Health Boards
Mon-22-12-2014, 21:35 PM
Auto-immunity primary or secondary.
If we look at the literature that has been incorporated in the prevalent posts, we can see that it is plausible that the auto immune reaction that is seen with psoriasis, is secondary to a not optimal functioning citric acid cycle. Not only in the skin and in the joints, but also, as we have seen, in the blood cells en possibly even in all tissue.
With an insufficient biological oxidation the forming of free radicals increases resulting in damage of the celmembranes (oxidation of lipoprotein). It has been shown that with psoriasis there is an increased concentration of free radicals in the blood. Anti bodies against, as well as T cell reactions on oxidized lipoproteins and proteins are in these circumstances known with mankind and animal.
How there reactions exactly elapse and how T-cell recognize normal body components and antigenes, when these have been changed by free radicals, is still not sufficiently known. Any way an auto immune reaction following on oxidative membrane damage is a well known phenomena. Adding fumarate repairs the physiological oxidative energyproduction, whereby the substrate for the auto immune reactions, the lipoproteins that were changed by the free radicals, will disappear. This information is of course very interesting, not only for the understanding of the etiology of psoriasis, but also of the etiology of other so-called auto-immune diseases, and of course for the treatment of them. Not to forget the total aging process, which is also powered by free radicals.
Exclusively based on the ground of the immunopathogenic equation with psoriasis on cellular level, dermatologist H.B. The (C: Leading dermatologist in the Netherlands) posited in his thesis that fumarate could possible be effective in the treatment of multiple scleroses. (C: Think of the new medication of Biogen against MS)
One could also connect the relation between fumarate and MS on the basis of another similarity between psoriasis and multiple sclerose, namely that between climate and incidence of both diseases. As in prevalent posts has been tried to show that both diseases have a mitochondrial source, that is also a point of similarity. In the mean time, research has shown that there is a connection concerning the treatment. Schimrigk S et al, told in 2006 about the results of fumarate treatment with ten patients with MS. Seen the positive results of this research, further research on the treatment of MS with fumarate should be done. In the mean time this resulted in new medication.
Kreuter A et al. publicized in 2005 on positive results of fumarate treatment with necrobiosis lipoidica and Venten l et al, had success with fumarate treatment with alopecia areata. Fumarate also has shown its value with some cases of Lichen Sclerosus, CDLE, MCTD and the M. Hailey & Hailey.
If we look at the literature that has been incorporated in the prevalent posts, we can see that it is plausible that the auto immune reaction that is seen with psoriasis, is secondary to a not optimal functioning citric acid cycle. Not only in the skin and in the joints, but also, as we have seen, in the blood cells en possibly even in all tissue.
With an insufficient biological oxidation the forming of free radicals increases resulting in damage of the celmembranes (oxidation of lipoprotein). It has been shown that with psoriasis there is an increased concentration of free radicals in the blood. Anti bodies against, as well as T cell reactions on oxidized lipoproteins and proteins are in these circumstances known with mankind and animal.
How there reactions exactly elapse and how T-cell recognize normal body components and antigenes, when these have been changed by free radicals, is still not sufficiently known. Any way an auto immune reaction following on oxidative membrane damage is a well known phenomena. Adding fumarate repairs the physiological oxidative energyproduction, whereby the substrate for the auto immune reactions, the lipoproteins that were changed by the free radicals, will disappear. This information is of course very interesting, not only for the understanding of the etiology of psoriasis, but also of the etiology of other so-called auto-immune diseases, and of course for the treatment of them. Not to forget the total aging process, which is also powered by free radicals.
Exclusively based on the ground of the immunopathogenic equation with psoriasis on cellular level, dermatologist H.B. The (C: Leading dermatologist in the Netherlands) posited in his thesis that fumarate could possible be effective in the treatment of multiple scleroses. (C: Think of the new medication of Biogen against MS)
One could also connect the relation between fumarate and MS on the basis of another similarity between psoriasis and multiple sclerose, namely that between climate and incidence of both diseases. As in prevalent posts has been tried to show that both diseases have a mitochondrial source, that is also a point of similarity. In the mean time, research has shown that there is a connection concerning the treatment. Schimrigk S et al, told in 2006 about the results of fumarate treatment with ten patients with MS. Seen the positive results of this research, further research on the treatment of MS with fumarate should be done. In the mean time this resulted in new medication.
Kreuter A et al. publicized in 2005 on positive results of fumarate treatment with necrobiosis lipoidica and Venten l et al, had success with fumarate treatment with alopecia areata. Fumarate also has shown its value with some cases of Lichen Sclerosus, CDLE, MCTD and the M. Hailey & Hailey.