SM04755 has potential as a topical therapy for psoriasis.

[Fred]

Samumed show preclinical results from in vitro and in vivo studies regarding the use of its small molecule compound SM04755 as a potential topical treatment for psoriasis.

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Samumed presented at the 2016 American College of Rheumatology (ACR) Annual Meeting preclinical results from in vitro and in vivo studies regarding the use of its small molecule compound SM04755 as a potential topical treatment for psoriasis. SM04755 is one of two small molecule Wnt pathway modulators (together with SM04690 which is in clinical trials for osteoarthritis and degenerative disc disease) for which Samumed has presented clinical and/or preclinical data across five different rheumatic diseases.
Psoriasis is an autoimmune disease of the skin, characterized by inflammation and fibrosis, producing patches of red, itchy and scaly skin. (Dees C and Distler JH. Exp Dermatol. 2013;22(11):710-3.) From in vitro studies, SM04755 inhibited inflammation, keratinocyte proliferation, and fibrosis. In an in vivo mouse model, topically applied SM04755 inhibited inflammation, cell proliferation, and decreased skin thickness compared to vehicle. These studies demonstrated that SM04755 has potential as a topical therapy for psoriasis.
Samumed presented, inter alia, the following images related to its in vivo study as part of its presentation at ACR on this potential treatment for psoriasis.

“Based on our study results, we are excited about SM04755’s potential as a treatment for psoriasis. Treatment of mild to moderate psoriasis using a safe and effective topical agent remains an area of intense medical research,” said Yusuf Yazici, M.D., Chief Medical Officer of Samumed. “Our Phase 1 trial for chronic tendinopathy using the same topical investigational drug will form the basis to expand into a Phase 2 study for psoriasis in 2017.”
From in vitro studies, anti-inflammatory activity was evaluated by measuring IL-6 and TNF-α secretion using ELISA in Lipopolysaccharides-stimulated THP-1 monocytes and anti-CD3/anti-CD28-stimulated peripheral blood mononuclear cells. Cytokine-induced keratinocyte proliferation was measured in primary human keratinocytes using an EdU incorporation assay. Finally, the effect on fibrosis was assessed in TGF-β1-stimulated human dermal fibroblasts by measuring smooth muscle actin, plasminogen activator inhibitor, connective tissue growth factor, and collagen expression by qPCR.
In vivo efficacy was evaluated in an imiquimod (IMQ)-induced mouse psoriasis model with daily topical IMQ (0.3mg/cm2) application on the back and ear for 20 days, along with daily treatment with topical SM04755 starting on day 3 after the first IMQ application. Efficacy was assessed by measurement of skin and ear thickness, spleen size and weight, cytokine levels in plasma, and histological measurements of inflammation. Dermal and epidermal thickness were assessed by hematoxylin & eosin staining and proliferation in the skin using bromodeoxyuridine labeling.

Source: samumed.com

[Caroline]

Very interesting.
Seems like a local treatment, without the use of corticosteroids, that may be very nice.

They are missing on the definition, that is a pity, only half the definition is mentioned:

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Psoriasis is an autoimmune disease of the skin, characterized by inflammation and fibrosis, producing patches of red, itchy and scaly skin. (Dees C and Distler JH. Exp Dermatol. 2013;22(11):710-3.)

See? PsA is totally missing. And the red part is totally wrong, as Psoriasis is an auto immune disease.... point... not of the skin, no just an autoimmune disease that a.o. expresses on the skin.

Still if the approach works, it remains interesting.

Jim will be very happy with the tests on the Mice.

[jiml]

Indeed very interesting, a new approach to topical treatment is very welcome ....particularly if unlike steroid based creams, they won't thin the skin, causing long term problems
This will be an interesting one to follow

Agreed it is an autoimmune disease that expresses itself on the skin and in the joints not actually a skin disease as it is often called



ahhh Caroline wrote in my thread RE: Fumaderm and hormone injections