Tremfya gets FDA approval for psoriasis treatment

[Fred]

Is there still no formal word on its effecacy in treating PsA Fred? Or is it targeting the wrong IL to help with PsA

The study for psoriatic arthritis is still going on, they usually get psoriasis done first and then go for psoriatic arthritis. It targets interleukin 23 whereas Cosentyx and Taltz target interleukin 17.

It remains to be seen if 23 is the right target or not, but it made sense for them to go for it as Stelara their other Bio aims at 12 and 23.

I'm sure they will go for psoriatic arthritis as Cosentyx is knocking Stelara off the top shelf so to speak and they will need something to cut their losses.

That won’t work. Il-17 is "the" psoriatic arthritis interleukin.

That is my thought to, but I think they are still playing around to find one that works for both.

I need a cross between Cosentyx and Stelara.

[jiml]

But stelara worked wonders on your PSA for years didn't it Fred

[Fred]

But stelara worked wonders on your PSA for years didn't it Fred

No not wonders Jim. It was excellent for the psoriasis and that had the knock on effect of helping the psoriatic arthritis. It was never as good as say Enbrel, but I could no longer take the TNF's.

I would say Stelara was the best thing ever for psoriasis, and  Coesntyx has been the best thing ever for psoriatic arthritis. But neither have given me a 100% result on what I would like to achieve.  

I can see why you questioned that as my old thread about Stelara will show how I was happy for over 6 years, but now having tried Coesntyx for almost 1 year my views are different.

What I need (and I'm guessing we all do) is something that will rid us of psoriasis and psoriatic arthritis in one, and in a simple form. That however is still a long way away as far as I'm concerned. It's not till you are riddled with both psoriasis and psoriatic arthritis that takes over your life that you find just a little bit of respite is wonderful in between treatments.

I'm sure one day it will come and it may be a little too late for me, but the future is bright for the young people with psoriasis and psoriatic arthritis. I will howver say that the future Is the Bio's and nothing else will ever compete.

*Just my opinion

[jiml]

No I agree with you that bios will be the way forward ....I thought that Stelara had unlocked your PSA ...that's why I mentioned it ...there will be a bio eventually that will hit the right cells of that there is no doubt the pharma companies are working on it.... I'm sure the first one to make one that fits all will make a fortune

[Fred]

No I agree with you that bios will be the way forward ....I thought that Stelara had unlocked your PSA ...that's why I mentioned it ...there will be a bio eventually that will hit the right cells of that there is no doubt the pharma companies are working on it.... I'm sure the first one to make one that fits all will make a fortune

I can see where you are coming from Jim looking at my old posts. But no Stelara never really unlocked the psoriatic arthritis, it certainly helped but I think in hindsight it was getting rid of the psoriasis that had a knock on effect. Cosentyx is the complete opposite for me, it's wiped out the psoriatic arthritis but isn't doing so well on the psoriasis. I'm hoping that will change.

[jiml]

Sorry I've gone

[Fred]

Update: The European Commission has approved Tremfya (guselkumab) for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy.

Tremfya (guselkumab)