edited 1 time in total.)
(Thu-20-05-2021, 21:16 PM)jiml Wrote: I would have guessed a short duration on methotrexate as it mirrors my experience of nausea and sickness I don't think I made a year on it myself

My personal experience was much much shorter, but I regularly hear from people who use it for a very long time.
But I see in the writing, that drug survival with people over 50, is more positive.
Quote
KatT Offline
100 + Member I Just Cant Stop !

100 + Member I Just Cant Stop !
Posts: 5,479
Threads: 42
Joined: Sep 2019
Gender: Female
Location: Canada
Psoriatic Arthritis Score: Off the chart!
Treatment: Simponi + hydroxychloroquine
#5
Thu-20-05-2021, 22:07 PM
I had no side effect whatsoever and was on it for a little over a year

I stopped because my dermatologist at the time wanted to send me for a liver biopsy....just as a precaution.

Went back on it after a year break but wasn't doing anything for my PSA.
Quote
Caroline Offline
You must hurry if you ever want to catch a chicken...
*
Forum Helper
Posts: 19,998
Threads: 92
Joined: Nov 2011
Gender: Female
Location: In between the tulips
Psoriasis Score: 3
Psoriatic Arthritis Score: 3
PQOLS: 4
Treatment: Got back to DMF slow release
#6
Thu-20-05-2021, 22:23 PM
(Thu-20-05-2021, 22:07 PM)KatT Wrote: I had no side effect whatsoever and was on it for a little over a year

I stopped because my dermatologist at the time wanted to send me for a liver biopsy....just as a precaution.

Went back on it after a year break but wasn't doing anything for my PSA.

I am not amazed that it did nothing for your Psoriatic Arthritis.
There is a publication of a research in Rheumatology. 2012;51(8), that says that MTX is useless with Psoriatic Arthritis. Strange enough all Rheumatologists inevitable start with giving MTX.
Now I must say, that there are people with PSA, who do seem to have positive results with it, but me also I did not have any positive effect out of it, only negative ones, exactly as this drug survival publication states.
Quote
Turnedlight Offline
100 + Member I Just Cant Stop !

100 + Member I Just Cant Stop !
Posts: 3,524
Threads: 41
Joined: Apr 2015
Gender: Female
Location: Uk
Treatment: Benepali
#7
Fri-21-05-2021, 09:55 AM
That is about how long it worked for me.

I stopped because it stopped actually working and my P got worse despite trying higher doses of mtx towards the end.
Quote
D Foster Offline
“You only live once, but if you do it right, once is enough.”

100 + Member I Just Cant Stop !
Posts: 19,764
Threads: 16
Joined: Dec 2014
Gender: Male
Location: East Yorkshire
Treatment: Stelara 90mg and G&T
#8
Fri-21-05-2021, 14:44 PM
I stopped using it in the end as it gradually stopped working however I was five years on oral and three years on injection. It worked for me though at times it certainly caused problems like nausea . I had blood tests every twelve weeks and liver/kidney tests were fine up until the last few months before I stopped.
Quote
« Next Oldest | Next Newest »


Possibly Related Threads…
Thread Author Replies Views Last Post
News Evaluating responses to Pfizer vaccine in patients taking methotrexate & biologicals Fred 0 597 Tue-13-07-2021, 16:47 PM
Last Post: Fred
News New EU measures to avoid potentially fatal dosing errors with methotrexate Fred 10 1,778 Mon-21-06-2021, 19:16 PM
Last Post: Fred
News Methotrexate and Covid vaccine Fred 6 1,129 Fri-18-06-2021, 19:11 PM
Last Post: Caroline
News More studies needed on IL-30 in psoriasis patients Fred 0 664 Mon-03-05-2021, 21:31 PM
Last Post: Fred
News Psoriasis patients should be careful of flammable skin creams Fred 11 5,326 Sun-07-03-2021, 23:43 PM
Last Post: D Foster



Users browsing this thread: 1 Guest(s)
    Contact us | Login | Register | Home | Cookies/GDPR | Portal | Types Of Psoriasis | Psoriasis Score | Members Only Boards
    Copyright © 2010 - 2022 Psoriasis Club All Rights Reserved | Founded May 2010 | Psoriasis Club Is Self Funded Without Sponsors Or Donations | Software by MyBB
Linear Mode
Threaded Mode