Could S100A12 protein be a biomarker for psoriasis

[Fred]

Here's an interesting study that looked at the S100 group of proteins to see if there is a biomarker for disease activity in patients with psoriasis, it suggests S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis.

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Background:
Psoriasis is a chronic skin disease with deregulation of proteins in the immune system. These proteins include members of the heterogeneous S100 family, which have been discussed as potential biomarkers for disease severity.

Objective:
The aim of this study was to evaluate the impact of S100A7, S100A8, S100A9 and S100A12 as possible markers for disease activity in patients with psoriasis skin disease.

Patients and Methods:
S100A7, S100A8, S100A9 and S100A12 mRNA expression was determined in the skin of patients with psoriasis and controls (N = 341) by gene expression analyses. In addition, S100 serum levels were investigated by ELISA in an independent cohort of psoriasis patients (i) untreated, with different manifestations (skin/joints), (ii) under treatment (etanercept) and (iii) healthy controls, (N = 55).

Results:
All S100-subtypes included are significantly upregulated in psoriasis skin lesions when compared with atopic dermatitis, lichen ruber and healthy donors. In untreated psoriasis patients, S100A12-serum levels showed the closest association with disease activity (PASI) (r = 0.542; P < 0.01). Serum levels decreased under treatment with etanercept (P < 0.05).

Conclusion:
Among the investigated S100-proteins, S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis.

Source: onlinelibrary.wiley.com

Funded by PFIZER GmbH

[jiml]

Another interesting study it's good to see the different directions some of the studies are going ,

[Fred]

Another interesting study it's good to see the different directions some of the studies are going ,

Yes I thought this was a good one, instead of telling us we may have depression, we should loose weight, we could die of heart attack, or we shouldn't drink alcohol. This one is looking at a possibility of trying to work out the reason for us having psoriasis, and could point people in the right direction for a solution in the future.

[Kat]

Another interesting study it's good to see the different directions some of the studies are going ,

Yes I thought this was a good one, instead of telling us we may have depression, we should loose weight, we could die of heart attack, or we shouldn't drink alcohol. This one is looking at a possibility of trying to work out the reason for us having psoriasis, and could point people in the right direction for a solution in the future.

It's good to see a study like this one.