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Psoriasis Club › HealthHealth Boards › Psoriasis And Psoriatic Arthritis Topics & News v
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Mirikizumab Superior to Cosentyx in phase 3 psoriasis study

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Mirikizumab Superior to Cosentyx in phase 3 psoriasis study
Fred Offline
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#1
News  Fri-17-07-2020, 20:43 PM
Makers of Taltz say their new IL 23 mirikizumab is better than Cosentyx.

Quote:
Eli Lilly announced today that mirikizumab, an investigational monoclonal antibody that binds to the p19-subunit of IL23, met the primary and all key secondary endpoints versus placebo at Week 16 (superiority) and all key secondary endpoints versus Cosentyx (secukinumab) at Week 16 (non-inferiority) and Week 52 (superiority) in the OASIS-2 study. OASIS-2 is a multicenter randomized, double-blind, placebo-controlled study comparing the efficacy and safety of mirikizumab to placebo and Cosentyx in patients with moderate to severe plaque psoriasis.

The safety profile was consistent with previously disclosed results for mirikizumab and known safety findings of other drugs in the IL23p19 class.

"The results from this study are promising to people around the world who are burdened by psoriasis and Lilly is grateful to the patients, providers and investigators for advancing science to benefit patients with immunologic conditions," said Patrik Jonsson, senior vice president and president of Lilly Bio-Medicines. "We look forward to bringing mirikizumab to market to provide patients with an additional treatment option that has the potential to provide near complete or complete skin clearance as measured by PASI 90 and PASI 100, with sustained results at 52 weeks."

"We are pleased with the positive results observed in the mirikizumab psoriasis development program (OASIS). Mirikizumab has the potential to be a meaningful treatment option for people living with psoriasis," said Andrew Blauvelt, M.D., M.B.A., president of Oregon Medical Research Center and a lead investigator in the OASIS program. "The data builds on our understanding of IL-23 inhibition in psoriasis and possible future applications."

In OASIS-2, the primary endpoints were the proportion of patients with a Static Physician's Global Assessment (sPGA) of (0,1) with at least a 2-point improvement and the proportion of patients with at least a 90 percent improvement from baseline in Psoriasis Area and Severity Index (PASI 90) at Week 16 compared to placebo. Similar endpoints were evaluated at Week 16 as key secondary endpoints compared to Cosentyx. Other key secondary endpoints compared to placebo at Week 16 include the proportion of patients with at least a 75 and 100 percent improvement from baseline in Psoriasis Area and Severity Index (PASI 75/PASI 100).

Key secondary endpoints at Week 52 compared to Cosentyx included the proportion of patients with a Static Physician's Global Assessment (sPGA) of (0,1) with at least a 2-point improvement and the proportion of patients with at least a 90 and 100 percent improvement from baseline in Psoriasis Area and Severity Index (PASI 90/PASI 100).

The most common treatment-emergent adverse events (≥5%) during the induction period (up to Week 16) were nasopharyngitis and upper respiratory infections and during the combined induction and maintenance treatment periods (up to Week 52) were nasopharyngitis, upper respiratory tract infections, headache, back pain, and arthralgia. The frequency of serious adverse events was comparable across treatment arms during the induction period (<2.5%) and combined induction and maintenance periods up to 52 weeks (<6%).

Source: lilly.com
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jiml Offline
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#2
Fri-17-07-2020, 21:14 PM
That's good news if it's another bio coming on stream soon for those that have tried others and failed . Hopefully another weapon in the dermatologists armoury soon
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JohnB Offline
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#3
Sat-18-07-2020, 20:54 PM
More ammo in the box is never a bad thing.  Thumb

One  thing has always puzzled me, why are they all something-or-other- umab?
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D Foster Online
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#4
Sat-18-07-2020, 21:22 PM
In Cosentyx Lilly had set itself a low bar; cross-trial comparisons suggest that two rival anti-IL-23s, Abbvie’s Skyrizi and Johnson & Johnson’s Tremfya, would have been harder for mirikizumab to beat.
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Fred Offline Author
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#5
Sun-19-07-2020, 11:25 AM
(Sat-18-07-2020, 20:54 PM)JohnB Wrote: One  thing has always puzzled me, why are they all something-or-other- umab?

