Epicardial fat & Carotid intima–media thickness in patients with psoriasis

[Fred]

This study published in The British Journal of Dermatology evaluates the association between Epicardial fat thickness (EFT) and Carotid intima–media thickness (CIMT) in patients with psoriasis.

Quote:

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Background:
Carotid intima–media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor.

Objective:
To evaluate the association between EFT and CIMT in patients with psoriasis.

Methods:
This was a cross-sectional and observational study; 65 patients with psoriasis and 50 age- and sex- matched control subjects were included. Data about echocardiographic EFT, CIMT, anthropometric measurements and metabolic profile were obtained.

Results:
The EFT and CIMT were significantly increased (7·3 ± 0·5 vs. 6·5 ± 0·5 mm, P < 0·01; 0·74 ± 0·11 vs. 0·60 ± 0·07 mm, P < 0·01, respectively) in patients with psoriasis compared with the controls. EFT was significantly correlated with CIMT (r = 0·69, P < 0·01). In a multiple linear regression model in which EFT was independently associated with psoriasis (β = 0·45, P < 0·01), age (β = 0·33, P = 0·01), CIMT (β = 0·50, P < 0·01), body mass index (β = 0·25, P = 0·01), high-sensitivity C-reactive protein (β = 0·32, P < 0·01) and duration of disease (β = 0·34, P = 0·03).

Conclusions:
We demonstrated that EFT and CIMT are increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis.

Source: onlinelibrary.wiley.com

[jiml]

This study published in The British Journal of Dermatology evaluates the association between Epicardial fat thickness (EFT) and Carotid intima–media thickness (CIMT) in patients with psoriasis.

Quote:

---

Background:
Carotid intima–media thickness (CIMT) is a potential indicator of subclinical atherosclerosis in patients with psoriasis. Epicardial fat thickness (EFT) is proposed as a new cardiometabolic risk factor.

Objective:
To evaluate the association between EFT and CIMT in patients with psoriasis.

Methods:
This was a cross-sectional and observational study; 65 patients with psoriasis and 50 age- and sex- matched control subjects were included. Data about echocardiographic EFT, CIMT, anthropometric measurements and metabolic profile were obtained.

Results:
The EFT and CIMT were significantly increased (7·3 ± 0·5 vs. 6·5 ± 0·5 mm, P < 0·01; 0·74 ± 0·11 vs. 0·60 ± 0·07 mm, P < 0·01, respectively) in patients with psoriasis compared with the controls. EFT was significantly correlated with CIMT (r = 0·69, P < 0·01). In a multiple linear regression model in which EFT was independently associated with psoriasis (β = 0·45, P < 0·01), age (β = 0·33, P = 0·01), CIMT (β = 0·50, P < 0·01), body mass index (β = 0·25, P = 0·01), high-sensitivity C-reactive protein (β = 0·32, P < 0·01) and duration of disease (β = 0·34, P = 0·03).

Conclusions:
We demonstrated that EFT and CIMT are increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with CIMT in patients with psoriasis. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis.

Source: onlinelibrary.wiley.com

Could anyone break that down into language I can understand, I am sure it's something I ought to know but It could have been written in Chinese and I might have understood more?

[Fred]

Could anyone break that down into language I can understand, I am sure it's something I ought to know but It could have been written in Chinese and I might have understood more?

I’ll have a go.

Atherosclerosis is a disease in which plaque builds up inside your arteries. (Subclinical relates to early stages.)

Carotid intima–media thickness (CIMT) is a measurement of the thickness of the innermost two layers of the arterial wall.

Epicardial fat thickness (EFT) is a measurement of the layer of fat around the heart.

So it’s basically saying that people with psoriasis have higher levels of fat, and a measurement of the Epicardial fat thickness (EFT) via an Echocardiogram (similar to ultrasound) could be a simple way of spotting an early problem with the arteries.

Well that’s my understanding, if anyone else has a better explanation please post here.

[jiml]

Could anyone break that down into language I can understand, I am sure it's something I ought to know but It could have been written in Chinese and I might have understood more?

I’ll have a go.

Atherosclerosis is a disease in which plaque builds up inside your arteries. (Subclinical relates to early stages.)

Carotid intima–media thickness (CIMT) is a measurement of the thickness of the innermost two layers of the arterial wall.

Epicardial fat thickness (EFT) is a measurement of the layer of fat around the heart.

So it’s basically saying that people with psoriasis have higher levels of fat, and a measurement of the Epicardial fat thickness (EFT) via an Echocardiogram (similar to ultrasound) could be a simple way of spotting an early problem with the arteries.

Well that’s my understanding, if anyone else has a better explanation please post here.

Thanks Fred that makes more sense now

[Fred]

Thanks Fred that makes more sense now

You're welcome, couldn't have done that in the evening though after a few glasses.