Fumaderm and hormone injections

[jiml]

Just had a phone chat with my dermatologist who has had some inconclusive answers from the makers of Fumaderm. we had a long discussion and agreed to keep on with the tablets and monitor my bloods more closely, and have a meeting in a couple of months to review the situation, if there are any significant changes she will phone me and negotiate the future.
Meantime I will act on Bills suggestion and Email Fumaderm for their slant on the subject.

Just had a letter from my dermatologist who has had a reply from Biogen the makers of Fumaderm they wrote and I quote
"In clinical trials with Fumaderm, patients with malignancies were excluded, thus no reliable study data regarding this topic is available.
The use of Fumaderm in patients with malignacies should be assessed with care. There is no evidence for an increased risk for malignancies under Fumaderm therapy. There are even studies with cell cultures and mouse models that show Fumaderm might be able to decrease the proliferation rate of tumor cells, induce apoptosis and inhibit metastatasis.*
However fumaric acid esters interact with the immunosystem and thus theoretically could also facilitate tumor growth"

* Loewe R et al. Dimethylfumerate impairs melanoma growth and metastasis 2006;66:11888-11896
and YamazoeY et al. Dimethylfumerate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells. 2009; 33:1087-1094

They suggest as you all have that we keep an eye on blood levels and see what happens
My dermotologist suggests if I do have to stop I could go onto acetretin.
I am just confused and dont know if I should continue or not the answer seems ambiguous on the one hand it might inhibit the cancer then in the next sentence it could feed the growth