Not all are "UMAB" But without going too far off topic, my understanding is the following.

They are part of the World Health Organization system which helps recognize drugs, a bit like the Latin name of a plant or animal.

The name is split up in parts which are easily identified.

Type.

Target.

What it's made from.

The drugs unique code.
Quote
Caroline Offline
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#6
Fri-24-07-2020, 06:10 AM
(Sun-19-07-2020, 11:25 AM)Fred Wrote:
(Sat-18-07-2020, 20:54 PM)JohnB Wrote: One  thing has always puzzled me, why are they all something-or-other- umab?

Not all are "UMAB" But without going too far off topic, my understanding is the following.

They are part of the World Health Organization system which helps recognize drugs, a bit like the Latin name of a plant or animal.

The name is split up in parts which are easily identified.

Type.

Target.

What it's made from.

The drugs unique code.

Not quite ... MAB stands for Monoclonal Anti Body. The biologicals ending with this have all the same type of working.
Quote
Fred Offline Author
I Wanted To Change the World But Got Up Far Too Late.
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Posts: 46,867
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Treatment: Tremfya / Coconut Oil
#7
Fri-24-07-2020, 11:41 AM
(Fri-24-07-2020, 06:10 AM)Caroline Wrote:
(Sun-19-07-2020, 11:25 AM)Fred Wrote:
(Sat-18-07-2020, 20:54 PM)JohnB Wrote: One  thing has always puzzled me, why are they all something-or-other- umab?

Not all are "UMAB" But without going too far off topic, my understanding is the following.

They are part of the World Health Organization system which helps recognize drugs, a bit like the Latin name of a plant or animal.

The name is split up in parts which are easily identified.

Type.

Target.

What it's made from.

The drugs unique code.

Not quite ... MAB stands for Monoclonal Anti Body.  The biologicals ending with this have all the same type of working.

Yes that is what I said the MAB part is the type.
Quote
Caroline Offline
You must hurry if you ever want to catch a chicken...
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#8
Fri-24-07-2020, 12:04 PM (This post was last modified: Fri-24-07-2020, 12:05 PM by Caroline. Edited 1 time in total.)
(Fri-24-07-2020, 11:41 AM)Fred Wrote:
(Fri-24-07-2020, 06:10 AM)Caroline Wrote:
(Sun-19-07-2020, 11:25 AM)Fred Wrote:
(Sat-18-07-2020, 20:54 PM)JohnB Wrote: One  thing has always puzzled me, why are they all something-or-other- umab?

Not all are "UMAB" But without going too far off topic, my understanding is the following.

They are part of the World Health Organization system which helps recognize drugs, a bit like the Latin name of a plant or animal.

The name is split up in parts which are easily identified.

Type.

Target.

What it's made from.

The drugs unique code.

Not quite ... MAB stands for Monoclonal Anti Body.  The biologicals ending with this have all the same type of working.

Yes that is what I said the MAB part is the type.

Five I see now, you went from right to left. Big Grin
Quote
Fred Offline Author
I Wanted To Change the World But Got Up Far Too Late.
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Posts: 46,867
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#9
Fri-24-07-2020, 12:07 PM
(Fri-24-07-2020, 12:04 PM)Caroline Wrote:
(Fri-24-07-2020, 11:41 AM)Fred Wrote:
(Fri-24-07-2020, 06:10 AM)Caroline Wrote:
(Sun-19-07-2020, 11:25 AM)Fred Wrote:
(Sat-18-07-2020, 20:54 PM)JohnB Wrote: One  thing has always puzzled me, why are they all something-or-other- umab?

Not all are "UMAB" But without going too far off topic, my understanding is the following.

They are part of the World Health Organization system which helps recognize drugs, a bit like the Latin name of a plant or animal.

The name is split up in parts which are easily identified.

Type.

Target.

What it's made from.

The drugs unique code.

Not quite ... MAB stands for Monoclonal Anti Body.  The biologicals ending with this have all the same type of working.

Yes that is what I said the MAB part is the type.

Five  I see now, you went from right to left.  Big Grin

Yes so as to explain the MAB Smile
Quote
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