Enbrel can work after Remicade and Humira

[Fred]

Not an exiting piece of news as this study was funded by Amgen the makers of Enbrel (Etanercept) but it may be helpful to those who have failed on Remicade or Humira.

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Background:
There is a paucity of data on the use of etanercept in patients who have previously failed a different tumour necrosis factor (TNF) alpha antagonist.

Objectives:
To study etanercept in patients who did not achieve a satisfactory response to adalimumab or who lost their response to adalimumab or infliximab and to explore the role of anti-adalimumab and anti-infliximab antibodies in etanercept response.

Methods:
Patients with psoriasis who did not achieve a satisfactory response to adalimumab or who lost their response to adalimumab or infliximab were included. All patients received etanercept 50 mg twice a week for 12 weeks followed by 50 mg once a week for 12 more weeks. Anti-infliximab and anti-adalimumab antibodies were measured at baseline. The primary objective was to study the efficacy of etanercept using the proportion of patients who achieved a physician global assessment (PGA) of 0 or 1.

Results:
A total of 81 patients were included. The proportion of patients who achieved a PGA of 0 or 1 after 24 weeks of etanercept was 20.0% (95% CI 4.8–35.2%) for patients who had an unsatisfactory response to adalimumab, 35.1% (95% CI 19.0–51.3%) and 35.7% (95% CI 7.0–64.4%) for patients who lost their response to adalimumab and infliximab respectively. The proportion of patients who achieved a PGA of 0 or 1 at week 24 was numerically higher for patients who had anti-adalimumab or anti-infliximab antibodies (36.5%) as compared to those without (17.2%; P = 0.08).

Conclusions:
Etanercept can be effective in patients with psoriasis who failed a previous TNF alpha antagonist.

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*Funded by Amgen

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