Fumaderm and hormone injections

[Bill]

< The 200 mg/kg/day dose of DMF (the only dose tested in the arthritis model and the dose showing elimination of clinical symptoms in the EAE model) was slightly higher than the human dose (~3 fold based on plasma AUC for a different strain, or ~5 fold based on body surface area (mg/m2)), but some anti-inflammatory activity in vivo was observed at lower doses. >

It is contained in a document submitted to the TGA by Biogen. I think that the anti-inflammatory and neuro-protective effects of DMF has led to investigation of its use for traumatic brain injuries.