Increased risk of psoriasis in childhood asthma

[Fred]

This Danish cohort study investigated the risk of psoriasis in subjects with childhood asthma, it concludes that there is a significantly increased risk of psoriasis and further studies are warranted to determine the clinical significance and effects of therapeutic interventions.

Quote:

---

Background:
Psoriasis and asthma are disorders driven by inflammation. Psoriasis may carry an increased risk of asthma, but the reverse relationship has not been investigated.

Objectives:
To investigate the risk of psoriasis in subjects with childhood asthma in a nationwide Danish cohort.

Methods:
Data on all Danish individuals aged 6–14 years at study entry between 1 January 1997 and 31 December 2011 (n = 1 478 110) were linked at an individual level in nationwide registers. Incidence rates per 10 000 person-years were calculated, and incidence rate ratios (IRRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by Poisson regression models.

Results:
There were 21 725 cases of childhood asthma and 6586 incident cases of psoriasis. There were 5697 and 889 incident cases of mild and severe psoriasis, respectively. The incidence rates of overall, mild and severe psoriasis were 4·49, 3·88 and 0·61 for the reference population, and 5·95, 5·18 and 0·83 for subjects with childhood asthma, respectively. The IRRs for overall, mild and severe psoriasis were 3·94 [95% confidence interval (CI) 2·16–7·17], 5·03 (95% CI 2·48–10·21) and 2·27 (95% CI 0·61–8·42) for patients with childhood asthma.

Conclusions:
Childhood asthma was associated with a significantly increased risk of psoriasis. Further studies are warranted to determine the clinical significance and effects of therapeutic interventions on this association.

Source: onlinelibrary.wiley.com

*Early view.
Funded by
Pfizer
LEO Foundation
Novo Nordisk Foundation

[Quest4Cure]

This Danish cohort study investigated the risk of psoriasis in subjects with childhood asthma, it concludes that there is a significantly increased risk of psoriasis and further studies are warranted to determine the clinical significance and effects of therapeutic interventions.

Quote:

---

Background:
Psoriasis and asthma are disorders driven by inflammation. Psoriasis may carry an increased risk of asthma, but the reverse relationship has not been investigated.

Objectives:
To investigate the risk of psoriasis in subjects with childhood asthma in a nationwide Danish cohort.

Methods:
Data on all Danish individuals aged 6–14 years at study entry between 1 January 1997 and 31 December 2011 (n = 1 478 110) were linked at an individual level in nationwide registers. Incidence rates per 10 000 person-years were calculated, and incidence rate ratios (IRRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by Poisson regression models.

Results:
There were 21 725 cases of childhood asthma and 6586 incident cases of psoriasis. There were 5697 and 889 incident cases of mild and severe psoriasis, respectively. The incidence rates of overall, mild and severe psoriasis were 4·49, 3·88 and 0·61 for the reference population, and 5·95, 5·18 and 0·83 for subjects with childhood asthma, respectively. The IRRs for overall, mild and severe psoriasis were 3·94 [95% confidence interval (CI) 2·16–7·17], 5·03 (95% CI 2·48–10·21) and 2·27 (95% CI 0·61–8·42) for patients with childhood asthma.

Conclusions:
Childhood asthma was associated with a significantly increased risk of psoriasis. Further studies are warranted to determine the clinical significance and effects of therapeutic interventions on this association.

Source: onlinelibrary.wiley.com

*Early view.
Funded by
Pfizer
LEO Foundation
Novo Nordisk Foundation

Interesting .There are many studies that have showed other immune diseases or systemic diseases are closely related to psoriasis. I wonder if some were hereditary, lifestyle, or geographical .

[jiml]

I can agree that some are hereditary but I think as there seem to be psoriasis sufferers world wide that geographically is not likely, I'm sure you are right that lifestyle contributes to it possibly to the severity

[Quest4Cure]

I can agree that some are hereditary but I think as there seem to be psoriasis sufferers world wide that geographically is not likely, I'm sure you are right that lifestyle contributes to it possibly to the severity

Asthma can be geographical... what I meant not P's. The dust storms in severe drought countries and areas where toxic waste is dumped then housing projects build above them. Most of the U.S. toxic waste today is shipped to India. Children are seen rummaging thru the debris. Made the news reciently as the asthma rates have been climbing in recient years. Any who... Thanks for catch'n that... No fishing allowed!