Insufficient evidence to show psoriasis is an independent risk factor of gout

[Fred]

This is a population-based cross-sectional study which set to evaluate the association between psoriasis, serum uric acid levels and gout in a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database.

Quote:

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Background:
Psoriasis has been reported to be associated with raised serum uric acid levels and gout, and uric acid has been demonstrated to mediate inflammatory pathways via secretion of pro-inflammatory chemokines.

Aim:
To evaluate the association between psoriasis, serum uric acid levels and gout in a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database.

Methods:
Data on clinical history of psoriasis, gout and other relevant medical conditions from the questionnaire as well as laboratory parameters for serum uric acid and lipid levels in the periods 2003–2006 and 2011–2012 were analysed. Multivariate analysis with logistic regression modelling was performed, with hyperuricaemia as the dependent variable, and age, sex, ethnicity, body mass index, metabolic syndrome, current smoking status, alcohol consumption and history of psoriasis as the independent variables.

Results:
Of the 11 282 study participants, 297 (2.6%) reported a history of psoriasis and 1493 (13.2%) were found to have hyperuricaemia. Patients with psoriasis were at increased risk of having hyperuricaemia, compared with those without psoriasis (OR = 1.37; P = 0.04). They were also more likely to report a history of gout (OR = 1.83; P < 0.05). However, neither association was significant after adjusting for potential confounders with multivariate logistic regression.

Conclusion:
In conclusion, there was insufficient evidence to show that psoriasis is an independent risk factor of hyperuricaemia or gout. A raised serum uric acid level may be a consequence of metabolic syndrome, which in turn is associated with psoriasis.

Source: onlinelibrary.wiley.com

*Early view funding unknown.

[jiml]

Well I guess that's good news, that we are at no more risk than the rest of the population to get gout.

[Fred]

Well I guess that's good news, that we are at no more risk than the rest of the population to get gout.  

I'll drink to that.

[jiml]

Well I guess that's good news, that we are at no more risk than the rest of the population to get gout.  

I'll drink to that.  

I'll have a large Port

[Fred]

I'll have a large Port

Felixstowe

[jiml]

I'll have a large Port

Felixstowe

larger maybe Dover

[Fred]

I'll have a large Port

Felixstowe

larger maybe Dover

Damn I took a guess on Felixstowe being the largest in your part of the world and was thinking of products not people.

Twiglet?

[Caroline]

I wish I'd paid more attention in the statistics lesson. I don't have a good understanding of what the numbers mean. But I do know that "significance" is a very difficult point and in history more or less arbitrary defined.

[mataribot]

The only thing I got out of stats class how people abuse numbers for their cause.

[Kit]

Well I guess that's good news, that we are at no more risk than the rest of the population to get gout.  

I've already got the T-shirt on this one Jim.  I'm also on tablets for Gout (Allopurinol) which I've had for at least 15 years..... But I'm pleased to say that the gout is totally controlled by the medication. A couple of years back I did an  experiment and stopped taking the Allopurinol for a few days - and sure enough back came the symptoms in my toes.

But whether there is a link between P and gout? Dunno.  Having said that my current Dermatologist (I was assigned a new one recently - hence why I'm back on Fumaderm) nodded sagely and said he wasn't surprised when I reeled off Allopurinol when he asked me to list my current meds.  So maybe he believes there could be a correlation.

The balance of course is to ensure the Allopurinol doseage is sufficient to precisely balance out my average volume of red wine intake. 

Cheers

Kit: