Health Boards
Mon-22-12-2014, 19:38 PM
Side effects are in fact the desired effect which is a bit too strong
It is the question why the stimulating effect of fumarate on the citric acid cycle is seen as an obsolete theory in the literature (Caroline comment: Indeed very strange, nothing happens without a reason in our bodies, so that is a stupid consideration). Possibly the idea has taken hold that the attempts to treat psoriasis with fumaric acid (DMF) did not show results but only gastro-intestinal complaints. A publication on this subject is missing.
What is a fixed result is that Schweckendieck really did get good results with the fumaric acid treatments and only later stepped over to the use of fumarates.
The arguments given for this and the publications on it do plead for the stimulating effect/action of fumarates on the citric acid cycle and against the feared long term effects, that are common with immuno suppression (this is where many dermatologists are afraid of, but they just don't have enough knowledge on this subject).
The years of practical experience of the (original) author and of internal disease specialist dr. F. van Loon, support this vision.
There are only transient 'negative' effects, like mucosal irritations, "flushing" and slight deviations of the normal blood picture, which immediately return to normal when stopping the treatment. This also happens when the treatment is continued, though slowly. The side effect is in this case a wished effect that is a bit too strong. With a controlled accompaniment this can be caught.
When there is a large occurrence of diarrhoea, there is an indication to execute a bacteriological and parasitic faeces examination. A pre-existent, masked intestine infection might have become manifest under the DMF treatment and should of course be treated.
It is the question why the stimulating effect of fumarate on the citric acid cycle is seen as an obsolete theory in the literature (Caroline comment: Indeed very strange, nothing happens without a reason in our bodies, so that is a stupid consideration). Possibly the idea has taken hold that the attempts to treat psoriasis with fumaric acid (DMF) did not show results but only gastro-intestinal complaints. A publication on this subject is missing.
What is a fixed result is that Schweckendieck really did get good results with the fumaric acid treatments and only later stepped over to the use of fumarates.
The arguments given for this and the publications on it do plead for the stimulating effect/action of fumarates on the citric acid cycle and against the feared long term effects, that are common with immuno suppression (this is where many dermatologists are afraid of, but they just don't have enough knowledge on this subject).
The years of practical experience of the (original) author and of internal disease specialist dr. F. van Loon, support this vision.
There are only transient 'negative' effects, like mucosal irritations, "flushing" and slight deviations of the normal blood picture, which immediately return to normal when stopping the treatment. This also happens when the treatment is continued, though slowly. The side effect is in this case a wished effect that is a bit too strong. With a controlled accompaniment this can be caught.
When there is a large occurrence of diarrhoea, there is an indication to execute a bacteriological and parasitic faeces examination. A pre-existent, masked intestine infection might have become manifest under the DMF treatment and should of course be treated.