Sun-24-01-2016, 08:18 AM
It's been two months since I went up to 35mg and the results have been identical. That is, a cyclical therapeutic effect and then a slight reassertion of the rash. Soles and palms in particular have remained as described.
The drug simply has not been effective.
I consulted with my derm today and he suggested my response had changed and suggested methotrexate as the next step.
Now, I accept the proposition that response changes over time and that a drug that works in one context may not work in others. Yet I feel some disquiet considering that for 30 years my response to Acitretin has always been nothing short of miraculous. I posited to my derm that the generic (Novatretin versus Neotigason) was the problem. He dismissed this. He may be right. But again, having used Acitretin on eight previous occasions with the same wonderful effect, this seems hard to believe.
Since it's summer here I'm going to try sun therapy along with a reduced dose of Novatretin (20mg). Then I will try methotrexate.
But I'm still wondering if there are any others who have used Novatrein versus Neotigason (or any other Acitrein product) and found their response to have been different.
The drug simply has not been effective.
I consulted with my derm today and he suggested my response had changed and suggested methotrexate as the next step.
Now, I accept the proposition that response changes over time and that a drug that works in one context may not work in others. Yet I feel some disquiet considering that for 30 years my response to Acitretin has always been nothing short of miraculous. I posited to my derm that the generic (Novatretin versus Neotigason) was the problem. He dismissed this. He may be right. But again, having used Acitretin on eight previous occasions with the same wonderful effect, this seems hard to believe.
Since it's summer here I'm going to try sun therapy along with a reduced dose of Novatretin (20mg). Then I will try methotrexate.
But I'm still wondering if there are any others who have used Novatrein versus Neotigason (or any other Acitrein product) and found their response to have been different.