Psoriasis in one location and years later in other places on human body?

[Caroline]

Does anyone notice psoriasis, and dupytren’s at ring finger and palm, and female hyperplasia? Or psoriasis started in one location, then collagen overgrowth of skin cells in another location some years later, like it spreads over several years? He’s anyone used gene therapy. Has anyone had genetic mapping to find alleles or amino acid sequences that are not normal. Gene mapping is about $700.00 in the Los Angeles, California area clinics and San Francisco clinics. Currently gene mapping is commonly used to find breast cancer such as Brac. I read up to 25%of people in Great Britain have collagen overgrowth issue in the palm of one of their hands during their lifetime.

Hello Avatar,

Welcome to Psoriasisclub.

Psoriasis has the ability to spread.
I don't know of anyone who has his gene  mapped in relation to psoriasis. That used to be expensive but it is very important to know where you would have to look.

I do know about research that has been done in Amsterdam on genes concerning psoriasis, which has been done by Hanna Niehues.
Below some quotes out of that research.

----------
The question the researchers ask themselves is: which DNA abnormality gives rise to a greater chance of psoriasis.

There are already about 50 known risk factors for Psoriasis. However, none of them are sure to cause Psoriasis. It is also known that people with the genetic abnormality in question do not necessarily have to get Psoriasis, just as there are people without the abnormality who do get Psoriasis.

Many of the risk factors are simple triggers, damage to the skin, environmental factors, bacterial infection in the oral cavity, or throatitis while the psoriasis manifests on the skin. There is evidence that certain pieces of a streptococcus are very similar to proteins that the skin itself produces. The immune system goes against the streptococcus, but may think that the protein in the skin should also be attacked, this is one of the thoughts why psoriasis can develop after such an infection.

Hanna became involved in this department and this research from her studies as an intern. In 2009, it was found that there is a genetic relationship, the LCE (Late Cornified Envelope) deletion, a mutation that lacks two LCE gene sets), which is more likely to develop Psoriasis. A previous researcher was already working on this topic and Hanna has become interested in it and has continued the research.
----------

The article is much longer, but above shows that there may be a higher incidence with psoriasis if you have that gene deviation.