Amgen dump brodalumab after some patients had suicidal thoughts.

[Caroline]

Welcome ItchyScratchy. How long did the trial go for before it was axed? How long did the brodalumab take to work for both p and psa? Also, when you say clear and no psa, does that mean no psoriasis and no pain? My apologies for the interrogation, but as the drug is new it is good to have a comparison with other drugs. I have reservations about how truthfully pharmaceutical companies portray the efficacy of their wares, so it would be nice to hear it from the horse's mouth.

Cheers,

Bill

If we go by you criteria there wouldn't be any drugs for anyone to take. The real question here is if the drug causes depression or it's just dumb luck that a few reported it.

Sometimes there are just one or two reported cases while thousands benefit from it. This also holds for 2 to 3 cases of PML in relation to DMF, or better... in relation to lymphoma (or lyphonemia, or whatever they call low lymph's) and not following a decent protocol.
There is no statistical proof, just these occasional cases, which is far from a scientific attitude.