Health Boards
Sun-03-06-2012, 17:47 PM
In 1985 the first large clinical research with fumarate was publicized in the netherlands by the original author of this post, dr. L. Kunst. This research was an open trial.
He described the positive effect of DMF with 100 psoriasis patients in his practice. By means of several tests he was able to conclude that DMF was the most active component of the combination preparate.
Together with F. Durlinger, pharmacist, he developed the, only DMF containing preparate, psorinovo.
It concerns a dosage form that provides a gradual as possible release of the active substances in the gut and then into the circulation.
In the tablet are DMF and a catalyst to promote biological oxidation. A special coating of the tablet prevents premature disintegration in the stomach.
The generic name of psorinovo is dimethylfumarate enteric coated slow release.
Because from the beginning on there was a difference in opinion on the mechanism of fumarate, the author in 1985 posted the open question on how this mechanism is working.
The last sentence of his article reads:"This aspect can only be studied in a scientific researchcentre, where e.g. are possibilities to observe the mechanism in celcultures." For long time then it remained a little silent on fumaric acid.
He described the positive effect of DMF with 100 psoriasis patients in his practice. By means of several tests he was able to conclude that DMF was the most active component of the combination preparate.
Together with F. Durlinger, pharmacist, he developed the, only DMF containing preparate, psorinovo.
It concerns a dosage form that provides a gradual as possible release of the active substances in the gut and then into the circulation.
In the tablet are DMF and a catalyst to promote biological oxidation. A special coating of the tablet prevents premature disintegration in the stomach.
The generic name of psorinovo is dimethylfumarate enteric coated slow release.
Because from the beginning on there was a difference in opinion on the mechanism of fumarate, the author in 1985 posted the open question on how this mechanism is working.
The last sentence of his article reads:"This aspect can only be studied in a scientific researchcentre, where e.g. are possibilities to observe the mechanism in celcultures." For long time then it remained a little silent on fumaric acid.