Cosentyx gives long-lasting inhibition of radiographic progression in PsA

[Fred]

This trial investigated the effect of Cosentyx on the signs and symptoms of psoriatic arthritis (PsA) and the inhibition of radiographic progression of PsA.

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Novartis announced today new data from the FUTURE 5 trial showing no radiographic progression (mTSS <0.5) in almost 90% of psoriatic arthritis (PsA) patients treated with Cosentyx® (secukinumab) 300mg over 2 years.

"Half of patients with psoriatic arthritis experience bone erosion within approximately two years. Left untreated, this can lead to irreversible joint damage and disability, having a substantial impact on quality of life," said Dr. Philip J. Mease, Director of Rheumatology Research, Swedish Medical Center/Providence St Joseph Health and Clinical Professor, University of Washington School of Medicine, Seattle, WA. "The availability of a treatment that is proven to inhibit progression of psoriatic arthritis through two years gives physicians and patients more choice in the management of this debilitating condition."

The trial investigated the effect of Cosentyx on the signs and symptoms of PsA, in addition to inhibition of radiographic progression of PsA. These data demonstrate that 89.5% (300mg), 82.3% (150mg) and 81.1% (150mg no loading dose [LD]) of PsA patients treated with Cosentyx found no radiographic progression at 2 years. Clinical responses, such as American College of Rheumatology criteria (ACR20/50) and Psoriasis Area and Severity Index (PASI 90/100) were also maintained through 2 years, with 77% of Cosentyx 300mg patients achieving ACR20, 51.9% ACR50, 70.1% PASI 90 and 49.5% PASI 100. Results were also achieved at the lowest dose of Cosentyx 150mg (79.4% ACR20, 52.6% ACR50, 59.2% PASI 90 and 44.2% PASI 100)[1]. These data are being presented at the Annual European Congress of Rheumatology (EULAR) on 12-15 June in Madrid, Spain.

"We are continuing to reimagine psoriatic arthritis therapy to improve patients' lives and provide a treatment option that addresses multiple manifestations and inhibits disease progression," said Eric Hughes, Global Development Unit Head, Immunology, Hepatology and Dermatology. "These data further reinforce Cosentyx as a comprehensive treatment that's backed by over 100 studies, including five-year data across psoriasis, psoriatic arthritis and ankylosing spondylitis."

Source: novartis.com

[jiml]

That makes great reading if it does halt or slow bone erosion in patients for two years
I'm guessing it's not possible to give long term results as it is such a new drug, but it certainly is good news

Related to this do other bios and methotrexate and dmf have the same effect on bone erosion or do most drugs that control it  just mask the symptoms

[Fred]

Related to this do other bios and methotrexate and dmf have the same effect on bone erosion or do most drugs that control it  just mask the symptoms

Goog question Jim, I don't know the answer but can confirm that Cosentyx is the best thing I have ever had for psoriatic arthritis.