Health Boards
Mon-22-12-2014, 20:38 PM
Persistant misconception,
As long as the scientific research for the influence of fumarate on the citric acid cycle and for the influence of it on the body temperature, c.q. of the basic metabolism is not done, the application of fumarates will hardly be done in the normal dermatological practice, as it is seen by dermatologists as an immunosuppressor, with the accompanying chance on damaging side effects (C:which there aren't).
The conclusion from the research of Litjens that there is hardly any evidence of damaging side effects, will therefore be ignored.
The years old misconception will continue to exist and, as is mentioned on the leaflet of the fumarate marketed version by Tiofarma, that says that the medication should only be used if all other medications have failed and then it should be only used under specialized monitoring. (C: This is what I really heard from the rheumatologist
)
Additional disadvantage of this way of working is, that serious liver- or kidney function disruptions can have been caused by these "usual" therapies that have harmed the health of the patient in such a serious way that the treatment with fumarates is too late.
Ciclosporine cannot be used for longer than a year because of the nefrotoxical action and cumulative toxicity; that is an absolute rule. With long term use there is a risk of the genesis of malignant neoplasm. These risks can also appear in relation to the 'biologicals', though there is large progress made over there. (C: this is the opinion of the original author.)
For many well-informed patients with psoriasis, this could be a reason never to start at those medications (C: I mean like cyclosporine over here).
However in the dermatological practice, ciclosporine is still often prescribed, anyway much more often than fumarates. The costly 'biologicals' are being pushed by the strong industrial lobby, withhout much attention for this important shadowside. (C: this is the opinion of the original author.)
Important signals when using medication that is exclusively developed for the suppression of the immune system can be found in repeated respiratory infections and badly healing wounds. The increased incidence of Borrelia infection and the alarming spreading of the MRSA bacteria via pig to human, do make the use of immune suppressors in this time not very attractive.
Increased vulnerability for infections with the many hundreds Psorinovo (DMF) users however, has never shown up in the past 30 years.
As long as the scientific research for the influence of fumarate on the citric acid cycle and for the influence of it on the body temperature, c.q. of the basic metabolism is not done, the application of fumarates will hardly be done in the normal dermatological practice, as it is seen by dermatologists as an immunosuppressor, with the accompanying chance on damaging side effects (C:which there aren't).
The conclusion from the research of Litjens that there is hardly any evidence of damaging side effects, will therefore be ignored.
The years old misconception will continue to exist and, as is mentioned on the leaflet of the fumarate marketed version by Tiofarma, that says that the medication should only be used if all other medications have failed and then it should be only used under specialized monitoring. (C: This is what I really heard from the rheumatologist
)Additional disadvantage of this way of working is, that serious liver- or kidney function disruptions can have been caused by these "usual" therapies that have harmed the health of the patient in such a serious way that the treatment with fumarates is too late.
Ciclosporine cannot be used for longer than a year because of the nefrotoxical action and cumulative toxicity; that is an absolute rule. With long term use there is a risk of the genesis of malignant neoplasm. These risks can also appear in relation to the 'biologicals', though there is large progress made over there. (C: this is the opinion of the original author.)
For many well-informed patients with psoriasis, this could be a reason never to start at those medications (C: I mean like cyclosporine over here).
However in the dermatological practice, ciclosporine is still often prescribed, anyway much more often than fumarates. The costly 'biologicals' are being pushed by the strong industrial lobby, withhout much attention for this important shadowside. (C: this is the opinion of the original author.)
Important signals when using medication that is exclusively developed for the suppression of the immune system can be found in repeated respiratory infections and badly healing wounds. The increased incidence of Borrelia infection and the alarming spreading of the MRSA bacteria via pig to human, do make the use of immune suppressors in this time not very attractive.
Increased vulnerability for infections with the many hundreds Psorinovo (DMF) users however, has never shown up in the past 30 years.