Fumaderm and hormone injections

[Caroline]

Of course on point #2 of Fred, He thinks he is going the correct proven road with MTX but he doesn't know how dangerous it is. Ask him if he will start using it for two weeks.
It is the DMF that is not dangerous.

I think I'm misunderstanding that comment.  

But just to clarify I wasn't suggesting for one minute Jim goes back onto Methotrexate. I was just saying that no matter what we think they have to follow the rules.

True, but the rules do not state that you are allowed to place the patient deliberately in a more dangerous situation that is necessary.

I have printed out the document that Bill pointed to as it does, rather knock their argument, to put me on mtx

A question for Caroline ....is Fumaderm an immunosuppressant drug like methotrexate is?

Jim,
There are several/many studies on DMF. But the total conclusions remain vague. It is said that is has an immunomodulative... blabla effect and that it seems to affect IL-6 end IL-12 and in the same studies it is said that this conclusion is opposite from other studies.
It is also said that it modulates the IL-17 and I have even heard of IL-23. (whatever those different receptors are for).

Quote:

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In our study, we demonstrate that DMF inhibits MSK1 activation through its upstream protein ERK1/2 (Fig. 7, Point 2). Our observation is in conflict with a study published by Gesser et al. (47) where DMF inhibits MSK1 without affecting p38 or ERK1/2. [/qt] (this stupid endquote does not work). [/qt]

Just picked out of some study. So that brings us....eh

[qt]In conclusion, we demonstrate that DMF inhibits DC maturation and function, and subsequently, suppresses Th1 and Th17 cell differentiation. Further, our molecular data demonstrate that DMF exerts its effect via suppression of both p65 and ERK1/2-MSK1 signaling. Our study provides an important mechanism for the action of DMF in modulating inflammation and provides insight into pathways that are effective targets for therapeutic intervention in inflammatory diseases

lots of the auto immune diseases are inflammatory, P, MS, Crohns, etc.

The article I got it from is called: "Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling"
It is so complex, with so many factors in it that I think it is a miracle that they got a conclusion out of it.
Still I think that my thread on DMF shows a lot of the why it works and is readable bij doctors and patients. Dimethylfumarates and Psoriasis

Specifically this post RE: Dimethylfumarates and Psoriasis, tells something about the misconception of the dermatologists and refers to the studie of Litjens, I don't have access to those studies, but doctors should have that access.